3,004 results match your criteria agc

Sulfur Regulates the Trade-Off Between Growth and Andrographolide Accumulation Nitrogen Metabolism in .

Front Plant Sci 2021 14;12:687954. Epub 2021 Jul 14.

Guangxi Key Laboratory of Medicinal Resource Protection and Genetic Improvement, Guangxi Botanical Garden of Medicinal Plants, Nanning, China.

Nitrogen (N) and sulfur (S) are essential mineral nutrients for plant growth and metabolism. Here, we investigated their interaction in plant growth and andrographolide accumulation in medicinal plant grown at different N (4 and 8 mmol·L) and S concentration levels (0.1 and 2. Read More

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Dynamics of carbon storage and status of standing vegetation in temperate coniferous forest ecosystem of north western Himalaya India.

Vegetos 2021 Jul 28:1-12. Epub 2021 Jul 28.

School of Studies in Botany, Jiwaji University, Gwalior, India.

Natural ecosystems, which operate as a sink, play an important role in determining the concentration of CO in the atmosphere and have a large storage capacity, assisting in mitigation of problem that has a negative impact on the human population. Forests are one of the most important carbon sinks in the terrestrial ecosystem, with the best example being the Western Himalaya, where healthy and sustainable vegetation is prized. Standard methodology was adopted for assessing the different parameters of carbon related information to enumerate the status of carbon storage and its trend in sustaining the ecosystem of the area. Read More

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The tails of PKA.

Mol Pharmacol 2021 Jul 30. Epub 2021 Jul 30.

Nutrition, University of Oslo, Norway.

The catalytic subunit of PKA is regulated by two tails that each wrap around the N- and C-lobes of the kinase core. While the Ct-Tail is classified as an intrinsically disordered region (IDR), the Nt-Tail is dominated by a strong helix that is flanked by short IDRs. In contrast to the Ct-Tail, which is a conserved and highly regulated feature of all AGC kinases, the Nt-Tail has evolved more recently and is not even conserved in non-mammalian PKAs. Read More

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Environmental Sources, Chemistry, Fate and Transport of Per- and Polyfluoroalkyl Substances: State of the Science, Key Knowledge Gaps, and Recommendations Presented at the August 2019 SETAC Focus Topic Meeting.

Environ Toxicol Chem 2021 Jul 29. Epub 2021 Jul 29.

Naval Sea Systems Command (NAVSEA), Laboratory Quality and Accreditation Office, Goose Creek, SC, USA.

A Society of Environmental Toxicology and Chemistry (SETAC) Focused Topic Meeting (FTM) on the environmental management of per- and polyfluoroalkyl substances (PFAS) convened during August 2019 in Durham, North Carolina (US). Experts from around the globe were brought together to critically evaluate new and emerging information on PFAS including chemistry, fate, transport, exposure, and toxicity. After plenary presentations, breakout groups were established and tasked to identify and adjudicate via panel discussions overarching conclusions and relevant data gaps. Read More

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The Role of Community-Based Organizations in Improving Chronic Care for Safety-Net Populations.

J Am Board Fam Med 2021 Jul-Aug;34(4):698-708

From the Center for Vulnerable Populations, University of California, San Francisco (KHN, JDF, AGC, RD, AA, WB, US, CRL); UCSF Department of Medicine, Division of General Internal Medicine at Zuckerberg, San Francisco General Hospital, CA (KHN, JDF, AGC, US, CRL); Department of Epidemiology and Biostatistics, University of California, San Francisco (KHN, JDF, RD, US, CRL); Kaiser Permanente Northern California, Division of Research, Oakland (AG, CRL); Streetwyze, Oakland, CA (TC, AS, AA); Social Innovation and Universal Opportunity Lab (SOUL), University of California, San Francisco, San Francisco State University (TC, AS, AA); Center for AIDS Prevention Studies, University of California, San Francisco (WB); Bakar Computational Health Science Institute, University of California, San Francisco (WB, CRL).

Introduction: Social determinants of health (SDoH) influence health outcomes and contribute to disparities in chronic disease in vulnerable populations. To inform health system strategies to address SDoH, we conducted a multi-stakeholder qualitative study to capture the multi-level influences on health for those living in socio-economically deprived contexts.

Methods: Varied qualitative inquiry methods - in-depth interviews, participant-led neighborhood tours, and clinic visit observations - involving a total of 23 participants (10 patients with chronic illnesses in San Francisco neighborhoods with high chronic disease rates, 10 community leaders serving the same neighborhoods, and 3 providers from San Francisco's public health care delivery system). Read More

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November 2020

Genetically predicted serum vitamin D and COVID-19: a Mendelian randomisation study.

BMJ Nutr Prev Health 2021 4;4(1):213-225. Epub 2021 May 4.

Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA.

Objectives: To investigate causality of the association of serum vitamin D with the risk and severity of COVID-19 infection.

Design: Two-sample Mendelian randomisation study.

Setting: Summary data from genome-wide analyses in the population-based UK Biobank and SUNLIGHT Consortium, applied to meta-analysed results of genome-wide analyses in the COVID-19 Host Genetics Initiative. Read More

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Significance of Tumor Mutation Burden Combined With Immune Infiltrates in the Progression and Prognosis of Advanced Gastric Cancer.

Front Genet 2021 9;12:642608. Epub 2021 Jul 9.

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Gastric cancer (GC) is a serious malignant tumor with high mortality and poor prognosis. The prognosis and survival are much worse for advanced gastric cancer (AGC). Recently, immunotherapy has been widely promoted for AGC patients, and studies have shown that tumor mutation burden (TMB) is closely related to immunotherapy response. Read More

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Prognostic Impact of Sarcopenia and Radiotherapy in Patients With Advanced Gastric Cancer Treated With Anti-PD-1 Antibody.

Front Immunol 2021 8;12:701668. Epub 2021 Jul 8.

Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Background: We explored the combined effects of sarcopenia (SAR) and radiotherapy (RT) on outcomes in patients with advanced gastric cancer (AGC) treated with immune-checkpoint blockade (ICB).

Methods: Among 185 patients with AGC treated with ICB, we defined SAR as skeletal muscle index <49 cm2/m2 for men and <31 cm2/m2 for women; 93 patients met criteria. We defined high neutrophil-to-lymphocyte ratio (hNLR) as NLR≥3. Read More

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Evaluation of dual-energy CT derived radiomics signatures in predicting outcomes in patients with advanced gastric cancer after neoadjuvant chemotherapy.

Eur J Surg Oncol 2021 Jul 20. Epub 2021 Jul 20.

Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No 197, Rui Jin 2nd Road, Shanghai, 200025, China. Electronic address:

Background: To investigate the prognostic value of dual-energy CT (DECT) based radiomics to predict disease-free survival (DFS) and overall survival (OS) for patients with advanced gastric cancer (AGC) after neoadjuvant chemotherapy (NAC).

Methods: From January 2014 to December 2018, a total of 156 AGC patients were enrolled and randomly allocated into a training cohort and a testing cohort at a ratio of 2:1. Volume of interest of primary tumor was delineated on eight image series. Read More

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Styrenated Oil Synthesis with Cyclic Carbonate Functional Groups on Polystyrene Segment.

Polymers (Basel) 2021 Jul 17;13(14). Epub 2021 Jul 17.

Department of Chemical Engineering, Istanbul Technical University, 34469 Maslak, Istanbul, Turkey.

In this study, an oil-modified copolymer of 4-[(prop-2-en-1-yloxy)methyl]-1,3-dioxolan- 2-one (AGC) with styrene was synthesized, and the resulting copolymer (OBMI-St-AGC) was silane functionalized by inserting (3-aminopropyl) triethoxysilane (APTES) into the polymer backbone. OBMI-St-AGC was prepared by using an oil-based macroinitiator (OBMI) obtained by the esterification of linseed oil partial glycerides (PGs) with 4,4-azobis-4-cyanopentanoyl chloride (ACPC). In the characterization, FTIR, H NMR, TGA, and DSC analyses were applied. Read More

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Akt Isoforms: A Family Affair in Breast Cancer.

Cancers (Basel) 2021 Jul 9;13(14). Epub 2021 Jul 9.

Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

Akt, also known as protein kinase B (PKB), belongs to the AGC family of protein kinases. It acts downstream of the phosphatidylinositol 3-kinase (PI3K) and regulates diverse cellular processes, including cell proliferation, cell survival, metabolism, tumor growth and metastasis. The PI3K/Akt signaling pathway is frequently deregulated in breast cancer and plays an important role in the development and progression of breast cancer. Read More

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Long-Term Outcomes of Laparoscopic Radical Gastrectomy for Highly Advanced Gastric Cancer: Final Report of a Prospective Phase II Trial (KUGC04).

Ann Surg Oncol 2021 Jul 19. Epub 2021 Jul 19.

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: This is the final report evaluating the long-term outcomes of a single-arm phase II clinical trial that demonstrated the short-term efficacy of laparoscopic gastrectomy (LG) for highly advanced gastric cancer (AGC) [KUGC04].

Patients And Methods: Seventy-three patients with histologically confirmed gastric adenocarcinoma and diagnosed with clinical stage II or higher, who potentially underwent curative resection between August 2009 and November 2014, were prospectively enrolled. Long-term outcomes with 5-year progression-free survival (PFS) and 5-year overall survival (OS) were evaluated according to clinical or pathological stages. Read More

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The clinical significance and utility of HPV-DNA testing in Korean women with atypical glandular cells in cervical Pap tests: An analysis of 311 cases at a single institution.

Cancer Invest 2021 Jul 19:1-15. Epub 2021 Jul 19.

Department of Obstetrics and Gynecology, Asan Medical center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea.

The aim of this study is to analyze the correlation between clinically significant histologic results and HPV in women with AGC in pap test. Of the 311 women confirmed as AGC, 111 women (35.7%) was identified as positive for HPV. Read More

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Two enteropathogenic strains representing novel serotypes and investigation of their roles in adhesion.

J Microbiol Biotechnol 2021 Jul 15;31. Epub 2021 Jul 15.

TEDA Institute of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin 300457, P.R China.

Enteropathogenic (EPEC), which belongs to the attaching and effacing diar¬rheagenic strain, is a major causative agent of life-threatening diarrhoea in infants in devel¬oping countries. Most EPEC isolates correspond to certain O serotypes; however, many strains are non-typeable. Two EPEC strains, EPEC001 and EPEC080, which could not be serotyped during routine detection, were isolated. Read More

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Specific Borrmann classification in advanced gastric cancer by an ensemble multilayer perceptron network: a multi-center research.

Med Phys 2021 Jul 14. Epub 2021 Jul 14.

CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.

Purpose: Borrmann classification in advanced gastric cancer (AGC) is necessarily associated with personalized surgical strategy and prognosis. But few radiomics researches have focused on specific Borrmann classification, and there is yet no consensus regarding what machine learning methods should be the most effective.

Methods: A combined size of 889 AGC patients were retrospectively enrolled from two centers. Read More

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Identifying prognostic factors associated with overall survival in second-line paclitaxel plus ramucirumab treated human epidermal growth factor receptor 2-negative advanced/recurrent gastric cancer.

Pharmazie 2021 Jul;76(7):328-333

Department of Pharmacy, Ogaki Municipal Hospital, Japan.

This study aimed to identify the overall survival prolongation index in patients who received paclitaxel plus ramucirumab as second line chemotherapy for human epidermal growth factor receptor (HER) 2-negative advanced/ recurrent gastric cancer (AGC). We included 77 patients who underwent second line chemotherapy (paclitaxel plus ramucirumab) for AGC at our institution between January 2015 and September 2020. To determine factors associated with survival, univariate and multivariate analyses were performed, and hazard ratios and their 95% confidence intervals (95% CI) were calculated. Read More

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Effect of arachidonic acid cascade inhibitors on body temperature and cognitive functions in rats in the Morris water maze after acute cold injury.

Pharmazie 2021 Jul;76(7):313-316

Educational and Scientific Institute of Applied Pharmacy, National University of Pharmacy, Kharkiv, Ukraine.

: The aim of the study was to evaluate the effect of arachidonic acid cascade inhibitors on body temperature and cognitive functions of rats (spatial memory, learning ability) in the Morris water maze test (MWM) after acute cold injury (CI). Animals were trained to find an escape platform in the MWM for two consecutive days. On the third day, rats were treated with saline (10 ml/kg), diclofenac sodium (7 mg/kg), etoricoxib (5 mg/kg), darbufelone mesylate (20 mg/kg) or montelukast (1 mg/kg) intragastrically (i. Read More

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Phosphate solubilizing rhizobacteria isolated from jujube plant stimulate wheat germination rate and seedlings growth.

PeerJ 2021 2;9:e11583. Epub 2021 Jul 2.

Molecular Microbiology laboratory, Coalition Center of Innovation and Prevention of Epidemies in Morocco (CIPEM), Mohammed VI Polytechnic University (UM6P), Ben Guerir, Morocco.

Jujube plant ( (L.) Desf.) can survive in arid climates and tolerates both biotic and abiotic stresses. Read More

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Oncologic Feasibility of Proximal Gastrectomy in Upper Third Advanced Gastric and Esophagogastric Junctional Cancer.

J Gastric Cancer 2021 Jun 23;21(2):169-178. Epub 2021 Jun 23.

Division of Gastrointestinal Surgery, Department of Surgery and Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Purpose: The aim of this study was to investigate the oncologic safety and identify potential candidates for proximal gastrectomy (PG) in upper third advanced gastric cancer (AGC) and esophagogastric junction (EGJ) cancers.

Materials And Methods: Among 5,665 patients who underwent gastrectomy for gastric adenocarcinoma between January 2011 and December 2017, 327 patients who underwent total gastrectomy with standard lymph node (LN) dissection for upper third AGC and Siewert type II EGJ cancers were enrolled. We analyzed the correlation between the metastatic rates of distal LNs (No. Read More

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Hb Tacoma: G>T or G>C, and Does It Matter?

Hemoglobin 2021 Jul 7:1-4. Epub 2021 Jul 7.

Molecular Pathology Laboratory, University of Otago, Christchurch, New Zealand.

Hb Tacoma [β30(B12)Arg→Ser] is a missense variant that is caused by either an AG>AG or AG>AG substitution at codon 30 of the gene. Currently, the latter is classified as a rare cause of β-thalassemia (β-thal). We propose that : c. Read More

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Analgecine regulates microglia polarization in ischemic stroke by inhibiting NF-κB through the TLR4 MyD88 pathway.

Int Immunopharmacol 2021 Jul 3;99:107930. Epub 2021 Jul 3.

Department of Pharmacy, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing Engineering Research Center for Nervous System Drugs, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China. Electronic address:

Therapeutic strategies used to attenuate inflammation and to increase recovery of neurons after a stroke include microglia anti-inflammatory (M2) polarization and repression of proinflammatory (M1). Extracts isolated from Vaccina variola-inoculated rabbit skin, for example analgecine (AGC), have been used as a therapy for patients experiencing lower back pain associated with degenerative diseases of the spine for about twenty years. In the study presented here, neuroprotective effect associated with AGC was analyzed as well as the anti-inflammatory mechanism linked to AGC in terms of attenuating microglia-mediated neuronal damage. Read More

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The Prognostic Value of Pre-treatment Hemoglobin (Hb) in Patients With Advanced or Metastatic Gastric Cancer Treated With Immunotherapy.

Front Oncol 2021 15;11:655716. Epub 2021 Jun 15.

Medical Oncology Department, The First Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China.

Background: Biomarkers such as prevailing PD-L1 expression and TMB have been proposed as a way of predicting the outcome of immunotherapy in patients with advanced gastric cancer (AGC) and metastatic gastric cancer (MGC). Our study aims to investigate whether there is a link between pretreatment hemoglobin (Hb) levels and survival to immunotherapy in patients with AGC and MGC.

Methods: We retrospectively reviewed patients with AGC or MGC treated at the oncology department of the Chinese PLA general hospital receiving PD-1 inhibitor. Read More

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Fine-Tuning of Platelet Responses by Serine/Threonine Protein Kinases and Phosphatases-Just the Beginning.

Hamostaseologie 2021 Jun 30;41(3):206-216. Epub 2021 Jun 30.

Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Comprehensive proteomic analyses of human and murine platelets established an extraordinary intracellular repertoire of signaling components, which control crucial functions. The spectrum of platelet serine/threonine protein kinases (more than 100) includes the AGC family (protein kinase A, G, C [PKA, PKG, PKC]), the mitogen-activated protein kinases (MAPKs), and others. PKA and PKG have multiple significantly overlapping substrates in human platelets, which possibly affect functions with clear "signaling nodes" of regulation by multiple protein kinases/phosphatases. Read More

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Self-assembly of the cationic surfactant -hexadecyl-trimethylammonium chloride in methyltrimethoxysilane aqueous solution: classical and reactive molecular dynamics simulations.

Phys Chem Chem Phys 2021 Jul;23(26):14486-14495

Materials Integration Laboratories, AGC Inc., Japan.

A flexible aerogel polymerized from methyltrimethoxysilane (MTMS) shows great promise as a high-performance insulator owing to its substantially low thermal conductivity and mechanical flexibility, attributed to its porous microstructure and organic-inorganic hybridization, respectively, which promote its industrial applications. Conventionally, the cationic surfactant n-hexadecyltrimethylammonium chloride (CTAC) is utilized to experimentally control the nanoscale microstructure and, consequently, the flexibility of the MTMS aerogel; however, the mechanism through which CTAC prevents MTMS aggregation in the solution is not yet fully understood. This study unravels the role of CTAC in preventing MTMS aggregation in aqueous solution using both classical and reactive molecular dynamics simulations. Read More

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Photo-on-Demand Base-Catalyzed Phosgenation Reactions with Chloroform: Synthesis of Arylcarbonate and Halocarbonate Esters.

J Org Chem 2021 Jul 28;86(14):9811-9819. Epub 2021 Jun 28.

Department of Chemistry, Graduate School of Science, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan.

Carbonate esters are utilized as solvents and reagents for C1 building blocks in organic synthesis. This study reports a novel photo-on-demand in situ synthesis of carbonate esters with CHCl solutions containing a mixture of an aromatic or haloalkyl alcohol having relatively high acidity, and an organic base. We found that the acid-base interaction of the alcohol and base in the CHCl solution plays a key role in enabling the photochemical reaction. Read More

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Association of the pretreatment lung immune prognostic index with survival outcomes in advanced gastric cancer patients treated with immune checkpoint inhibitors.

Clin Res Hepatol Gastroenterol 2021 Jun 25;45(5):101748. Epub 2021 Jun 25.

Department of Oncology, Chinese PLA General Hospital, Beijing, China. Electronic address:

Purpose: Recently, the lung immune prognostic index (LIPI) is considered to be associated with outcomes in multiple solid tumors treated with immune checkpoint inhibitors (ICIs). We sought to determine whether LIPI has the same predictive effect in advanced gastric cancer (AGC).

Methods: The clinical data of a real-world, retrospective cohort of AGC patients treated with ICIs were retrospectively analyzed. Read More

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Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina.

Front Genet 2021 11;12:671467. Epub 2021 Jun 11.

Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and Herzegovina.

Human Y-chromosomal haplogroups are an important tool used in population genetics and forensic genetics. A conventional method used for Y haplogroup assignment is based on a set of Y-single nucleotide polymorphism (SNP) markers deployed, which exploits the low mutation rate nature of these markers. Y chromosome haplogroups can be successfully predicted from Y-short tandem repeat (STR) markers using different software packages, and this method gained much attention recently due to its labor-, time-, and cost-effectiveness. Read More

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Reinfection, reactivation or delayed complication of the initial SARS-CoV-2 infection.

Med Clin (Barc) 2021 Apr 28. Epub 2021 Apr 28.

Centro de Salud Mieres Sur, Área Sanitaria VII, Mieres, Asturias, España.

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Similar tree species richness-productivity response but differing effects on carbon stocks and timber production in eastern US and continental Spain.

Sci Total Environ 2021 Jun 18;793:148399. Epub 2021 Jun 18.

US Department of Agriculture, Forest Service, Northern Research Station, Durham, NH, 03824, USA.

Unimodal response of tree species richness to increases in aboveground productivity is evident in grasslands but to a lesser extent in forests, where confounding factors (e.g., abiotic factors and management regimes) may alter the response and compromise the delivery of ecosystem services. Read More

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Mol Pharmacol 2021 Jun 21. Epub 2021 Jun 21.

Pharmacology, University of California San Diego, United States

The family of AGC kinases not only regulate cellular biology by phosphorylating substrates, but are themselves controlled by phosphorylation. Phosphorylation generally occurs at two conserved regions in these kinases: a loop near the entrance to the active site, termed the activation loop, that correctly aligns residues for catalysis, and a C-terminal tail whose phosphorylation at a site termed the hydrophobic motif stabilizes the active conformation. Whereas phosphorylation of the activation loop is well established to be catalyzed by the phosphoinositide-dependent kinase 1 (PDK1), the mechanism of phosphorylation of the C-tail hydrophobic motif has been controversial. Read More

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