3,294 results match your criteria age 643

Training Strategies Maintain Performance Characteristics in Marines Selected for Marine Forces Special Operations Individualized Training Course.

Mil Med 2021 Apr 7. Epub 2021 Apr 7.

Sports Medicine Research Institute, College of Health Sciences, University of Kentucky, Lexington, KY 40506, USA.

Introduction: Marines must complete an intensive Assessment and Selection (A&S) course before becoming a U.S. Marine Forces Special Operations Command (MARSOC) Raider. Read More

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Outcomes following implementation of a high-volume medical retina virtual clinic utilising a diagnostic hub during COVID-19.

Eye (Lond) 2021 Apr 6. Epub 2021 Apr 6.

Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Background: To describe the clinical outcomes following implementation of a high-volume medical retina virtual clinic utilising a diagnostic hub.

Methods: Retrospective consecutive case-series of all patients attending the medical retina virtual clinics at Moorfields Eye Hospital (City Road) for 6 weeks from September 21, 2020.

Results: In 6 weeks, 1006 patients attended the medical retina virtual clinics, which included an appointment in the diagnostic hub followed by an assessment asynchronously the following working day. Read More

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Back pain and heart failure in community-dwelling older adults: Findings from the Health ABC study.

Geriatr Nurs 2021 Apr 3;42(3):643-649. Epub 2021 Apr 3.

School of Nursing, University of Connecticut, Storrs, CT, USA.

This study explored the association of back pain and heart failure (HF) with health outcomes among community-dwelling older adults. Older adults who completed a follow-up in the 11th year (2007-2008) of the Health, Aging, and Body Composition (Health ABC) study were included. The mean age was 83. Read More

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Contemporary hormonal contraception and cervical cancer in women of reproductive age.

Int J Cancer 2021 Apr 5. Epub 2021 Apr 5.

Academic Primary Care, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.

To determine cervical cancer risk associated with contemporary hormonal contraceptives, we conducted a cohort study of women aged 15-49 living in Denmark through 1995-2014, using routinely collected information about redeemed prescriptions, incident cancer and potential confounders. Poisson regression calculated adjusted cervical cancer risks among different contraceptive user groups by duration of use, time since last use, hormonal content and cancer histology. During >20 million person-years, 3,643 incident cervical cancers occurred. Read More

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Efficacy and safety of dolutegravir with emtricitabine and tenofovir alafenamide fumarate or tenofovir disoproxil fumarate, and efavirenz, emtricitabine, and tenofovir disoproxil fumarate HIV antiretroviral therapy regimens started in pregnancy (IMPAACT 2010/VESTED): a multicentre, open-label, randomised, controlled, phase 3 trial.

Lancet 2021 Apr;397(10281):1276-1292

David Geffen School of Medicine, Division of Infectious Diseases, University of California, Los Angeles, Los Angeles, CA, USA.

Background: Antiretroviral therapy (ART) during pregnancy is important for both maternal health and prevention of perinatal HIV-1 transmission; however adequate data on the safety and efficacy of different ART regimens that are likely to be used by pregnant women are scarce. In this trial we compared the safety and efficacy of three antiretroviral regimens started in pregnancy: dolutegravir, emtricitabine, and tenofovir alafenamide fumarate; dolutegravir, emtricitabine, and tenofovir disoproxil fumarate; and efavirenz, emtricitabine, and tenofovir disoproxil fumarate.

Methods: This multicentre, open-label, randomised controlled, phase 3 trial was done at 22 clinical research sites in nine countries (Botswana, Brazil, India, South Africa, Tanzania, Thailand, Uganda, the USA, and Zimbabwe). Read More

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Heart Images on Food Labels: A Health Claim or Not?

Foods 2021 Mar 18;10(3). Epub 2021 Mar 18.

Nutrition and Public Health Research Group, Nutrition Institute, Tržaška cesta 40, SI-1000 Ljubljana, Slovenia.

Health claims on food labels are used by food manufacturers to inform consumers about the health effects of a product, and such claims can have notable effects on consumer preferences. According to regulatory definitions, health claims can be either worded or presented as images, but it is not clear under which conditions an image on a food label should be considered a health claim. This question has important practical implications, as the use of health claims is strictly regulated. Read More

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Noise sensitivity associated with nonrestorative sleep in Chinese adults: a cross-sectional study.

BMC Public Health 2021 Apr 1;21(1):643. Epub 2021 Apr 1.

Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China.

Background: Nonrestorative sleep is a common sleep disorder with a prevalence ranging from 1.4 to 35%, and is associated with various psychological and physical health issues. Noise exposure and noise sensitivity have been proposed to contribute to nonrestorative sleep. Read More

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Management of low periprosthetic distal femoral fractures.

Bone Joint J 2021 Apr;103-B(4):635-643

Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, UK.

Aims: Debate continues regarding the optimum management of periprosthetic distal femoral fractures (PDFFs). This study aims to determine which operative treatment is associated with the lowest perioperative morbidity and mortality when treating low (Su type II and III) PDFFs comparing lateral locking plate fixation (LLP-ORIF) or distal femoral arthroplasty (DFA).

Methods: This was a retrospective cohort study of 60 consecutive unilateral (PDFFs) of Su types II (40/60) and III (20/60) in patients aged ≥ 60 years: 33 underwent LLP-ORIF (mean age 81. Read More

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Pharmacologic Restraint Use During Mental Health Visits in Pediatric Emergency Departments.

J Pediatr 2021 Mar 23. Epub 2021 Mar 23.

Department of Emergency Medicine, Harvard Medical School; Division of Emergency Medicine, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School.

Objectives: To evaluate the trends and hospital variation in the use of pharmacologic restraint among pediatric mental health visits in the emergency department (ED).

Study Design: We examined ED visits with a mental health diagnosis in patients 3-21 years of age at children's hospital EDs from 2009-2019. We calculated the frequency of pharmacologic restraint use and determined visit characteristics associated with restraint use. Read More

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Stress-associated neurobiological activity associates with the risk for and timing of subsequent Takotsubo syndrome.

Eur Heart J 2021 Mar 26. Epub 2021 Mar 26.

Cardiology Division, Massachusetts General Hospital and Harvard Medical School, MA, USA.

Aims: Activity in the amygdala, a brain centre involved in the perception of and response to stressors, associates with: (i) heightened sympathetic nervous system and inflammatory output and (ii) risk of cardiovascular disease. We hypothesized that the amygdalar activity (AmygA) ratio is heightened among individuals who develop Takotsubo syndrome (TTS), a heart failure syndrome often triggered by acute stress. We tested the hypotheses that (i) heightened AmygA precedes development of TTS and (ii) those with the highest AmygA develop the syndrome earliest. Read More

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Clustering of neuropsychological traits of preschoolers.

Sci Rep 2021 Mar 22;11(1):6533. Epub 2021 Mar 22.

Laboratorio de Neuropsicología y Neurolingüística, Instituto de Neurociencias, Universidad de Guadalajara, Guadalajara, México.

Neuropsychological tests (targeting cognitive, linguistic, motor, and executive abilities) are grouped in neuropsychological domains that are thought to be stable through adulthood. However, this assumption does not always hold true, particularly during young children's early developmental phase. Here, we explored how the neuropsychological profile of typical Spanish-speaking preschoolers varied and consolidated with age. Read More

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Prolonged Postoperative Mechanical Ventilation (PPMV) in children undergoing abdominal operations: An analysis of the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database.

J Pediatr Surg 2021 Feb 21. Epub 2021 Feb 21.

Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA. Electronic address:

Background: Prolonged postoperative mechanical ventilation (PPMV) increases length of stay, hospitalization costs, and postoperative complications. Independent risk factors associated with PPMV are not well-known for children.

Method: We identified children (<18 years) in the ACS NSQIP-P database who underwent a general surgical abdominal operation. Read More

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February 2021

Promoting Men's Health With the "Don't Change Much" e-Program.

Am J Mens Health 2021 Mar-Apr;15(2):15579883211001189

Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

Men's e-health promotion programs can offer end-user anonymity and autonomy that provide avenues for supporting positive health behavior change. The twofold purpose of the current study was to use a benchmark cohort as a reference group to: (1) describe associations between men's usage levels of the e-health program Don't Change Much (DCM) and their recent and intended health behavior changes, and (2) report an exploratory analysis of the moderating effects of demographic variables on the associations between DCM users and their recent and intended health behavior changes. Based on self-report, DCM users were classified into limited ( = 613, 34. Read More

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The Correlation Between Urinary Sodium Excretion and Blood Pressure in Hospitalized Adult Patients with Hypertension.

Adv Ther 2021 Mar 19. Epub 2021 Mar 19.

Department of Cardiology, The First Hospital of Shanxi Medical University, Taiyuan, 030001, China.

Introduction: This study was designed to understand the baseline salt intake of adult patients with hypertension in Shanxi Province, and to analyze the correlation between urinary sodium excretion and blood pressure.

Methods: From June 2018 to December 2019, 16 hospitals with regional representativeness and experimental conditions in Shanxi Province were selected, and 643 eligible adult inpatients with primary hypertension were enrolled from these hospitals. The ages of patients ranged from 18 to 80 years. Read More

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Regional variation in cost of neonatal intensive care for extremely preterm infants.

BMC Pediatr 2021 Mar 17;21(1):134. Epub 2021 Mar 17.

Medicine and Health Policy Management and Evaluation, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.

Background: Regional variation in cost of neonatal intensive care for extremely preterm infant is not documented. We sought to evaluate regional variation that may lead to benchmarking and cost saving.

Methods: An analysis of a Canadian national costing data from the payor perspective. Read More

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Seasonal trends in morpho-physiological attributes and bioactive content of Jones under full sunlight and shade conditions.

Physiol Mol Biol Plants 2021 Feb 18;27(2):327-340. Epub 2021 Feb 18.

G. B. Pant National Institute of Himalayan Environment (GBP-NIHE), Kosi-Katarmal, Almora, Uttarakhand 263 643 India.

Jones an important medicinal herb of the Himalayan region, is an essential source of many therapeutic compounds and is traded/consumed in very high volume. The hypothesis of this study was that different seasons and light conditions may affect the content of medicinally valuable components with changes in the morpho-physiological attributes of the plant. Growing plants under suitable light conditions and harvesting of appropriate plant parts in optimum season is crucial for harnessing the full potential of the crop. Read More

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February 2021

Clinical Course and Outcome of COVID-19 Acute Respiratory Distress Syndrome: Data From a National Repository.

J Intensive Care Med 2021 Mar 9:885066621994476. Epub 2021 Mar 9.

VA Western New York Healthcare System, Buffalo, NY, USA.

Background: Mortality attributable to coronavirus disease-19 (COVID-19) 2 infection occurs mainly through the development of viral pneumonia-induced acute respiratory distress syndrome (ARDS).

Research Question: The objective of the study is to delineate the clinical profile, predictors of disease progression, and 30-day mortality from ARDS using the Veterans Affairs Corporate Data Warehouse.

Study Design And Methods: Analysis of a historical cohort of 7,816 hospitalized patients with confirmed COVID-19 infection between January 1, 2020, and August 1, 2020. Read More

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Evaluating the frequency, consumers' motivation and perception of online medicinal, herbal, and health products purchase safety in Saudi Arabia.

Saudi Pharm J 2021 Feb 11;29(2):166-172. Epub 2021 Jan 11.

Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Objectives: Purchasing medicinal products from the internet has become more popular in the last three decades. Understanding consumers' use and perception of the safety of medicinal products obtained online is essential. Therefore, this study aims to evaluate the extent of medicines purchased from the internet in Saudi Arabia, types of products, sources of information, the satisfaction, the motivational factors, and estimate consumers' vigilance and tendency to report ADRs if occurred. Read More

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February 2021

Influence of Enzyme Supplementation in the Diets of Broiler Chickens Formulated with Different Corn Hybrids Dried at Various Temperatures.

Animals (Basel) 2021 Feb 28;11(3). Epub 2021 Feb 28.

Department of Poultry Science, Texas A&M University, College Station, TX 77845, USA.

We evaluated the influence of enzymatic supplementation on the growth performance and cecal microbiota of broilers. A total of 2160 1-day-old male chicks were used in a 3 × 2 × 2 factorial arrangement (three corn hybrids, two drying temperatures -80 and 110 °C, with or without the inclusion of an enzymatic blend (amylase, xylanase, and protease) (20 birds/pen, = 9). For all performance and digestibility parameters, we observed, in general, isolated effects of the corn hybrids and drying temperature. Read More

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February 2021

Predicting the risk of developing type 2 diabetes in Chinese people who have coronary heart disease and impaired glucose tolerance.

J Diabetes 2021 Mar 4. Epub 2021 Mar 4.

Diabetes Trials Unit, University of Oxford, Oxford, UK.

Aims: Robust diabetes risk estimates in Asian patients with impaired glucose tolerance (IGT) and coronary heart disease (CHD) are lacking. We developed a Chinese type 2 diabetes risk calculator using Acarbose Cardiovascular Evaluation (ACE) trial data.

Methods: There were 3105 placebo-treated ACE participants with requisite data for model development. Read More

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Racial disparities in diabetes care among incident breast, prostate, and colorectal cancer survivors: a SEER Medicare study.

J Cancer Surviv 2021 Mar 4. Epub 2021 Mar 4.

Weill Cornell Medicine, New York, NY, USA.

Background: Many cancer survivors with co-morbid diabetes receive less diabetes management than their non-cancer counterparts. We sought to determine if racial/ethnic disparities exist in recommended diabetes care within 12 months of an incident breast, prostate, or colorectal cancer diagnosis. Because co-morbid diabetes decreases long-term survival, identifying predictors of guideline-concordant diabetes care is important. Read More

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Assessing the Quality, Content, and Readability of Freely Available Online Information for Patients Regarding Age-Related Macular Degeneration.

Semin Ophthalmol 2021 Mar 1:1-6. Epub 2021 Mar 1.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

: One of the top ten causes of disability in the United States is vision loss, primarily due to age-related eye diseases such as age-related macular degeneration. With an aging population, the number of people affected by this condition is expected to rise. Patients increasingly turn to the internet for health-related information, but no standard exists across published websites. Read More

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Reperfusion Treatment and Stroke Outcomes in Hospitals With Telestroke Capacity.

JAMA Neurol 2021 Mar 1. Epub 2021 Mar 1.

Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts.

Importance: Telestroke is increasingly used in hospital emergency departments, but there has been limited research on its impact on treatment and outcomes.

Objective: To describe differences in care patterns and outcomes among patients with acute ischemic stroke who present to hospitals with and without telestroke capacity.

Design, Setting, And Participants: Patients with acute ischemic stroke who first presented to hospitals with telestroke capacity were matched with patients who presented to control hospitals without telestroke capacity. Read More

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Influence of left ventricular systolic function on the long-term benefit of beta-blockers after ST-segment elevation myocardial infarction.

Rev Port Cardiol 2021 Apr 26;40(4):285-290. Epub 2021 Feb 26.

Department of Cardiology. Hospital General Universitario Gregorio Marañón, CIBERCV, Madrid, Spain; Universidad Complutense, Madrid, Spain; Universidad Europea, Madrid, Spain. Electronic address:

Introduction: Beta-blockers are recommended after ST-elevation myocardial infarction (STEMI), but their benefit in patients with preserved left ventricular ejection fraction (LVEF) is unclear.

Methods: Consecutive patients discharged in sinus rhythm after STEMI between January 2010 and April 2015 were followed until December 2017. Percutaneous coronary intervention (PCI) was performed in 969 (99. Read More

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Identifying the Prognostic Risk Factors of Synaptojanin 2 and Its Underlying Perturbations Pathways in Hepatocellular Carcinoma.

Bioengineered 2021 Dec;12(1):855-874

Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.

Synaptojanin 2 (SYNJ2) regulates cell proliferation and apoptosis via dephosphorylating plasma membrane phosphoinositides. Aim of this study is to first seek the full-scale expression levels and potential emerging roles of SYNJ2 in hepatocellular carcinoma (HCC). We systematically analyzed SYNJ2 mRNA expression and protein levels in HCC tissues based on large-scale data and in-house immunohistochemistry (IHC). Read More

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December 2021

CUB and Sushi Multiple Domains (CSMD1) Gene Polymorphisms and Susceptibilities to Idiopathic Parkinson's Disease in Northern Chinese Han Population: A Case-Control Study.

Parkinsons Dis 2021 12;2021:6661162. Epub 2021 Feb 12.

Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.

Evidence has shown that the CUB and Sushi Multiple Domains () gene is an inhibitor of the complement activation pathway and is also involved in central nervous system inflammation. Previous studies have revealed that the gene is related to familial Parkinson's disease. This study aimed to investigate the relationship between gene and susceptibility to Parkinson's disease in population of northern China. Read More

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February 2021

National trends and predictors of mastectomy with immediate breast reconstruction.

Am J Surg 2021 Feb 17. Epub 2021 Feb 17.

Division of General Surgery, Department of Surgery, University of California, Los Angeles, CA, United States. Electronic address:

Purpose: This study aimed to evaluate national trends in utilization, resource use, and predictors of immediate breast reconstruction (IR) after mastectomy.

Methods: The 2005-2014 National Inpatient Sample database was used to identify adult women undergoing mastectomy. IR was defined as any reconstruction during the same inpatient stay. Read More

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February 2021

The Effect of Occupational Stress on the Quality of Life of Pharmacists in Saudi Arabia.

Yasser Almogbel

Risk Manag Healthc Policy 2021 16;14:643-654. Epub 2021 Feb 16.

Department of Pharmacy Practice, College of Pharmacy, Qassim University, Buraidah, 51452, Qassim, Saudi Arabia.

Purpose: The job of a pharmacist is extremely demanding, and pharmacists play a vital role in improving the success of patients' treatment plans and disease management outcomes. The objective of this study was to evaluate the association between pharmacists' quality of life (QOL) and occupational stress in Saudi Arabia.

Methods: This was a prospective, paper-based, cross-sectional survey. Read More

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February 2021

Radiation-Induced Optical Coherence Tomography Angiography Retinal Alterations in Patients With Nasopharyngeal Carcinoma.

Front Med (Lausanne) 2020 3;7:630880. Epub 2021 Feb 3.

Department of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

The aim of the study was to investigate the early neurovascular alterations of the retina in radiation encephalopathy (RE) patients with normal-ranged visual acuity after radiotherapy for nasopharyngeal carcinoma. Fifty-five RE patients and 54 healthy age-matched subjects were enrolled in this retrospective cross-sectional case-control study. The best corrected visual acuity (LogMAR) of the included eye should not be more than 0. Read More

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February 2021

Oral frailty and gait performance in community-dwelling older adults: findings from the Takashimadaira study.

J Prosthodont Res 2021 Feb 22. Epub 2021 Feb 22.

Tokyo Metropolitan Institute of Gerontology, Tokyo.

Purpose: This cross-sectional study compared gait performance between community-dwelling older adults with and without accumulated deficits in oral health, defined as oral frailty.

Methods: A total of 1,082 individuals (439 men and 643 women; mean age, 77.1 years) from the Takashimadaira study were included in the current analysis. Read More

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February 2021