15 results match your criteria aftn total

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Is TSH necessary for initial assessment of thyroid nodules?

Clin Endocrinol (Oxf) 2017 Feb 22;86(2):263-269. Epub 2016 Sep 22.

Department of Nuclear Medicine, Tongji University School of Medicine, Shanghai Tenth People's Hospital, Shanghai, China.

Objective: The use of thyrotropin (TSH) in the initial assessment of thyroid nodules is inefficient and leads to unnecessary assessment costs. We compared the total costs of thyroid nodule assessment with or without the use of TSH in the initial assessment.

Methods: A total of 1808 patients with thyroid nodules received TSH, fine-needle aspiration (FNA) and thyroid scintigraphy (TS) assessment, including 83 autonomously functioning thyroid nodule (AFTN) cases and 1725 non-AFTN cases. Read More

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February 2017

A Rare Presentation of Autonomously Functioning Papillary Thyroid Cancer: Malignancy in Marine-Lenhart Syndrome Nodule.

Case Rep Surg 2016 27;2016:8740405. Epub 2016 Mar 27.

Department of General Surgery, Bahcesehir University Medical Faculty, 34353 Istanbul, Turkey.

Objective. Marine-Lenhart Syndrome (MLS) is defined as concomitant occurrence of autonomously functioning thyroid nodule (AFTN) with Graves' disease (GD). Malignancy in a functional nodule is rare. Read More

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Marine-Lenhart syndrome with papillary thyroid carcinoma.

J Res Med Sci 2015 Apr;20(4):412-5

Department of Nuclear Medicine, Ondokuz Mayis University Medical School, Samsun, Turkey.

Graves' disease with accompanying functioning nodules is known as Marine-Lenhart syndrome. Autonomously functioning thyroid nodules (AFTNs) also within Graves' thyroid tissue are almost always bening in nature. A 45-year-old man developed hyperthyroidism due to the coexistence of Graves' disease and AFTN. Read More

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Papillary carcinoma masquerading as clinically toxic adenoma in very young children.

J Pediatr Endocrinol Metab 2011 ;24(11-12):1051-4

Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Background: Autonomously functioning thyroid nodules (AFTN) are extremely rare in children. Malignancy may be rarely found in hyperfunctioning 'hot' nodules in adults. However, there are limited reports of AFTNs in young children presenting as or developing malignancy in future. Read More

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February 2012

Treatment of autonomously functioning thyroid nodules at a single institution: radioiodine therapy, surgery, and ethanol injection therapy.

Ann Nucl Med 2011 Dec 5;25(10):749-54. Epub 2011 Oct 5.

Ito Hospital, 4-3-6 Jingu-mae, Shibuya, Tokyo 150-8308, Japan.

Objective: The purpose of this study was to clarify the efficacy of radioiodine (RI) therapy in Japanese patients with autonomously functioning thyroid nodules (AFTNs).

Methods: We performed a retrospective analysis to assess the management of AFTN patients. Thyroid lobectomy was performed to treat toxic adenoma (TA) patients, and total thyroidectomy to treat toxic multinodular goiter (TMNG) patients. Read More

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December 2011

The relationship between 24 h/4 h radioiodine-131 uptake ratio and outcome after radioiodine therapy in 1402 patients with solitary autonomously functioning thyroid nodules.

Ann Nucl Med 2009 May 26;23(3):229-34. Epub 2009 Mar 26.

Department of Clinical Sciences, Nuclear Medicine, Policlinico Umberto I, 'La Sapienza' University, Viale del Policlinico 155, 00161 Rome, Italy.

Objective: To evaluate the role of 24 h/4 h uptake ratio (UR) in response to radioiodine-131 ((131)I) therapy in patients with autonomously functioning thyroid nodules (AFTN).

Methods: A total of 1402 consecutive hyperthyroid patients were treated with (131)I, between 1958 and 2005. Therapeutic doses (D) were calculated according to the formula: D = weight of nodule x dose per gram of nodular tissue (q)/24 h (131)I uptake. Read More

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Percutaneous laser ablation in the treatment of toxic and pretoxic nodular goiter.

Endocr Pract 2007 Jan-Feb;13(1):30-6

The Sezione Endocrinologia, Spedali Riuniti Livorno, Livorno, Italy.

Objective: To report data regarding treatment with use of percutaneous laser ablation (PLA) in autonomously functioning thyroid nodules (AFTN).

Methods: We treated 18 patients (10 women and 8 men, 31 to 80 years old) who presented with a single hyperfunctioning thyroid nodule (8 patients) or a multi-nodular goiter (10 patients) with clearly hyperfunctioning areas on a thyroid scintiscan. In 5 cases, free thyroxine (FT4) and free triiodothyronine (FT3) levels were high, and in these patients and a further 9 patients with cardiovascular symptoms, methimazole therapy was initiated to restore euthyroidism. Read More

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Safety and efficacy of surgical management of hyperthyroidism: 15-year experience from a tertiary care center in a developing country.

World J Surg 2007 Feb;31(2):306-12; discussion 313

Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae-Bareillei Road, Lucknow, Uttar Pradesh, 226014, India.

Background: Ideal management of toxic goiter still remains elusive. Though surgical management of toxic multinodular goiter (MNG) is well accepted, surgical treatment of Graves' disease (GD) is still controversial in view of the presumed increased incidence of complications. In this paper, we discuss the experience of the surgical management of hyperthyroidism at a specialized tertiary care endocrine center in a developing country, highlighting the minimal morbidity and satisfactory outcome in experienced hands. Read More

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February 2007

Loss of heterozygocity at the thyroid peroxidase gene locus in solitary cold thyroid nodules.

Authors:
K Krohn R Paschke

Thyroid 2001 Aug;11(8):741-7

III. Medical Department, University of Leipzig, Germany.

Germline mutations in both alleles of the thyroid peroxidase (TPO) gene have been reported as a frequent cause of congenital hypothyroidism resulting from a total iodide organification defect (TIOD). Because TPO mutations have a prevalence of 1 in 66,000 newborns and is inherited in an autosomal recessive mode the frequency of a heterozygous germline mutation in the TPO gene should reach about 1 in 260 in the population. A somatic TPO mutation coinciding with a somatic loss of one of the TPO alleles or a TPO germline mutation could lead to somatic loss of TPO activity with impairment of thyroid hormone synthesis and decrease of growth control. Read More

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[Point mutations of the thyrotropin receptor gene in autonomously functioning thyroid gland nodules: correlation with clinical findings and morphology].

Verh Dtsch Ges Pathol 1997 ;81:145-50

Institut für Pathologie, Karl-Franzens-Universität Graz.

Seventeen autonomously functioning thyroid nodules (AFTN) were analyzed for the most frequent mutations of the thyrotropin (TSH) receptor gene at codons 619, 631, 632 and 633. DNA was extracted from formalin-fixed, paraffin-embedded samples from both nodules and surrounding tissue after micro- or macrodissection. A fragment of the TSH receptor gene (bp 1762-1976) encoding the third cytoplasmic loop and the sixth transmembranous domain was amplified by PCR. Read More

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Percutaneous ethanol injection therapy for autonomously functioning thyroid nodule.

Ann Nucl Med 1996 May;10(2):171-6

Department of Nuclear Medicine, Hokkaido University School of Medicine, Sapporo, Japan.

Four patients with solitary autonomously functioning thyroid nodule (AFTN; 2 toxic and 2 subclinically toxic) received ultrasonography (US)-guided percutaneous ethanol injection therapy (PEIT). The pretreatment scintigraphic appearance of the nodule was hot, and radioactivity in the extranodular tissue was completely suppressed throughout. Ninety-nine percent ethanol was slowly injected under US guidance. Read More

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Routine measurement of serum calcitonin in nodular thyroid diseases allows the preoperative diagnosis of unsuspected sporadic medullary thyroid carcinoma.

J Clin Endocrinol Metab 1994 Apr;78(4):826-9

Istituto di Endocrinologia, University of Pisa, Italy.

To assess whether routine measurement of serum calcitonin (CT) could improve the preoperative diagnosis of sporadic medullary thyroid carcinoma (MTC), 1385 consecutive patients presenting for nodular thyroid disease during the year 1991 were submitted to serum CT determination and fine needle aspiration cytology (FNAC). The clinical diagnosis was nontoxic nodular goiter in 1197 (86.4%) patients, toxic multinodular goiter in 65 (4. Read More

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Comparison of two multiple blood sampling regimens using an indwelling vascular access device for investigations of the hen's ovulatory cycle and calcium metabolism.

Poult Sci 1993 Jan;72(1):172-84

Department of Animal Science, University of British Columbia, Vancouver, Canada.

The objectives of the present study were to compare the effects of two regimens of serial blood sampling on the concentrations of hormones and ions during the ovulatory cycle of the domestic hen, and to examine the effectiveness of an indwelling vascular access device for repeated collection of blood samples. Single Comb White Leghorn hens were bled every 2 h over a period of 24 to 26 h, either from one oviposition to the next oviposition (OVIP-OVIP), or from 10 h prior to ovulation until the same time 24 h later (AFTN-AFTN). Whole blood was analyzed for ionized calcium concentration. Read More

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January 1993

Autonomously functioning thyroid nodules in childhood and adolescence.

Surgery 1987 Dec;102(6):1101-8

Department of Surgery, University of North Carolina School of Medicine, Chapel Hill 27514.

Autonomously functioning thyroid nodules (AFTNs) in children and adolescents (under age 18) are unusual but are not as rare as earlier reports suggested. These lesions have a significantly different biologic potential than similar lesions in older patients. In the younger age group there is a more rapid progression toward toxicity and a higher incidence of thyroid carcinoma. Read More

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December 1987

Solitary autonomously functioning thyroid nodules and iodine deficiency.

J Clin Endocrinol Metab 1983 Feb;56(2):283-7

The prevalence, characteristics, and evolution of autonomously functioning thyroid nodules (AFTN) were studied in two population groups from northeastern Sicily. One group was living in an iodine-deficient area and another was living in an iodine-sufficient area. The prevalence of AFTN was significantly higher in the iodine-deficient area (4. Read More

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February 1983
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