2,619,075 results match your criteria adverse effects

Use of Ketamine or Xylazine to Provide Balanced Anesthesia with Isoflurane in C57BL/6J Mice.

J Am Assoc Lab Anim Sci 2022 Aug 8. Epub 2022 Aug 8.

University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, Pennsylvania.

Balanced anesthesia—the use of a combination of drugs to achieve a desired anesthetic plane—offers many benefits, including smoother induction and recovery and fewer adverse effects than occur with individual drugs. Although premedication prior to inhalant anesthesia is routine in other species, mice are commonly induced with gas anesthesia alone. The hypothesis of this study was that premedication with ketamine or xylazine would safely reduce the stress of isoflurane induction and lower the minimum alveolar concentration (MAC) of isoflurane. Read More

View Article and Full-Text PDF

Long-term outcomes following antenatal exposure to low-dose aspirin: study protocol for the 4-year follow-up of the APRIL randomised controlled trial.

BMJ Open 2022 Aug 8;12(8):e060632. Epub 2022 Aug 8.

Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Obstetrics and Gynaecology, De Boelelaan 1117, Amsterdam, The Netherlands.

Introduction: The use of low-dose aspirin by pregnant women to prevent preterm pre-eclampsia is gradually increasing. The administration of aspirin during pregnancy improves perinatal outcome, which could translate into improved child outcome in the long term. However, antenatal exposure to aspirin could have adverse effects on child development that may manifest later in life. Read More

View Article and Full-Text PDF

Safety, tolerability and efficacy of agonist anti-CD27 antibody (varlilumab) administered in combination with anti-PD-1 (nivolumab) in advanced solid tumors.

J Immunother Cancer 2022 Aug;10(8)

R & D, Celldex Therapeutics Inc, Hampton, New Jersey, USA.

Background: Phase 1/2 dose-escalation and expansion study evaluating varlilumab, a fully human agonist anti-CD27 mAb, with nivolumab in anti-PD-1/L1 naïve, refractory solid tumors.

Methods: Phase 1 evaluated the safety of varlilumab (0.1-10 mg/kg) with nivolumab (3 mg/kg) administered once every 2 weeks. Read More

View Article and Full-Text PDF

Arid5a Mediates an IL-17-Dependent Pathway That Drives Autoimmunity but Not Antifungal Host Defense.

J Immunol 2022 Aug 8. Epub 2022 Aug 8.

Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA; and

IL-17 contributes to the pathogenesis of certain autoimmune diseases, but conversely is essential for host defense against fungi. Ab-based biologic drugs that neutralize IL-17 are effective in autoimmunity but can be accompanied by adverse side effects. is a commensal fungus that is the primary causative agent of oropharyngeal and disseminated candidiasis. Read More

View Article and Full-Text PDF

Precision therapy with quinidine of KCNT1-related epileptic disorders: a systematic review.

Br J Clin Pharmacol 2022 Aug 8. Epub 2022 Aug 8.

Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Aims: Despite numerous studies on quinidine therapies for epilepsies associated with KCNT1 gene mutations, there is no consensus on its clinical utility. Thus, we reviewed studies evaluating the efficacy and safety of quinidine in KCNT1-related epileptic disorders.

Methods: Electronic databases were queried for in vivo and in vitro studies on quinidine therapy in KCNT1-related epilepsies published on or before May 1st, 2022. Read More

View Article and Full-Text PDF

Secondary healing property using Neoveil®, a polyglycolic acid bioabsorbable sheet on the oral mucosal defects.

J Stomatol Oral Maxillofac Surg 2022 Aug 5. Epub 2022 Aug 5.

Department of Oral and Maxillofacial Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Electronic address:

Neoveil® is a wound surface-covering agent composed of polyglycolic acid(PGA) effective for secondary healing. This study evaluated the secondary healing property of oral cavity mucosal defects using the PGA sheet. Thirty-four patients who underwent surgical excision of oral benign and malignant lesions, precancerous lesions, and tumors were evaluated. Read More

View Article and Full-Text PDF

A review on the impacts of nanomaterials on neuromodulation and neurological dysfunction using a zebrafish animal model.

Comp Biochem Physiol C Toxicol Pharmacol 2022 Aug 5:109428. Epub 2022 Aug 5.

Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea. Electronic address:

Nanomaterials have been widely employed from industrial to medical fields due to their small sizes and versatile characteristics. However, nanomaterials can also induce unexpected adverse effects on health. In particular, exposure of the nervous system to nanomaterials can cause serious neurological dysfunctions and neurodegenerative diseases. Read More

View Article and Full-Text PDF

Development of ecological risk assessment for Diisobutyl phthalate and di-n-octyl phthalate in surface water of China based on species sensitivity distribution model.

Chemosphere 2022 Aug 5:135932. Epub 2022 Aug 5.

Environmental Engineering Research Centre, Department of Civil Engineering, The University of Hong Kong, Hong Kong, China.

Phthalic acid esters (PAEs) are commonly used as plasticizer and are emerging concern worldwide for potent adverse effects of aquatic organisms. Certain PAEs were often detected in different environmental matrices but related toxicity data were still lacking to support their risk assessment. The study investigated the acute toxicity of Diisobutyl phthalate (DiBP) and Di-n-octyl phthalate (DnOP) using 6 Chinese resident aquatic organisms from 3 phyla and 6 species and constructed the species sensitivity distribution (SSD) models for ecological risk assessment. Read More

View Article and Full-Text PDF

Mushroom mycetism - A neglected and challenging medical emergency in the Indian subcontinent: A road map for its prevention and treatment.

Toxicon 2022 Aug 5. Epub 2022 Aug 5.

Division of Life Sciences, Institute of Advanced Study in Science and Technology, Vigyan Path, Paschim Boragaon, Garchuk, Guwahati, 781035, Assam, India. Electronic address:

Edible mushrooms, a class of macroscopic fungi, serve as delicious and nutritious food supplements around the world. Nevertheless, accidental consumption of poisonous mushrooms that results in fatality or severe illness is typical in all countries, especially among the tribal indigenous communities that forage wild mushrooms for food. In the Indian subcontinent, mushroom poisoning cases are underreported and neglected. Read More

View Article and Full-Text PDF

Flavonoid-containing supplements for preventing acute respiratory tract infections: A systematic review and meta-analysis of 20 randomized controlled trials.

Complement Ther Med 2022 Aug 5:102865. Epub 2022 Aug 5.

Department of Endocrinology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510000, China. Electronic address:

Background: This systematic review and meta-analysis was conducted to investigate the efficacy and safety of flavonoid-containing supplements in preventing acute respiratory tract infection (ARTI).

Methods: Randomized controlled trials (RCTs) investigating the effects of flavonoid-containing supplements on ARTI prevention in the aspects of ARTI incidence, mean ARTI sick days, symptoms, bio-immune markers, and adverse effects were searched in 5 databases. Data were searched from inception to November 26, 2021. Read More

View Article and Full-Text PDF

Repeated dose toxicity study to assess the safety and reproductive/developmental safety of 7-methyl-2H-1,5-Benzodioxepin-3(4H)-One (Calone®) and the read across approach to its biodegradation metabolite 7-methyl-2H-1,5-benzodioxepin-3-ol (Calol).

Food Chem Toxicol 2022 Aug 5:113328. Epub 2022 Aug 5.

Firmenich Inc., Plainsboro, NJ, USA. Electronic address:

7-Methyl-2H-1,5-benzodioxepin-3(4H)-one (Calone®) is used in fragrances to impart a marine note. It is produced industrially at volumes requiring repeated dose and developmental/reproductive toxicology data (OECD TG 422) under European chemicals legislation (i.e. Read More

View Article and Full-Text PDF

Functionalized magnetic nanostructured composites and hybrids for photocatalytic elimination of pharmaceuticals and personal care products.

Sci Total Environ 2022 Aug 5:157683. Epub 2022 Aug 5.

School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian 223003, China. Electronic address:

Due to rapid urbanization and globalization, an enormous use of pharmaceuticals and personal care products (PPCPs) has resulted their excessive release in water bodies leading to several environmental issues. This release into the environment takes place via household sewage, hospital effluents, manufacturing units and landfill sites etc. The pharmaceuticals and personal care products (PPCPs) are recently listed as emerging contaminants having many adverse effects towards aquatic life, human beings, and the whole ecosystem. Read More

View Article and Full-Text PDF

Natural copper isotopic abnormity in maternal serum at early pregnancy associated to risk of spontaneous preterm birth.

Sci Total Environ 2022 Aug 5:157872. Epub 2022 Aug 5.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Spontaneous preterm birth (SPB) has drawn public attention due to its increasing incidence and adverse effects on fetal growth. Effect of copper (Cu) imbalance in maternal bodies on the risk of SPB remains a subject of debate, and the related mechanisms are still unraveled. Here we applied natural stable copper isotopes to explore the underlying association and mechanism of copper imbalance with SPB using a nested case-control study. Read More

View Article and Full-Text PDF

Gender Discrimination, Career Aspirations, and Access to Mentorship Among Medical Students in Brazil.

J Surg Res 2022 Aug 5;279:702-711. Epub 2022 Aug 5.

McGill University, Montreal, Quebec, Canada. Electronic address:

Introduction: Gender-based discrimination (GBD) creates a hostile environment that can affect medical students. Mentorship has been recognized as a mitigating factor for GBD. We aimed to investigate the impacts of GBD on career selection and well-being of medical students in Brazil and to explore access to mentorship among these students. Read More

View Article and Full-Text PDF

Exogenous spermidine modulates polyamine metabolism and improves stress responsive mechanisms to protect tomato seedlings against salt stress.

Plant Physiol Biochem 2022 Jul 19;187:1-10. Epub 2022 Jul 19.

Key Laboratory of Southern Vegetable Crop Genetic Improvement in Ministry of Agriculture, College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China; Suqian Academy of Protected Horticulture, Nanjing Agricultural University, Suqian, 223800, China. Electronic address:

Salt stress negatively affects plant growth, development, and crop productivity causing serious economic loss to agricultural production. Here, we investigated the exogenous application of spermidine (Spd) on tomato seedlings grown under salt stress. Salt stress reduced plant growth, biomass accumulation and chlorophyll contents, thus negatively affecting photosynthesis. Read More

View Article and Full-Text PDF

Use of long-acting injectable buprenorphine in the correctional setting.

J Subst Abuse Treat 2022 Jul 29;142:108851. Epub 2022 Jul 29.

Warren Alpert Medical School of Brown University, 222 Richmond St, Providence, RI 02903, USA.

Background: As overdoses due to opioids rise, medications for opioid use disorder (MOUD) continue to be underemployed, resulting in limited access to potentially life-saving treatment. Substance use disorders are prevalent in individuals who are incarcerated, and these individuals are at increased risk for death postrelease due to overdose. Few jails and prisons offer MOUD and most limit access. Read More

View Article and Full-Text PDF

The oxytocin signalling gene pathway contributes to the association between loneliness and cardiometabolic health.

Psychoneuroendocrinology 2022 Jul 28;144:105875. Epub 2022 Jul 28.

Norwegian Centre for Mental Disorders Research (NORMENT), Division for Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway; Department of Psychology, University of Oslo, Oslo, Norway; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway; NevSom, Department of Rare Disorders, Oslo University Hospital, Oslo, Norway. Electronic address:

Increasing evidence has shown adverse effects of loneliness on cardiometabolic health. The neuromodulator and hormone oxytocin has traditionally been linked with social cognition and behaviour. However, recent implications of the oxytocin system in energy metabolism and the overrepresentation of metabolic issues in psychiatric illness suggests that oxytocin may represent a mechanism bridging mental and somatic traits. Read More

View Article and Full-Text PDF

Association between road traffic accidents and drugs belonging to the anti-seizure medications class: a pharmacovigilance analysis in VigiBase®.

Br J Clin Pharmacol 2022 Aug 8. Epub 2022 Aug 8.

Department of Pharmacology, Caen University Hospital, Caen, France.

Aim: Due to their central mechanism of action, anti-seizure medications (ASMs) could lead to adverse effects likely to impair driving skills. Their extended use to neuropsychiatric disorders makes it a class of drugs to monitor for their road traffic accidental (RTA) potential. We aimed to assess the reporting association between ASMs and RTA using the WHO pharmacovigilance database (Vigibas®). Read More

View Article and Full-Text PDF

Laparoscopic total extra-peritoneal (TEP) inguinal hernia repair under local anesthesia by topical lidocaine injection.

Hernia 2022 Aug 8. Epub 2022 Aug 8.

Department of Surgery, College of Medicine, Kyung Hee University, 23, Kyung Hee Dae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.

Purpose: Laparoscopic total extra-peritoneal (TEP) inguinal hernia repair is usually performed under general anesthesia (GA) for muscle relaxation. However, TEP hernia repair may be reluctant in high-risk patients of GA. The aim of this study was to compare the outcomes of the TEP under GA and local anesthesia (LA). Read More

View Article and Full-Text PDF

Adverse Outcome Pathways and Linkages to Transcriptomic Effects Relevant to Ionizing Radiation Injury.

Int J Radiat Biol 2022 Aug 8:1-26. Epub 2022 Aug 8.

Health Canada, Ottawa, Canada.

Background: In the past three decades, a large body of data on the effects of exposure to ionizing radiation and the ensuing changes in gene expression has been generated. These data have allowed for an understanding of molecular-level events and shown a level of consistency in response despite the vast formats and experimental procedures being used across institutions. However, clarity on how this information may inform strategies for health risk assessment needs to be explored. Read More

View Article and Full-Text PDF

Partner Gender and Binegativity Uniquely Impact Relationship Quality among Bisexual Men.

J Sex Res 2022 Aug 8:1-9. Epub 2022 Aug 8.

Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University.

Romantic relationships both buffer and exacerbate adverse health outcomes among bisexual individuals, so understanding determinants of their functioning may be key to correcting health inequities affecting this population. Binegativity (i.e. Read More

View Article and Full-Text PDF

Smoking cessation for secondary prevention of cardiovascular disease.

Cochrane Database Syst Rev 2022 Aug 8;8:CD014936. Epub 2022 Aug 8.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Background: Smoking is a leading cause of cardiovascular disease (CVD), particularly coronary heart disease (CHD). However, quitting smoking may prevent secondary CVD events in people already diagnosed with CHD.  OBJECTIVES: To examine the impact of smoking cessation on death from CVD and major adverse cardiovascular events (MACE), in people with incident CHD. Read More

View Article and Full-Text PDF

Halocyclopentadienes: An Emerging Class of Toxic DBPs in Chlor(am)inated Drinking Water.

Environ Sci Technol 2022 Aug 8. Epub 2022 Aug 8.

Department of Chemistry and Biochemistry, University of South Carolina, Columbia 29208, South Carolina, United States.

Although >700 disinfection by-products (DBPs) have been identified to date, most DBPs in drinking water are still unknown. Identifying unknown DBPs is an important step for improving drinking water quality because known DBPs do not fully account for the adverse health effects noted in epidemiologic studies. Using gas chromatography high-resolution mass spectrometry, six chloro- and bromo-halocyclopentadienes (HCPDs) were identified in chlorinated and chloraminated drinking water non-target analysis; five HCPDs are reported for the first time as new alicyclic DBPs. Read More

View Article and Full-Text PDF

Immediate possible adverse event rates in infants treated with oral propranolol for infantile haemangiomas at an Australian urban tertiary hospital between 2016 and 2019.

Australas J Dermatol 2022 Aug 8. Epub 2022 Aug 8.

Division of Medicine, University of Adelaide, Adelaide, South Australia, Australia.

Background/objectives: Infantile haemangiomas (IH) are common benign tumours of childhood. The current guideline recommended treatment is oral propranolol, the use of which for IH is relatively recent and there are no safety audits in Australian children published. As a result, it is a primarily inpatient initiated treatment. Read More

View Article and Full-Text PDF

'Poppers Maculopathy' and the adverse ophthalmic outcomes from the recreational use of alkyl nitrate inhalants: a systematic review.

Semin Ophthalmol 2022 Aug 7:1-9. Epub 2022 Aug 7.

Discipline of Orthoptics, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia.

Objective: The aim of this systematic review and meta-analysis was to provide an overview of reported cases of poppers maculopathy and a statistical analysis of the clinical presentations, anatomical changes and treatment and follow-up of the rare disease.

Methods: A systematic search of CINAHL, Embase and PubMed databases was conducted, including a search of the grey literature. Data were pooled to provide a summary of the clinical characteristics and outcomes of poppers maculopathy. Read More

View Article and Full-Text PDF

Statins for primary cardiovascular disease prevention among people with HIV: emergent directions.

Curr Opin HIV AIDS 2022 Sep 16;17(5):293-300. Epub 2022 Jul 16.

Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: While people with HIV (PWH) are living longer due to advances in antiretroviral therapy, recent data have demonstrated an increased risk of cardiovascular disease (CVD) among this population. This increased risk is thought to be due to both traditional (for example, smoking, diabetes) and HIV-specific (for example, inflammation, persistent immune activation) risk factors. This review focuses on the potential for statin therapy to mitigate this increased risk. Read More

View Article and Full-Text PDF
September 2022

Supporting children's nurses to deliver trauma-informed care.

Nurs Child Young People 2022 Aug 8. Epub 2022 Aug 8.

School of Medical and Health Sciences, Bangor University, Bangor, Wales.

World events, such as the conflict in Ukraine, the humanitarian crisis in Afghanistan and the coronavirus disease 2019 pandemic, have highlighted the effects of trauma and adverse childhood experiences on children and young people. Adverse childhood experiences can lead to suboptimal health and risk-taking behaviours during adolescence and adulthood, while multiple adverse childhood experiences can manifest as complex trauma, toxic stress, anxiety or depression across a person's lifespan. This article discusses adverse childhood experiences and the concept of trauma-informed care, which involves recognising and understanding the negative events that have affected a person and how these relate to suboptimal health. Read More

View Article and Full-Text PDF

Different effects of intravenous and local anesthesia in patients undergoing ultrasound-guided radiofrequency ablation of thyroid nodules: a prospective cohort study.

Int J Hyperthermia 2022 ;39(1):1036-1043

Department of Ultrasound, the First Affiliated Hospital of Dalian Medical University, Dalian, China.

Purpose: To compare the efficacy and safety of intravenous anesthesia (IV) with local anesthesia (LA) in patients undergoing ultrasound (US)-guided radiofrequency ablation (RFA) of thyroid nodules.

Methods: 50 patients with American Society of Anesthesiologists classification grades I-II undergoing US-guided thyroid RFA were enrolled and randomly (1:1) divided into IV (conscious sedation with Ramsay Sedation Scale [RSS] scores of 2-3 with an anesthesiologist) and LA (subcutaneous anesthesia with lidocaine without an anesthesiologist) groups. Pre-, intra- and post-procedural blood pressure (BP) (SBP/DBP, SBP/DBP, and SBP/DBP), intra- and post-procedural pain (NRS and NRS), ablated area volume, treatment time and adverse events were analyzed and compared. Read More

View Article and Full-Text PDF
January 2022

Miller Fisher syndrome following COVID-19 vaccines: A scoping review.

Acta Neurol Scand 2022 Aug 8. Epub 2022 Aug 8.

Department of Neurology, Hallym University College of Medicine, Chuncheon, Korea.

Background And Purpose: Miller Fisher syndrome (MFS), a variant of Guillain-Barré Syndrome (GBS), could be underestimated in evaluations of its adverse events (AEs) following COVID-19 vaccination. We aimed to identify and characterize MFS following COVID-19 vaccination.

Materials And Methods: Relevant studies reported on during the COVID-19 pandemic were identified in the MEDLINE, Embase, and other databases. Read More

View Article and Full-Text PDF