Ann Surg 2022 Jan 25. Epub 2022 Jan 25.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy Department of Hepatobiliary and General Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy School of Medicine and Surgery, University of Milan-Bicocca, Department of Surgery, San Gerardo Hospital, Monza, Italy Hepatobiliary Surgery Division, IRCCS San Raffaele Scientific Institute, Milan, Italy Hepatobiliary Surgery Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University of the Sacred Heart, Rome, Italy, Rome, Italy Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy Division of Gastroenterology and Hepatology, Department Promozione della Salute, Materno Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Italy Department of General and Oncological Surgery, Mauriziano Hospital "Umberto I", Turin, Italy Department of Internal Medicine, Ospedale per gli Infermi di Faenza, Faenza, Italy Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Italy Internal Medicine and Hepatology Unit, Department of Experimental and Clinical Medicine, University of Firenze, Florence, Italy Department of Medicine and Surgery, University of Parma, Parma, Italy Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, Padua University, Padua, Italy Liver Injury and Transplant Unit, Polytechnic University of Marche, Ancona, Italy Division of Clinical and Molecular Hepatology, University of Messina, Messina, Italy Division of Gastroenterology, Bolzano Regional Hospital, Bolzano, Italy Department of Emergency and Robotic Surgery, ASST Lecco, Lecco, Italy Unit of General Surgery 1, University of Pavia and Foundation IRCCS Policlinico San Matteo, Pavia, Italy Division of Internal Medicine and Gastroenterology, Policlinico Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy Alma Mater Studiorum, University of Bologna, AOU Sant'Orsola Malpighi, IRCCS at Maggiore Hospital, Bologna, Italy Division of Hepatobiliarypancreatic Unit, IRCCS - Regina Elena National Cancer Institute, Rome, Italy Division of Internal Medicine and Gastroenterology, Complesso Integrato Columbus, Università Cattolica del Sacro Cuore, Rome, Italy Division of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy Gastroenterology Unit, Department of Clinical Medicine and Surgery, University of Napoli "Federico II", Napoli, Italy Gastroenterology and Digestive Endoscopy Unit, Foggia University Hospital, Foggia, Italy Department of Hepato-Pancreatic-Biliary Surgery, Miulli Hospital, Bari, Italy Department of Surgery, L. Sacco Hospital, Milan, Italy Department of Surgery, Monza Policlinic, Monza, Italy Center of Biostatistics for Clinical Epidemiology, School of Medicine and Surgery, University of Milan - Bicocca, Monza, Italy HPB Surgical Unit, San Paolo Hospital, Savona, Italy Vita-Salute San Raffaele University, Milan, Italy IRCCS Azienda Ospedaliero-universitaria di Bologna, Bologna, Italy Department of Medical and Surgical Sciences, Semeiotics Unit, Alma Mater Studiorum-University of Bologna, Bologna, Italy.
Objective: The aim of the study was to compare surgery (SURG) vs sorafenib (SOR) regarding the overall survival (OS) and progression-free survival (PFS) in a real-world clinical scenario.
Background Data: The treatment for advanced non-metastatic hepatocellular carcinoma (HCC) belonging to the Barcelona Clinic Liver Cancer stage C (BCLC C) is still controversial.
Methods: BCLC C patients without extra-hepatic spread and tumoral invasion of the main portal trunk were considered. Read More