2,869,889 results match your criteria age [57


A model for predicting gestational diabetes mellitus in early pregnancy: a prospective study in Thailand.

Obstet Gynecol Sci 2022 Jan 26. Epub 2022 Jan 26.

Department of Epidemiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.

Objective: To develop a predictive model using the risk factors of gestational diabetes mellitus (GDM) and construct a predictive nomogram for GDM risk in women during early pregnancy.

Methods: A prospective study was conducted in two tertiary hospitals among pregnant women with gestational age ≤14 weeks. Early GDM was diagnosed if an abnormal 100 g oral glucose tolerance test was detected using the Carpenter and Coustan criteria after an abnormal 50 g glucose challenge test. Read More

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January 2022

Contraception in the COVID-19 pandemic: recommendations from the Korean society of contraception and reproductive health.

Obstet Gynecol Sci 2022 Jan 26. Epub 2022 Jan 26.

Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Coronavirus disease 2019 (COVID-19) is associated with a systemic inflammatory response that activates coagulation in symptomatic patients. In addition, a rare form of thrombosis has been reported in people who received the COVID-19 vaccine, most of whom were women younger than 50 years of age. Considering that hormonal contraceptive methods that are widely used by women of childbearing age increase the risk of thrombosis, the development of guidelines for the use of hormonal contraceptives in the era of the COVID-19 pandemic is necessary. Read More

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January 2022

Pregnancy, delivery, and neonatal outcomes among women with psoriatic arthritis, a population based study.

J Perinat Med 2022 Jan 21. Epub 2022 Jan 21.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, McGill University, Montreal, QC, Canada.

Objectives: Many autoimmune diseases negatively affect pregnancies. Studies report conflicting data about the effects of psoriatic arthritis (PsA) in pregnancy. We sought to evaluate the pregnancy, delivery, and neonatal outcomes among women with PsA. Read More

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January 2022

Microbiomes in physiology: Insights into 21 century global medical challenges.

Exp Physiol 2022 Jan 26. Epub 2022 Jan 26.

Quadram Institute Bioscience, Food Innovation and Health & Gut microbes in Health and Disease programmes, Norwich Research Park, Norwich, NR4 7UQ, United Kingdom.

New Findings: What is the topic of this review? This review summarises the role of the gut microbiome in physiology and how it can be targeted as an effective strategy against two of the most important global medical challenges of our time namely, metabolic diseases and antibacterial resistance. What advances does it highlight? We outline the critical roles of the microbiome in regulating host physiology and discuss how microbiome analysis is useful for disease stratification to enable informed clinical decisions and develop interventions such as faecal microbiota transplantation (FMT), prebiotics, and probiotics. We also discuss the limitations of microbiome modulation, including the potential for probiotics to enhance antimicrobial resistance gene reservoirs, and that currently a "healthy microbiome" that can be used as a biobank for transplantation is yet to be defined. Read More

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January 2022

[Flow-Experience in Old Age: An Investigation of Influencing Factors and Therapy Benefits for Geriatric Patients].

Psychother Psychosom Med Psychol 2022 Jan 26. Epub 2022 Jan 26.

Klinik für Psychosomatische Medizin und Psychotherapie, Universitätsklinik der Paracelsus Medizinischen Privatuniversität, Klinikum Nürnberg, Deutschland.

Flow experience, a feeling of being absorbed in an activity without reflection and with maximum depth, has positive effects on psychological and physical well-being, performance, and life satisfaction. Little research has been done on flow experience in old age, and there are no studies on geriatric patients. In the present study, elderly patients (mean age:81. Read More

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January 2022

Treatment of Postoperative Lymphatic Leakage Applying Transpedal Lymphangiography - Experience in 355 Consecutive Patients.

Rofo 2022 Jan 26. Epub 2022 Jan 26.

Clinic of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Germany.

Purpose:  Report of experience from a single institution in treating postoperative lymphatic leakage (PLL) applying conventional transpedal lymphangiography (TL).

Materials And Methods:  453 patients with the initial diagnosis of PLL receiving TL between 03/1993 and 09/2018 were identified in the database. Only patients with confirmed PLL were included in the study. Read More

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January 2022

Cystatin C Concentration During the First Three Postnatal Days in Healthy Term Newborns.

Z Geburtshilfe Neonatol 2022 Jan 26. Epub 2022 Jan 26.

Department of Obstetrics and Gynaecology, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina.

Objective: Cystatin C (Cys-C) concentration has not been examined sufficiently among healthy newborn population, particularly in terms of reference values. This study aimed to establish gender-, postnatal age- and birth weight-specific Cys-C concentration for healthy term newborns. Its objective was also to examine if there were any differences between our measured concentration and the reference interval established by the CALIPER study. Read More

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January 2022

Distal Triceps Tendon Tears: Magnetic Resonance Imaging Patterns Using a Systematic Classification.

J Comput Assist Tomogr 2022 Jan 25. Epub 2022 Jan 25.

From the Division of Musculoskeletal Imaging and Intervention, Department of Radiology Department of Orthopedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Objective: This study aimed to evaluate distal triceps tendon tear patterns using a systematic classification based on the tendon's layered structure.

Methods: We retrospectively identified Magnetic resonance imaging (MRI) examinations with triceps tendon tears that underwent reconstructive surgery. Magnetic resonance images were reviewed independently by 2 musculoskeletal radiologists to determine tendon layer involvement and ancillary findings, including tear size, involvement of triceps lateral expansion, and presence of olecranon bursal fluid. Read More

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January 2022

Are Burns a Chronic Condition? Examining Patient Reported Outcomes up to 20 Years after Burn Injury - A Burn Model System National Database Investigation.

J Trauma Acute Care Surg 2022 Jan 25. Epub 2022 Jan 25.

Spaulding Rehabilitation Hospital - Boston, MA Boston University School of Public Health - Boston, MA University of Washington - Seattle, WA Indiana University School of Medicine - Indianapolis, IN Rehabilitation Hospital of Indiana - Indianapolis, IN University of Texas South Western Medical Center - Dallas, TX University of Texas Medical Branch - Galveston, TX Shriners Hospitals for Children Galveston - Galveston, TX Harborview Injury Prevention and Research Center - Seattle, WA Massachusetts General Hospital - Boston, MA Harvard Medical School - Boston, MA Spaulding Research Institute - Boston, MA Shriners Hospitals for Children Boston - Boston, MA.

Background: People living with burn injury often face long-term physical and psychological sequelae associated with their injuries. Few studies have examined the impacts of burn injuries on long-term health and function, life satisfaction, and community integration beyond five years post-injury. The purpose of this study was to examine these outcomes up to 20 years after burn injury. Read More

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January 2022

Obesity Among Industrial Workers in Brazil: A Cross-sectional Study on Prevalence and Associated Factors.

J Occup Environ Med 2022 Jan 25. Epub 2022 Jan 25.

Post-graduate Program in Collective Health, University of Vale do Rio dos Sinos, UNISINOS, São Leopoldo, RS, Brazil (Xavier, Garcez, da Silva, Olinto); Life Sciences Area, University of West Santa Catarina, UNOESC, Joaçaba, SC, Brazil (Xavier); Post-graduate Program in Nutrition Sciences, Federal University of Health Science of Porto Alegre, UFCSPA, Porto Alegre, RS, Brazil (Garcez); Social Service of Industry of Rio Grande do Sul (SESI-RS), Porto Alegre, RS, Brazil (Cibeira, Germano); Post-graduate Program in Food, Nutrition and Health, Federal University of Rio Grande do Sul State, UFRGS, Porto Alegre, RS, Brazil (Olinto).

Objective: Estimate the prevalence of obesity and its associated factors among industrial workers.

Methods: This is a cross-sectional study of secondary data from workers aged 18 to 59 years in the State of Rio Grande do Sul, Brazil.

Results: A total of 20,820 workers (12,372 male and 8,448 female) were investigated. Read More

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January 2022

Effects of Emergency Duties on Cardiovascular Diseases in Firefighters: A 13-Year Retrospective Cohort Study.

J Occup Environ Med 2022 Jan 25. Epub 2022 Jan 25.

Department of Dental Hygiene, Hanyang Woman's University, Seoul, Korea (Jeung); Task Force for Launching Non-benefit Service Reporting, National Health Insurance Service, Wonju, Korea (Hyun); Department of Occupational and Environmental Medicine, Hanyang University College of Medicine, Seoul, Korea (Kim); Department of Preventive Medicine & Institute of Occupational Environmental Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea (Chang).

Objectives: This study aimed to examine the effects of firefighters' emergency duties on the incidence of cardiovascular disease (CVD).

Methods: We used a 13-year follow-up in a nationwide retrospective cohort study. A total of 363,137 employees were recruited. Read More

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January 2022

Retinal microvascular abnormalities and risks of incident stroke and its subtypes: The Circulatory Risk in Communities Study.

J Hypertens 2022 Jan 25. Epub 2022 Jan 25.

Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita Yao City Public Health Center, Yao Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba, Tsukuba Ibaraki Western Medical Center, Chikusei Department of Epidemiology School of Medicine, Fukushima Medical University, Fukushima Department of Public Health and Nursing, Faculty of Medicine, University of Tsukuba, Tsukuba Department of Public Health, School of Medicine, Dokkyo Medical University, Tochigi Department of Internal Medicine, Okanami General Hospital, Mie Department of Public Health, Graduate School of Medicine, Juntendo University, Tokyo, Japan.

Background: This study aimed to investigate the association between retinal microvascular abnormalities and the risk of incident stroke and its subtypes in the general Japanese population.

Methods: A total of 12 965 residents aged 40-74 years without a history of stroke and/or coronary heart disease underwent retinal photography during the annual health checkups of four Japanese communities between 1990 and 1999. Retinal microvascular abnormalities, such as the presence or absence of generalized arteriolar narrowing, focal arteriolar narrowing, arteriovenous nicking, enhanced arteriolar light reflex, and retinal hemorrhages were graded using standard protocols. Read More

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January 2022

Aortic diastolic pressure decay explains sex-related differences in the subendocardial viability ratio: the Wakuya study.

J Hypertens 2022 Jan 25. Epub 2022 Jan 25.

Miyagi University of Education Medical Center, Sendai Wakuya National Health Insurance Hospital Wakuya Medical and Welfare Center, Miyagi, Japan.

Objective: Coronary heart disease is the leading cause of mortality in women. Despite a higher risk of heart failure after the first myocardial infarction in women compared with men, the sex-specific mechanisms are unknown. We hypothesized that myocardial ischemia is attributable to sex-related diastolic alterations in the central hemodynamics. Read More

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January 2022

Hypertension and contraceptive use among women of child-bearing age in the United States from 2001 to 2018.

J Hypertens 2022 Jan 25. Epub 2022 Jan 25.

Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Chan Medical School University of Massachusetts Chan Medical School Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School Department of Obstetrics and Gynecology, University of Massachusetts Chan Medical School, Worcester Division of General Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston Departments of Pediatrics and Psychiatry, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.

Background: Hypertension (HTN) in pregnancy is a leading cause of maternal mortality in the United States. Contraception is widely used, and estrogen-based combined hormonal forms are known to increase blood pressure (BP). With nearly half of pregnancies unplanned and many antihypertensive medications teratogenic, appropriate contraception is critical in child-bearing age women with HTN. Read More

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January 2022

Hepatectomy Versus Sorafenib in Advanced Non-Metastatic Hepatocellular Carcinoma: A Real-Life Multicentric Weighted Comparison.

Ann Surg 2022 Jan 25. Epub 2022 Jan 25.

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy Department of Hepatobiliary and General Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy School of Medicine and Surgery, University of Milan-Bicocca, Department of Surgery, San Gerardo Hospital, Monza, Italy Hepatobiliary Surgery Division, IRCCS San Raffaele Scientific Institute, Milan, Italy Hepatobiliary Surgery Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University of the Sacred Heart, Rome, Italy, Rome, Italy Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy Division of Gastroenterology and Hepatology, Department Promozione della Salute, Materno Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Italy Department of General and Oncological Surgery, Mauriziano Hospital "Umberto I", Turin, Italy Department of Internal Medicine, Ospedale per gli Infermi di Faenza, Faenza, Italy Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Italy Internal Medicine and Hepatology Unit, Department of Experimental and Clinical Medicine, University of Firenze, Florence, Italy Department of Medicine and Surgery, University of Parma, Parma, Italy Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, Padua University, Padua, Italy Liver Injury and Transplant Unit, Polytechnic University of Marche, Ancona, Italy Division of Clinical and Molecular Hepatology, University of Messina, Messina, Italy Division of Gastroenterology, Bolzano Regional Hospital, Bolzano, Italy Department of Emergency and Robotic Surgery, ASST Lecco, Lecco, Italy Unit of General Surgery 1, University of Pavia and Foundation IRCCS Policlinico San Matteo, Pavia, Italy Division of Internal Medicine and Gastroenterology, Policlinico Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy Alma Mater Studiorum, University of Bologna, AOU Sant'Orsola Malpighi, IRCCS at Maggiore Hospital, Bologna, Italy Division of Hepatobiliarypancreatic Unit, IRCCS - Regina Elena National Cancer Institute, Rome, Italy Division of Internal Medicine and Gastroenterology, Complesso Integrato Columbus, Università Cattolica del Sacro Cuore, Rome, Italy Division of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy Gastroenterology Unit, Department of Clinical Medicine and Surgery, University of Napoli "Federico II", Napoli, Italy Gastroenterology and Digestive Endoscopy Unit, Foggia University Hospital, Foggia, Italy Department of Hepato-Pancreatic-Biliary Surgery, Miulli Hospital, Bari, Italy Department of Surgery, L. Sacco Hospital, Milan, Italy Department of Surgery, Monza Policlinic, Monza, Italy Center of Biostatistics for Clinical Epidemiology, School of Medicine and Surgery, University of Milan - Bicocca, Monza, Italy HPB Surgical Unit, San Paolo Hospital, Savona, Italy Vita-Salute San Raffaele University, Milan, Italy IRCCS Azienda Ospedaliero-universitaria di Bologna, Bologna, Italy Department of Medical and Surgical Sciences, Semeiotics Unit, Alma Mater Studiorum-University of Bologna, Bologna, Italy.

Objective: The aim of the study was to compare surgery (SURG) vs sorafenib (SOR) regarding the overall survival (OS) and progression-free survival (PFS) in a real-world clinical scenario.

Background Data: The treatment for advanced non-metastatic hepatocellular carcinoma (HCC) belonging to the Barcelona Clinic Liver Cancer stage C (BCLC C) is still controversial.

Methods: BCLC C patients without extra-hepatic spread and tumoral invasion of the main portal trunk were considered. Read More

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January 2022

Ethnic/Racial Disparities in Longitudinal Neurocognitive Decline in People with HIV.

J Acquir Immune Defic Syndr 2022 Jan 25. Epub 2022 Jan 25.

University of California, San Diego, San Diego, CA; Fordham University, New York, NY; Icahn School of Medicine at Mount Sinai, New York, NY; University of Washington School of Medicine, Seattle, WA; Washington University School of Medicine, St. Louis, MO; University of Texas Medical Branch, Galveston, TX.

Background: To examine longitudinal neurocognitive decline among Latino, non-Latino Black, and non-Latino White people with HIV (PWH) and factors that might explain ethnic/racial disparities in neurocognitive decline.

Methods: 499 PWH (13.8% Latino, 42. Read More

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January 2022

Acute traumatic brain injury in frail patients: the next pandemic.

Curr Opin Crit Care 2022 Jan 25. Epub 2022 Jan 25.

University of Piemonte Orientale, Novara University of Pavia, Pavia School of Medicine and Surgery, University of Milano-Bicocca, Milan Neurointensive Care Unit, San Gerardo Hospital, ASST-Monza, Monza, Italy.

Purpose Of Review: To highlight recent findings on the evaluation and impact of frailty in the management of patients with traumatic brain injury (TBI).

Recent Findings: Frailty is not a direct natural consequence of aging. Rather, it commonly results from the intersection of age-related decline with chronic diseases and conditions. Read More

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January 2022

Age, sex and racial differences in fibrin formation and fibrinolysis within the healthy population.

Blood Coagul Fibrinolysis 2022 Jan 25. Epub 2022 Jan 25.

Northern Pathology Victoria, Northern Health Australian Centre for Blood Diseases, Monash University Department of Medicine (Austin Health & Northern Health), University of Melbourne, Melbourne, Victoria, Australia.

Increased fibrin generation and reduced fibrinolytic potential have been detected using global coagulation assays in several hypercoagulable states including cardiovascular disease and venous thromboembolism. We aimed in this study to define the impact of age, sex and race on fibrin generation and lysis using the Overall Haemostatic Potential (OHP) assay in a group of stringently defined healthy adults. Healthy adult patients not receiving anticoagulation and without a history of thrombotic disease were prospectively recruited. Read More

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January 2022

Impact of Community Referral on Colonoscopy Quality Metrics in a Veterans Affairs Medical Center.

Clin Transl Gastroenterol 2022 Jan 26. Epub 2022 Jan 26.

Digestive Diseases and Nutrition Section, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA.

Introduction: The Veterans Access, Choice, Accountability Act of 2014 expands the number of options veterans have to ensure timely access to high-quality care. There is minimal data currently available analyzing the impact and quality of colonoscopy metrics in veterans receiving procedures within the Department of Veterans' Affairs (VA) vs community settings.

Methods: All patients at our academic VA medical center who were referred to a community care colonoscopy (CCC) for positive fecal immunochemical testing, colorectal cancer screening, and adenoma surveillance from 2015 to 2018 were identified and matched for sex, age, and year of procedure to patients referred for a VA-based colonoscopy (VAC). Read More

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January 2022

Risk Factors for Mortality in Patients with COVID-19: The Kuwait Experience.

Med Princ Pract 2022 Jan 26. Epub 2022 Jan 26.

Objectives: To describe the baseline characteristics and evaluate the risk factors for in-hospital mortality in patients admitted to hospitals with coronavirus disease (COVID-19) in Kuwait.

Subjects And Methods: This retrospective cohort analysed data of patients admitted to two hospitals in Kuwait with COVID-19. The outcome was assessed by using multivariable analysis of factors affecting survival and mortality. Read More

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January 2022

Cardiometabolic and Vascular Disease Factors and Mild Cognitive Impairment and Dementia.

Gerontology 2022 Jan 26:1-9. Epub 2022 Jan 26.

Gerontology Research Programme, Department of Psychological Medicine, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Introduction: There is empirical evidence that cardiovascular risk factors and vascular pathology contribute to cognitive impairment and dementia.

Methods: We profiled cardiometabolic and vascular disease (CMVD) and CMVD burden in community-living older adults in the Singapore Longitudinal Ageing Study cohort and examined the association of CMVD risk markers with the prevalence and incidence of mild cognitive impairment (MCI) and dementia from a median 3.8 years of follow-up. Read More

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January 2022

Endoscopic Nasobiliary Drainage Comparable with Endoscopic Biliary Stenting as a Preoperative Drainage Method for Malignant Hilar Biliary Obstruction: A Multicenter Retrospective Study.

Digestion 2022 Jan 26:1-12. Epub 2022 Jan 26.

Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo, Japan.

Introduction: Preoperative endoscopic biliary drainage (PEBD) for malignant hilar biliary obstruction (MHBO) is widely accepted. Recent PEBD consists of endoscopic nasobiliary drainage (ENBD), conventional endoscopic biliary stenting (CEBS) with plastic stents across the papilla, and endoscopic biliary inside stenting (EBIS) with plastic stents above the papilla, while ENBD is the primary procedure in Asian countries. Thus, we aimed to compare the efficacy of ENBD with those of CEBS and EBIS as a means of PEBD for MHBO. Read More

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January 2022

Effect of BMI on the thermogenic response to cold exposure and associated changes in metabolism and browning markers in adult humans.

Obes Facts 2022 Jan 26. Epub 2022 Jan 26.

Introduction: Brown adipose tissue (BAT) serves to produce heat by non-shivering thermogenesis. Activation of BAT increases energy expenditure and is seen as a putative strategy to treat obesity. There is conflicting data on the capacity for cold induced thermogenesis in individuals with higher BMI. Read More

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January 2022

The Potential of a Stroke Registry Using Diagnosis Procedure Combination Data from All Hospitals in a Japanese Prefecture.

Cerebrovasc Dis 2022 Jan 26:1-6. Epub 2022 Jan 26.

Department of Hygiene and Preventive Medicine, Iwate Medical University, Yahaba, Japan.

Objectives: In Japan, many hospitals have joined the diagnosis procedure combination/per-diem payment system (DPC/PDPS), which provides unified information about inpatients. DPC data are digitized, and the number of participating hospitals has increased recently. Herein, we evaluated the potential of a stroke registry constructed using these unified DPC data from all hospitals in the Iwate Prefecture, Japan. Read More

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January 2022

Epithelial-Cell-Derived Cytokines in Patients with Obesity before and after Bariatric Surgery.

Int Arch Allergy Immunol 2022 Jan 26:1-6. Epub 2022 Jan 26.

Department of General and Bariatric Surgery and Emergency Medicine in Zabrze, Medical University of Silesia, Katowice, Poland.

Abstract/Purpose: Epithelial signals such as interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) are stimulators of group 2 innate lymphoid cells (ILCs2) that are integral regulators of adipose tissue type 2 immunity. The purpose of this study was to assess cytokines activating ILCs2 in the serum of patients with obesity and the effect of bariatric surgery on these parameters.

Material And Methods: In a single-center prospective study, serum IL-25, IL-33, TSLP, and ST2L levels were assayed at the baseline and at 6 months after bariatric surgery and correlated with anthropometric changes and metabolism parameters. Read More

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January 2022

Healthcare, Clinical Factors and Rehabilitation Predicting Quality of Life in First-time Stroke Patients: A 12-month Longitudinal Study.

J Stroke Cerebrovasc Dis 2022 Jan 23;31(4):106300. Epub 2022 Jan 23.

Centre for Economics and Finance, University of Porto.

Objectives: One of the long-term rehabilitation goals in stroke survivors is to achieve the best health-related quality of life (HRQoL). This study analyzes the evolution of HRQoL one-year post-stroke to establish the main pre-stroke, clinical, health care and rehabilitation predictors.

Materials And Methods: This study uses patient-level data from a one-year single-center prospective cohort study of first stroke patients, assessed at baseline, 3, 6 and 12 months. Read More

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January 2022

Differences in treatment and survival of older patients with operable breast cancer between the United Kingdom and the Netherlands - A comparison of two national prospective longitudinal multi-centre cohort studies.

Eur J Cancer 2022 Jan 23;163:189-199. Epub 2022 Jan 23.

Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.

Background: Previous studies have shown that survival outcomes for older patients with breast cancer vary substantially across Europe, with worse survival reported in the United Kingdom. It has been hypothesised that these differences in survival outcomes could be related to treatment variation.

Objectives: We aimed to compare patient and tumour characteristics, treatment selection and survival outcomes between two large prospective cohorts of older patients with operable breast cancer from the United Kingdom (UK) and The Netherlands. Read More

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January 2022

Prenatal metal(loid) mixtures and birth weight for gestational age: A pooled analysis of three cohorts participating in the ECHO program.

Environ Int 2022 Jan 23;161:107102. Epub 2022 Jan 23.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, 1 Medical Center Dr, Lebanon, NH 03766, USA.

Background: A growing number of studies have identified both toxic and essential metals which influence fetal growth. However, most studies have conducted single-cohort analyses, which are often limited by narrow exposure ranges, and evaluated metals individually. The objective of the current study was to conduct an environmental mixture analysis of metal impacts on fetal growth, pooling data from three geographically and demographically diverse cohorts in the United States participating in the Environmental Influences on Child Health Outcomes program. Read More

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January 2022

Post-mortem MRI in stillbirth: Normal imaging appearances.

Eur J Radiol 2022 Jan 19;148:110166. Epub 2022 Jan 19.

Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Post-mortem MRI (PMMRI) can reliably detect most major organ malformations in cases of stillbirth. However, variable normal post-mortem changes mimicking pathology make the interpretation difficult. Varying morphological appearances of internal organs could be due to differences in gestational age of the fetuses being evaluated or the presence of maceration changes which occur after fetal demise in-utero. Read More

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January 2022

Outcomes of Allogeneic Hematopoietic Cell Transplantation in T-cell Prolymphocytic Leukemia: A Contemporary Analysis from the Center for International Blood and Marrow Transplant Research.

Transplant Cell Ther 2022 Jan 23. Epub 2022 Jan 23.

Department of Internal Medicine, Mayo Clinic, Rochester, MN; Department of Medicine, Sheikh Shakhbout Medical City, Abu Dhabi, UAE.

Background: T-cell prolymphocytic leukemia (T-PLL) is a rare, aggressive malignancy with limited treatment options and poor long-term survival. Previous studies of allogeneic hematopoietic cell transplantation (alloHCT) for T-PLL are limited by small numbers, and descriptions of patient and transplant characteristics and outcomes after alloHCT are sparse.

Objective: To describe outcomes of alloHCT in T-PLL and identify predictors of post-transplant relapse and survival. Read More

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January 2022