52,450 results match your criteria age fetuses


The fetal outcomes after neoadjuvant platinum and paclitaxel chemotherapy during pregnancy: analysis of three cases and review of the literature.

Arch Gynecol Obstet 2021 Jun 11. Epub 2021 Jun 11.

Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, 17 Qihelou St, Dongcheng District, Beijing, 100006, China.

Objective: Data on the outcomes of fetus who are exposed to neoadjuvant platinum and paclitaxel chemotherapy during pregnancy are lacking.

Methods: Relevant data were abstracted from patients in our institution, PubMed, Embase and Cochrane Library databases. The primary assessment was the frequency of fetal death and congenital abnormalities. Read More

View Article and Full-Text PDF

[Application of extracorporeal membrane oxygenation in critically ill pregnant women].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):605-608

Department of Intensive Care Unit, Nanjing Drum Tower Hospital, the Affiliated Hospital to Nanjing University Medical School, Nanjing 210009, Jiangsu, China. Corresponding author: Gu Qin, Email:

Objective: To investigate the safety and effectiveness of extracorporeal membrane oxygenation (ECMO) in emergency treatment of critically ill pregnant women.

Methods: Clinical data of 8 pregnant women with severe cardiopulmonary dysfunction during the perinatal period treated by ECMO in the department of intensive care unit (ICU) of Nanjing Drum Tower Hospital, the Affiliated Hospital to Nanjing University Medical School from September 2017 to November 2020 were retrospectively analyzed.

Results: For the 8 pregnant women, the mean age was (32. Read More

View Article and Full-Text PDF

Isolated CHDs and neurodevelopmental follow-up using the Bayley Scales of Infant and Toddler Development and the Ages and Stages Questionnaire at 18 and 36 months.

Cardiol Young 2021 Jun 11:1-8. Epub 2021 Jun 11.

Institute for Clinical Medicine, Aarhus University, Aarhus, Denmark.

Objectives: To compare early neurocognitive development in children born with and without isolated CHD using the Bayley Scales of Infant and Toddler Development (3rd edition) and the Ages and Stages Questionnaire (3rd edition).

Methods: Recruitment took place before birth. Women expecting fetuses with and without CHD causing disturbances in the flow of oxygenated blood to the fetal brain were included in a prospective cohort study comprising fetal MRI (previously published) and neurodevelopmental follow-up. Read More

View Article and Full-Text PDF

A Novel Model of Fetal Spinal Cord Exposure Allowing for Long-Term Postnatal Survival.

Fetal Diagn Ther 2021 Jun 10:1-7. Epub 2021 Jun 10.

Department of Surgery, University of California-Davis, Sacramento, California, USA.

Background: The inherent morbidity associated with fetal ovine models of myelomeningocele (MMC) has created challenges for long-term survival of lambs. We aimed to develop a fetal ovine surgical spinal exposure model which could be used to evaluate long-term safety after direct spinal cord application of novel therapeutics for augmentation of in utero MMC repair.

Methods: At gestational age (GA) 100-106, fetal lambs underwent surgical intervention. Read More

View Article and Full-Text PDF

A Case of Balanced Translocation: 46, XY, t(9;22) (q22;q13) Accompanied with Oligospermia and Asthenospermia.

Clin Lab 2021 Jun;67(6)

Background: Balanced translocation of chromosomes has a negative impact on male fertility, which can easily cause clinical manifestations such as oligospermia and asthenospermia. It is necessary to conduct cytogenetic examination on men of childbearing age to guide them in their fertility.

Methods: We report a case of balanced translocation: 46, XY, t(9;22) (q22;q13) accompanied with oligospermia and asthenospermia. Read More

View Article and Full-Text PDF

Three-Dimensional Sonographic Evaluation of the Position of the Fetal Conus Medullaris at First Trimester.

Fetal Diagn Ther 2021 Jun 9:1-8. Epub 2021 Jun 9.

Department of Medicine and Surgery, Obstetrics and Gynecology Unit, University of Parma, Parma, Italy.

Objective: The objective of this study was to assess the position of the conus medullaris (CM) at the first trimester 3D ultrasound in a cohort of structurally normal fetuses.

Methods: This was a multicenter prospective study involving a consecutive series of structurally normal fetuses between 11 and 13 weeks of gestation (CRL between 45 and 84 mm). All fetuses were submitted to 3D transvaginal ultrasound using a sagittal view of the spine as the starting plane of acquisition. Read More

View Article and Full-Text PDF

Randomized Trial of Fetal Surgery for Severe Left Diaphragmatic Hernia.

N Engl J Med 2021 Jun 8. Epub 2021 Jun 8.

From the Department of Obstetrics and Gynecology, KU Leuven (J.A.D., F.M.R.) and Academic Department of Development and Regeneration, Biomedical Sciences, University Hospitals KU Leuven, Leuven, Belgium (J.A.D., B.V.C., F.M.R.); King's College Hospital (K.H.N.) and the Institute for Women's Health, University College London Hospital (J.A.D.) - both in London; Hospital Antoine-Béclère, Université Paris-Saclay, Clamart, France (A.B.); Hospital Clinic and Sant Joan de Déu, Barcelona (E.G.); Mount Sinai Hospital, Toronto (G.R.); Hospital Maggiore Policlinico, Milan (N.P.); the National Center for Child Health and Development, Tokyo (H.S.); Children's Memorial Hermann Hospital, Houston (A.J.); the Medical University of Warsaw, Warsaw, Poland (M.W.); and University Hospital Bonn, Bonn, Germany (C.B.).

Background: Observational studies have shown that fetoscopic endoluminal tracheal occlusion (FETO) has been associated with increased survival among infants with severe pulmonary hypoplasia due to isolated congenital diaphragmatic hernia on the left side, but data from randomized trials are lacking.

Methods: In this open-label trial conducted at centers with experience in FETO and other types of prenatal surgery, we randomly assigned, in a 1:1 ratio, women carrying singleton fetuses with severe isolated congenital diaphragmatic hernia on the left side to FETO at 27 to 29 weeks of gestation or expectant care. Both treatments were followed by standardized postnatal care. Read More

View Article and Full-Text PDF

Randomized Trial of Fetal Surgery for Moderate Left Diaphragmatic Hernia.

N Engl J Med 2021 Jun 8. Epub 2021 Jun 8.

From the Department of Obstetrics and Gynecology, University Hospitals KU Leuven (J.A.D., P.L.J.D.) and Academic Department of Development and Regeneration, Biomedical Sciences, KU Leuven, Leuven, Belgium (J.A.D., B.V.C., P.L.J.D.); Hospital Antoine-Béclère, Université Paris-Saclay, Clamart (A.B.), and Necker-Enfants Malades Hospital, Paris (Y.V.) - both in France; Hospital Clinic and Sant Joan de Déu, Barcelona (E.G.); Institute for Women's Health, University College London Hospital (J.A.D.) and King's College Hospital(K.H.N.) - both in London; the University Hospital Bonn, Bonn, Germany (C.B.); Hospital Maggiore Policlinico, Milan (N.P.), and Bambino Gesù Children's Hospital, Rome (F.M.) - both in Italy; Baylor College of Medicine and Texas Children's Hospital (M.B.) and Children's Memorial Hermann Hospital (A.J.) - all in Houston; Mater Mothers' Hospital, Brisbane, QLD, Australia (G.J.G.); the Medical University of Warsaw, Warsaw, Poland (M.W.); and Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands (P.L.J.D.).

Background: Fetoscopic endoluminal tracheal occlusion (FETO) has been associated with increased postnatal survival among infants with severe pulmonary hypoplasia due to isolated congenital diaphragmatic hernia on the left side, but data are lacking to inform its effects in infants with moderate disease.

Methods: In this open-label trial conducted at many centers with experience in FETO and other types of prenatal surgery, we randomly assigned, in a 1:1 ratio, women carrying singleton fetuses with a moderate isolated congenital diaphragmatic hernia on the left side to FETO at 30 to 32 weeks of gestation or expectant care. Both treatments were followed by standardized postnatal care. Read More

View Article and Full-Text PDF

Diagnosing antenatal fetal distress.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Erzincan Binali Yildirim University Mengucek Gazi Training and Research Hospital, Department of Gynecology and Obstetrics, Turkey.

Objectives: The values of acceleration capacity and deceleration capacity are known to capture fetal neurological development. The fetal growth restriction was found to be featured by decreased variables of phase rectified signal averaging. We have speculated that acceleration capacity and deceleration capacity could be of use in the detection of antenatal fetal distress during fetal growth restriction. Read More

View Article and Full-Text PDF

Diagnostic performance of cerebroplacental and umbilicocerebral ratio in appropriate for gestational age and late growth restricted fetuses attempting vaginal delivery: a multicenter, retrospective study.

J Matern Fetal Neonatal Med 2021 Jun 8:1-7. Epub 2021 Jun 8.

Fetal Medicine Unit, Maternal and Child Health and Development Network, Department of Obstetrics and Gynecology, University Hospital 12 de Octubre, Complutense University of Madrid, Madrid, Spain.

Background: Cerebroplacental Doppler studies have been advocated to predict the risk of adverse perinatal outcome (APO) irrespective of fetal weight.

Objective: To report the diagnostic performance of cerebroplacental (CPR) and umbilicocerebral (UCR) ratios in predicting APO in appropriate for gestational age (AGA) fetuses and in those affected by late fetal growth restriction (FGR) attempting vaginal delivery.

Study Design: Multicenter, retrospective, nested case-control study between 1 January 2017 and January 2020 involving five referral centers in Italy and Spain. Read More

View Article and Full-Text PDF

[Analysis of the clinical perinatal characteristics of 226 patients with Prader-Willi syndrome in China].

Zhonghua Er Ke Za Zhi 2021 Jun;59(6):466-470

Department of Pediatrics, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To enhance the early recognition of Prader-Willi syndrome by summarizing the clinical characteristics of Prader-Willi syndrome (PWS) during perinatal period. Through a nationwide cross-sectional study in the Department of Pediatrics, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences,226 children diagnosed as PWS by molecular genetics were recruited from September 2019 to March 2020. Clinical data including fetuses Age, birth weight, fetal movement, fetal position, amniotic fluid, mode of bith, crying, muscle tension, feeding, and cryptorchidism were collected to analyze the clinical characteristics of Chinese PWS patients in the perinatal period, and according to the mode of birty, birth weight and genotypes to perform subgroup analysis. Read More

View Article and Full-Text PDF

Perinatal Outcome and its Prediction Using Longitudinal Feto-Maternal Doppler Follow-Up in Late Onset Small for Gestational Age Fetuses - A Prospective Cohort Study.

Ultraschall Med 2021 Jun 8. Epub 2021 Jun 8.

Department of Pediatric Cardiology and Congenital Heart Defects, German Heart Centre Munich, München, Germany.

Purpose:  To describe the perinatal outcome of a prospective cohort of late-onset small-for-gestational-age (SGA) fetuses and to test adverse perinatal outcome (APO) prediction using Doppler measurements.

Methods:  Singleton pregnancies from 32 weeks with suspicion of SGA (followed-up each 2 weeks) and randomly selected healthy controls at a university hospital were included. The whole SGA group was divided into the FGR subgroup or SGA percentile 3-10 subgroup. Read More

View Article and Full-Text PDF

Can developmental dysplasia of the hip be identified in the prenatal period? A pilot study: Ultrasonographic evaluation and postnatal follow-up results of fetal hips in the third trimester.

Acta Orthop Traumatol Turc 2021 May;55(3):196-200

Department of Orthopedics and Traumatology, Hitit University, School of Medicine, Çorum, Turkey.

Objective: This study aimed to determine the predictability of developmental dysplasia of the hip (DDH) in the prenatal period by means of evaluating fetal hips using the Graf method on obstetric ultrasonography (US) after the 34th week of gestation.

Methods: A total of 84 pregnant women (mean age = 27.04; age range = 19-46 years), who were referred to our radiology clinic for an obstetric US examination in the third trimester, and their fetuses were included in this study. Read More

View Article and Full-Text PDF

Individualized growth assessment in pregnancies complicated by fetal gastroschisis.

J Matern Fetal Neonatal Med 2021 Jun 7:1-11. Epub 2021 Jun 7.

Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA.

Objective: Prenatal ultrasound (US) has been shown to overestimate the incidence of suspected fetal growth restriction (FGR) in gastroschisis cases. This is largely because of altered sonographic abdominal circumference (AC) measurements when comparing gastroschisis cases with population nomograms. Individualized Growth Assessment (IGA) evaluates fetal growth using serial US measurements that allow consideration of the growth potential for a given case. Read More

View Article and Full-Text PDF

Contemporary Outcomes in Tetralogy of Fallot With Absent Pulmonary Valve After Fetal Diagnosis.

J Am Heart Assoc 2021 Jun 8:e019713. Epub 2021 Jun 8.

Division of Cardiology Children's National HospitalDepartment of PediatricsGeorge Washington University School of Medicine and Health Sciences Washington DC.

Background Tetralogy of Fallot with absent pulmonary valve is associated with high mortality, but it remains difficult to predict outcomes prenatally. We aimed to identify risk factors for mortality in a large multicenter cohort. Methods and Results Fetal echocardiograms and clinical data from 19 centers over a 10-year period were collected. Read More

View Article and Full-Text PDF

Characterization of hemodynamic patterns in human fetuses with cyanotic congenital heart disease using MRI.

Ultrasound Obstet Gynecol 2021 Jun 7. Epub 2021 Jun 7.

Division of Paediatric Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada.

Objectives: To characterize the distribution of blood flow and oxygen transport in human fetuses with congenital heart disease (CHD) subtypes that present with neonatal cyanosis using magnetic resonance imaging (MRI).

Methods: Blood flow was measured in the major vessels of 152 late gestation human fetuses with CHD and 40 gestational age-matched normal fetuses using cine phase contrast MRI. Oxygen saturation (SaO2) was measured in the major vessels of 57 fetuses with CHD and 40 controls. Read More

View Article and Full-Text PDF

Automated quantitative evaluation of atrioventricular annular plane systolic excursion in human fetuses.

Ultrasound Obstet Gynecol 2021 Jun 7. Epub 2021 Jun 7.

Department of Clinical Science, Intervention and Technology - CLINTEC, Karolinska Institutet, Stockholm, Sweden.

Objectives: The primary aim of this study was to evaluate the feasibility of measuring fetal atrioventricular plane displacement (AVPD) using an automated analysis software. The secondary objectives were to establish reference ranges for AVPD during the second half of normal pregnancy, assess fetal AVPD in prolonged pregnancies in relation to adverse perinatal outcome and in fetuses with a suspicion of intrauterine growth restriction (IUGR).

Methods: The reference population consisted of women with uncomplicated pregnancies at 18-42 weeks of gestation (n=201). Read More

View Article and Full-Text PDF

Maternal and fetal outcome of burn during pregnancy: 3 report from Kermanshah, Iran.

Int J Burns Trauma 2021 15;11(2):90-95. Epub 2021 Apr 15.

Department of Pediatrics, Imam Reza Hospital, Kermanshah University of Medical Sciences Kermanshah, Iran.

Objective: Burn injuries in the course of pregnancy can lead to significant complications and mortality for both mother and fetus. Mortality and morbidity depend on the severity of burn. The current article is the third report authored on burn during pregnancy from Kermanshah, Iran. Read More

View Article and Full-Text PDF

Neuropathological hallmarks of fetal hydrocephalus linked to CCDC88C pathogenic variants.

Acta Neuropathol Commun 2021 Jun 6;9(1):104. Epub 2021 Jun 6.

UNIROUEN, Inserm U1245 and Rouen University Hospital, Department of Genetics and Reference Center for Developmental Disorders, Normandy Center for Genomic and Personalized Medicine, Normandie Univ, 76000, Rouen, France.

The prevalence of congenital hydrocephalus has been estimated at 1.1 per 1000 infants when including cases diagnosed before 1 year of age after exclusion of neural tube defects. Classification criteria are based either on CSF dynamics, pathophysiological mechanisms or associated lesions. Read More

View Article and Full-Text PDF

Combined exome sequencing and deep phenotyping in highly selected fetuses with skeletal dysplasia during the first and second trimesters improves diagnostic yield.

Prenat Diagn 2021 Jun 6. Epub 2021 Jun 6.

Department of Obstetrics and Gynecology, 1st Medical Center of Chinese PLA General Hospital, Beijing, China.

Objective: To investigate the genetic etiology of skeletal dysplasia in highly selected fetuses during the first and second trimesters using deep phenotyping and exome sequencing (ES).

Method: Fetuses with short femurs were identified using the established prenatal diagnostic approach. A multidisciplinary team reviewed fetal phenotypic information (prenatal ultrasound findings, fetal postmortem, and radiographs) in a cohort of highly selected fetuses with skeletal dysplasia during the first and second trimesters. Read More

View Article and Full-Text PDF

Intrapulmonary artery Doppler to predict mortality and morbidity in fetuses with mild and moderate left-sided congenital diaphragmatic hernia.

Ultrasound Obstet Gynecol 2021 Jun 5. Epub 2021 Jun 5.

Fetal i+D Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu),, Institut Clínic de Ginecologia, Obstetricia i Neonatologia, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain.

Objective: In fetuses with left-sided isolated congenital diaphragmatic hernia (LCDH), prenatal detection of severe pulmonary hypoplasia is relevant since fetal therapy can improve survival. Moderate and mild hypoplasia still carry a considerable mortality and morbidity risk, but there has been less interest in the accurate prediction of these. In this study on fetuses with moderate or mild CDH, we aimed to investigate: (1) the correlation between intra-pulmonary-artery Doppler (IPaD) findings and mortality, (2) whether adding these improves prediction of mortality based on lung size and liver herniation; and (3) whether the IPaD correlates with early neonatal morbidity. Read More

View Article and Full-Text PDF

Guideline No. 420: Cytomegalovirus Infection in Pregnancy.

J Obstet Gynaecol Can 2021 Jun 2. Epub 2021 Jun 2.

Calgary, AB.

Objective: To provide an update on current recommendations for cytomegalovirus (CMV) infection during pregnancy. The objectives of this guideline are: To improve perinatal care providers' awareness of the consequences of maternal CMV infection for the fetus and the infant; To emphasize the importance of educating patients about how to prevent CMV acquisition during pregnancy To raise perinatal care providers' awareness of new developments in CMV screening and treatment To highlight that a substantial proportion of disability due to congenital CMV (cCMV) can be modified to some extent TARGET POPULATION: Patients of child-bearing age, pregnant patients, and patients planning a pregnancy.

Benefits, Harms, And Costs: The patient partners urged us to make awareness of preventive strategies a high priority, despite concern that discussing CMV with patients could cause unnecessary anxiety. Read More

View Article and Full-Text PDF

Guideline No. 420 :  Cytomegalovirus Infection in Pregnancy.

J Obstet Gynaecol Can 2021 Jun 2. Epub 2021 Jun 2.

Calgary, AB.

Objective: To provide an update on current recommendations for cytomegalovirus (CMV) infection during pregnancy. The objectives of this guideline are: To improve perinatal care providers' awareness of the consequences of maternal CMV infection for the fetus and the infant; To emphasize the importance of educating patients about how to prevent CMV acquisition during pregnancy To raise perinatal care providers' awareness of new developments in CMV screening and treatment To highlight that a substantial proportion of disability due to congenital CMV (cCMV) can be modified to some extent Target Population: Patients of child-bearing age, pregnant patients, and patients planning a pregnancy.

Benefits, Harms, And Costs: The patient partners urged us to make awareness of preventive strategies a high priority, despite concern that discussing CMV with patients could cause unnecessary anxiety. Read More

View Article and Full-Text PDF

Neonatal lymphocyte subpopulations analysis and maternal preterm premature rupture of membranes: a pilot study.

Clin Chem Lab Med 2021 Jun 4. Epub 2021 Jun 4.

Neonatal Intensive Care Unit, Department of Women's and Children's Health, University of Padova, Padova, Italy.

Objectives: Preterm premature rupture of membranes (pPROM) causes preterm delivery, and increases maternal T-cell response against the fetus. Fetal inflammatory response prompts maturation of the newborn's immunocompetent cells, and could be associated with unfavorable neonatal outcome. The aims were to examine the effects of pPROM (Mercer BM. Read More

View Article and Full-Text PDF

Abnormal umbilical cord insertions in singleton deliveries: placental histology and neonatal outcomes.

J Clin Pathol 2021 Jun 3. Epub 2021 Jun 3.

Obstetrics and Gynecology Clinic, Padua University Hospital, Padova, Italy.

Aims: This study aimed to identify any microscopic features associated with abnormal (membranous/velamentous or marginal) placental cord insertions and to analyse their adverse neonatal outcomes.

Methods: We retrospectively analysed the records-including pathological findings, clinical information and pregnancy outcomes-for 1060 singleton pregnancies, involving newborn delivered after 24 weeks of gestation.

Results: Marginal cord insertions were identified in 26. Read More

View Article and Full-Text PDF

Quantifying Proximal Collecting Tubule Deficiency in Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Fetopathy.

Pediatr Dev Pathol 2021 Jun 3:10935266211018922. Epub 2021 Jun 3.

Division of Anatomical Pathology, British Columbia Children's Hospital and Women's Hospital and Health Center, Vancouver, Canada.

Introduction: Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers (AAs) are used for several indications, with cessation recommended in pregnancy due to toxic effects. AA fetopathy phenotype is similar to renal tubular dysgenesis including reduced proximal convoluted tubules (PCTs). Our study aimed to quantify the reduction of PCTs in fetuses and infants with prenatal exposure to AAs. Read More

View Article and Full-Text PDF

Interval growth across gestation in pregnancies with fetal gastroschisis.

Am J Obstet Gynecol MFM 2021 May 31:100415. Epub 2021 May 31.

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco.

Background: Gastroschisis is frequently complicated by fetal growth restriction, preterm delivery, and prolonged neonatal hospitalization. Prenatal management and delivery decisions are often based upon estimated fetal weight and interval growth, however appropriate interval growth from week to week across gestation for these fetuses is poorly understood.

Objectives: To determine the median increase in overall estimated fetal weight and individual biometric measurements across each week of gestation in pregnancies with fetal gastroschisis, and to assess if lower in utero fetal weight gain is predictive of postnatal growth or adverse neonatal outcomes. Read More

View Article and Full-Text PDF

[Sleep apnea syndrome, pregnancy and fetal condition].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(4. Vyp. 2):103-109

Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.

Objective: To assess fetal cardiac activity with simultaneous polysomnographic (PSG) study of pregnancy with obstructive sleep apnea syndrome (OSAS).

Materials And Methods: Forty-nine women, aged 18-30 years, 30-34 weeks pregnant, complaining of snoring, with a positive rating in 2 and/or 3 sections of the Berlin Sleep Questionnaire were included in the study. Sixteen pregnant women with the corresponding gestational age, without complaints of snoring, made up the control group. Read More

View Article and Full-Text PDF

Risk factors for stillbirth after 28 complete weeks of gestation.

J Matern Fetal Neonatal Med 2021 Jun 1:1-5. Epub 2021 Jun 1.

Department of Pediatrics, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Purpose: To identify the risk factors for stillbirth (SB).

Material And Methods: This case-control study was carried out between 1 December 2019 and 30 April 2020. Women whose fetuses died after the 28 week of gestation, but before delivery and women whose newborns were alive and healthy after delivery were examined. Read More

View Article and Full-Text PDF

Prenatal intracranial hypotension syndrome: new insights into the mechanisms of fenestration of septi pellucidi and ventriculomegaly in fetuses with open spinal dysraphism.

J Matern Fetal Neonatal Med 2021 Jun 1:1-7. Epub 2021 Jun 1.

FETALMED - Maternal-Fetal Diagnostic Center, Fetal Imaging Unit, Santiago, Chile.

Objective: To study the prevalence of abnormalities of the septi pellucidi (SP) in a cohort of fetuses with open spinal dysraphism (OSD) and to determine whether this condition is secondary to obstructive ventriculomegaly and, therefore, part of the natural history of prenatal intracranial hypotension (PICH) syndrome.

Methods: Magnetic resonance imaging (MRI) studies from fetuses with OSD were analyzed. The SP were assessed using axial and coronal T2-weighted images of the fetal brain and classified as intact, partially absent, or completely absent. Read More

View Article and Full-Text PDF