113,980 results match your criteria adverse reactions


Anti-seizure activity of African medicinal plants: the identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model.

J Ethnopharmacol 2021 Jun 9:114282. Epub 2021 Jun 9.

Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria, South Africa, 0001. Electronic address:

Ethnopharmacological Relevance: Epilepsy is one of the major chronic diseases that does not have a cure to date. Adverse drug reactions have been reported from the use of available antiepileptic drugs (AEDs) which are also effective in only two-thirds of the patients. Accordingly, the identification of scaffolds with promising anti-seizure activity remains an important first step towards the development of new anti-epileptic therapies, with improved efficacy and reduced adverse effects. Read More

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Efficacy and safety of TAS-115, a novel oral multi-kinase inhibitor, in osteosarcoma: an expansion cohort of a phase I study.

Invest New Drugs 2021 Jun 12. Epub 2021 Jun 12.

Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Background osteosarcoma is a rare, primary malignant bone tumour with limited available treatments for advanced or recurrent disease, resulting in a poor prognosis for patients. TAS-115 is a novel tyrosine kinase inhibitor under investigation in a phase I study in patients with solid tumours. We report data of osteosarcoma patients in the expansion cohort of this ongoing study. Read More

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Risk of Bleeding Associated with Antidepressant Drugs: The Competitive Impact of Antithrombotics in Quantitative Signal Detection.

Drugs Real World Outcomes 2021 Jun 11. Epub 2021 Jun 11.

Department of Psychiatry and Psychotherapy III, University of Ulm, Leimgrubenweg 12-14, 89075, Ulm, Germany.

Background: To date, disproportionality analysis has been unable to demonstrate the increased bleeding risk associated with antidepressant drugs, especially selective serotonin reuptake inhibitors.

Objective: We hypothesised that a potential signal for an increased bleeding risk may be mitigated by the effects of agents other than antidepressant drugs that are strongly associated with haemorrhages, especially antithrombotics. In addition, we investigated if the use of more specific search terms of the Medical Dictionary for Regulatory Activities facilitates the detection of signals. Read More

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Whole blood chromium concentration is very rarely elevated independently of whole blood cobalt.

Sci Rep 2021 Jun 11;11(1):12352. Epub 2021 Jun 11.

Coxa Hospital for Joint Replacement and Faculty of Medicine and Health Technologies, Tampere University, Niveltie 4, 33520, Tampere, Finland.

Due to the risk of adverse reactions to metal debris resulting from increased wear of the arthroplasty more than one million metal-on-metal (MoM) hip replacements worldwide are in active follow-up. Follow-up usually includes measurement of both whole blood cobalt (Co) and chromium (Cr) concentrations. Our experience is that Cr is seldom independently elevated. Read More

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Unexpected overdose of oral cyclosporine in a kidney transplant patient: a case report.

Eur J Hosp Pharm 2021 Jun 11. Epub 2021 Jun 11.

Univ Rennes, CHU Rennes, Inserm, EHESP, IRSET (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.

Cyclosporine is a widely used immunosuppressive agent to prevent rejection of solid organ transplant. Here, we describe the case of a 71-year-old man who received the prescribed dose of cyclosporine 10 times 6 days after a kidney transplantation because of a concentration miscalculation involving two galenic forms. The patient presented gastrointestinal and neurological disorders. Read More

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Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents.

Bioorg Med Chem 2021 Jun 8;42:116251. Epub 2021 Jun 8.

Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates; College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates. Electronic address:

Selective inhibition of histone deacetylases (HDACs) is an important strategy in the field of anticancer drug discovery. However, lack of inhibitors that possess high selectivity toward certain HDACs isozymes is associated with adverse side effects that limits their clinical applications. We have initiated a collaborative initiatives between multi-institutions aimed at the discovery of novel and selective HDACs inhibitors. Read More

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Ethnomedicinal uses, phytochemistry, pharmacological activities and toxicological profile of Glycosmis pentaphylla (Retz.) DC.: A review.

J Ethnopharmacol 2021 Jun 8:114313. Epub 2021 Jun 8.

Department of Pharmacy, International Islamic University Chittagong, Chittagong, 4318, Bangladesh; Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur, Malaysia. Electronic address:

Ethnopharmacological Relevance: Glycosmis pentaphylla (Retz.) DC. is a perennial shrub indigenous to the tropical and subtropical regions of India, China, Sri Lanka, Myanmar, Bangladesh, Indonesia, Malaysia, Thailand, Vietnam, Philippine, Java, Sumatra, Borneo and Australia. Read More

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High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study.

PLoS One 2021 11;16(6):e0253159. Epub 2021 Jun 11.

Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Three months of weekly rifapentine plus isoniazid (3HP) is a short course regimen for latent tuberculosis infection treatment with satisfied safety and efficacy. However, research on its use in children is limited. In this study, we evaluated the completion rate and safety of the 3HP regimen among children in China. Read More

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A Phase 3, Open-label, Single-arm Study of Vadadustat for Anemia in Chronic Kidney Disease for Japanese Patients on Hemodialysis not Receiving Erythropoiesis-stimulating Agents.

Ther Apher Dial 2021 Jun 11. Epub 2021 Jun 11.

Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.

Vadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor approved in Japan for the treatment of anemia in patients with chronic kidney disease (CKD). This phase 3, open-label, single-arm study evaluated the efficacy and safety of vadadustat in 24 Japanese patients with CKD-associated anemia on hemodialysis who were not receiving erythropoiesis-stimulating agents (ESAs). Patients received vadadustat for 24 weeks; the starting dose was 300 mg/day and doses were adjusted to achieve the target hemoglobin (Hb) range of 10. Read More

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Efficacy and safety of acupuncture combined with analgesics on lung cancer pain: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26225

Jiangxi University of Chinese Medicine.

Background: Lung cancer (LC) is the malignant tumor with the highest incidence in the world, and treatment methods include surgery, radiotherapy, chemotherapy, and immunotherapy. Cancer pain is a common symptom in patients with LC, and the clinical treatment is to relieve it with analgesics. Acupuncture can relieve cancer pain. Read More

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Acupoint injection combined with pelvic floor rehabilitation in the treatment of postpartum pelvic floor disorders: A protocol of randomized controlled trial.

Medicine (Baltimore) 2021 Jun;100(23):e25511

Chongqing Ninth People's Hospital.

Background: Female pelvic floor dysfunction is one of the common chronic diseases affecting women's physical and mental health. Pregnancy and delivery are one of the main causes. Pelvic floor rehabilitation is a common method for the treatment of postpartum pelvic floor dysfunction, but it has some defects. Read More

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TRough vs. AUC Monitoring of cyclosporine: A randomized comparison of adverse drug reactions in adult allogeneic stem cell recipients (TRAM study).

Eur J Haematol 2021 Jun 11. Epub 2021 Jun 11.

Clinical pharmacist/ clinical pharmacologist, Amsterdam University Medical Centers, department of Clinical Pharmacology and Pharmacy, Amsterdam, The Netherlands.

Objective: To investigate the incidence and severity of adverse drug reactions of cyclosporine using AUC targeted Therapeutic Drug Monitoring (TDM) compared to trough levels (C ) targeted TDM in adult allogeneic stem cell recipients.

Methods: Blind, monocentre, intervention study. Subjects were 1:1 randomized into either an AUC group or a C group. Read More

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Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD'18 adherent clinical trial in dogs in the United Kingdom.

J Vet Intern Med 2021 Jun 11. Epub 2021 Jun 11.

Hill's Pet Nutrition, Inc, Topeka, Kansas 66616, USA.

Background: Adverse reactions to food are a common dermatological condition in dogs, requiring nutritional intervention using novel or hydrolysate protein-based foods.

Objective: To evaluate a therapeutic food containing egg and phytonutrients in dogs with food allergies using an activity monitor and core outcome set for canine atopic dermatitis (COSCAD'18) in a controlled double-masked, multicenter, prospective clinical trial.

Animals: Adult dogs with a history of adverse food reaction as diagnosed by a food elimination trial were recruited from general practices. Read More

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Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD'18 adherent clinical trial in dogs in the United States.

J Vet Intern Med 2021 Jun 11. Epub 2021 Jun 11.

Pet Nutrition Center, Hill's Pet Nutrition, Inc, Topeka, Kansas 66616, USA.

Background: Adverse reactions to food are a common dermatological condition in dogs, requiring nutritional intervention using a novel or hydrolysate protein-based food.

Objective: To evaluate a therapeutic food containing egg and phytonutrients in dogs with food allergies using an activity monitor and core outcome set for canine atopic dermatitis (COSCAD'18) guidelines and in a controlled double-masked, multicenter, prospective clinical trial.

Animals: Adult dogs with a history of adverse food reaction as diagnosed by a food elimination trial were recruited from general practices. Read More

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Apoptotic mechanism of premature ovarian failure and rescue effect of Traditional Chinese Medicine: a review.

J Tradit Chin Med 2021 Jun;41(3):492-498

Department of Reproductive Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Social and environmental factors render premature ovarian failure (POF) as a major cause of decline or loss of female fertility. The natural pregnancy rate of patients with POF is only 5%-10%. Follicular atresia is the main factor in the pathogenesis of POF. Read More

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Antirheumatic drugs in older adults and polypharmacy issues.

Z Gerontol Geriatr 2021 Jun 10. Epub 2021 Jun 10.

Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Older individuals experience various noninflammatory and autoimmune inflammatory rheumatic diseases. Given the increased incidence of rheumatic conditions in older adults, it is of great importance for healthcare providers to be aware of the potential benefits and risks of antirheumatic drugs. The present article aims to provide a comprehensive review regarding antirheumatic drug use in older patients, particularly by focusing on safety issues and polypharmacy. Read More

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Applicationofthe "immunization islands" model to improve quality, ef ficiency and safet y of a COVID-19 mass vaccination site.

Ann Ig 2021 Jun 11. Epub 2021 Jun 11.

Presidenza Gruppo San Donato, expert in Public Health and Health Organization, Milano, Italy.

Abstract: After SARS-CoV-2 vaccines development came at an unprecedented speed, ensuring safe and efficient mass immunization, vaccine delivery became the major public health mandate. Although mass-vaccination sites have been identified as essential to curb COVID-19, their organization and functioning is challenging. In this paper we present the planning, implementation and evaluation of a massive vaccination center in Lombardy - the largest Region in Italy and the most heavily hit by the pandemic. Read More

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The Efficacy and Safety of Carbon Ion Radiotherapy for Meningiomas: A Systematic Review and Meta-Analysis.

Front Oncol 2021 25;11:620534. Epub 2021 May 25.

Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.

Objective: The purpose of this systematic review and meta-analysis is to evaluate the efficacy and safety of carbon ion radiotherapy (CI-RT) in improving meningioma by comparing photon and protons radiotherapy.

Methods: A comprehensive search for relevant studies published until March 17, 2021, was conducted in PubMed, the Cochrane Library, Chinese Biomedical Literature Database and EMBASE. Statistical analyses were performed with R 4. Read More

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Posterior Reversible Encephalopathy Syndrome (PRES) and Drug-Induced Hypersensitivity Syndrome (DIHS) following Immunotherapy and BRAF/MEK Inhibition with Continued Response in Metastatic Melanoma.

Case Rep Oncol Med 2021 12;2021:8845063. Epub 2021 May 12.

Blue Ridge Cancer Care, 2013 S Jefferson St, Roanoke, VA 24014, USA.

. The role of immunotherapy continues to evolve across both solid and hematologic malignancies. However, while use of immunotherapy has increased via the advent of checkpoint inhibition, chimeric antigen receptors, and vaccines against malignant cells, there remains uncertainty regarding the recognition and management of delayed immune-related reactions and post treatment immune-related sensitivity to subsequent medications, such as BRAF/MEK kinase inhibitors. Read More

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Effect of Lidocaine Pre-Treatment on Protamine-Induced Pulmonary Vascular Reaction During the Repair of Congenital Heart Disease.

Int J Gen Med 2021 3;14:2249-2258. Epub 2021 Jun 3.

Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin, 300074, People's Republic of China.

Background: Protamine is a polycationic, and a strong basic peptide isolated from Clupeidae or Salmonidae fishes' sperm, which is rich in arginine and highly alkaline.

Objective: To explore the effect of lidocaine pre-treatment on protamine-induced pulmonary vascular reaction during the repair of congenital heart disease.

Methods: Eighty patients undergoing repair of congenital heart disease were randomly divided into four groups: A (non-pulmonary hypertension + lidocaine pre-treatment) group, A (non-pulmonary hypertension + normal saline) group, B (pulmonary hypertension + lidocaine pre-treatment) group, and B (pulmonary hypertension + normal saline) group. Read More

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Relevant essential oil components: a minireview on increasing applications and potential toxicity.

Toxicol Mech Methods 2021 Jun 10:1-27. Epub 2021 Jun 10.

Laboratory of Toxicology, Faculty of Pharmacy, Universitat de València. Av. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.

Phenolic compounds carvacrol, thymol, eugenol and vanillin are four of the most thoroughly investigated essential oil components given their relevant biological properties. These compounds are generally considered safe for consumption and have been used in a wide range of food and non-food applications. Significant biological properties, including antimicrobial, antioxidant, analgesic, anti-inflammatory, anti-mutagenic or anti-carcinogenic activity, have been described for these components. Read More

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Bioleaching of indium from waste LCD panels by Aspergillus niger: Method optimization and mechanism analysis.

Sci Total Environ 2021 May 29;790:148151. Epub 2021 May 29.

School of Environment and Energy, South China University of Technology, Guangzhou 510006, PR China; The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters, Ministry of Education, Guangzhou 510006, PR China.

Using Aspergillus niger (A. niger) to produce low-concentration organic acids is challenging for dissolving InO from waste LCD (liquid crystal display) panels with high toxicity. In this study, three bioleaching approaches from the general and the optimized fermentation systems were investigated respectively to compare indium recovery effects and firstly clarified its bioleaching mechanism. Read More

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Distributed Ledger Infrastructure to Verify Adverse Event Reporting (DeLIVER): Proposal for a Proof-of-Concept Study.

JMIR Res Protoc 2021 Jun 10;10(6):e28616. Epub 2021 Jun 10.

Centre for Health Technology, University of Plymouth, Plymouth, United Kingdom.

Background: Adverse drug event reporting is critical for ensuring patient safety; however, numbers of reports have been declining. There is a need for a more user-friendly reporting system and for a means of verifying reports that have been filed.

Objective: This project has 2 main objectives: (1) to identify the perceived benefits and barriers in the current reporting of adverse events by patients and health care providers and (2) to develop a distributed ledger infrastructure and user interface to collect and collate adverse event reports to create a comprehensive and interoperable database. Read More

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Assessing Mothers' Automatic Affective and Discipline Reactions to Child Behavior in Relation to Child Abuse Risk: A Dual-Processing Investigation.

Assessment 2021 Jun 10:10731911211020114. Epub 2021 Jun 10.

University of Michigan, Ann Arbor, MI, USA.

Given the scope and adverse clinical consequences of child abuse, assessment of salient etiological factors can lend critical insights needed for abuse prevention. Increasingly, dual-processing models have been applied to aggression, which postulate that parallel automatic and conscious processes can evoke aggressive behavior, implicating both affective and cognitive elements in both routes. Using two samples of mothers ( = 110 and = 195), the current investigation considered evidence of the reliability and convergent, concurrent, and construct validity of the new Automatic Parent Emotion Analog Response task relevant to parent-child aggression, contrasted with a self-reported conscious processing measure. Read More

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[DSA types and treatment strategy of venous malformations of the tongue: an analysis of 132 consecutive patients].

Shanghai Kou Qiang Yi Xue 2021 Apr;30(2):145-150

First People's Hospital of Foshan. Foshan 528000, Guangdong Province, China.

Purpose: To explore the DSA classification and treatment strategy of tongue venous malformation.

Methods: From February 2016 to February 2019, the DSA manifestations of 132 cases with venous malformations of the tongue were summarized. They were classified into 4 types according to imaging characteristics: typeⅠ(non-drainage type), typeⅡ(lower- drainage type), type Ⅲ (higher-drainage type), type Ⅳ(extensive type). Read More

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Adverse reactions of drugs specifically used for treatment of SARS-CoV-2 infection.

Med Clin (Engl Ed) 2021 Jun 5;156(11):576. Epub 2021 Jun 5.

Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu City 610041, China.

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Application of fluorescein combined with methylene blue in sentinel lymph node biopsy of breast cancer.

Sci Rep 2021 Jun 9;11(1):12119. Epub 2021 Jun 9.

Department of Breast Surgery, Zibo Central Hospital, Shandong First Medical University, Zibo, Shandong Province, China.

Sentinel lymph node biopsy (SLNB) for axillary lymph node staging in early breast cancer has been widely recognized. The combination of radio-colloids and dye method is the best method recognized. The reagents and equipment required in the process of the combined method are complex and expensive, so there are certain restrictions in the use of primary medical institutions. Read More

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Anaphylaxis after rabies vaccination for dogs in Japan.

J Vet Med Sci 2021 Jun 9. Epub 2021 Jun 9.

Laboratory of Veterinary Microbiology I, Azabu University.

Severe adverse reactions after rabies vaccination in dogs were examined from 317 cases reported to the Ministry of Agriculture, Forestry and Fisheries (MAFF) in Japan during 15-year period from April 2004 to March 2019. We found that 109 of the 317 dogs showed anaphylaxis (0.15/100,000 vaccinated dogs), and 71 of the 109 cases of anaphylaxis resulted in death (0. Read More

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Aqueous chlorhexidine 1% versus 2% for neonatal skin antisepsis: a randomised non-inferiority trial.

Arch Dis Child Fetal Neonatal Ed 2021 Jun 9. Epub 2021 Jun 9.

Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.

Objective: To evaluate whether 1% aqueous chlorhexidine gluconate (CHG) when compared with 2% aqueous chlorhexidine gluconate is non-inferior for neonatal skin antisepsis.

Design: Parallel, blinded, non-inferiority randomised trial.

Setting: Level III, academic, neonatal intensive care unit. Read More

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