6,877 results match your criteria age 345


Cross-Cultural Comparison of Nonopioid and Multimodal Analgesic Prescribing in Orthopaedic Trauma.

J Am Acad Orthop Surg Glob Res Rev 2020 May;4(5):e2000051

From the Harvard Medical School (Mr. Young, Dr. Bhashyam, Dr. Dyer); the Harvard Combined Orthopaedic Residency Program (Dr. Bhashyam, Dr. Dyer); Boston, MA; the Department of Orthopaedic Surgery (Dr. Parisien), University of Pennsylvania; Philadelphia, PA; the Department of Trauma Surgery (Dr. Van der Vliet), University Medical Center Utrecht; Utrecht, the Netherlands; the Department of Orthopaedics, Nemours (Dr. Qudsi)/A.I. duPont Hospital for Children; Wilmington, DE; and the Department of Orthopaedic Surgery (Dr. Fils, Dr. Dyer), Brigham and Women's Hospital, Boston, MA.

Background: After musculoskeletal injury, US providers prescribe opioids more frequently and at higher dosages than prescribers in the Netherlands and Haiti; however, the extent of variation in nonopioid analgesic prescribing is unknown. The aim of our study was to evaluate how nonopioid prescribing by orthopaedic residents varies by geographic context.

Methods: Orthopaedic residents in three countries in which residents are the primary prescribers of postoperative analgesia in academic medical centers (Haiti, the Netherlands, and the United States) responded to surveys using vignette-based musculoskeletal trauma case scenarios. Read More

View Article and Full-Text PDF

Clinical and ultrasound evaluation of patients with haemophilia on prophylaxis.

Haemophilia 2021 May 10. Epub 2021 May 10.

Haemophilia Foundation of Argentina, Buenos Aires, Argentina.

Introduction: Primary prophylaxis is the current gold standard in haemophilia care for the prevention of bleeding and ensuing joint damage. Early detection of joint bleeding, whether symptomatic or subclinical, preferably during childhood, helps prevent joint deterioration and subsequent disability. The aim of this study is to evaluate the level of agreement between the Haemophilia Joint Health Score and the Haemophilia Early Arthropathy Detection with Ultrasound tools in children with severe haemophilia on primary and secondary prophylaxis. Read More

View Article and Full-Text PDF

High rates of JCV seroconversion in a large international cohort of natalizumab-treated patients.

Ther Adv Neurol Disord 2021 16;14:1756286421998915. Epub 2021 Apr 16.

Department of Neuroscience, Monash University, 99 Commercial Rd, Melbourne, VC 3004, Australia.

Aims: To retrospectively assess factors associated with John Cunningham virus (JCV) seroconversion in natalizumab-treated patients.

Background: Natalizumab is highly effective for the treatment of relapsing-remitting multiple sclerosis (RRMS), but its use is complicated by opportunistic JCV infection. This virus can result in progressive multifocal leukoencephalopathy (PML). Read More

View Article and Full-Text PDF

Assessment of airway reversibility in asthmatic children using forced oscillation technique - A single-center experience from North India.

Lung India 2021 May-Jun;38(3):229-235

Department of Pediatrics, Division of Pediatric Emergency, Critical Care, Pulmonology and Allergic Disorders, Institute of Child Health, Sir Ganga Ram Hospital, New Delhi, India.

Background: Lung function testing is recommended for the management of asthma. Due to certain limitations of conventional spirometry in vulnerable patients, forced oscillation technique (FOT) has been studied with promising results. As there is a paucity of data from developing world, we planned to conduct this study in children using FOT. Read More

View Article and Full-Text PDF

Thirst distress in outpatients with heart failure in a Mediterranean zone of Spain.

ESC Heart Fail 2021 May 3. Epub 2021 May 3.

Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.

Aims: This study aimed to evaluate psychometric properties of the Spanish version of the Thirst Distress Scale for patients with Heart Failure (TDS-HF) and to describe thirst distress-associated factors in outpatients at a heart failure (HF) clinic in Spain. Thirst is common in patients with HF, but thirst distress has rarely been addressed and may significantly decrease quality of life.

Methods And Results: A cross-sectional study was performed assessing perceived thirst distress by patients with HF during the preceding 3 days, with the TDS-HF (scores 8 to 40). Read More

View Article and Full-Text PDF

Comparative Effectiveness of Lobectomy, Segmentectomy, and Wedge Resection for Pathological Stage I Non-small Cell Lung Cancer in Elderly Patients: A Population-Based Study.

Front Surg 2021 15;8:652770. Epub 2021 Apr 15.

Department of Thoracic Surgery, Peking University First Hospital, Beijing, China.

This study was designed to assess the long-term survival of lobectomy, segmentectomy, and wedge resection for pathological stage I non-small cell lung cancer (NSCLC) in patients over 75 years of age. Pathological stage I NSCLC patients aged ≥75 years who underwent lobectomy, segmentectomy, or wedge resection were identified from the Surveillance, Epidemiology, and End Results database. Propensity score-matched and competing risks analyses were conducted. Read More

View Article and Full-Text PDF

Preventable multiple high-risk birth behaviour and infant survival in Nigeria.

BMC Pregnancy Childbirth 2021 May 1;21(1):345. Epub 2021 May 1.

Department of Epidemiology and Medical Statistics, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background: Globally, infant mortality has declined considerably but has remained unacceptably high in sub-Saharan Africa, especially Nigeria where infant mortality rate is 67/1000 live births. To facilitate infant mortality reduction in Nigeria, an understanding of the synergistic effect of bio-demographic characteristics of mothers known as High Risk Birth Behaviours (HrBBs) is important. We therefore investigated the influence of HrBBs on infant survival in Nigeria. Read More

View Article and Full-Text PDF

Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study.

Lancet Infect Dis 2021 Apr 27. Epub 2021 Apr 27.

Department of Twin Research & Genetic Epidemiology, King's College London, London, UK.

Background: The Pfizer-BioNTech (BNT162b2) and the Oxford-AstraZeneca (ChAdOx1 nCoV-19) COVID-19 vaccines have shown excellent safety and efficacy in phase 3 trials. We aimed to investigate the safety and effectiveness of these vaccines in a UK community setting.

Methods: In this prospective observational study, we examined the proportion and probability of self-reported systemic and local side-effects within 8 days of vaccination in individuals using the COVID Symptom Study app who received one or two doses of the BNT162b2 vaccine or one dose of the ChAdOx1 nCoV-19 vaccine. Read More

View Article and Full-Text PDF

Association between number of teeth and Alzheimer's disease using the National Database of Health Insurance Claims and Specific Health Checkups of Japan.

PLoS One 2021 30;16(4):e0251056. Epub 2021 Apr 30.

Japan Dental Association, Tokyo, Japan.

Associations of numbers of teeth present and of missing teeth with Alzheimer's disease were cross-sectionally analyzed using the National Database of Health Insurance Claims and Specific Health Checkups of Japan. Dental care claims data of patients aged 60 years or older diagnosed with periodontitis (n = 4,009,345) or missing teeth (n = 662,182) were used to obtain information about the numbers of teeth present and of missing teeth, respectively, and they were combined with medical care claims data including the diagnosis of Alzheimer's disease. Numbers of teeth present and of missing teeth excluding third molars were calculated using the dental formula in the claims for periodontitis and missing teeth, respectively, and categorized into three groups each. Read More

View Article and Full-Text PDF

Genomics of aging: The role of sirtuin and metabolic health.

J Am Assoc Nurse Pract 2021 May 21;33(5):345-347. Epub 2021 May 21.

Uniformed Services University, Bethesda, Maryland.

Abstract: Healthy aging is not the result of a single factor. Genes, dietary choices/options, exercise, and environmental exposures all play a role. A family of seven nicotinamide adenine dinucleotide (NAD)-dependent sirtuin proteins are very involved in various metabolic functions, such as glucose and fat regulation, and polymorphisms in these genes have been associated with the development of obesity, type 2 diabetes, cancer, cardiovascular disease, and longevity. Read More

View Article and Full-Text PDF

Patterns of Alcohol Consumption in the PURE Poland Cohort Study and Their Relationship with Health Problems.

Int J Environ Res Public Health 2021 Apr 15;18(8). Epub 2021 Apr 15.

Department of Social Medicine, Wroclaw Medical University, 50-345 Wrocław, Poland.

(1) Background: Alcohol is a leading risk factor of premature morbidity and mortality. The objective of this study was to investigate the patterns of alcohol consumption in the PURE Poland cohort study baseline. (2) Methods: A Polish cohort was enrolled in the baseline study in 2007-2010. Read More

View Article and Full-Text PDF

Early Prevention of Atherosclerosis: Detection and Management of Hypercholesterolaemia in Children and Adolescents.

Life (Basel) 2021 Apr 14;11(4). Epub 2021 Apr 14.

Centre for Paediatric Dyslipidaemias, Paediatrics and Neonatology Unit, Guglielmo da Saliceto Hospital, 29121 Piacenza, Italy.

Coronary heart disease (CHD) is the main cause of death and morbidity in the world. There is a strong evidence that the atherosclerotic process begins in childhood and that hypercholesterolaemia is a CHD major risk factor. Hypercholesterolaemia is a modifiable CHD risk factor and there is a tracking of hypercholesterolaemia from birth to adulthood. Read More

View Article and Full-Text PDF

Familial Correlates of Leisure Time Activities among Polish Early School-Age Children: A Cross-Sectional Study.

Int J Environ Res Public Health 2021 Apr 1;18(7). Epub 2021 Apr 1.

Department of Hygiene, Wroclaw Medical University, 50-345 Wroclaw, Poland.

The after-school period may play a critical role in the accumulation of children's physical activity and sedentary time. The study aimed to characterize familial correlates of early school-age children's leisure time activities. A cross-sectional study was conducted among a group of 223 children (mean age 8. Read More

View Article and Full-Text PDF

Does the Age Affect the Outcomes of Cardiac Resynchronization Therapy in Elderly Patients?

J Clin Med 2021 Apr 1;10(7). Epub 2021 Apr 1.

Department of Advanced Biomedical Sciences, Federico II University of Naples, 80138 Naples, Italy.

Background: More and more heart failure (HF) patients aged ≥ 75 years undergo cardiac resynchronization therapy (CRT) device implantation, however the data regarding the outcomes and their predictors are scant. We investigated the mid- to long-term outcomes and their predictors in CRT patients aged ≥ 75 years.

Methods: Patients in the Cardiac Resynchronization Therapy Modular (CRT MORE) Registry were divided into three age-groups: <65 (group A), 65-74 (group B) and ≥75 years (group C). Read More

View Article and Full-Text PDF

Arthroscopic Correction of Femoroacetabular Impingement for Concomitant Inguinal Disruption in Athletes With Dual Pathology.

Am J Sports Med 2021 Apr 29:3635465211007144. Epub 2021 Apr 29.

The Hip and Groin Clinic, UPMC Whitfield, Waterford, Ireland.

Background: Inguinal disruption and femoroacetabular impingement (FAI) are well-recognized sources of groin pain in athletes; however, the relationship between inguinal disruption and FAI remains unclear. In cases of dual pathology, where both entities coexist, there is no definitive consensus regarding which pathology should be prioritized for treatment in the first instance.

Purpose: (1) To examine the 2-year effectiveness and clinical outcome in athletes presenting with dual pathology in which the FAI component alone was treated with arthroscopic deformity correction. Read More

View Article and Full-Text PDF

Can organizational efforts lead to less secondary traumatic stress? A longitudinal investigation of change.

Am J Orthopsychiatry 2021 Apr 29. Epub 2021 Apr 29.

College of Public Health, University of Kentucky.

Current best practice approaches suggest that to address secondary traumatic stress (STS) a two-pronged perspective that considers individual and organizational factors over time is warranted. However, research documenting the impact of organizational efforts on individual experience with STS is lacking. In this study, it was hypothesized that as an organization becomes more STS informed, there would be decreases in reported levels of STS and burnout (BO) in individuals over time; and these changes would be associated with higher levels of implementation activity and increased use of interventions to improve physical and psychological safety. Read More

View Article and Full-Text PDF

Relationships between hormonal parameters, body fat distribution and bone mineral density in women with functional menstrual disorders.

Ginekol Pol 2021 Apr 29. Epub 2021 Apr 29.

Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University, Szczecin, Poland.

Objectives: Available evidence implies that unfavorable changes in the distribution of adipose tissue resulting from hormonal imbalance associated with ovarian insufficiency might influence bone mineral density (BMD). The purpose of our study was to verify if volumes of visceral (VAT), female (FAT) and android (AAT) body fat as determined by densitometry determined influence BMD in women with functional menstrual disorders, and if these correlates some endocrine factors.

Material And Methods: We examined 293 women (mean age 26. Read More

View Article and Full-Text PDF

Utilization of Healthcare Resources in Osteoarthritis: A Cost of Illness Analysis Based on Real-World Data in Italy.

Ther Clin Risk Manag 2021 21;17:345-356. Epub 2021 Apr 21.

Real World Solutions, IQVIA Solutions Italy S.r.l., Milan, Italy.

Purpose: Understand the demographics and clinical features of patients with osteoarthritis (OA), quantify healthcare resource utilization by OA patients, and estimate the annual direct medical costs per OA patient from a National Health Service (NHS) perspective in Italy.

Patients And Methods: Retrospective observational cohort analysis using data from electronic medical records captured by the Italian IQVIA Longitudinal Patient Database (LPD). Only direct medical costs reimbursed by the NHS were considered. Read More

View Article and Full-Text PDF

Efficacy and safety of nelfinavir in asymptomatic and mild COVID-19 patients: a structured summary of a study protocol for a multicenter, randomized controlled trial.

Trials 2021 Apr 28;22(1):309. Epub 2021 Apr 28.

Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.

Objectives: The aim of this trial is to evaluate the antiviral efficacy, clinical efficacy, and safety of nelfinavir in patients with asymptomatic and mild COVID-19.

Trial Design: The study is designed as a multicenter, open-label, blinded outcome assessment, parallel group, investigator-initiated, exploratory, randomized (1:1 ratio) controlled clinical trial.

Participants: Asymptomatic and mild COVID-19 patients will be enrolled in 10 university and teaching hospitals in Japan. Read More

View Article and Full-Text PDF

Effect of COVID-19 on childhood Mycoplasma pneumoniae infection in Chengdu, China.

BMC Pediatr 2021 04 28;21(1):202. Epub 2021 Apr 28.

Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), West China Second University Hospital, Ministry of Education, Sichuan University, No.20 section3 South Renmin Road, Sichuan Province, 610041, Chengdu, China.

Background: Following the outbreak of the COVID-19 pandemic, a change in the incidence and transmission of respiratory pathogens was observed. Here, we retrospectively analyzed the impact of COVID-19 on the epidemiologic characteristics of Mycoplasma pneumoniae infection among children in Chengdu, one of the largest cities of western China.

Method: M. Read More

View Article and Full-Text PDF

XPG is Modulated by miR-4715-3p and rs873601 Genotypes in Lung Cancer.

Cancer Manag Res 2021 19;13:3417-3427. Epub 2021 Apr 19.

Department of Environmental and Occupational Health, School of Public Health, Hainan Medical University, Haikou, 571199, Hainan, People's Republic of China.

Objective: (Xeroderma pigmentosum group G, ), a single strand-specific DNA endonuclease in the nucleotide excision repair pathway, has been implicated in lung cancer. Potentially functional rs873601 in is consistently associated with gastrointestinal cancer, and miR-4715-3p, targeting 3UTR of , also influences the process of gastrointestinal carcinogenesis, however, the relationships between and miR-4715-3p and rs873601 in lung cancer have not been elucidated.

Methods: A case-control study included 264 lung cancer patients and 264 cancer-free healthy controls and was designed to determine the relationships between rs873601 and lung cancer and the effect of miR-4715-3p on expression in lung cancer. Read More

View Article and Full-Text PDF

Characteristics of physicians working at geriatric health service facilities in Japan, 1996-2016.

PLoS One 2021 27;16(4):e0250589. Epub 2021 Apr 27.

Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Background: In Japan, which has the most rapidly aging population worldwide, the number of geriatric health service facilities (GHSFs) has been increasing. GHSF physicians play significant roles in integrated care for the elderly. However, little is known about the temporal trends of physicians working in GHSFs. Read More

View Article and Full-Text PDF

Prenatal Education in the Digital Age.

Clin Obstet Gynecol 2021 Jun;64(2):345-351

University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

The millennial pregnant patient expects an innovative approach to prenatal care. Patients are reaching to peer support online communities or engaging in direct-to-consumer mobile applications during their pregnancy. Currently developed solutions show promise, however, the clinical impact and generalizability of these solutions remains unclear. Read More

View Article and Full-Text PDF

Transfusion requirement prediction score for patients undergoing cardiac surgery: An experience from a tertiary care set-up from South India.

Transfus Med 2021 Apr 25. Epub 2021 Apr 25.

Cardiothoracic Surgery, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.

Background: Prediction of transfusion requirement is part of preoperative management in a surgical case. We aimed to develop one such tool for patients undergoing cardiac surgery.

Methods: A retrospective study for a period of 3 years was done to develop the scoring tool, Transfusion Requirement Prediction Score for Cardiac Surgery (TRPS), and internal validation was done prospectively. Read More

View Article and Full-Text PDF

Sociodemographic and Clinical Characteristics of Highly Active Antiretroviral Treatment-Naïve Human Immunodeficiency Virus-Seropositive Patients in Uyo, Nigeria: Are the Demographics Changing?

Niger Med J 2020 Nov-Dec;61(6):345-350. Epub 2020 Dec 19.

Department of Internal Medicine, University of Calabar Teaching Hospital, University of Calabar, Calabar, Cross River State, Nigeria.

Background: Human immunodeficiency virus (HIV) infection poses a great health and economic burden, especially in developing nations where a high burden of disease has been described. A previous study in Uyo shows that some characteristics associated with a higher prevalence of HIV infection include female gender, exposure to tertiary level of education, and late disease presentation. This study aimed at determining the sociodemographic and the clinical characteristics of highly active antiretroviral treatment-naïve (HAART-naïve) HIV-seropositive patients at Uyo, Nigeria. Read More

View Article and Full-Text PDF
December 2020

MeDiGes Study. Metformin versus insulin in gestational diabetes: Glycemic control, and obstetrical and perinatal outcomes. Randomized prospective trial.

Am J Obstet Gynecol 2021 Apr 19. Epub 2021 Apr 19.

Department of Endocrinology and Nutrition, Hospital Regional Universitario de Málaga. IBIMA; CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM).

Background: Gestational diabetes not properly controlled with diet has been commonly treated with insulin. In recent years several studies have published that metformin can lead to, at least, similar obstetrical and perinatal outcomes as insulin. Nevertheless, not all clinical guidelines endorse its use, and clinical practice is heterogeneous. Read More

View Article and Full-Text PDF

Immediate versus delayed frozen embryo transfer in patients following a stimulated IVF cycle: a randomised controlled trial.

Hum Reprod 2021 Apr 22. Epub 2021 Apr 22.

Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.

Study Question: Is there any difference in the ongoing pregnancy rate after immediate versus delayed frozen embryo transfer (FET) following a stimulated IVF cycle?

Summary Answer: Immediate FET following a stimulated IVF cycle produced significantly higher ongoing pregnancy and live birth rate than did delayed FET.

What Is Known Already: Embryo cryopreservation is an increasingly important part of IVF, but there is still no good evidence to advise when to perform FET following a stimulated IVF cycle. All published studies are retrospective, and the findings are contradictory. Read More

View Article and Full-Text PDF

Monocyte-to-High-Density Lipoprotein Cholesterol Ratio Is Independently Associated With All-Cause Mortality in Deceased Donor Kidney Transplant Recipients.

Exp Clin Transplant 2021 Apr 16. Epub 2021 Apr 16.

From the Department of Urology, Faculty of Medicine, Uludag University, Bursa, Turkey.

Objectives: The primary objective of this study was to evaluate the impact of monocyte-to-high-density lipoprotein cholesterol ratio on all-cause mortality in deceased donor kidney transplant recipients.

Materials And Methods: This was a retrospective observational study in which all deceased donor kidney transplant recipients were included. Relevant data for analyses included clinical and demographic features, laboratory values, number of HLA matches, occurrence of delayed graft function, cold ischemia time, and survival status. Read More

View Article and Full-Text PDF

Network analysis in aged C. elegans reveals candidate regulatory genes of ageing.

Biogerontology 2021 Jun 19;22(3):345-367. Epub 2021 Apr 19.

Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 116 35, Athens, Greece.

Ageing is a biological process guided by genetic and environmental factors that ultimately lead to adverse outcomes for organismal lifespan and healthspan. Determination of molecular pathways that are affected with age and increase disease susceptibility is crucial. The gene expression profile of the ideal ageing model, namely the nematode Caenorhabditis elegans mapped with the microarray technology initially led to the identification of age-dependent gene expression alterations that characterize the nematode's ageing process. Read More

View Article and Full-Text PDF

Diabetes, Age, and Duration of Supplementation Subgroup Analysis for the Effect of Coenzyme Q10 on Oxidative Stress: A Systematic Review and Meta-Analysis.

Complement Med Res 2021 Apr 16:1-14. Epub 2021 Apr 16.

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Background: Coenzyme Q10 (CoQ10) has been known as ubiquinone or ubidecarenone, which is a kind of lipid-soluble and vitamin-like antioxidant. It has a potent antioxidant effect against oxidation status via various mechanisms, including its ability to regenerate other antioxidants, such as vitamin E and vitamin C, and to increase antioxidant enzymes. Moreover, CoQ10 can quench free radicals and prevent lipid peroxidation. Read More

View Article and Full-Text PDF