16,819 results match your criteria aga


Childhood obesity on the rise during COVID-19: A request for global leaders to change the trajectory.

Obesity (Silver Spring) 2021 Sep 27. Epub 2021 Sep 27.

The Hospital for Sick Children, Centre for Global Child Health, Toronto, Ontario, Canada.

Childhood obesity has been rising in all world regions - 2019 estimates were that 158 million children aged 5-19 are living with obesity, of whom many live in LMICs . Yet there has been limited to no progress to halt the rise in more than 20 years and this number is projected to increase to 254 million by 2030 . NCD Child, a global multi-stakeholder coalition focused on the prevention and control of noncommunicable diseases (NCDs) in children, is concerned with the rising rates of obesity during childhood and its consequences. Read More

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September 2021

COVID-19 and family planning in the Eastern Mediterranean Region.

East Mediterr Health J 2021 Sep 21;27(9):857-860. Epub 2021 Sep 21.

Larkin Health System, South Miami, Florida, United States of America.

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September 2021

The family planning "know-do" gap among married women of reproductive age in urban Pakistan.

Public Health Action 2021 Sep;11(3):132-138

Centre of Excellence for Women and Child Health, Aga Khan University, Karachi, Pakistan.

Objective: To examine the prevalence and predictors of family planning (FP) know-do gaps among married women of reproductive age (MWRA) in low socio-economic urban areas of Karachi, Pakistan.

Design: This was a cross-sectional survey of randomly selected 7288 MWRA (16-49 years) to identify predictors of the know-do gap in FP using a logistic regression model.

Results: More than one third (35. Read More

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September 2021

Acute Generalized Exanthematous Pustulosis Induced by Cetuximab.

Cureus 2021 Aug 19;13(8):e17309. Epub 2021 Aug 19.

Dermatology, Aga Khan University Hospital, Karachi, PAK.

A wide variety of diseases and drugs can cause cutaneous pustular eruptions. Acute generalized exanthematous pustulosis (AGEP) is a unique drug-induced dermatosis clinically presented as erythematous papular and pustular eruption, usually caused by certain systemic drugs. We are presenting a very rare association of AGEP with a biological agent, cetuximab. Read More

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Efficacy of remote dielectric sensing (ReDS) in the prevention of heart failure rehospitalizations: a meta-analysis.

J Community Hosp Intern Med Perspect 2021 20;11(5):646-652. Epub 2021 Sep 20.

Detroit Medical Center, Detroit, MI, USA.

The clinical efficacy of remote dielectric sensing (ReDS) monitoring is not well known. Digital databases were searched to identify relevant articles. Pooled unadjusted odds ratio (OR) for dichotomous outcomes were calculated using a random-effects model. Read More

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September 2021

Platelet-Rich Plasma with Microneedling in Androgenetic Alopecia: Study of Efficacy of the Treatment and the Number of Sessions Required.

J Cutan Aesthet Surg 2021 Apr-Jun;14(2):184-190

Venkat Center for Skin and Plastic Surgery, Bengaluru, Karnataka, India.

Background: Platelet-rich plasma (PRP) is a simple and safe procedure, which has been used for soft tissue and wound healing. PRP has been used in dermatology for skin rejuvenation and alopecia.

Objective: The objective of our study was to study efficacy of PRP with microneedling in patients with androgenetic alopecia (AGA) and to assess number of sessions required for a patient. Read More

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September 2021

Increased Fibroblast Growth Factor 21 (FGF21) Concentration in Early Second Trimester Amniotic Fluid and Its Association with Fetal Growth.

Metabolites 2021 Aug 28;11(9). Epub 2021 Aug 28.

Neonatal Department, National and Kapodistrian University of Athens Medical School, Aretaieio Hospital, 11526 Athens, Greece.

Altered fetal growth, either reduced or exacerbated, is associated with adverse perinatal outcomes. The underlying pathogenetic mechanisms of altered growth remain unclear. Fibroblast growth factor 21 (FGF21) and insulin are both considered to be major regulators of tissue growth and metabolism. Read More

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Making the case for librarian expertise to support evidence synthesis for the Sustainable Development Goals.

Res Synth Methods 2021 Sep 25. Epub 2021 Sep 25.

Department of Global Development, Cornell University, Ithaca, New York, USA.

Evidence syntheses that engage librarians as co-authors produce higher-quality results than those that do not. Trained as teachers, researchers and information managers, librarians possess expert knowledge on research methodologies and information retrieval approaches that are critical for evidence synthesis. Researchers are under increasing pressure to produce evidence syntheses to inform practice and policymaking. Read More

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September 2021

Exploring digital health interventions to support community health workers in low-and-middle-income countries during the COVID-19 pandemic: a scoping review protocol.

BMJ Open 2021 Sep 24;11(9):e053871. Epub 2021 Sep 24.

Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan.

Introduction: COVID-19 has significantly affected community health workers' (CHWs) performance as they are expected to perform pandemic-related tasks along with routine essential healthcare services. A plausible way to optimise CHWs' functioning during this pandemic is to couple the efforts of CHWs with digital tools. So far, no systematic evidence is available on the use of digital health interventions to support CHWs in low-middle-income countries (LMICs) amid the COVID-19 pandemic. Read More

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September 2021

Experiences from implementing an Lessons from teaching psychiatry trainees at a tertiary care hospital in Karachi, Pakistan.

Asian J Psychiatr 2021 Sep 17;65:102865. Epub 2021 Sep 17.

Department of Psychiatry, Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan. Electronic address:

Early childhood trauma can have adverse effects on brain development. This results in higher rates of mental health and medical problems in adults. Unfortunately, psychiatry trainees are not adequately trained in dealing with trauma survivors. Read More

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September 2021

Does mass drug administration of azithromycin reduce child mortality?

Lancet Glob Health 2021 Sep 21. Epub 2021 Sep 21.

School of Nursing and Midwifery, Aga Khan University, Nairobi, Kenya; Laboratory of Neurogenetics of Language, The Rockefeller University, New York, NY, USA.

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September 2021

Head and Neck Low-Grade Fibromyxoid Sarcoma: A Clinicopathologic Study of 15 Cases.

Head Neck Pathol 2021 Sep 24. Epub 2021 Sep 24.

Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan.

Low-grade fibromyxoid sarcoma (LGFMS) is an uncommon mesenchymal tumor usually arising in the lower extremities and trunk. Only rare examples in the head and neck region have been reported. Fifteen cases of head and neck LGFMS were retrieved. Read More

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September 2021

International versus national growth charts for identifying small and large-for-gestational age newborns: A population-based study in 15 European countries.

Lancet Reg Health Eur 2021 Sep 15;8:100167. Epub 2021 Jul 15.

Université de Paris, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOPé, INSERM, INRA, F-75004 Paris, France.

Background: To inform the on-going debate about the use of universal prescriptive versus national intrauterine growth charts, we compared perinatal mortality for small and large-for-gestational-age (SGA/LGA) infants according to international and national charts in Europe.

Methods: We classified singleton births from 33 to 42 weeks of gestation in 2010 and 2014 from 15 countries ( = 1,475,457) as SGA (birthweight <10th percentile) and LGA (>90th percentile) using the international Intergrowth-21st newborn standards and national charts based on the customised charts methodology. We computed sex-adjusted odds ratios (aOR) for stillbirth, neonatal and extended perinatal mortality by this classification using multilevel models. Read More

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September 2021

Nucleotide sequences of the infectious DNA clones of two mink enteritis virus isolates exhibit the diversity of the terminal palindromic sequences and predicted secondary structures.

Virus Res 2021 Sep 20:198574. Epub 2021 Sep 20.

Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Taian, Shandong, 271018, China; College of Veterinary Medicine, Shandong Agricultural University, Taian, Shandong, 271018, China. Electronic address:

In this study, the infectious RF-DNA clones of two mink enteritis viruses, MEV-SD1 and MEV-SD7, were constructed, which generated progeny virions and seemed to contain an almost or completely full-length genome. The genomes of MEV-SD1 and MEV-SD7 were 5162 bp and 5113 bp in length, respectively. The genomic organizations of MEV-SD1 and MEV-SD7 were similar to that of the other carnivore parvoviruses. Read More

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September 2021

Designing dna probe from hpv 18 and 58 in e6 region for sensing element in the development of genosensor based gold nanoparticles.

Biotechnol Appl Biochem 2021 Sep 23. Epub 2021 Sep 23.

Malaysia Genome Institute (MGI), National Institute of Biotechnology (NIBM), Kajang, Selangor, 43000, Malaysia.

E6 region has higher protuberant probability annealing than consensus probe focusing on another region in Human Papillomavirus (HPV) genome in terms of detection and screening method. Here, we designed the first multiple virus ssDNA for multiple detections in an early phase of screening for cervical cancer in the E6 region and became a fundamental evolution of detection electrochemical HPV biosensor. Gene profiling of the virus ssDNA sequences have been carried by high-end bioinformatics tools such as GenBank, Basic Local Alignment Searching Tools (BLAST), and Clustal OMEGA in a row. Read More

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September 2021

Organ-specific autoimmune markers in adult patients with type 1 diabetes mellitus.

Int J Clin Pract 2021 Sep 22:e14842. Epub 2021 Sep 22.

Department of Endocrinology and Metabolism, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Turkey.

Aim: We aimed to investigate the presence of thyroid, celiac disease (CD) and anti-parietal cell antibodies (APCA) in adult type 1 diabetes (T1DM) patients.

Methods: Data of 287 T1DM patients >16 years old were reviewed retrospectively. Thyroid disease related, CD related antibodies and APCA were evaluated. Read More

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September 2021

Spasmolytic Effect of Fruit Extract on Isolated Smooth Muscles is Mediated via Multiple Pathways.

Evid Based Complement Alternat Med 2021 13;2021:5583372. Epub 2021 Sep 13.

Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Sind, Pakistan.

Background: Linn, or phalsa, is a commonly consumed fruit in Pakistan. The fruit is employed in the traditional medicine practice of Pakistan as a smooth muscle relaxant in different gastrointestinal (GI) and cardiovascular diseases. In this investigation, we show the antispasmodic and vasorelaxant actions of fruit extract. Read More

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September 2021

Editorial: Vitamin D Deficiency and Sufficiency in Reproduction and Bone Metabolism.

Front Endocrinol (Lausanne) 2021 6;12:740021. Epub 2021 Sep 6.

Department of Medicine, Rehman Medical Institute, Peshawar, Pakistan.

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September 2021

Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.

Nat Commun 2021 Sep 22;12(1):5577. Epub 2021 Sep 22.

Division of Haematopathology, European Institute of Oncology IRCCS, Milan, Italy.

Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis of some ALCL subgroups is still unsatisfactory, and already in second line effective treatment options are lacking. To identify genes defining ALCL cell state and dependencies, we here characterize super-enhancer regions by genome-wide H3K27ac ChIP-seq. Read More

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September 2021

Mental health and well-being of older adults living with HIV in sub-Saharan Africa: a systematic review.

BMJ Open 2021 Sep 22;11(9):e052810. Epub 2021 Sep 22.

Department of Clinical Research (Neurosciences), KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

Objective: In this systematic review, we aimed to summarise the empirical evidence on common mental disorders (CMDs), cognitive impairment, frailty and health-related quality of life (HRQoL) among people living with HIV aged ≥50 years (PLWH50 +) residing in sub-Saharan Africa (SSA). Specifically, we document the prevalence and correlates of these outcomes.

Design, Data Sources And Eligibility Criteria: The following online databases were systematically searched: PubMed, CINAHL, PsycINFO, Embase and Scopus up to January 2021. Read More

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September 2021

Divergent degeneration of creA antitoxin genes from minimal CRISPRs and the convergent strategy of tRNA-sequestering CreT toxins.

Nucleic Acids Res 2021 Sep 22. Epub 2021 Sep 22.

CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

Aside from providing adaptive immunity, type I CRISPR-Cas was recently unearthed to employ a noncanonical RNA guide (CreA) to transcriptionally repress an RNA toxin (CreT). Here, we report that, for most archaeal and bacterial CreTA modules, the creA gene actually carries two flanking 'CRISPR repeats', which are, however, highly divergent and degenerated. By deep sequencing, we show that the two repeats give rise to an 8-nt 5' handle and a 22-nt 3' handle, respectively, i. Read More

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September 2021

Association of Risk Factors for Early Childhood Disability in Rural Pakistan.

Asia Pac J Public Health 2021 Sep 22:10105395211048318. Epub 2021 Sep 22.

Aga Khan University Hospital, Karachi, Pakistan.

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September 2021

Cephalometric predictors of optimal soft tissue profile outcomes in growing Asian skeletal class II subjects treated with twin-block appliance: a retrospective study.

Minerva Dent Oral Sci 2021 Sep 22. Epub 2021 Sep 22.

Section of Dentistry, Department of Surgery, The Aga Khan University Hospital, Karachi, Pakistan.

Background: Clark's Twin-Block (TB) functional appliance is commonly used to treat mandibular deficiency in skeletal class II growing patients. There have been no prior research that have examined determinants of a optimal soft tissue profile outcome after TB utilising both subjective and objective assessments of soft tissue profile outcome. Therefore, this study was conducted to identify predictors for favorable soft tissue outcomes after TB appliance. Read More

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September 2021

Cigarette smokers' perceptions of smoking cessation and associated factors in Karachi, Pakistan.

Public Health Nurs 2021 Sep 21. Epub 2021 Sep 21.

College of Nursing, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Objectives: The study explored the perceptions of adult smokers with cardiovascular and respiratory diseases regarding cigarette smoking cessation. We also explored factors that may hinder or facilitate smoking cessation process.

Design: Qualitative descriptive exploratory design SAMPLE: Purposive sample of 13 adult smokers with cardiovascular or respiratory diseases visiting outpatient cardiac and respiratory clinics at a private tertiary care hospital MEASUREMENTS: In-depth, face-to-face, and semi-structured interviews were conducted. Read More

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September 2021

Evaluation of Radiation-induced Pleural Effusions after Radiotherapy to Support Development of Animal Models of Radiation Pneumonitis.

Health Phys 2021 Oct;121(4):434-443

Department of Biostatistics, Medical College of Wisconsin, Milwaukee, WI.

Abstract: Not all animal models develop radiation-induced pleural effusions (RIPEs) as a form of radiation-induced lung injury (RILI). Such effusions are also not well characterized in humans. The purpose of this study is to identify occurrences of RIPE in humans, provide justification for development of relevant animal models, and further characterize its risk factors in cancer patients. Read More

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October 2021

Lead encephalopathy in an adult opioid abuser.

BMJ Case Rep 2021 Sep 20;14(9). Epub 2021 Sep 20.

Department of Haematology, Aga Khan University Hospital, Karachi, Pakistan.

A 38-year-old man presented at the emergency department with abdominal pain, vomiting, generalised weakness and altered consciousness. He had been ingesting opioids for over 5 years and had several past hospital admissions for abdominal pain. His investigations showed deranged liver function tests, anaemia and basophilic stippling on the peripheral blood smear. Read More

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September 2021

Geographic Variability of Nodular Lymphocyte-Predominant Hodgkin Lymphoma.

Am J Clin Pathol 2021 Sep 20. Epub 2021 Sep 20.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Objectives: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) differs from classic Hodgkin lymphoma (CHL) in terms of clinicopathologic features, including Epstein-Barr virus (EBV) association. CHL geographic variability is well known, with higher frequencies of mixed-cellularity subtype and EBV positivity in low/middle-income countries (LMICs), but there are few well-characterized series of NLPHL from LMICs.

Methods: We detail clinicopathologic findings of 21 NLPHL cases received in consultation from Kenya and summarize reports of NLPHL with EBV testing published since 2000. Read More

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September 2021

Safety and efficacy of ALRV5XR in men with androgenetic alopecia: A randomised, double-blinded, placebo-controlled clinical trial.

EClinicalMedicine 2021 Oct 11;40:101124. Epub 2021 Sep 11.

Universidad San Francisco de Quito (USFQ), Quito, Ecuador.

Background: Androgenetic alopecia (AGA) is the most common hair loss disorder seen in men. It can have an early onset but has also been associated with ageing and senescence. It often induces pronounced psychological impact. Read More

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October 2021

Maturation and Patency Rates in Basilic Transposition Arteriovenous Fistula Under Regional Versus General Anesthesia: A Single-Center, Retrospective, Observational Study.

Cureus 2021 Aug 8;13(8):e16991. Epub 2021 Aug 8.

Department of Surgery, Aga Khan University Hospital, Karachi, PAK.

Background Basilic transposition arteriovenous fistula (BT AVF) is a viable option for dialysis-dependent patients, which can be performed under either general or regional anesthesia. Regional anesthesia is reported to cause vascular dilatation during the perioperative period, leading to improved fistula success. Regional anesthesia is also considered safe as compared to general anesthesia in terms of hemodynamic stability. Read More

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Transcatheter Occlusion of a Giant Coronary Artery Fistula in a Neonate.

Am J Case Rep 2021 Sep 20;22:e933079. Epub 2021 Sep 20.

Department of Pediatrics, Akita University Hospital, Akita, Japan.

BACKGROUND Although large coronary artery fistulas are uncommon; they lead to substantial over-circulation in the pulmonary vascular beds and left heart system. Fistula occlusions are achieved via surgical or transcatheter technique; however, reports on successful outcomes of transcatheter treatment during the neonatal period are limited. CASE REPORT A female infant was born at the gestational age of 37 weeks with a birth weight of 2615 grams via normal vaginal delivery. Read More

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September 2021