59 results match your criteria aer cumulative


Ultrasound-Guided Intercostal Nerve Block and Subcostal Transversus Abdominis Plane Block for Postoperative Analgesia in Patients Posted for Open Cholecystectomy: A Randomized Controlled Trial.

Anesth Essays Res 2020 Jul-Sep;14(3):376-383. Epub 2021 Mar 22.

Department of Anesthesiology, UPUMS Saifai, Etawah, Uttar Pradesh, India.

Background: Effective postoperative analgesia leads to early mobilization, fewer pulmonary complications, and shorter hospital stay.

Aims: We compared the analgesic effects of ultrasound-guided intercostal nerve (ICN) blocks, subcostal transversus abdominis plane (SCTAP) block, and a control group in open cholecystectomy.

Settings And Design: This was a prospective, randomized controlled, double-blind, multi-arm and parallel study. Read More

View Article and Full-Text PDF

Cancer predisposition syndromes as a risk factor for early second primary neoplasms after childhood cancer - A national cohort study.

Eur J Cancer 2021 03 7;145:71-80. Epub 2021 Jan 7.

Institute of Social and Preventive Medicine, University of Bern, Switzerland; Division of Pediatric Hematology and Oncology, University Children`s Hospital Bern, Switzerland. Electronic address:

Background: Childhood cancer patients are at increased risk of second primary neoplasms (SPNs). We assessed incidence and risk factors for early SPNs with a focus on cancer predisposition syndromes (CPSs).

Patients And Methods: This cohort study used data from the Swiss Childhood Cancer Registry. Read More

View Article and Full-Text PDF

Second primary malignancies in patients with papillary thyroid carcinoma after effect of post-chernobyl irradiation: A risk analysis of more than two decades of observations.

Cancer Epidemiol 2021 02 28;70:101860. Epub 2020 Nov 28.

School of Medicine, Griffith University, Gold Coast, QLD, 4222, Australia. Electronic address:

Background: Second primary malignancy in patients with papillary thyroid carcinoma after Chernobyl accident is an emerging problem. The aims of the study are to investigate the rates and distribution of second primary malignant tumours in Belarus survivors of post-Chernobyl papillary thyroid carcinoma and the cumulative rate of developing a second primary malignancy in a group of patients with metachronous second primaries.

Methods: Patients aged 18 or younger at the time of Chernobyl accident who were diagnosed with papillary thyroid carcinoma after 1986 were identified from the Belarus Cancer Registry. Read More

View Article and Full-Text PDF
February 2021

Risk of somatic diseases in offspring of survivors with childhood or adolescent central nervous system tumor in Sweden.

Int J Cancer 2021 05 23;148(9):2184-2192. Epub 2020 Nov 23.

Center for Primary Health Care Research, Lund University/Region Skåne, Malmö, Sweden.

With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared to population controls. Children of survivors with CNS tumor below age of 20 were identified between 1973 and 2014 by combining the several Swedish registers. Read More

View Article and Full-Text PDF

Relative and absolute cancer risks among Nordic kidney transplant recipients-a population-based study.

Transpl Int 2020 12 25;33(12):1700-1710. Epub 2020 Sep 25.

Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

Kidney transplant recipients (KTRs) have an increased cancer risk compared to the general population, but absolute risks that better reflect the clinical impact of cancer are seldom estimated. All KTRs in Sweden, Norway, Denmark, and Finland, with a first transplantation between 1995 and 2011, were identified through national registries. Post-transplantation cancer occurrence was assessed through linkage with cancer registries. Read More

View Article and Full-Text PDF
December 2020

Risk of a second cancer in Canadians diagnosed with a first cancer in childhood or adolescence.

EClinicalMedicine 2019 Nov 23;16:107-120. Epub 2019 Oct 23.

Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, 785 Carling Ave, Room 611B1, Ottawa K1A 0K9, Ontario, Canada.

Background: Second cancers are an adverse outcome experienced by childhood cancer survivors. We quantify the risk and correlates of a second cancer in Canadians diagnosed with a first cancer prior to age 20 years.

Methods: Using death-linked Canadian Cancer Registry data, a population-based cohort diagnosed with a first cancer between 1992 and 2014, prior to age 20 years, were followed for occurrence of a second cancer to the end of 2014. Read More

View Article and Full-Text PDF
November 2019

Efficacy of Adding Midazolam to Bupivacaine for Transversus Abdominis Plane Block on Postoperative Analgesia after Hysterectomy: A Randomized Controlled Study.

Anesth Essays Res 2019 Jul-Sep;13(3):522-527

Department of Obstetrics and Gynaecology, College of Medicine, Mansoura University, Mansoura, Egypt.

Background And Aim: Different adjuncts have been utilized to promote the quality and prolong the duration of local anesthetics for a variety of regional block techniques. This study aimed to assess the effects of midazolam coadministered with bupivacaine in transversus abdominis plane (TAP) block on the 24-h morphine consumption, the postoperative analgesia duration and adverse effects.

Settings And Design: A prospective, randomized, controlled double-blind trial that was carried out at a university hospital. Read More

View Article and Full-Text PDF
October 2019

Neurologic disorders in long-term survivors of neuroblastoma - a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) research program.

Acta Oncol 2020 Feb 8;59(2):134-140. Epub 2019 Oct 8.

Danish Cancer Society Research Center, Childhood Cancer Research Group, Copenhagen, Denmark.

Neuroblastoma is the commonest extracranial solid tumor of childhood, yet rare, and with poor survival before 1990, especially for high-risk disease; thus, information on late effects is sparse. With great advances in cancer treatment, survival has reached 80% in the Nordic countries. The aim of the study was to investigate the risk of developing neurologic disorders after neuroblastoma. Read More

View Article and Full-Text PDF
February 2020

Twenty-four-month clinical performance of different universal adhesives in etch-and-rinse, selective etching and self-etch application modes in NCCL - a randomized controlled clinical trial.

J Appl Oral Sci 2019 11;27:e20180358. Epub 2019 Apr 11.

Department of Restorative Dentistry, School of Dentistry, Hacettepe University, Ankara, Turkey.

Objective: The aim of this randomized, controlled, prospective clinical trial was to evaluate the performances of two different universal adhesives and one etch-rinse adhesive for restoration of non-carious cervical lesions (NCCLs).

Material And Methods: Twenty patients with at least seven NCCLs were enrolled. Lesions were divided into seven groups according to adhesive systems and application modes: GSE: GLUMA Universal-self-etch, GSL: GLUMA Universal-selective etching, GER: GLUMA Universal-etch-and-rinse, ASE: All-Bond Universal-self-etch, ASL: All-Bond Universal-selective etching, AER: All-Bond Universal-etch-and-rinse, SBE (Control): Single Bond2-etch-and-rinse. Read More

View Article and Full-Text PDF

Patterns of Cause-Specific Mortality Among 2053 Survivors of Retinoblastoma, 1914-2016.

J Natl Cancer Inst 2019 09;111(9):961-969

Background: Previous studies of hereditary retinoblastoma survivors have reported elevated mortality, particularly for sarcomas, compared with the general population. However, cause-specific mortality patterns for long-term hereditary and nonhereditary retinoblastoma survivors are poorly understood.

Methods: Among 2053 retinoblastoma patients diagnosed during 1914-2006 at two major US treatment centers and followed to 2016, we estimated cumulative mortality, standardized mortality ratios (SMRs), and absolute excess risks (AERs) compared with the US general population. Read More

View Article and Full-Text PDF
September 2019

Cardiovascular and other competing causes of death among patients with cancer from 2006 to 2015: An Australian population-based study.

Cancer 2019 02 12;125(3):442-452. Epub 2018 Oct 12.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.

Background: With improved cancer survivorship, cardiovascular disease (CVD) and other noncancer events compete with cancer as the underlying cause of death, but the risks of mortality in competing-risk settings have not been well characterized.

Methods: The authors identified 21,637 individuals who had a first cancer registered between 2006 and 2013, with follow-up to 2015, in the Australian population-based Tasmanian Cancer Registry. The cumulative incidence of deaths from specific competing events was assessed in competing-risk analyses. Read More

View Article and Full-Text PDF
February 2019

Possible Bias in the Publication Trends of High Impact Factor Anesthesiology and Gastroenterology Journals -An Analysis of 5 Years' Data.

Anesth Essays Res 2018 Jul-Sep;12(3):611-617

Cherry Hill High School East, NJ, USA.

Background: We hypothesize that being an editorial board member (EBM) in a high impact factor specialty medical journal increases the chances of publishing in the same journal.

Materials And Methods: The publication trends of the first five EBMs in the five highest impact factor Anesthesiology and Gastroenterology journals were analyzed. Preceding 5 years' publications appearing on PubMed were grouped into as follows: number of publications in the journal in which the EBM serves (N1), number of publications by the same author in the other four highest impact factor (IF) journals (N2) and number of publications in all the other journals (N3). Read More

View Article and Full-Text PDF
October 2018

Celiac Autoimmunity Is Associated With Lower Blood Pressure and Renal Risk in Type 1 Diabetes.

J Clin Endocrinol Metab 2018 10;103(10):3828-3836

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.

Context: Though the long-term consequences of celiac disease (CD) in type 1 diabetes are unclear, CD has been associated with increased prevalence of end-stage renal disease (ESRD) independent of type 1 diabetes.

Objective: We evaluated whether celiac autoimmunity is related to the cumulative incidence of microalbuminuria [albumin excretion rate (AER) 20 to 200 µg/min], macroalbuminuria (AER >200 µg/min), and ESRD.

Design, Patients, And Methods: In the prospective follow-up of the Pittsburgh Epidemiology of Diabetes Complications study of childhood-onset type 1 diabetes, 618 participants were screened for tissue transglutaminase (tTG) antibodies with a clinical assay. Read More

View Article and Full-Text PDF
October 2018

Comparison of Intrapleural with Paravertebral Levobupivacaine Analgesia for Thoracoscopic Sympathectomy: A Randomized Controlled Study.

Anesth Essays Res 2018 Apr-Jun;12(2):417-422

Department of Surgery, Mansoura University, Mansoura, Egypt.

Background: Palmar hyperhidrosis is a benign disease of excessive sweating in the palm that exceeds the physiological state. Thoracoscopic sympathectomy is an effective surgical treatment for localized hyperhidrosis.

Aims: The aim of this study was to compare paravertebral block (PVB) with intrapleural analgesia in thoracoscopic sympathectomy. Read More

View Article and Full-Text PDF

Effect of Intravenous Magnesium Sulfate on the Minimum Alveolar Concentrations of Desflurane Using Bispectral Index Monitoring: A Prospective Randomized Double-blind Controlled Study.

Anesth Essays Res 2017 Oct-Dec;11(4):1004-1008

Department of Anaesthesiology, SKIMS Medical College, Srinagar, Jammu and Kashmir, India.

Background: Magnesium sulfate has been implicated to influence the minimum alveolar concentration (MAC) of various volatile anesthetics, but its effect on desflurane remains unanswered so far.

Aim: To study the effect of perioperative intravenous magnesium sulfate on MAC of desflurane using bispectral index (BIS) monitoring.

Settings: Operating room of a tertiary care hospital. Read More

View Article and Full-Text PDF
December 2017

Development of an in Vitro-Based Risk Assessment Framework for Predicting Ambient Particulate Matter-Bound Polycyclic Aromatic Hydrocarbon-Activated Toxicity Pathways.

Environ Sci Technol 2017 Dec 1;51(24):14262-14272. Epub 2017 Dec 1.

National Institute of Environmental Health Sciences, National Health Research Institutes , Zhunan, Taiwan 35053, ROC.

Polycyclic aromatic hydrocarbons (PAHs) are widely distributed throughout the atmosphere as mixtures attached to ambient particulate matter (PM). PAHs usually elicit similar toxicological pathways but do so with varying levels of efficacy. In this study, we utilized high-throughput screening (HTS) in vitro data of PAHs to predict health risks associated with coarse and fine PM. Read More

View Article and Full-Text PDF
December 2017

Relative Efficacy of Ultrasound-guided Ilioinguinal-iliohypogastric Nerve Block versus Transverse Abdominis Plane Block for Postoperative Analgesia following Lower Segment Cesarean Section: A Prospective, Randomized Observer-blinded Trial.

Anesth Essays Res 2017 Jul-Sep;11(3):713-717

Department of Anaesthesiology and Critical Care, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth University, Puducherry, India.

Background: Quality of postoperative analgesia after cesarean section makes difference to mother in child bonding, early ambulation, and discharge. Ilioinguinal iliohypogastric (ILIH) and transverse abdominis plane (TAP) block had been tried to reduce the opioid analgesics, but the relative efficacy is unknown. Hence, this study was designed to compare the efficacy of these two regional analgesic techniques in sparing postoperative rescue analgesic requirement following lower segment cesarean section (LSCS). Read More

View Article and Full-Text PDF
September 2017

Risks of different skin tumour combinations after a first melanoma, squamous cell carcinoma and basal cell carcinoma in Dutch population-based cohorts: 1989-2009.

J Eur Acad Dermatol Venereol 2018 Mar 17;32(3):382-389. Epub 2017 Oct 17.

Department of Dermatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Background: Skin cancer patients are primarily at increased risk of developing subsequent skin cancers of the same type. Shared risk factors might also increase the occurrence of a different type of subsequent skin cancer.

Objective: To investigate risks of different skin tumour combinations after a first melanoma, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Read More

View Article and Full-Text PDF

Second cancer incidence in primary mediastinal B-cell lymphoma treated with methotrexate with leucovorin rescue, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin regimen with or without rituximab and mediastinal radiotherapy: Results from a monoinstitutional cohort analysis of long-term survivors.

Hematol Oncol 2017 Dec 12;35(4):554-560. Epub 2017 Jan 12.

Department of Cellular Biotechnologies and Hematology, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.

Our aim is to assess the incidence of second cancer in long-time surviving primary mediastinal B-cell lymphoma (PMBCL) patients treated with combined radiochemoimmunotherapy (standard methotrexate with leucovorin rescue, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin with rituximab and mediastinal radiation therapy at a dose of 30 to 36 Gy). For this purpose, 92 points were evaluated. After a median overall survival of 137 months (range 76-212), we recorded second cancer in 3 of 80 long-surviving patients (3. Read More

View Article and Full-Text PDF
December 2017

Comparison of oxycodone and sufentanil for patient-controlled intravenous analgesia after laparoscopic radical gastrectomy: A randomized double-blind clinical trial.

Anesth Essays Res 2016 Sep-Dec;10(3):557-560

Department of Urology, The First Hospital of Jilin University, Changchun, Jilin, China.

Background: Sufentanil is widely used for patient-controlled intravenous analgesia (PCIA). Oxycodone has a powerful analgesic effect and mild side effects. We conducted this study to compare the efficacy of oxycodone and sufentanil for PCIA on postoperative pain after laparoscopic radical gastrectomy. Read More

View Article and Full-Text PDF
October 2016

Long-term risk of renal and urinary tract diseases in childhood cancer survivors: A population-based cohort study.

Eur J Cancer 2016 09 18;64:52-61. Epub 2016 Jun 18.

Department of Pediatrics, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.

Background: Childhood cancer has been associated with long-term risk of urinary tract diseases, but risk patterns remain to be comprehensively investigated. We analysed the lifetime risk of urinary tract diseases in survivors of childhood cancer in the Nordic countries.

Methods: We identified 32,519 one-year survivors of childhood cancer diagnosed since the 1940s and 1950s in the five Nordic cancer registries and selected 211,156 population comparisons of a corresponding age, sex, and country of residence from the national population registries. Read More

View Article and Full-Text PDF
September 2016

Intraoperative hemodynamics with vecuronium bromide and rocuronium for maintenance under general anesthesia.

Anesth Essays Res 2016 Jan-Apr;10(1):59-64

Department of Anesthesia, KVG Medical College and Hospital, Sullia, Dakshina Kannada, Karnataka, India.

Aims: The present study is undertaken to compare the hemodynamic effects using vecuronium versus rocuronium for maintenance in patients undergoing general surgical procedures.

Settings And Design: It is a prospective, randomized, and cohort study.

Subjects And Methods: 100 patients were randomly divided into two groups. Read More

View Article and Full-Text PDF

An observational study of the feasibility of Airtraq guided intubations with Ring Adair Elvin tubes in pediatric population with cleft lip and palate.

Anesth Essays Res 2015 Sep-Dec;9(3):359-63

Department of Anaesthesiology and Intensive Care, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Context: The airway management requires refined skills and technical help when associated with cleft lip and palate. Airtraq has improved our airway management skills and has been successfully used for rescue intubation in difficult pediatric airways.

Aims: This study was to evaluate the efficacy of Airtraq as the primary intubation device in patients with cleft lip and palate. Read More

View Article and Full-Text PDF
December 2015

Increased risk of second malignant neoplasms in adolescents and young adults with cancer.

Cancer 2016 Jan 6;122(1):116-23. Epub 2015 Oct 6.

Department of Pediatrics, University of California San Francisco Benioff Children's Hospital San Francisco, San Francisco, California.

Background: The authors describe the incidence and characteristics of secondary malignant neoplasms (SMNs) in adolescent and young adult (AYA) cancer survivors compared with those in younger and older cancer survivors.

Methods: Children aged ≤ 14 years, AYAs aged 15 to 39, and older adults aged ≥ 40 years at the time of primary diagnosis who were reported as cancer survivors in the Surveillance, Epidemiology, and End Results (SEER) program between 1973 and 2011 were compared in this population-based analysis. The primary analysis was the risk that an SMN would occur ≥ 5 years after the original diagnosis for patients who had the more common AYA cancers (leukemia, lymphoma, testicular malignancy, ovarian malignancy, melanoma, and cancers of the thyroid, breast, soft tissue, or bone). Read More

View Article and Full-Text PDF
January 2016

Risk of second primary malignancies and survival of adult patients with polycythemia vera: A United States population-based retrospective study.

Leuk Lymphoma 2016 1;57(1):129-33. Epub 2015 Sep 1.

e Division of Hematology and Oncology, Department of Internal Medicine , University of Nebraska Medical Center , NE , USA.

Although the median survival in polycythemia vera (PV) is 14 years, mortality is higher than in an age- and sex-matched population. This study included 3941 PV patients diagnosed between 2000-2012 from Surveillance, Epidemiology and End Results (SEER) 13 registry to determine 5-year survival and the incidence of second primary malignancies (SPM). The actuarial 5 year survival in the overall cohort was 79. Read More

View Article and Full-Text PDF
October 2016

Secondary Malignancies Following Treatment for Hodgkin's Lymphoma in Childhood and Adolescence.

Dtsch Arztebl Int 2015 May;112(18):320-7, i

Department of Pediatrics, HELIOS Klinikum Berlin-Buch, Department of Pediatric Rheumatology and Immunology, University Children's Hospital Münster, Protestant Lung Hospital, Berlin.

Background: About 155 persons under age 18 develop Hodgkin's lymphoma (HL) in Germany every year. More than 90% survive at least 20 years. They may, however, suffer from late sequelae of treatment, including secondary malignant neoplasia (SMN). Read More

View Article and Full-Text PDF

A randomized double-blind study to evaluate efficacy and safety of epidural magnesium sulfate and clonidine as adjuvants to bupivacaine for postthoracotomy pain relief.

Anesth Essays Res 2015 Jan-Apr;9(1):15-20

Department of Anaesthesiology and Critical Care, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.

Background: The aim of the study was to compare postoperative pain relief in patients undergoing an elective thoracotomy with thoracic epidural analgesia using single shot magnesium and clonidine as adjuvants to bupivacaine.

Methods: In a randomized prospective study, 60 patients of American Society of Anesthesiologists physical status I-III of either sex, between 20 and 60 years undergoing elective unilateral thoracotomy, were allocated to three equal groups of 20 patients. Each patient received thoracic epidural analgesia using bupivacaine alone (Group A) or with magnesium (Group B) or clonidine (Group C) at the end of surgery during skin closure. Read More

View Article and Full-Text PDF

Perioperative analgesic effects of intravenous paracetamol: Preemptive versus preventive analgesia in elective cesarean section.

Anesth Essays Res 2014 Sep-Dec;8(3):339-44

Department of Anesthesia and Critical Care, Faculty of Medicine, Zagazig University, Egypt.

Background: Cesarean section (CS) is the one of the most common surgical procedure in women. There is preoperative stress effect before the delivery of the baby as (intubation and skin incision). There is acute postoperative pain, which may be progressed to chronic pain. Read More

View Article and Full-Text PDF

Leisure-time physical activity and development and progression of diabetic nephropathy in type 1 diabetes: the FinnDiane Study.

Diabetologia 2015 May 30;58(5):929-36. Epub 2015 Jan 30.

Folkhälsan Institute of Genetics, Folkhälsan Research Centre, Helsinki, Finland.

Aims/hypothesis: The aim of this study was to assess how physical activity predicts the development and progression of diabetic nephropathy in patients with type 1 diabetes.

Methods: This prospective study (follow-up time 6.4 ± 3. Read More

View Article and Full-Text PDF

Personal exposure to mixtures of volatile organic compounds: modeling and further analysis of the RIOPA data.

Res Rep Health Eff Inst 2014 Jun(181):3-63

Introduction: Emission sources of volatile organic compounds (VOCs*) are numerous and widespread in both indoor and outdoor environments. Concentrations of VOCs indoors typically exceed outdoor levels, and most people spend nearly 90% of their time indoors. Thus, indoor sources generally contribute the majority of VOC exposures for most people. Read More

View Article and Full-Text PDF