J Biol Chem 2014 Sep 4;289(39):26722-26732. Epub 2014 Aug 4.
Department of Biological Sciences, Columbia University, New York, New York 10027, and; Vascular Biology and Inflammation Department, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Cl. Melchor Fernández Almagro 3, 28029 Madrid, Spain.
Neurodegenerative diseases share a common characteristic, the presence of intracellular or extracellular deposits of protein aggregates in nervous tissues. Amyotrophic Lateral Sclerosis (ALS) is a severe and fatal neurodegenerative disorder, which affects preferentially motoneurons. Changes in the redox state of superoxide dismutase 1 (SOD1) are associated with the onset and development of familial forms of ALS. Read More