133,138 results match your criteria adverse pregnancy

One Vax Two Lives: A Social Media Campaign and Research Program to Address COVID-19 Vaccine Hesitancy in Pregnancy.

Am J Obstet Gynecol 2022 Jun 22. Epub 2022 Jun 22.

Departments of Obstetrics & Gynecology and Global Health, University of Washington, Seattle, Washington, United States of America.

The coronavirus disease 2019 (COVID-19) pandemic has disproportionately impacted pregnant people by increasing health risks of maternal morbidity and mortality, stillbirth, and preterm birth. Although numerous studies have supported the safety and efficacy of COVID-19 vaccination in pregnancy to prevent or mitigate risk for these adverse outcomes, many pregnant people remain hesitant. Approximately half of U. Read More

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Expectant versus medical management for retained products of conception after medical termination of pregnancy: A randomized controlled study.

Am J Obstet Gynecol 2022 Jun 22. Epub 2022 Jun 22.

Department of Obstetrics and Gynecology, Lis Hospital for Women's Health, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Despite the rise of medical treatments for the termination of pregnancy, to-date no prospective trial has evaluated the efficacy of misoprostol in treating retained products of conception after induced termination of pregnancy.

Objective: To compare medical management with misoprostol with expectant management for retained products of conception after first trimester medical termination of pregnancy.

Study Design: An open-label randomized controlled trial conducted at a university-affiliated tertiary medical center. Read More

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Extreme temperatures during pregnancy and adverse birth outcomes: Evidence from 2009 to 2018 U.S. national birth data.

Health Econ 2022 Jun 25. Epub 2022 Jun 25.

Department of Economics, Bryn Mawr College, Bryn Mawr, Pennsylvania, USA.

We provide the first estimates of the impacts of prenatal exposure to extreme temperatures on infant health at birth using the latest national birth data from 2009 to 2018 from all U.S. states. Read More

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Inattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life.

Braz J Psychiatry 2022 Jun 24. Epub 2022 Jun 24.

Departamento de Psiquiatria, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.

Objective: : Maternal attention-deficit/hyperactivity disorder has not been investigated in relation to parenting skills in adolescent mothers. This study investigated whether maternal inattention and hyperactivity/impulsivity symptoms early in pregnancy predict poorer parenting skills and infant maltreatment during the first year of life in adolescent mothers living in adverse environmental conditions.

Methods: : The participants in this study were 80 adolescent mothers aged 14-19 years and their babies who were taking part in a randomized controlled trial on the effects of a home-visiting program on infant development. Read More

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Evaluation of the feasibility of the FAST-M maternal sepsis intervention in Pakistan: a protocol.

Pilot Feasibility Stud 2022 Jun 24;8(1):130. Epub 2022 Jun 24.

Institute of Life Course and Medical Sciences, University of Liverpool, William Henry Duncan Building, Liverpool, L7 8TX, UK.

Background: Maternal sepsis is a life-threatening condition, defined by organ dysfunction caused by infection during pregnancy, childbirth, and the postpartum period. It is estimated to account for between one-tenth and half (4.7% to 13. Read More

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Minding the Baby versus usual care: study protocol for a quasi-cluster-randomized controlled study in Denmark of an early interdisciplinary home-visiting intervention for families at increased risk for adversity.

Trials 2022 Jun 24;23(1):529. Epub 2022 Jun 24.

Yale Child Study Center, 230 S Frontage Rd, New Haven, CT, USA.

Background: Inequality in health can have profound effects on a child's opportunities later in life. To prevent these downstream effects in families at increased risk of adversity, programs are needed to provide support and improve well-being across several domains. The present trial is aimed at assessing the effectiveness of the Minding the Baby® (MTB) home visiting intervention in improving the mother-child relationship, parental reflective functioning, well-being, and mental health, as well as child development and well-being in families at known risk of adverse health, relational, and developmental outcomes. Read More

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The trend in delayed childbearing and its potential consequences on pregnancy outcomes: a single center 9-years retrospective cohort study in Hubei, China.

BMC Pregnancy Childbirth 2022 Jun 24;22(1):514. Epub 2022 Jun 24.

Department of Pediatrics, Taixing People Hospital, Taizhou, Jiangsu, China.

Background: Due to the advancement of modern societies, the proportion of women who delay childbearing until or beyond 30 years has dramatically increased in the last three decades and has been linked with adverse maternal-neonatal outcomes.

Objective: To determine the trend in delayed childbearing and its negative impact on pregnancy outcomes.

Material And Methods: A tertiary hospital-based retrospective study was conducted in Wuhan University Renmin Hospital, Hubei Province, China, during the years 2011-2019. Read More

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Fetal hyperhomocysteinemia is associated with placental inflammation and early breakdown of maternal-fetal tolerance in Pre-term birth.

Am J Reprod Immunol 2022 Jun 24. Epub 2022 Jun 24.

Department of Obstetrics and Gynecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.

Problem: Hyperhomocysteinemia (hypHcy) due to impaired folate metabolism is shown to be a risk factor for preterm birth (PTB) and low birth weight (LBW) in mothers. However, the relationship of fetal hypHcy with adverse pregnancy outcomes is under-represented. The present study aims to investigate the association of fetal hypHcy with oxidative stress and placental inflammation that can contribute to an early breakdown of maternal-fetal tolerance in pre-term birth (PTB). Read More

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Drugs for sexually transmitted infections.


Med Lett Drugs Ther 2022 Jun;64(1653):97-104

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Development of the Sepsis-Associated Adverse Outcomes in Pregnancy Score.

Am J Perinatol 2022 Jun 24. Epub 2022 Jun 24.

Obstetrics & Gynecology, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, United States.

Objective: To develop and evaluate a scoring system-called Sepsis-Associated Adverse Outcomes in Pregnancy (SAAP) Score-to identify individuals with maternal infection that have composite maternal adverse outcomes (CMAO).

Study Design: Using ICD codes, we identified pregnant and postpartum (up to 6 weeks after birth) individuals admitted at our center with a primary diagnosis of infection. The primary outcome was CMAO, which included any of the following: maternal intensive care unit admission, surgical intervention, vasopressor use, acute respiratory distress syndrome, pulmonary edema, mechanical ventilation, high flow nasal cannula, disseminated intravascular coagulation, dialysis, organ failure, venous thromboembolism, or maternal death. Read More

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Maternal obesity-associated disruption of polarized lactate transporter MCT4 expression in human placenta.

Reprod Toxicol 2022 Jun 22;112:1-6. Epub 2022 Jun 22.

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

Maternal obesity is associated with an increased risk of adverse pregnancy outcomes including stillbirth, and their etiology is thought to be related to placental and fetal hypoxia. In this study, we sought to investigate the levels of lactate in maternal and umbilical cord blood, a well characterized biomarker for hypoxia, and expression of plasma membrane lactate transporter MCT1 and MCT4 in the placental syncytiotrophoblast (STB), which are responsible for lactate uptake and extrusion, respectively, from pregnant women with a diagnosis of obesity following a Cesarean delivery at term. With use of approaches including immunofluorescence staining, Western blot, RT-qPCR and ELISA, our results revealed that in controls the expression of MCT1 was equally observed between basal (fetal-facing, BM) and microvillous (maternal-facing, MVM) membrane of the STB, whereas MCT4 was predominantly expressed in the MVM but barely detected in the BM. Read More

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Presepsin levels in neonatal cord blood are not influenced by maternal SARS-CoV-2 infection.

Clin Chem Lab Med 2022 Jun 24. Epub 2022 Jun 24.

Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy.

Objectives: Coronavirus disease (COVID-19) can present with various symptoms and can involve multiple organs. Women infected during pregnancy have a higher incidence of obstetrical complications and infants born to "positive" mothers may get the infection with different manifestations. Presepsin seems to be a promising sepsis biomarker in adults and neonates. Read More

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Evaluation of the tolerability of monoclonal antibody therapy for pregnant patients with COVID-19.

J Obstet Gynaecol Res 2022 Jun 24. Epub 2022 Jun 24.

Department of Obstetrics and Gynecology, Mie University Faculty Medicine, Mie, Japan.

Aim: To evaluate the tolerability of casirivimab and imdevimab (CAS/IMB) therapy in pregnant women with COVID-19 in Japan and its impact on the neonate and process of delivery.

Methods: Eight cases of pregnancy complicated by COVID-19 and requiring hospitalization during the delta variant epidemic were included. Gestational age, initial symptoms, pregnancy complications and outcome, severity of illness, blood test findings at the time of treatment initiation and on days 3-5 after administration, body temperature at administration, and 8, 24, and 48 h post-administration, delivery outcome, and neonatal findings were recorded. Read More

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Hepatitis C is associated with more adverse pregnancy outcomes than hepatitis B: A 7-year national inpatient sample study.

Hepatol Commun 2022 Jun 24. Epub 2022 Jun 24.

Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Prior international studies have shown mixed results regarding the association of hepatitis B and hepatitis C with adverse pregnancy outcomes. We performed an updated evaluation of the prevalence of associated adverse pregnancy outcomes and evaluated trends over time of diagnosis of chronic hepatitis B (HBV) and chronic hepatitis C (HCV) in pregnant women in a national database. All pregnant women with HBV and HCV were identified from the National Inpatient Sample database 2012 to 2018. Read More

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Plasma level of mannose-binding lectin is associated with the risk of recurrent pregnancy loss but not pregnancy outcome after the diagnosis.

Hum Reprod Open 2022 7;2022(3):hoac024. Epub 2022 Jun 7.

Department of Obstetrics and Gynaecology, Centre for Recurrent Pregnancy Loss of Western Denmark, Aalborg University Hospital, Aalborg, Denmark.

Study Question: Are low or high plasma mannose-binding lectin (p-MBL) levels associated with recurrent pregnancy loss (RPL) and the reproductive and perinatal outcomes before and after RPL?

Summary Answer: The prevalence of low p-MBL levels was significantly higher in RPL patients, while high levels were significantly less prevalent. No association was found between p-MBL level and reproductive and perinatal outcomes before and after RPL.

What Is Known Already: Mannose-binding lectin (MBL) is an important component in the innate immune system. Read More

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The magnitude and determinants of depressive symptoms amongst women in early pregnancy in Southern Nigeria: A cross-sectional study.

S Afr J Psychiatr 2022 31;28:1691. Epub 2022 May 31.

Department of General Practice, LAUTECH Teaching Hospital, Osogbo, Nigeria.

Background: Antenatal depression (AD) is prevalent and associated with adverse pregnancy, maternal and child outcomes, yet no study has addressed its magnitude and predictors in early pregnancy in Nigeria.

Aim: To determine the prevalence and factors associated with AD in first half of pregnancy.

Setting: Multicentric health facilities in Southern Nigeria. Read More

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An Integrative Review of the Research on Teen Mothers' Resilience.

West J Nurs Res 2022 Jun 23:1939459221106989. Epub 2022 Jun 23.

Boromarajonani College of Nursing, Buddhachinaraj, Phitsanulok, Thailand.

Greater attention to teen mothers' strengths and aspirations has generated interest in their resilience. An integrative review of the research was undertaken to determine how teen mothers' resilience, risks, and protective factors are conceptualized across methodological approaches. In total, 10 databases were searched in 2021 to identify relevant studies. Read More

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A Whole Genome Sequencing-Based Epidemiological Investigation of a Pregnancy-Related Invasive Listeriosis Case in Central Italy.

Pathogens 2022 Jun 8;11(6). Epub 2022 Jun 8.

Food Microbiology Unit, Istituto Zooprofilattico Sperimentale del Lazio e della Toscana "M. Aleandri", 00178 Rome, Italy.

Listeriosis is currently the fifth most common foodborne disease in Europe. Most cases are sporadic; however, outbreaks have also been reported. Compared to other foodborne infections, listeriosis has a modest incidence but can cause life-threatening complications, especially in elderly or immunocompromised people and pregnant women. Read More

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Maternal One-Carbon Supplement Reduced the Risk of Non-Alcoholic Fatty Liver Disease in Male Offspring.

Nutrients 2022 Jun 19;14(12). Epub 2022 Jun 19.

Department of Nutrition, Texas A&M University, College Station, TX 77840, USA.

Recent studies have suggested that prevention of obesity and non-alcoholic fatty liver disease (NAFLD) should start with maternal dietary management. We previously reported disrupted methionine cycle, associated with NAFLD, in male offspring liver due to maternal high-fat (HF) diet, thus we hypothesize that maternal one-carbon supplement may reduce the risk of NAFLD in offspring via the normalizing methionine cycle. To test it, female mice (F0) were exposed to either a maternal normal-fat diet (NF group) a maternal HF diet (HF group), or a maternal methyl donor supplement (H1S or H2S group) during gestation and lactation. Read More

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Role of Beta Cell Function and Insulin Resistance in the Development of Gestational Diabetes Mellitus.

Nutrients 2022 Jun 13;14(12). Epub 2022 Jun 13.

School for Oncology and Developmental Biology (GROW), Maastricht University, 6229 ER Maastricht, The Netherlands.

Background: Gestational diabetes mellitus (GDM) is a pregnancy complication characterized by second trimester hyperglycemia. Untreated, GDM is related to an increased risk for adverse pregnancy outcomes. Both beta cell dysfunction and insulin resistance underlie impaired glucose tolerance. Read More

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Umbilical Cord Knots: Is the Number Related to Fetal Risk?

Medicina (Kaunas) 2022 May 25;58(6). Epub 2022 May 25.

Institute for Maternal and Child Health IRCCS "Burlo Garofolo", 34137 Trieste, Italy.

True knots of the umbilical cord (UC) are a rare occurrence and are reported in 0.4-1.2% of deliveries. Read More

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Maternal Obesity as a Risk Factor for Caesarean Delivery in Sub-Saharan Africa: A Systematic Review.

Life (Basel) 2022 Jun 17;12(6). Epub 2022 Jun 17.

Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2SF, UK.

Maternal obesity is associated with several adverse reproductive outcomes. It is a growing public health burden in sub-Saharan Africa, a region with low resources and capacity to care for the large, affected population. To assess the evidence of maternal obesity as a risk factor for caesarean delivery in women in sub-Saharan Africa. Read More

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Neurodevelopment in Normocephalic Children Exposed to Zika Virus in Utero with No Observable Defects at Birth: A Systematic Review with Meta-Analysis.

Int J Environ Res Public Health 2022 Jun 14;19(12). Epub 2022 Jun 14.

ISGlobal, Hospital Clínic-Universitat de Barcelona, 132 Rosselló Street, 08036 Barcelona, Spain.

Zika virus (ZIKV) infection during pregnancy is a cause of pregnancy loss and multiple clinical and neurological anomalies in children. This systematic review aimed to assess the effect of ZIKV exposure in utero on the long-term neurodevelopment of normocephalic children born to women with ZIKV infection in pregnancy. This review was conducted according to the PRISMA guidelines for systematic reviews and meta-analyses. Read More

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Risk Measurement of Perinatal and Neonatal Morbidity Characteristics and Applicability of GAIA Case Definitions: Results and Lessons Learnt of a Hospital-Based Prospective Cohort Study in the Valencia Region (2019-2020).

Int J Environ Res Public Health 2022 Jun 10;19(12). Epub 2022 Jun 10.

Vaccines Research Department, Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (Fisabio), Av. de Catalunya, 21, 46020 Valencia, Spain.

Post-marketing safety surveillance of new vaccines aimed to be administered during pregnancy is crucial to orchestrate efficient adverse events evaluation. This is of special relevance in the current landscape of new vaccines being introduced in the pregnant women population, and particularly due to the recent administration of COVID-19 vaccines in pregnant women. This multi-center prospective cohort study, nested within the WHO-Global Vaccine Safety-MCC study, involved two hospitals in the Valencia region. Read More

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"We Are Having a Huge Problem with Compliance": Exploring Preconception Care Utilization in South Africa.

Healthcare (Basel) 2022 Jun 6;10(6). Epub 2022 Jun 6.

School of Nursing and Public Health, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa.

Background: Preconception care (PCC), a policy directive from the World Health Organisation (WHO), comprises all the health interventions offered to women and couples before conception and is intended to improve their overall health status and the pregnancy outcomes. Although PCC should be an essential part of maternal and child health services in most African countries, its provision and utilization are not widely documented. Hence, this study aimed to explore the factors influencing preconception care utilization among high-risk women in South Africa. Read More

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Maternal HPV Infection and the Estimated Risks for Adverse Pregnancy Outcomes-A Systematic Review.

Diagnostics (Basel) 2022 Jun 15;12(6). Epub 2022 Jun 15.

Obstetrics and Gynecology Clinic, Department of Obstetrics and Gynecology, Faculty of General Medicine, Elias University Hospital, Carol Davila University of Medicine and Pharmacy, 011461 Bucharest, Romania.

Background: Human Papilloma Virus (HPV) represents the most prevalent genital infection in young women of reproductive age.

Objective: This systematic review aims to estimate the effect of HPV infection during pregnancy and assess the correlation between HPV and adverse pregnancy outcomes.

Materials And Methods: The search strategy has been developed based on the PICOS framework: Population (pregnant women infected with HPV), Intervention (HPV infection confirmed by molecular tests), Comparator (pregnant women without HPV infection), Outcomes (adverse pregnancy outcomes) and Study design (observational studies). Read More

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The Maternal-Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study.

Diagnostics (Basel) 2022 May 27;12(6). Epub 2022 May 27.

Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, China.

Objective: This study aimed to investigate the maternal-neonatal outcomes of twin pregnancies of mothers with preeclampsia and their association with assisted reproductive technology (ART).

Methods: A retrospective study on the clinical and maternal-neonatal outcome data of 698 women with twin pregnancies who delivered in our hospital from December 2013 to September 2021 was conducted. Continuous variables were analyzed using a Student's -test or Wilcoxon rank-sum test. Read More

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Stem Cell-Based Trophoblast Models to Unravel the Genetic Causes of Human Miscarriages.

Cells 2022 Jun 14;11(12). Epub 2022 Jun 14.

Research Institute of Medical Genetics, Tomsk National Research Medical Center, 634050 Tomsk, Russia.

Miscarriage affects approximately 15% of clinically recognized pregnancies, and 1-3% of couples experience pregnancy loss recurrently. Approximately 50-60% of miscarriages result from chromosomal abnormalities, whereas up to 60% of euploid recurrent abortions harbor variants in candidate genes. The growing number of detected genetic variants requires an investigation into their role in adverse pregnancy outcomes. Read More

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Stretch Causes Cell Stress and the Downregulation of Nrf2 in Primary Amnion Cells.

Biomolecules 2022 May 31;12(6). Epub 2022 May 31.

Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.

Nuclear-factor-E2-related factor 2 (Nrf2) is a key transcription factor for the regulation of cellular responses to cellular stress and inflammation, and its expression is significantly lower after spontaneous term labor in human fetal membranes. Pathological induction of inflammation can lead to adverse pregnancy outcomes such as pre-eclampsia, preterm labor, and fetal death. As stretch forces are known to act upon the fetal membranes in utero, we aimed to ascertain the effect of stretch on Nrf2 to increase our understanding of the role of this stimulus on cells of the amnion at term. Read More

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Hospital Admission in the Latent versus the Active Phase of Labor: Comparison of Perinatal Outcomes.

Children (Basel) 2022 Jun 20;9(6). Epub 2022 Jun 20.

Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi University Hospital, University of Florence, Largo Brambilla, 50134 Florence, Italy.

Background: Admission in the latent phase of labor has been associated with increased risk of obstetric interventions compared to admission in the active phase. We aimed to investigate the relationship between labor phase at admission and obstetric and neonatal outcomes.

Methods: A retrospective cohort study was conducted on 1005 women with uncomplicated singleton pregnancy admitted for spontaneous labor. Read More

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