2,433,596 results match your criteria adverse effects

Cushing's disease: Does low-dose pasireotide offer a comparable efficacy and safety to high-dose?

Endocrinol Diabetes Metab Case Rep 2021 Feb 26;2021. Epub 2021 Feb 26.

Department of Diabetes and Endocrinology, Townsville University Hospital, Queensland, Australia.

Summary: Whilst literature is expanding on pasireotide use in the management of Cushing's disease (CD), there is still currently much unknown about long-term and low-dose pasireotide use in CD. We present a 60-year-old female with residual CD after transphenoidal surgery (TSS), being successfully managed with S.C. Read More

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February 2021

Risk assessment of occupational exposure to anesthesia Isoflurane in the hospital and veterinary settings.

Sci Total Environ 2021 Apr 5;783:146894. Epub 2021 Apr 5.

Environmental Health and Radiation Safety, Temple University, Philadelphia, PA, USA.

Despite the modern ventilation and waste anesthetic gas (WAG) scavenging systems, occupational exposure to common volatile anesthesia, isoflurane, can occur in the hospital and veterinary settings, but limited information exists on potential exposure and health risk of isoflurane. We assessed exposure dose rates and risks among clinicians and veterinary professionals from occupational exposure to isoflurane. Through a critical review of open literature (1965 to 2020), we summarized potential adverse effects and exposure scenarios of isoflurane among the professional groups, including anesthetists, nurses, operating room personnel, researchers, and/or veterinarians. Read More

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Fucoxanthin rescues dexamethasone induced C2C12 myotubes atrophy.

Biomed Pharmacother 2021 Apr 14;139:111590. Epub 2021 Apr 14.

Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical University, China. Electronic address:

Muscle atrophy and weakness are the adverse effects of long-term or high dose usage of glucocorticoids. In the present study, we explored the effects of fucoxanthin (10 μM) on dexamethasone (10 μM)-induced atrophy in C2C12 myotubes and investigated its underlying mechanisms. The diameter of myotubes was observed under a light microscope, and the expression of myosin heavy chain (MyHC), proteolysis-related, autophagy-related, apoptosis-related, and mitochondria-related proteins was analyzed by western blots or immunoprecipitation. Read More

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Effects of Music Intervention on Sleep Quality of Older Adults: A Systematic Review and Meta-Analysis.

Complement Ther Med 2021 Apr 14:102719. Epub 2021 Apr 14.

School of Nursing, Jilin University, Changchun, China; Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, China. Electronic address:

Background: Music interventions have several benefits for sleep quality. However, the effects of music interventions on sleep quality in older adults are controversial.

Objective: To summarize and evaluate the efficacy of music interventions on sleep quality in older adults. Read More

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Low Rates of Urologic Side Effects Following COVID Vaccination: An Analysis of the FDA Vaccine Adverse Event Reporting System.

Urology 2021 Apr 14. Epub 2021 Apr 14.

Division of Urology, Cedars-Sinai Medical Center, Los Angeles CA. Electronic address:

Objective: To quantify and describe urologic adverse events and symptoms after vaccination with the Pfizer-BioNTech and Moderna COVID-19 vaccines.

Methods And Materials: We queried the FDA Vaccine Adverse Event Reporting System (VAERS) for all reported symptoms following the Pfizer-BioNTech and Moderna vaccines as of February 12th, 2021. All urologic symptoms were isolated and the reported adverse events associated with each symptom were reviewed. Read More

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Heart-lung interactions in COVID-19: prognostic impact and usefulness of bedside echocardiography for monitoring of the right ventricle involvement.

Michael Dandel

Heart Fail Rev 2021 Apr 17. Epub 2021 Apr 17.

German Centre for Heart and Circulatory Research (DZHK) Partner Site, Berlin, Berlin, Germany.

Due to the SARS-CoV-2 infection-related severe pulmonary tissue damages associated with a relative specific widespread thrombotic microangiopathy, the pathophysiologic role of heart-lung interactions becomes crucial for the development and progression of right ventricular (RV) dysfunction. The high resistance in the pulmonary circulation, as a result of small vessel thrombosis and hypoxemia, is the major cause of right heart failure associated with a particularly high mortality in severe COVID-19. Timely identification of patients at high risk for RV failure, optimization of mechanical ventilation to limit its adverse effects on RV preload and afterload, avoidance of medication-related increase in the pulmonary vascular resistance, and the use of extracorporeal membrane oxygenation in refractory respiratory failure with hemodynamic instability, before RV failure develops, can improve patient survival. Read More

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Targeted therapy for pediatric low-grade glioma.

Childs Nerv Syst 2021 Apr 17. Epub 2021 Apr 17.

Pediatric Hematology and Oncology, Hospital Sant Joan de Déu, Barcelona, Spain.

Purpose: Pediatric low-grade gliomas are the most frequent brain tumors in children. The standard approach for symptomatic unresectable tumors is chemotherapy. Recently, key molecular alterations/pathways have been identified and targeted drugs developed and tested in clinical trials. Read More

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Cardiovascular toxicity of breast cancer treatment: an update.

Cancer Chemother Pharmacol 2021 Apr 17. Epub 2021 Apr 17.

Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528, Athens, Greece.

Novel chemotherapeutic agents have marked a new era in oncology during the past decade, prolonging significantly the overall survival of breast cancer patients. Nevertheless, contemporary antineoplastic treatments can frequently cause adverse cardiovascular side effects. Common manifestations of chemotherapy-induced cardiotoxicity include cardiomyopathy, ischemia, conduction disturbances, hypertension and thromboembolic events, while the type of the treatment regimen administered crucially determines clinical outcome. Read More

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Social stress and risk of declining cognition: a longitudinal study of men and women in the United States.

Soc Psychiatry Psychiatr Epidemiol 2021 Apr 17. Epub 2021 Apr 17.

Division of Geriatrics, David Geffen School of Medicine, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.

Limited research is available on the relationship between social stress and risk of declining cognition. We sought to examine whether social stress has adverse effects on risk of declining episodic memory and executive functioning in aging individuals. We used data from the MIDUS study, a national probability sample of non-institutionalized, English speaking respondents aged 25-74 living in the 48 contiguous states of the United States. Read More

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Complications of Botulinum toxin A: An Update Review.

J Cosmet Dermatol 2021 Apr 17. Epub 2021 Apr 17.

Department of Dermatology, University Medical Center Mainz, Mainz, Germany.

Cosmetic surgery procedures have increased manifolds all over the world owing to the ever-increasing demand of people to look beautiful and young. Injectable treatments like botulinum toxin are becoming more popular owing to their rapid, well defined and lasting results for the reduction of facial fine lines, wrinkles and facial rejuvenation. These emerging treatments are quite safe but can have certain adverse effects. Read More

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Results from a PrEP Demonstration Project for At-Risk Cisgender Women in the United States.

Clin Infect Dis 2021 Apr 17. Epub 2021 Apr 17.

Department of Medicine, Ronald Reagan UCLA Medical Center, University of California Los Angeles, Los Angeles, CA, USA.

Background: Daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) is effective for reducing HIV acquisition among cisgender women. We report results from the first United States observational open-label demonstration project of PrEP among at-risk cisgender women.

Methods: Adherence Enhancement Guided by Individualized Texting and Drug Levels (AEGiS) was a 48-week single-arm open-label demonstration study of daily oral TDF/FTC in cisgender women ≥18 years old at-risk for HIV. Read More

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Effectiveness of fecal microbiota transplant for the treatment of Clostridioides difficile diarrhea: A systematic review and meta-analysis.

Lett Appl Microbiol 2021 Apr 16. Epub 2021 Apr 16.

Department of Medicine, Faculty of Health Sciences, Universidad Cardenal Herrera, CEU Universities, Valencia, Spain.

Clostridioides difficile is a major cause of health-care related infections and antibiotic-associated diarrhea. High recurrence rates following antibiotic treatment, along with the emergence of hypervirulent and multidrug resistant ribotypes makes essential the development of safe, effective, novel therapies for the treatment of C. difficile infections. Read More

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The effects of adding quinolones to beta-lactam antibiotics for sepsis.

Acta Anaesthesiol Scand 2021 Apr 16. Epub 2021 Apr 16.

Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region of Denmark, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Sepsis is common, deadly, and a major challenge to treat. Quinolones added to beta-lactam antibiotics are currently recommended as a second-line empiric regimen in sepsis, but the evidence regarding their benefits and harms is unclear.

Objective: To assess the benefits and harms of adding quinolones to standard care for sepsis. Read More

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Effects of Gocovri (Amantadine) Extended Release Capsules on Non-Motor Symptoms in Patients with Parkinson's Disease and Dyskinesia.

Neurol Ther 2021 Apr 17. Epub 2021 Apr 17.

Adamas Pharmaceuticals, Inc., Emeryville, CA, USA.

Introduction: Gocovri (amantadine) extended release capsules are approved for treatment of dyskinesia and as a levodopa adjunct for OFF episodes in patients with Parkinson's disease (PD). We report treatment-related effects on non-motor symptoms (NMS) assessed as secondary outcomes in two trials using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part I.

Methods: EASE LID and EASE LID 3 enrolled levodopa-treated patients with PD and ≥ 1 h/day ON time with troublesome dyskinesia. Read More

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Combined effects of crude oil exposure and warming on eggs and larvae of an arctic forage fish.

Sci Rep 2021 Apr 16;11(1):8410. Epub 2021 Apr 16.

Department of Arctic and Marine Biology, UiT The Arctic University of Norway, 9037, Tromsø, Norway.

Climate change, along with environmental pollution, can act synergistically on an organism to amplify adverse effects of exposure. The Arctic is undergoing profound climatic change and an increase in human activity, resulting in a heightened risk of accidental oil spills. Embryos and larvae of polar cod (Boreogadus saida), a key Arctic forage fish species, were exposed to low levels of crude oil concurrently with a 2. Read More

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Implementation conditions leading to the scale-up of an innovation involving the optimal use of antipsychotics in long-term care centers: The Optimizing Practices, use, Care and Services-Antipsychotics (OPUS-AP) program.

Res Social Adm Pharm 2021 Apr 12. Epub 2021 Apr 12.

University of Sherbrooke, Canada; Research Center on Aging of CIUSSS de L'Estrie-CHUS, Canada. Electronic address:

Background: Antipsychotics are often used for the first-line management of behavioral and psychological symptoms of dementia despite their limited efficacy and the risk of serious adverse drug events, compounded with disregard for guidelines recommending prioritizing non-pharmacological interventions. Some innovative interventions promote the deprescription of antipsychotics in long term care (LTC) settings.

Objective: The objective of this article is to present the conditions leading to the scale-up of an innovative program on the appropriate use of antipsychotics in LTC centers. Read More

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Kratom Ingestion and Emergency Care: Summary and a Case Report.

Alex Hall Dora Hall

J Emerg Nurs 2021 Apr 13. Epub 2021 Apr 13.

Kratom ingestion for its psychotropic effect or to self-treat opioid withdrawal symptoms has increased over the last 10 years in the United States. Although mild adverse effects have been observed in users, reports of respiratory failure and shock after kratom consumption remain rare. In this case, a 35-year-old man initially presented to the emergency department with profound circulatory shock, metabolic acidosis, hypoxia, and symptoms of autonomic nervous system dysfunction. Read More

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Climate change and heat stress: Impact on production, reproduction and growth performance of poultry and its mitigation using genetic strategies.

J Therm Biol 2021 Apr 30;97:102867. Epub 2021 Jan 30.

Department of Veterinary Parasitology, LUVAS, Hisar, 125004, Haryana, India. Electronic address:

Heat stress is an important environmental determinant which adversely affects the performance of poultry worldwide. The present communication reviews the impact of heat stress on production, reproduction and growth performance of poultry, and its alleviation using genetic strategies. The adverse effects of high environmental temperature on poultry include decrease in growth rate, body weight, egg production, egg weight, egg quality, meat quality, semen quality, fertility and hatchability, which cause vast financial losses to the poultry industry. Read More

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Effects of Pair Housing on Patency of Jugular Catheters in Rats (Rattus norvegicus).

J Am Assoc Lab Anim Sci 2021 Apr 16. Epub 2021 Apr 16.

Chronic vascular access devices are widely used in a variety of species for repeated blood sampling or substance administration. Jugular catheters are commonly used for studying addiction-related behaviors in rats. Rats with catheters have historically been individually housed for the duration of the study to prevent cage mates from damaging the catheter. Read More

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A novel MSC-based immune induction strategy for ABO-incompatible liver transplantation: a phase I/II randomized, open-label, controlled trial.

Stem Cell Res Ther 2021 Apr 16;12(1):244. Epub 2021 Apr 16.

Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Guangzhou, 510630, Guangdong, China.

Background: ABO-incompatible liver transplantation (ABO-i LT) has become a rescue therapeutic option for patients with severe hepatic failure. Although the use of rituximab greatly reduces the morbidity of antibody-mediated rejection (AMR), severe adverse effects, such as infection and biliary complications, still seriously threaten the survival of transplant recipients. The aim of this study was to evaluate the safety and feasibility of using mesenchymal stem cells (MSCs) to replace rituximab in ABO-i LT. Read More

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Cytomegalovirus-associated esophagitis on early esophageal cancer in immunocompetent host: a case report.

Gut Pathog 2021 Apr 16;13(1):24. Epub 2021 Apr 16.

Department of Endoscopy, New Tokyo Hospital, 1271 Wanagaya, Matsudo, Chiba, 270-2232, Japan.

Background: Cytomegalovirus (CMV)-associated gastrointestinal diseases usually occur in immunocompromised patients; however, few cases has also been described in healthy hosts despite still unclear pathological mechanisms. CMV esophagitis causes various lesions, such as erythematous mucosa, erosions, and ulcers, although such inflammatory changes can appear in superficial esophageal cancers or in surrounding areas. CMV-associated esophagitis has been also reported in cancer patients, but typically in those with advanced and/or terminal stage cancers secondary to chemoradiotherapy-induced immunosuppression or the physiologic demands of the malignancy itself. Read More

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The clinical effects of cerebral near-infrared spectroscopy monitoring (NIRS) versus no monitoring: a protocol for a systematic review with meta-analysis and trial sequential analysis.

Syst Rev 2021 Apr 16;10(1):111. Epub 2021 Apr 16.

Department of Neonatology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Background: Multiple clinical conditions are associated with cerebral hypoxia/ischaemia and thereby an increased risk of hypoxic-ischaemic brain injury. Cerebral near-infrared spectroscopy monitoring (NIRS) is a tool to monitor brain oxygenation and perfusion, and the clinical uptake of NIRS has expanded over recent years. Specifically, NIRS is used in the neonatal, paediatric, and adult perioperative and intensive care settings. Read More

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Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: a systematic review and meta-analysis.

Crit Care 2021 Apr 16;25(1):146. Epub 2021 Apr 16.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Background: It is unclear whether vasopressors can be safely administered through a peripheral intravenous (PIV). Systematic review and meta-analysis methodology was used to examine the incidence of local anatomic adverse events associated with PIV vasopressor administration in patients of any age cared for in any acute care environment.

Methods: MEDLINE, EMBASE, CINAHL, the Cochrane Central Register of controlled trials, and the Database of Abstracts of Reviews of Effects were searched without restriction from inception to October 2019. Read More

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Characteristics associated with clinical response to Comano thermal spring water balneotherapy in pediatric patients with atopic dermatitis.

Ital J Pediatr 2021 Apr 16;47(1):91. Epub 2021 Apr 16.

"Giovan Battista Mattei" Research Institute, Stenico, Italy.

Background: Several studies have investigated the efficacy of balneotherapy in atopic dermatitis (AD), including a pediatric open randomized clinical trial conducted at the Comano thermal spring water center, which showed a significant reduction in AD severity and an improvement of the quality of life. However, so far many studies on balneotherapy in pediatric AD have included relatively small populations without identifying patients' characteristics associated with their response. The aim of the present study was to identify any features associated with the clinical response to the Comano thermal spring water balneotherapy in a large cohort of pediatric AD patients. Read More

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Early clinical outcomes and comparison between trans-PRK and PRK, regarding refractive outcome, wound healing, pain intensity and visual recovery time in a real-world setup.

Harald C Gaeckle

BMC Ophthalmol 2021 Apr 16;21(1):181. Epub 2021 Apr 16.

Augenlaserzentrum Neu-Ulm, Edisonallee 19, 89231, Neu-Ulm, Germany.

Purpose: To compare early clinical outcomes of single-step transepithelial photorefractive keratectomy (tPRK) and photorefractive keratectomy (PRK) regarding refractive outcome, visual acuity, wound healing, pain intensity and visual recovery time.d.

Methods: In this prospective clinical observational study 200 eyes of 100 consecutive patients with mild to moderate myopia with or without mild astigmatism were included. Read More

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Dihydroisotanshinone I induced ferroptosis and apoptosis of lung cancer cells.

Biomed Pharmacother 2021 Apr 13;139:111585. Epub 2021 Apr 13.

Department of Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.

Danshen (Salvia miltiorrhiza Bunge) is broadly utilized in traditional Chinese medicine for lung cancer. However, it's exact effort and mechanism on lung cancer is fully unclear. In this study, we found that dihydroisotanshinone I (DT), a pure compound extracted from danshen, can inhibit the growth of A549 cells and H460 cells. Read More

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Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries: France, Spain and Belgium.

Int J Hyg Environ Health 2021 Apr 13;234:113747. Epub 2021 Apr 13.

VITO Flemish Institute for Technological Research, Unit Health, Mol, Belgium.

Cadmium (Cd) is a toxic heavy metal widespread in the environment leading to human exposure in particular through diet (when smoking is excluded), as documented by recent human biomonitoring (HBM) surveys. Exposure to Cd at environmental low-exposure levels has been associated with adverse effects such as renal toxicity and more recently bone effects. The implication, even if limited, of Cd in the etiology of osteoporosis can be of high importance at the population level given the significant prevalence of osteoporosis and the ubiquitous and life-long exposure to Cd. Read More

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Differences in transcriptome response to air pollution exposure between adult residents with and without chronic obstructive pulmonary disease in Beijing: A panel study.

J Hazard Mater 2021 Apr 1;416:125790. Epub 2021 Apr 1.

SKL-ESPC and BIC-ESAT, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China. Electronic address:

Ambient air pollution is a major risk factor for the prevalence and exacerbation of chronic obstructive pulmonary disease (COPD). Based on the COPDB (COPD in Beijing) panel study, whole-blood transcriptomes were repeatedly measured in 48 COPD patients and 62 healthy participants. Ambient mass concentrations of fine particulate matter (PM), temperature, and relative humidity were continuously monitored at a monitoring station. Read More

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Sources of polychlorinated biphenyls (PCBs) and dichlorodiphenyltrichloroethanes (DDTs) found in surface sediment from coastal areas of Beibu Gulf: A reflection on shipping activities and coastal industries.

Mar Pollut Bull 2021 Apr 13;167:112318. Epub 2021 Apr 13.

Institute of Marine Science, Shantou University, Shantou 515063, China. Electronic address:

The presence of polychlorinated biphenyls (PCBs) and dichlorodiphenyltrichloroethanes (DDTs) was determined in the sediments of Beibu Gulf, a newly developing industry and port in South China, to evaluate whether the rapid development of coastal cities has accelerated the organic pollution in the region. The levels of PCBs and DDTs ranged from 1.17 to 8. Read More

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