206,502 results match your criteria age distribution


Anatomic Distribution of Cherry Angiomas in the General Population.

Dermatology 2021 Jul 22:1-9. Epub 2021 Jul 22.

The University of Queensland Diamantina Institute, The University of Queensland, Dermatology Research Centre, Brisbane, Queensland, Australia.

Background: Cherry angiomas are common benign vascular skin lesions of unknown aetiology, found largely on the trunk. However, their exact anatomic distribution besides their truncal predisposition, and how they manifest in the general population, has not been characterised.

Methods: Three-dimensional (3D) total body imaging was obtained from 163 adult participants of a general population cohort study in Brisbane, Australia. Read More

View Article and Full-Text PDF

Effect of Sustained Interventions from Infancy to Toddlerhood in Children with Cleft Lip and Palate for Preventing Early Childhood Caries.

Caries Res 2021 Jul 22:1-9. Epub 2021 Jul 22.

Department of Pediatric and Preventive Dentistry, Pushpagiri College of Dental Sciences, Thiruvalla, India.

The study aimed to evaluate the effectiveness of sustained interventions in children with cleft lip and palate (CLP) for preventing early childhood caries (ECC). This prospective, nonrandomized interventional cohort study was conducted in infants aged 0-12 months with congenital CLP. Interventions were given to parents/primary caregivers in the form of combined oral health-care measures (sterile wet gauze piece, finger brush, toothbrush, and toothpaste) by a motivational interviewing approach. Read More

View Article and Full-Text PDF

Persistence and vertical distribution of neonicotinoids in soils under different citrus orchards chrono sequences from southern China.

Chemosphere 2021 Jul 17;286(Pt 1):131584. Epub 2021 Jul 17.

Jiangxi Academy of Water Science and Engineering, Nanchang, 330029, China; Jiangxi Provincial Key Laboratory of Soil Erosion and Prevention, Nanchang, 330029, China.

Continual input of neonicotinoid insecticides occurs in the citrus orchards from southern China. However, it is still unknown about the variations in the distribution and accumulation of neonicotinoids in soil profiles along a long-term chronosequence of cultivation and the driving factors contributing to these shifts. Here, changes of neonicotinoids in the 0-100 cm soil profiles with distinct orchard cultivation age (1, 10, and 20 years) were investigated, and their related factors were further determined. Read More

View Article and Full-Text PDF

STRIDES - STudying Risk to Improve DisparitiES in Cervical Cancer in Mississippi - Design and baseline results of a Statewide Cohort Study.

Prev Med 2021 Jul 19:106740. Epub 2021 Jul 19.

National Cancer Institute, Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, Rockville, MD, United States of America. Electronic address:

Cervical cancer rates in Mississippi are disproportionately high, particularly among Black individuals; yet, research in this population is lacking. We designed a statewide, racially diverse cohort of individuals undergoing cervical screening in Mississippi. Here, we report the baseline findings from this study. Read More

View Article and Full-Text PDF

Body weight and premature retirement: population-based evidence from Finland.

Eur J Public Health 2021 Jul 19. Epub 2021 Jul 19.

Department of Mathematics and Statistics, University of Jyväskylä, Jyväskylä, Finland.

Background: Health status is a principal determinant of labour market participation. In this study, we examined whether excess weight is associated with withdrawal from the labour market owing to premature retirement.

Methods: The analyses were based on nationally representative data from Finland over the period 2001-15 (N ∼ 2500). Read More

View Article and Full-Text PDF

Age-Dependent Changes in Total and Free Water Content of In Vivo Human Lenses Measured by Magnetic Resonance Imaging.

Invest Ophthalmol Vis Sci 2021 Jul;62(9):33

Department of Physiology, School of Medical Sciences, New Zealand National Eye Centre, University of Auckland, New Zealand.

Purpose: To use magnetic resonance imaging (MRI) to measure age-dependent changes in total and free water in human lenses in vivo.

Methods: Sixty-four healthy adults aged 18 to 86 years were recruited, fitted with a 32-channel head receiver coil, and placed in a 3 Tesla clinical MR scanner. Scans of the crystalline lens were obtained using a volumetric interpolated breath-hold examination sequence with dual flip angles, which were corrected for field inhomogeneity post-acquisition using a B1-map obtained using a turbo-FLASH sequence. Read More

View Article and Full-Text PDF

Geographical variations in maternal dietary patterns during pregnancy associated with birth weight in Shaanxi province, Northwestern China.

PLoS One 2021 22;16(7):e0254891. Epub 2021 Jul 22.

Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, P.R. China.

The geographical variation of maternal dietary patterns related to birth outcomes is important for improving the health of mothers and children; however, it is currently unknown. Thus, the objective of the study was to investigate geographical variations of maternal dietary pattern during pregnancy, and evaluate the spatial varying association of maternal dietary patterns in pregnancy with abnormal birth weight. A population-based cross-sectional study was conducted in Shaanxi province in Northwest China in 2013 to evaluate the relationship between abnormal birth weight and dietary pattern using the Geographically Weighted Logistic Regression (GWLR). Read More

View Article and Full-Text PDF

Population Pharmacokinetics of Favipiravir in Patients with COVID-19.

CPT Pharmacometrics Syst Pharmacol 2021 Jul 22. Epub 2021 Jul 22.

Department of Pharmacy, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, Kobe, 650-0047, Japan.

The antiretroviral drug favipiravir inhibits RNA-dependent RNA polymerase. It has been developed for the treatment of novel coronavirus (SARS-CoV-2) infection disease (COVID-19). However, its pharmacokinetics in patients with COVID-19 is poorly understood. Read More

View Article and Full-Text PDF

Hepatitis B Virus (HBV) Genotype: A Significant Risk Factor in Determining which Patients with Chronic HBV Infection should Undergo Surveillance for Hepatocellular Carcinoma: The Hepatitis B Alaska (HEP-B-AK) Study.

Hepatology 2021 Jul 22. Epub 2021 Jul 22.

Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, Alaska, USA.

Background And Aims: Information is limited regarding hepatitis B virus (HBV) genotype and the outcome of chronic HBV (CHB) infection. We examined HBV genotype on hepatocellular carcinoma (HCC) occurrence in Alaska Native (AN) persons with CHB where five HBV genotypes are found, A2, B6, C2, D and F1.

Approach And Results: We calculated HCC incidence per 1000 person-years of follow-up to determine which groups by age, sex, and genotype met current American Association for the Study of Liver Diseases HCC surveillance criteria. Read More

View Article and Full-Text PDF

Evaluation of the Frequency of RETN c.62G>A and RETN c.-180C>G Polymorphisms in the Resistin Coding Gene in Girls with Anorexia Nervosa.

Endokrynol Pol 2021 Jul 22. Epub 2021 Jul 22.

Department of Adult Psychiatry, University of Medical Sciences in Poznań, Poland.

Introduction: Anorexia nervosa (AN) is a serious psychosomatic syndrome, classified as an eating disorder. AN patients strive to lose weight below normal limits defined for a specific age and height, achieving their goal even at the expense of extreme emaciation. AN has a multifactorial etiology. Read More

View Article and Full-Text PDF

Evaluation of the Frequency of ADIPOQ c.45 T>G and ADIPOQ c.276 G>T Polymorphisms in the Adiponectin Coding Gene in Girls with Anorexia Nervosa.

Endokrynol Pol 2021 Jul 22. Epub 2021 Jul 22.

Department of Adult Psychiatry, University of Medical Sciences in Poznań, Poland.

Introduction: Anorexia nervosa (AN) is a serious chronic psychosomatic disorder, the essence of which are attempts to obtain a slim silhouette by deliberate weight loss (restrictive diet, strenuous physical exercise, provoking vomiting). The etiology of this disorder is multifactorial. Genetic factors which influence the predisposition to AN have been searched for. Read More

View Article and Full-Text PDF

Relationship Between Antithymocyte Globulin Concentrations and Lymphocyte Sub-Populations in Kidney Transplant Patients.

Clin Pharmacokinet 2021 Jul 22. Epub 2021 Jul 22.

University of Tours, EA4245 T2I, Tours, France.

Background: Rabbit antithymocyte globulins (rATGs) are polyclonal antibodies used to prevent acute cellular rejection in kidney transplantation. Their dosing remains largely empirical and the question of an individualized dose is still unresolved.

Methods: Data from a prospective study in 17 kidney transplant patients were used to develop a model describing the dose-concentration-response relationship of rATG with T-lymphocyte subpopulation counts over time. Read More

View Article and Full-Text PDF

Preclinical and clinical study on [F]DRKXH1: a novel β-amyloid PET tracer for Alzheimer's disease.

Eur J Nucl Med Mol Imaging 2021 Jul 22. Epub 2021 Jul 22.

Department of Nuclear Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1665, Kongjiang Street, Yangpu District, Shanghai, 200092, China.

Background: The deposition of β-amyloid (Aβ) in the brain is a biomarker of Alzheimer's disease (AD). Highly sensitive Aβ positron emission tomography (PET) imaging plays an essential role in diagnosing and evaluating the therapeutic effects of AD.

Aim: To synthesize a new Aβ tracer [F]DRKXH1 (5-(4-(6-(2-[18]fluoroethoxy)ethoxy)imidazo[1,2-alpha]pyridin-2-yl)phenyl) and evaluate the tracer performance by biodistribution analysis, in vivo small-animal PET-CT dynamic scan, ex vivo and in vitro autoradiography, and PET in human subjects. Read More

View Article and Full-Text PDF

The impact of COVID-19 related restrictions on social and daily activities of parents, people with disabilities and older adults: Protocol for a longitudinal, mixed-methods study.

JMIR Res Protoc 2021 Jun 30. Epub 2021 Jun 30.

Department of Occupational Science and Occupational Therapy, Faculty of Medicine, University of British Columbia, Vancouver, CA.

Background: Background: The COVID-19 pandemic has led to wide-scale changes in societal organization. This has dramatically altered people's daily activities, especially among families with young children, those living with disabilities such as spinal cord injury (SCI), those who have experienced a stroke, and older adults. We aim to 1) investigate how COVID restrictions influence daily activities 2) track the psychosocial effects of these restrictions over time; and 3) identify strategies to mitigate the potential negative effects of these restrictions. Read More

View Article and Full-Text PDF

Intention to get vaccinated against COVID-19 among the general population in France: Associated factors and gender disparities.

Hum Vaccin Immunother 2021 Jul 22:1-12. Epub 2021 Jul 22.

Southeastern Health Regional Observatory (ORS Paca), Faculté De Médecine, Marseille Cedex 5, France.

As the coronavirus disease 2019 (COVID-19) spreads across the world, the rapid distribution of an effective vaccine and its acceptability among the population constitute priorities for health authorities. This study aimed to document attitudes of the general population toward a future vaccine against COVID-19. We used the national COCONEL surveys conducted during the lockdown to identify factors associated with vaccine refusal, in the whole population, and separately among men and women. Read More

View Article and Full-Text PDF

An Anthropometric Study of Lung Donors.

Prog Transplant 2021 Jul 22:15269248211024611. Epub 2021 Jul 22.

University of Kentucky, Albert B Chandler Hospital, Lexington, KY, USA.

Purpose: A difference in the lower body to upper body ratio between similarly heighted individuals could lead to inadequately matched transplants. There has been a perception in clinical circles that body ratio varies between people of different races, and investigating this supposition would prove useful in increasing transplant match accuracy. The investigation's purpose was to derive an equation with a greater correlation to lung length than height alone. Read More

View Article and Full-Text PDF

Recognition of seizure semiology and semiquantitative FDG-PET analysis of anti-LGI1 encephalitis.

CNS Neurosci Ther 2021 Jul 22. Epub 2021 Jul 22.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.

Aims: Anti-leucine-rich glioma-inactivated 1 (LGI1) autoimmune encephalitis (AE) is characterized by complex manifestations of seizures. Here, we report a new seizure semiology, attempt to classify the disease by semiology type, and explore the metabolic pattern of each group.

Methods: Anti-LGI1 AE patients were retrospectively screened between May 2014 and September 2019 in our tertiary epilepsy center. Read More

View Article and Full-Text PDF

How can we improve the quality of cataract services for all? A global scoping review.

Clin Exp Ophthalmol 2021 Jul 21. Epub 2021 Jul 21.

International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Background: Cataract is a leading cause of blindness and vision impairment globally. Cataract surgery is one of the most frequently performed operations worldwide, but good quality services are not universally available. This scoping review aims to summarise the nature and extent of published literature on interventions to improve the quality of services for age-related cataract globally. Read More

View Article and Full-Text PDF

Health risk assessment of As due to rice ingestion based on iAs distribution and actual consumption patterns for the residents in Beijing: a cross-sectional study.

Environ Geochem Health 2021 Jul 21. Epub 2021 Jul 21.

Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants, School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing, 100083, People's Republic of China.

As a well-known human carcinogen, arsenic (As) could pose various detrimental health effects to humans mainly through the exposure pathway of food ingestion. In comparison with other foods, rice can accumulate more arsenic due to its tissue specificity. Thus, it is of great significance to assess the health risk of As due to rice ingestion. Read More

View Article and Full-Text PDF

Characteristics of normal human retinal pigment epithelium cells with extremes of autofluorescence or intracellular granule count.

Ann Eye Sci 2021 Mar 15;6. Epub 2021 Mar 15.

Department of Ophthalmology, University Hospital Bonn, Bonn, Germany.

Background: Cells of the retinal pigment epithelium (RPE) accumulate different kinds of granules (lipofuscin, melanolipofuscin, melanosomes) within their cell bodies, with lipofuscin and melanolipofuscin being autofluorescent after blue light excitation. High amounts of lipofuscin granules within the RPE have been associated with the development of RPE cell death and age-related macular degeneration (AMD); however, this has not been confirmed in histology so far. Here, based on our previous dataset of RPE granule characteristics, we report the characteristics of RPE cells from human donor eyes that show either high or low numbers of intracellular granules or high or low autofluorescence (AF) intensities. Read More

View Article and Full-Text PDF

The Toll Route to Structural Brain Plasticity.

Front Physiol 2021 5;12:679766. Epub 2021 Jul 5.

Plasticity and Regeneration Lab, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.

The human brain can change throughout life as we learn, adapt and age. A balance between structural brain plasticity and homeostasis characterizes the healthy brain, and the breakdown of this balance accompanies brain tumors, psychiatric disorders, and neurodegenerative diseases. However, the link between circuit modifications, brain function, and behavior remains unclear. Read More

View Article and Full-Text PDF

Case-control study of hypertension and Parkinson's disease.

NPJ Parkinsons Dis 2021 Jul 21;7(1):63. Epub 2021 Jul 21.

Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.

We evaluate the association of hypertension with PD in an Asian population and performed a meta-analysis on similar studies to address the effect of hypertension on PD risk. A matched case-control study involving 1342 Chinese subjects (671 PD and 671 age and gender-matched controls (with a mean age of 63.9 ± 9. Read More

View Article and Full-Text PDF

National surveillance of antimicrobial susceptibilities to dalbavancin, telavancin, tedizolid, eravacycline, omadacycline and other comparator antibiotics and serotype distribution of invasive Streptococcus pneumoniae isolates in adults: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) programme in 2017-2020.

J Glob Antimicrob Resist 2021 Jul 18. Epub 2021 Jul 18.

Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Departments of Laboratory Medicine and Internal Medicine, China Medical University Hospital, School of Medicine, China Medical University, Taichung, Taiwan. Electronic address:

Objectives: This study aimed to investigate the trends in serotypes and in vitro susceptibility of Streptococcus pneumoniae causing adult invasive pneumococcal disease (IPD) to dalbavancin, telavancin, tedizolid, eravacycline, omadacycline and other comparator antibiotics from 2017 to 2020, following implementation of the 13-valent pneumococcal conjugate vaccine (PCV-13) and during the COVID-19 pandemic.

Methods: During the study period, a total of 237 isolates of S. pneumoniae were collected from non-duplicate patients, covering 15% of IPD cases in Taiwan. Read More

View Article and Full-Text PDF

Comparison Between Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling to Select Paediatric Doses of Gepotidacin in Plague.

Br J Clin Pharmacol 2021 Jul 21. Epub 2021 Jul 21.

GlaxoSmithKline, Collegeville, PA.

Aims: Develop physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PopPK) models to predict effective doses of gepotidacin in paediatrics for the treatment of pneumonic plague (Yersinia pestis).

Methods: Gepotidacin PBPK model was constructed using a population-based absorption, distribution, metabolism, and excretion simulator, Simcyp®, with physicochemical and in vitro data, then optimized with clinical data from a dose-escalation intravenous (IV) study and a human mass balance study. A PopPK model was developed with pooled PK data from Phase 1 studies with IV gepotidacin in healthy adults. Read More

View Article and Full-Text PDF

Comparison Of Clinical And Biochemical Features Of Hospitalized COVID-19 And Influenza Pneumonia Patients.

J Med Virol 2021 Jul 21. Epub 2021 Jul 21.

University of Health Sciences, Yedikule Chest Disease and Surgery Training and Research Hospital, Istanbul, Turkey.

Aim: Both SARS-COV-2 and influenza viruses cause similar clinical presentations. It is essential to assess severely ill patients presenting with a viral syndrome for diagnostic and prognostic purposes. We aimed to compare clinical and biochemical features between pneumonia patients with COVID-19 and H1N1 METHOD: Sixty patients diagnosed with COVID-19 pneumonia and 61 patients diagnosed with influenza pneumonia hospitalized between October 2020- January 2021 and October 2017- December 2019 respectively. Read More

View Article and Full-Text PDF

Impact of KCNJ11 rs5219, UCP2 rs659366, and MTHFR rs1801133 Polymorphisms on Type 2 Diabetes: A Cross-Sectional Study.

Rev Diabet Stud 2021 10;17(1):21-29. Epub 2021 May 10.

Department of Preventive and Rehabilitative Dietetics, Federal Research Centre of Nutrition, Biotechnology and Food Safety, Kashirskoe sh., 21, Moscow, Russian Federation, 115446.

Objective: Type 2 diabetes (T2D) is a multifactorial disease. Its occurrence and prognosis are affected by many genes, including KCNJ11, UCP2, and MTHFR. The objective of this study was to investigate the distribution of various variants of these genes and evaluate their contribution to the outcome of T2D. Read More

View Article and Full-Text PDF

Spatial epidemiological study of the distribution, clustering, and risk factors associated with early COVID-19 mortality in Mexico.

PLoS One 2021 21;16(7):e0254884. Epub 2021 Jul 21.

Research Division, Instituto Nacional de Geriatria, Mexico City, Mexico.

COVID-19 is a respiratory disease caused by SARS-CoV-2, which has significantly impacted economic and public healthcare systems worldwide. SARS-CoV-2 is highly lethal in older adults (>65 years old) and in cases with underlying medical conditions, including chronic respiratory diseases, immunosuppression, and cardio-metabolic diseases, including severe obesity, diabetes, and hypertension. The course of the COVID-19 pandemic in Mexico has led to many fatal cases in younger patients attributable to cardio-metabolic conditions. Read More

View Article and Full-Text PDF

Socioeconomic inequalities in abdominal obesity among Peruvian adults.

PLoS One 2021 21;16(7):e0254365. Epub 2021 Jul 21.

Universidad Peruana Cayetano Heredia, Facultad de Ciencias y Filosofía, Lima, Peru.

Objectives: Abdominal obesity (AO) has become a public health issue due to its impact on health, society and the economy. The relationship between socioeconomic disparities and the prevalence of AO has yet to be studied in Peru. Thus, our aim was to analyze the socioeconomic inequalities in AO distribution defined using the International Diabetes Federation (IDF) cut-off points in Peruvian adults in 2018-2019. Read More

View Article and Full-Text PDF

Working characteristics for practicing dental hygienists in two countries in different hemispheres.

Int J Dent Hyg 2021 Jul 20. Epub 2021 Jul 20.

Department of Oral Sciences, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.

Objectives: The study aimed to collect and compare practice characteristics for dental hygienists (DHs) in New Zealand (NZ) and Sweden.

Methods: Dental hygienists from NZ and Sweden were invited to participate in an anonymous online survey focusing on their working practices. An email, with a link to the online survey and a participant information sheet, was sent to DHs registered with their professional association in their respective country. Read More

View Article and Full-Text PDF

Prevalence of active HCV infection and genotypic distribution among the general population of district Mardan, Pakistan.

Braz J Biol 2021 14;83:e244977. Epub 2021 Jul 14.

Lanzhou University, School of Life Sciences, MOE Key Laboratory of Cell Activities and Stress Adaptations, Lanzhou, Gansu, China.

Hepatitis C virus (HCV) is the serious global public health burden of liver disease. Approximately 170 million people in the world are infected with (HCV). In Pakistan, where the disease has high occurrence rate. Read More

View Article and Full-Text PDF