2,884 results match your criteria age 704


Infliximab use in the Netherlands: Uptake and characteristics of originator and biosimilars over time.

Br J Clin Pharmacol 2021 Sep 27. Epub 2021 Sep 27.

PHARMO Institute for Drug Outcomes Research, Utrecht, Netherlands.

Aims: The objective of this retrospective cohort study was to provide an overview of the utilization of originator and biosimilar infliximab in the Netherlands.

Methods: All infliximab dispensings were selected from the PHARMO In-patient Pharmacy Database from 2002-2018. Descriptive analyses were performed in order to characterise initiators and to describe switching patterns over time. Read More

View Article and Full-Text PDF
September 2021

Total Cerebral Small Vessel Disease Burden on MRI Correlates With Medial Temporal Lobe Atrophy and Cognitive Performance in Patients of a Memory Clinic.

Front Aging Neurosci 2021 8;13:698035. Epub 2021 Sep 8.

Department of Neurology, Peking University People's Hospital, Beijing, China.

Cerebral small vessel disease (cSVD) and neurodegeneration are the two main causes of dementia and are considered distinct pathological processes, while studies have shown overlaps and interactions between the two pathological pathways. Medial temporal atrophy (MTA) is considered a classic marker of neurodegeneration. We aimed to investigate the relationship of total cSVD burden and MTA on MRI using a total cSVD score and to explore the impact of the two MRI features on cognition. Read More

View Article and Full-Text PDF
September 2021

Incidence of sympathetic ophthalmia after inciting events: a national database study in Japan.

Ophthalmology 2021 Sep 21. Epub 2021 Sep 21.

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Objective: To analyze the incidence of sympathetic ophthalmia (SO) after inciting events (eye trauma or intraocular surgery).

Design: Retrospective cohort study.

Subjects: Patients undergoing inciting events between 2012 and 2019. Read More

View Article and Full-Text PDF
September 2021

Atrial high-rate episodes predict major adverse cardio/cerebrovascular events in patients with cardiac implantable electrical devices.

Sci Rep 2021 Sep 23;11(1):18992. Epub 2021 Sep 23.

Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan, 704, Taiwan.

Patients with atrial high-rate episodes (AHRE) have a high risk of neurologic events, although the causal role and optimal cutoff threshold of AHRE for major adverse cardio/cerebrovascular events (MACCE) are unknown. This study aimed to identify independent factors for AHRE and subsequent atrial fibrillation (AF) after documented AHRE. We enrolled 470 consecutive patients undergoing cardiac implantable electrical device (CIED) implantations. Read More

View Article and Full-Text PDF
September 2021

Impact of COVID-19 on Heart Failure Patients in South Korea.

Int Heart J 2021 Sep 17. Epub 2021 Sep 17.

Division of Cardiology, Department of Internal Medicine, Dong-A University College of Medicine.

Cardiovascular diseases can affect the clinical course of coronavirus disease 2019 (COVID-19); however, evaluation of COVID-19 contribution to prognosis for each individual disease, such as heart failure, is lacking in South Korea. Therefore, this study aimed to investigate COVID-19 patients with heart failure by matching them with patients with heart failure only and those with COVID-19 only. We performed a nationwide population-based retrospective study using data from the National Health Insurance System. Read More

View Article and Full-Text PDF
September 2021

Short Communication: Plasma Lymphocyte Activation Gene 3 and Subclinical Coronary Artery Disease in the Multicenter AIDS Cohort Study.

AIDS Res Hum Retroviruses 2021 Sep 20. Epub 2021 Sep 20.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Chronic inflammation, including among people with HIV (PWH), elevates immune cell expression of lymphocyte activation gene 3 (LAG3); however, low plasma LAG3 predicts cardiovascular disease (CVD) events in the general population. The associations among LAG3 plasma levels, subclinical atherosclerosis, inflammation, and HIV infection have not been well described. We measured plasma LAG3 in 704 men with and without HIV from the multicenter AIDS cohort study, who underwent coronary computed tomography angiography. Read More

View Article and Full-Text PDF
September 2021

Novel Drug Interaction index and Risk of Mortality in Older Patients With Atrial Fibrillation Receiving Non Vitamin K Oral Anticoagulants (NOEL Drug).

Authors:
İbrahim Ersoy

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211038685

534521Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.

Drug interactions with novel oral anticoagulants (NOACs) may decrease their advantages. We aimed to explore the drug interaction rates with NOACs and impacts of drug interaction index (DII) on mortality among older patients with atrial fibrillation (AF). In this retrospective cohort study, we enrolled 704 eligible patients aged 65≤ with AF between January 1, 2018 and December 30, 2019 in a tertiary outpatient cardiology clinic. Read More

View Article and Full-Text PDF
September 2021

Novel model combining contrast-enhanced ultrasound with serology predicts hepatocellular carcinoma recurrence after hepatectomy.

World J Clin Cases 2021 Aug;9(24):7009-7021

Department of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, Fujian Province, China.

Background: Surgery is the primary curative option in patients with hepatocellular carcinoma (HCC). However, recurrence within 2 years is observed in 30%-50% of patients, being a major cause of mortality.

Aim: To construct and verify a non-invasive prediction model combining contrast-enhanced ultrasound (CEUS) with serology biomarkers to predict the early recurrence of HCC. Read More

View Article and Full-Text PDF

Changes in activity levels, physical functioning, and fall risk during the COVID-19 pandemic.

J Am Geriatr Soc 2021 Sep 18. Epub 2021 Sep 18.

Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA.

Background: Physical function worsens with older age, particularly for sedentary and socially isolated individuals, and this often leads to injuries. Through reductions in physical activity, the COVID-19 pandemic may have worsened physical function and led to higher fall-related risks.

Methods: A nationally representative online survey of 2006 U. Read More

View Article and Full-Text PDF
September 2021

The prevalence of vertebral fractures among Indian perimenopausal women and its association with ovarian biomarkers.

J Bone Miner Metab 2021 Sep 17. Epub 2021 Sep 17.

Departments of Endocrinology, Christian Medical College and Hospital, Vellore, India.

Introduction: There is dearth of data on prevalent vertebral fractures in perimenopausal women in India and limited literature on the utility of FSH, AMH and estradiol in evaluating bone health them. The objective was to study the prevalence of vertebral fractures (VF) and to assess the utility of FSH, estradiol and AMH in predicting them in Indian perimenopausal women MATERIALS AND METHODS: It was a cross-sectional study. Perimenopausal women aged 40-49 years underwent assessment for prevalent vertebral fractures, bone mineral density (BMD) and trabecular bone score (TBS). Read More

View Article and Full-Text PDF
September 2021

Factors associated with the refusal of surgery and the associated impact on survival in patients with rectal cancer using the National Cancer Database.

J Gastrointest Oncol 2021 Aug;12(4):1482-1497

Department of Radiation Oncology, Huntsman Cancer Institute, Salt Lake City, Utah, USA.

Background: Surgical resection is an integral component of the curative-intent treatment for most patients with non-metastatic rectal cancer. However, some patients refuse surgery for a number of reasons. Utilizing the National Cancer Database (NCDB), we investigated the sociodemographic and clinical factors associated with patients who were coded as having been offered but refused surgery, and the factors affecting overall survival (OS) in these patients. Read More

View Article and Full-Text PDF

Comparison of revised EWGSOP2 criteria of sarcopenia in patients with cancer using different parameters of muscle mass.

PLoS One 2021 14;16(9):e0257446. Epub 2021 Sep 14.

Postgraduate Program in Health Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

Calf circumference (CC) has been established as a marker of muscle mass (MM) with good performance for predicting survival in individuals with cancer. The study aims to determine the prevalence of sarcopenia according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria and to evaluate the accuracy of sarcopenia using low CC relative to MM assessment by computed tomography (CT) at third lumbar vertebra level (L3) as a reference. Cross-sectional study with cancer patients aged ≥ 60 years. Read More

View Article and Full-Text PDF
September 2021

Association between 9-month isoniazid prophylaxis of latent tuberculosis and severe hepatitis in patients treated with TNF inhibitors.

Sci Rep 2021 Sep 9;11(1):18013. Epub 2021 Sep 9.

Department of Internal Medicine, Division of Allergy, Immunology, and Rheumatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No. 138 Shen-Li Rd., Tainan, 704, Taiwan.

To investigate associations between isoniazid for latent tuberculosis and risk of severe hepatitis, affecting patients with rheumatoid arthritis or ankylosing spondylitis whose treatment includes tumor necrosis factor inhibitors. Our self-controlled case series study analyzed Taiwan's National Health Insurance Database from 2003 to 2015 to identify RA or AS patients, aged ≥ 20 years, receiving TNF inhibitors and a 9-month single isoniazid treatment. The outcome of interest was hospitalization due to severe hepatitis. Read More

View Article and Full-Text PDF
September 2021

The Regrowth of Mandibular Coronoid Process After Coronoidectomy: A Retrospective Analysis of 57 Cases.

J Oral Maxillofac Surg 2021 Aug 10. Epub 2021 Aug 10.

Resident, Professor, Associate Professor and Head, Associate Professor, The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China; Resident, Professor, Associate Professor and Head, Associate Professor, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China. Electronic address:

Purpose: Coronoidectomy is carried out frequently as a part of the cranial-maxillofacial surgery procedure. There are few articles on the fate of coronoid process after coronoidectomy, except that several case reports mentioned that coronoid process had regenerated. This study aimed to radiographically access the anatomic outcomes of coronoid process and investigate which factors were associated with the outcomes after coronoidectomy. Read More

View Article and Full-Text PDF

Comparative Effectiveness of Cartilage Grafts in Functional Rhinoplasty for Nasal Sidewall Collapse.

Facial Plast Surg Aesthet Med 2021 Sep 7. Epub 2021 Sep 7.

Department of Otolaryngology, Massachusetts Eye and Ear, Boston, Massachusetts, USA.

To compare the patient-reported outcomes among patients with nasal obstruction undergoing two rhinoplasty techniques to a control group. Prospective longitudinal study in a university-based tertiary care medical center. All patients undergoing functional septorhinoplasty for correction of lateral wall insufficiency between October 2015 and March 2019 were included;  = 704, mean age (standard deviation) 39. Read More

View Article and Full-Text PDF
September 2021

Neurophysiologic Complexity in Children Increases with Developmental Age and Is Reduced by General Anesthesia.

Anesthesiology 2021 Sep 7. Epub 2021 Sep 7.

Background: Neurophysiologic complexity in the cortex has been shown to reflect changes in the level of consciousness in adults but remains incompletely understood in the developing brain. This study aimed to address changes in cortical complexity related to age and anesthetic state transitions. This study tested the hypotheses that cortical complexity would (1) increase with developmental age and (2) decrease during general anesthesia. Read More

View Article and Full-Text PDF
September 2021

Reliability and Reproducibility of Hadamard Encoded Pseudo-Continuous Arterial Spin Labeling in Healthy Elderly.

Front Neurosci 2021 19;15:711898. Epub 2021 Aug 19.

German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.

The perfusion parameters cerebral blood flow (CBF) and arterial transit time (ATT) measured with arterial spin labeling (ASL) magnetic resonance imaging (MRI) provide valuable essentials to assess the integrity of cerebral tissue. Brain perfusion changes, due to aging, an intervention, or neurodegenerative diseases for example, could be investigated in longitudinal ASL studies with reliable ASL sequences. Generally, pseudo-continuous ASL (pCASL) is preferred because of its larger signal-to-noise ratio (SNR) compared to pulsed ASL (PASL) techniques. Read More

View Article and Full-Text PDF

Outcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study.

Sci Rep 2021 09 6;11(1):17730. Epub 2021 Sep 6.

Institute of Anaesthesia and Intensive Care, Padua University Hospital, Padua, Italy.

The efficacy of non-invasive ventilation (NIV) in acute respiratory failure secondary to SARS-CoV-2 infection remains controversial. Current literature mainly examined efficacy, safety and potential predictors of NIV failure provided out of the intensive care unit (ICU). On the contrary, the outcomes of ICU patients, intubated after NIV failure, remain to be explored. Read More

View Article and Full-Text PDF
September 2021

The interaction of hypertension and homocysteine increases the risk of mortality among middle-aged and older population in the United States.

J Hypertens 2021 Sep 1. Epub 2021 Sep 1.

Department of General Practice Department of Neurosurgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College Department of General Practice, Hangzhou Zhaohui Jiedao Community Healthcare Center, Hangzhou, Zhejiang, China.

Objectives: To investigate the interaction of hypertension and total plasma homocysteine (tHcy) levels on risk of all-cause and cardiovascular disease (CVD) mortality among middle-aged and older population.

Methods: This observational cohort study analyzed data from the National Health and Nutrition Examination Survey database (1999-2002 survey cycle). A generalized additive model (GAM) based on Cox proportional hazards models was applied to estimate the relationship of tHcy level with all-cause and CVD mortality. Read More

View Article and Full-Text PDF
September 2021

Understanding the determinants of vaccine hesitancy and vaccine confidence among adolescents: a systematic review.

Hum Vaccin Immunother 2021 Sep 2:1-17. Epub 2021 Sep 2.

Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Vaccine hesitancy (VH) in the age of adolescence is a major public health issue, though it has not been widely examined in the scientific literature. This systematic review aims to address the determinants of VH among adolescents aged 10-19. PubMed, Scopus, and Web of Science were searched from the inception until 11 December 2020. Read More

View Article and Full-Text PDF
September 2021

The ATRIA score is superior to the m-CHA2DS2-Vasc score in predicting in-hospital mortality in COVID-19.

Rev Assoc Med Bras (1992) 2021 Mar;67(3):443-448

Adana City Training and Research Hospital, Cardiology - Adana, Turkey.

Objective: Coronavirus disease 2019 (COVID-19) has become a health and social problem all over the world. Most of the deaths occur from embolism and thrombus formation. We aimed to compare the predictive value of the anticoagulation and risk factors in atrial fibrillation (ATRIA) and m-CHA2DS2-Vasc scores in in-hospital mortality in COVID-19. Read More

View Article and Full-Text PDF

Gene expression analysis of and the clock gene in individuals with bipolar disorder compared to healthy controls.

World J Biol Psychiatry 2021 Sep 1:1-19. Epub 2021 Sep 1.

Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.

Circadian rhythms are associated with bipolar disorder (BD). This cross-sectional study aimed at investigating and gene expression differences (1) between individuals with BD and controls, (2) between affective episodes, and (3) the relationship between and expression. and gene expression in peripheral mononuclear blood cells were analyzed from fasting blood samples (BD n= 81, controls n= 54) with quantitative real-time PCR operating on TaqMan® assays (normalized to 18S RNA expression). Read More

View Article and Full-Text PDF
September 2021

An Internet-based study on the impact of COVID-19 pandemic-related lockdown on migraine in India.

Acta Neurol Scand 2021 Aug 30. Epub 2021 Aug 30.

Neurology, GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.

Objectives: To assess the impact of lockdown during the COVID-19 pandemic on migraine patients in India on disease activity, healthcare accessibility, and quality of life (QoL).

Materials & Methods: This internet-based survey study using a structured questionnaire was conducted from 27th April to 31st July 2020. Previous physician-diagnosed migraine patients or those fulfilling any two of three clinical features (limitation of activities for >1 day, associated nausea or vomiting, and photophobia or phonophobia) were diagnosed as migraine patients. Read More

View Article and Full-Text PDF

Long-term monitoring of two endangered freshwater mussels (Bivalvia: Unionidae) reveals how demographic vital rates are influenced by species life history traits.

PLoS One 2021 27;16(8):e0256279. Epub 2021 Aug 27.

U.S. Fish and Wildlife Service, Asheville, North Carolina, United States of America.

To meet monitoring and recovery planning needs, demographic vital rates of two endangered freshwater mussels (Bivalvia: Unionidae)-the Cumberlandian Combshell (Epioblasma brevidens, Lea 1831) and Oyster Mussel (Epioblasma capsaeformis, Lea 1834), species endemic to the Tennessee and Cumberland river basins, U.S.A-were estimated and compared using census methodologies. Read More

View Article and Full-Text PDF

Chemosensory dysfunctions induced by COVID-19 can persist up to 7 months: A study of over 700 healthcare workers.

Chem Senses 2021 Aug 23. Epub 2021 Aug 23.

Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.

Several studies have revealed either self-reported chemosensory alterations in large groups or objective quantified chemosensory impairments in smaller populations of patients diagnosed with COVID-19. However, due to the great variability in published results regarding COVID-19-induced chemosensory impairments and their follow-up, prognosis for chemosensory functions in patients with such complaints remains unclear. Our objective is to describe the various chemosensory alterations associated with COVID-19 and their prevalence and evolution after infection. Read More

View Article and Full-Text PDF

Extreme Binge Drinking During Adolescence: Associations With Subsequent Substance Use Disorders in American Indian and Mexican American Young Adults.

J Addict Med 2021 Jan 28. Epub 2021 Jan 28.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA (CLE, DW, DAG); Alcohol Research Group, Public Health Institute, Suite 450, Emeryville, CA (KJK-J).

Objective: This study collected retrospective data on adolescent binge drinking (ABD) (5 drinks for boys, 4 for girls per occasion at least once per month) and/or extreme adolescent binge drinking (EABD) (10 or more drinks per occasion at least once per month) and tested for associations with demographic and diagnostics variables including alcohol and other substance use disorders (AUD/SUD).

Methods: Cross-sectional data were collected from young adult (age 18-30 yrs) American Indians (AI) (n = 534) and Mexican Americans (MA) (n = 704) using a semi-structured diagnostic instrument.

Results: Thirty percent (30%) of the sample reported ABD and 21% reported EABD. Read More

View Article and Full-Text PDF
January 2021

Clinical determinants of coronary artery disease burden and vulnerability using optical coherence tomography co-registered with intravascular ultrasound.

Coron Artery Dis 2021 Aug 17. Epub 2021 Aug 17.

Clinical Trials Center, Cardiovascular Research Foundation Division of Cardiology, NewYork-Presbyterian Hospital/Columbia University Irving Medical Center, New York, New York, USA Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China Cardiovascular Medicine, Tsuchiura Kyodo Hospital, Ibaraki, Japan.

Objectives: We investigated clinical determinants of disease burden and vulnerability using optical coherence tomography (OCT) co-registered with intravascular ultrasound (IVUS) in a large cohort of patients.

Methods: A total of 704 patients [44.5% with acute coronary syndromes (ACS)] underwent coronary intervention. Read More

View Article and Full-Text PDF

Effect of wing length on the prevalence of trypanosomes in Glossina morsitans morsitans in eastern Zambia.

Parasit Vectors 2021 Aug 18;14(1):409. Epub 2021 Aug 18.

Department of Paraclinical Studies, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia.

Background: Tsetse flies (Diptera: Glossinidae) transmit trypanosomiasis (sleeping sickness in humans and nagana in livestock). Several studies have indicated that age, sex, site of capture, starvation and microbiome symbionts, among others, are important factors that influence trypanosome infection in tsetse flies. However, reasons for a higher infection rate in females than in males still largely remain unknown. Read More

View Article and Full-Text PDF

Marrow failure and aging: The role of "Inflammaging".

Best Pract Res Clin Haematol 2021 06 3;34(2):101283. Epub 2021 Jul 3.

Department of Medicine, Hematology-Oncology Division, James P Wilmot Cancer Institute, Box 704, 601 Elmwood Ave, Rochester, NY, 14642, USA. Electronic address:

Despite aging and the enormous cellular output required of the marrow every day of the lifespan, most aged patients do not suffer significant marrow failure or cytopenias, an attestation to the proliferative capacity of this system. However, as marrow and its hematopoietic stem cells age, a reduction in ability to maintain homeostasis after stress or with exposure to prolonged chronic inflammation, so-called "inflammaging," may contribute to cytopenias, inadequate immune responses, and dysplasia/leukemia. In some instances, these changes may be intrinsic to the stem cell but in others, there may be extrinsic environmental influences. Read More

View Article and Full-Text PDF

The Quantitative Examination of the Relationship Between Job Satisfaction and Organization Fit in Athletic Trainers.

J Athl Train 2021 Aug 17. Epub 2021 Aug 17.

Statistics and Data Science Program Faculty, Department of Mathematics and Statistics, University of North Carolina Wilmington, 910-962-7654,

Context: Athletic trainers' (ATs) job satisfaction has been extensively researched, yet little is known about how satisfaction relates to organizational culture.

Objective: To examine ATs' level of job satisfaction and organizational fit perceptions within their employment setting.

Design: Cross-sectional study. Read More

View Article and Full-Text PDF