5,639,806 results match your criteria advanced age


A Phase II study of nab-Paclitaxel (nab-P) in patients with advanced non-small cell lung cancer with EGFR mutations after frontline tyrosine kinase inhibitor therapy.

Cancer Treat Res Commun 2021 Jun 9;28:100416. Epub 2021 Jun 9.

University of Washington, Department of Medicine, Division of Medical Oncology United States.

Background: Patients with metastatic non-small cell lung cancer (NSCLC) harboring a sensitizing EGFR mutation have effective targeted therapy options initially but most patients eventually progress and receive cytotoxic chemotherapy. In this single-institution phase II study, we evaluated the role of nab-paclitaxel monotherapy in this patient population.

Patients And Methods: Patients with metastatic NSCLC with an activating EGFR mutation whose disease progressed after frontline tyrosine kinase inhibitor therapy and who were chemotherapy naïve received nab-paclitaxel 125 mg/m2 on days 1, 8 and 15 in a 28-day cycle. Read More

View Article and Full-Text PDF

Transient neural network dynamics in cognitive ageing.

Neurobiol Aging 2021 May 14;105:217-228. Epub 2021 May 14.

MRC Cognition & Brain Sciences Unit, University of Cambridge, Cambridge, UK; Department of Psychiatry, University of Cambridge, Cambridge, UK.

It is important to maintain cognitive function in old age, yet the neural substrates that support successful cognitive ageing remain unclear. One factor that might be crucial, but has been overlooked due to limitations of previous data and methods, is the ability of brain networks to flexibly reorganize and coordinate over a millisecond time-scale. Magnetoencephalography (MEG) provides such temporal resolution, and can be combined with Hidden Markov Models (HMMs) to characterise transient neural states. Read More

View Article and Full-Text PDF

Population-based mammography screening attendance in Sweden 2017-2018: A cross-sectional register study to assess the impact of sociodemographic factors.

Breast 2021 Jun 2;59:16-26. Epub 2021 Jun 2.

Department of Translational Medicine, Diagnostic Radiology, Lund University, Skåne University Hospital, 205 02 Malmö, Sweden.

Sweden has a population-based mammography screening programme for women aged 40-74. The objective of this study was to examine the association between mammography screening attendance and sociodemographic factors in 15 of Sweden's 21 health care regions. Register-based information was collected on all mammography screening invitations and attendance during 2017 and 2018, and linked to individual-level sociodemographic data from Statistics Sweden. Read More

View Article and Full-Text PDF

Is there a relationship between nursing students' smartphone use, their fear of missing out and their care-related behaviour?

Nurse Educ Pract 2021 Jun 3;54:103111. Epub 2021 Jun 3.

Aged Care Program, Nevsehir Haci Bektaş Veli University, Health Services Vocational School, Nevşehir, Turkey. Electronic address:

Aim: This study aims to determine the relationship between smartphone use among intern nursing students, fear of missing out and their care-related behaviour.

Background: Today, smartphone use is common and fear of missing out is a prominent issue in our society; this behaviour and issue are linked and may lead to adverse consequences.

Design: The study is conducted as a cross-sectional design. Read More

View Article and Full-Text PDF

US estimates for dog bite injuries presenting to emergency departments.

Authors:
S Ramgopal M L Macy

Public Health 2021 Jun 9;196:1-3. Epub 2021 Jun 9.

Division of Emergency Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Mary Ann & J. Milburn Smith Child Health Outcomes, Research, and Evaluation Center, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Objectives: Dog bites are a frequent source of injury requiring emergency department (ED) management. We sought to evaluate the longitudinal burden of dog bites presenting to US EDs.

Study Design: Cross-sectional study of a complex survey. Read More

View Article and Full-Text PDF

The cascade of care for opioid use disorder among youth in British Columbia, 2018.

J Subst Abuse Treat 2021 Apr 18;130:108404. Epub 2021 Apr 18.

Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada; BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada. Electronic address:

Background: Medication for opioid use disorder (MOUD) is associated with substantial reductions in the risk of mortality, and American and Canadian guidelines recommend it as part of the full range of available treatments for youth with opioid use disorder (OUD). We estimated the OUD cascade of care for all adolescents (ages 12-18) and young adults (19-24) with OUD in British Columbia, Canada (BC) in 2018.

Methods: Using a provincial-level linkage of six health administrative databases, we classified youth with OUD as adolescents (ages 12-18) or young adults (19-24) to compare with older adults (≥25) and described key factors known to influence engagement in health care. Read More

View Article and Full-Text PDF

Clinical correlates of white matter lesions in Parkinson's disease using automated multi-modal segmentation measures.

J Neurol Sci 2021 Jun 1;427:117518. Epub 2021 Jun 1.

Singapore General Hospital, Singapore; Duke-NUS Medical School, Singapore. Electronic address:

Background: Age-related white matter lesions (WML) are common, impact neuronal connectivity, and affect motor function and cognition. In addition to pathological nigrostriatal losses, WML are also common co-morbidities in Parkinson's disease (PD) that affect postural stability and gait. Automated brain volume measures are increasingly incorporated into the clinical reporting workflow to facilitate precision in medicine. Read More

View Article and Full-Text PDF

Retinal thickness and microvascular pathway in Idiopathic Rapid eye movement sleep behaviour disorder and Parkinson's disease.

Parkinsonism Relat Disord 2021 Jun 6;88:40-45. Epub 2021 Jun 6.

Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, Section of Neurosciences, University of Catania, Catania, CT, Italy. Electronic address:

Introduction: Retinal impairment has previously been described in Parkinson's Disease (PD), also in early stage of disease. Idiopathic Rapid-eye-movement sleep Behavior Disorder (iRBD) is considered the strongest marker in the diagnosis of "Prodromal PD". Thus, we evaluated the thickness of retinal layers and the microvascular retinal pattern in a group of iRBD patients compared to PD and healthy subjects (HCs). Read More

View Article and Full-Text PDF

Cross-sectional associations of leisure and transport related physical activity with depression and anxiety.

J Psychiatr Res 2021 Jun 4;140:228-234. Epub 2021 Jun 4.

Departmento de Clínica Médica, Faculdade de Medicina da USP & Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil; Laboratory of Neurosciences (LIM-27), Institute of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da USP, Brazil.

Background: Previous evidence supports the notion that the physical activity (PA) domain (leisure-time or transport), and the amount of time spent in PA, influence the association of PA with depressive and anxiety symptoms. However, no study evaluated the associations of different volumes of leisure-time PA (LTPA) and transport PA (TPA) with prevalent depression, anxiety, and co-occurring depression and anxiety (D&A) disorders.

Aim: To investigate the associations between different volumes of LTPA and TPA with prevalent depression, anxiety, and D&A. Read More

View Article and Full-Text PDF

Genome-wide DNA methylation patterns associated with general psychopathology in children.

J Psychiatr Res 2021 May 28;140:214-220. Epub 2021 May 28.

Department of Child and Adolescent Psychiatry/ Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.

Psychiatric symptoms are interrelated and found to be largely captured by a general psychopathology factor (GPF). Although epigenetic mechanisms, such as DNA methylation (DNAm), have been linked to individual psychiatric outcomes, associations with GPF remain unclear. Using data from 440 children aged 10 years participating in the Generation R Study, we examined the associations of DNAm with both general and specific (internalizing, externalizing) factors of psychopathology. Read More

View Article and Full-Text PDF

Differential lncRNA expression profiling of cognitive function in middle and old aged monozygotic twins using generalized association analysis.

J Psychiatr Res 2021 Jun 2;140:197-204. Epub 2021 Jun 2.

Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Denmark; Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Denmark. Electronic address:

Cognitive impairment is the most prominent symptom in neurodegenerative disorders affecting quality of life and mortality. However, despite years of research, the molecular mechanism underlying the regulation of cognitive function and its impairment is poorly understood. This study aims to elucidate the role of long non-coding RNAs (lncRNAs) expression and lncRNA-mRNA interaction networks, by analyzing lncRNA expression in whole blood samples of 400 middle and old aged monozygotic twins in association with cognitive function using both linear models and a generalized correlation coefficient (GCC) to capture the diverse patterns of correlation. Read More

View Article and Full-Text PDF

Application of a new serratus anterior plane block in modified radical mastectomy under ultrasound guidance: A prospective, randomized controlled trial.

J Clin Anesth 2021 Jun 9;74:110377. Epub 2021 Jun 9.

Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Electronic address:

Study Objectives: Post-operative pain is a significant concern following modified radical mastectomy in breast cancer patients. The serratus anterior plane block has recently been described as an effective technique for post-operative analgesia of modified radical mastectomy. The purpose of this study was to evaluate the analgesic efficacy and safety of a new serratus anterior plane (SAP) block for post-operative pain of mastectomy. Read More

View Article and Full-Text PDF

Model infant biscuits release the opioid-acting peptides milk β-casomorphins and gluten exorphins after in vitro gastrointestinal digestion.

Food Chem 2021 Jun 1;362:130262. Epub 2021 Jun 1.

Dipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente, Università degli Studi di Milano, Via G. Celoria 2, 20133 Milan, Italy.

Infant biscuits (IBs) are commonly used during the complementary feeding of infants from the 6th month of life. They contain wheat flour and dairy ingredients, which can release the opioid-acting peptides β-casomorphins (BCMs) and gluten exorphins (GEs) after gastrointestinal digestion. In the present study, five model IBs were prepared with or without gluten and different powdered milk derivatives in the formulations. Read More

View Article and Full-Text PDF

Evaluating the associations of adult heel BMD with birth weight and growth parameters at age 10 in UK biobank cohort.

Bone 2021 Jun 9:116038. Epub 2021 Jun 9.

Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China. Electronic address:

Objective: This study was aimed to evaluate the associations of adult heel bone mineral density (BMD) with birth weight and growth parameters at the age of ten years.

Methods: The analysis data (97178-178,494 subjects) was derived from the UK Biobank cohort. Birth weight, comparative body size and height size at the age of ten years were determined by self-report. Read More

View Article and Full-Text PDF

Rate of treatment success and associated factors in the program for drug susceptible tuberculosis in the Forest Region, Republic of Guinea, 2010-2017: a real-world retrospective observational cohort study.

Int J Infect Dis 2021 Jun 9. Epub 2021 Jun 9.

Centre Hospitalier Régional Spécialisé, Quartier Fassankoni, Commune urbaine Macenta, Région N'Zérékoré, Région Forestière, Guinée; Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Switzerland.

Objectives: To analyze the treatment success rate (TSR = sum of cured or treatment completed) in the tuberculosis (TB) program for drug susceptible TB (DS-TB) of the "Centre Hospitalier Régional Spécialisé" in Macenta, Forest Region, Republic of Guinea.

Methods: This cohort study included patients starting treatment for DS-TB between 2010 and 2017. Data collection was part of the documentation for the national TB program. Read More

View Article and Full-Text PDF

Are antimicrobial stewardship interventions effective and safe in long-term care facilities? A systematic review and meta-analysis.

Clin Microbiol Infect 2021 Jun 9. Epub 2021 Jun 9.

Department of Infectious Diseases, Microbiology and Preventive Medicine, Infectious Diseases Research Group, Institute of Biomedicine of Seville (IBiS), University of Seville/CSIC/University Hospital Virgen del Rocio, 41013 Seville, Spain. Electronic address:

Background: Long-term care facilities (LTCFs) are health care settings with high antimicrobial consumption and hence need to develop effective antimicrobial stewardship programs (ASPs).

Objective: To assess the effects of ASPs on care-related, clinical, and ecological outcomes in LTCFs.

Methods: Data sources were PubMed, EMBASE, CINAHL, and SCOPUS. Read More

View Article and Full-Text PDF

Movement-based mind-body practices and cognitive function in middle-aged and older adults: Findings from the Midlife in the United States (MIDUS) study.

Complement Ther Med 2021 Jun 9;60:102751. Epub 2021 Jun 9.

Florida Policy Exchange Center on Aging, School of Aging Studies, University of South Florida, Tampa, FL, USA.

Objectives: Cognitive function is a key component of healthy aging. While conventional physical activities (walking, jogging, etc.) have been shown to support physical and cognitive health in late-life, it remains unclear whether traditional Eastern movement-based mind-body practices (MBP) have long-term cognitive benefits above and beyond conventional leisure physical activities. Read More

View Article and Full-Text PDF

The association of family functioning with possible major depressive disorders and complicated grief among bereaved family members of patients with cancer: Results from the J-HOPE4 study, a nationwide cross-sectional follow-up survey in Japan.: Family function association with depression.

J Pain Symptom Manage 2021 Jun 9. Epub 2021 Jun 9.

Department of Palliative Nursing, Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan.

Context: Family functioning is a modifiable factor associated with major depressive disorder (MDD) and complicated grief (CG) among the bereaved families of patients with advanced cancer; however, the evidence regarding this association is limited.

Objectives: We aimed to explore the association of family functioning with possible MDD and CG among the bereaved families of patients with advanced cancer who died in palliative care units.

Methods: This study is a part of the J-HOPE4 study, a nationwide cross-sectional multi-purpose questionnaire survey conducted in 2018. Read More

View Article and Full-Text PDF

Assessment of functional sit-to-stand muscle power: Cross-sectional trajectories across the lifespan.

Exp Gerontol 2021 Jun 9;152:111448. Epub 2021 Jun 9.

Geriatric Research Unit, Geriatric Department, Bispebjerg University Hospital, Copenhagen, Denmark; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet-Glostrup University Hospital, Copenhagen, Denmark; Geriatric Research Unit, Department of Internal Medicine, Herlev-Gentofte University Hospital, Copenhagen, Denmark. Electronic address:

Background: The 30-s sit-to-stand (STS) muscle power test is a valid test to assess muscle power in older people; however, whether it may be used to assess trajectories of lower-limb muscle power through the adult lifespan is not known. This study evaluated the pattern and time course of variations in relative, allometric and specific STS muscle power throughout the lifespan.

Methods: Subjects participating in the Copenhagen Sarcopenia Study (729 women and 576 men; aged 20 to 93 years) were included. Read More

View Article and Full-Text PDF

Prognostic performance of seven biomarkers compared to liver biopsy in early alcohol-related liver disease.

J Hepatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Gastroenterology and Hepatology, Odense University Hospital, Denmark; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

Background & Aims: Alcohol is the most common cause of liver-related mortality and morbidity. We therefore aimed to assess and compare the prognostic performance of elastography and blood-based markers to predict time to the first liver-related event, severe infection, and all-cause mortality in patients with a history of excess drinking.

Methods: Prospective cohort study of patients with early, compensated alcohol-related liver disease. Read More

View Article and Full-Text PDF

Delgocitinib ointment in pediatric patients with atopic dermatitis: a phase 3, randomized, double-blind, vehicle-controlled study and a subsequent open-label, long-term study.

J Am Acad Dermatol 2021 Jun 9. Epub 2021 Jun 9.

Pharmaceutical Division, Japan Tobacco Inc., Tokyo, Japan.

Background: Delgocitinib 0.5% ointment, a topical JAK inhibitor, has been approved for adult patients with atopic dermatitis (AD) in Japan.

Objective: To evaluate the efficacy and safety of delgocitinib ointment in pediatric patients with AD. Read More

View Article and Full-Text PDF

Exploring experience of and engagement in coercive pregnancy behaviors among sexually active young men from five clinics in Baltimore, MD.

Contraception 2021 Jun 9. Epub 2021 Jun 9.

Johns Hopkins University, School of Medicine 1800 Orleans Street, Baltimore, MD 21287, USA. Electronic address:

Objectives: To explore young men's perceived experience of coercive pregnancy behaviors by female partners, and engagement in and behavioral overlap of these occurrences in this sample.

Study Design: Heterosexually active young men aged 15-24 (n=39), recruited from three primary care and two sexually transmitted disease clinics in Baltimore, MD city over a two-week period, were surveyed on their perceived experience of and engagement in coercive pregnancy behaviors, attitudes about women, and background characteristics.

Results: Of 130 invited, sixty-six (51%) agreed to participate, 39 of whom were heterosexual young men; 87% were non-Hispanic Black and 59% were aged 20-24. Read More

View Article and Full-Text PDF

Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG.

J Mol Cell Cardiol 2021 Jun 9. Epub 2021 Jun 9.

Department of Biomedical Engineering, Case School of Engineering, Case Western Reserve University, Cleveland, OH, USA. Electronic address:

Controlling fibrosis is an essential part of regenerating the post-ischemic heart. In the post-ischemic heart, fibroblasts differentiate to myofibroblasts that produce collagen-rich matrix to physically stabilize the infarct area. Infarct models in adult mice result in permanent scarring unlike newborn animals which fully regenerate. Read More

View Article and Full-Text PDF

Pralsetinib for RET fusion-positive non-small-cell lung cancer (ARROW): a multi-cohort, open-label, phase 1/2 study.

Lancet Oncol 2021 Jun 9. Epub 2021 Jun 9.

Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Oncogenic alterations in RET have been identified in multiple tumour types, including 1-2% of non-small-cell lung cancers (NSCLCs). We aimed to assess the safety, tolerability, and antitumour activity of pralsetinib, a highly potent, oral, selective RET inhibitor, in patients with RET fusion-positive NSCLC.

Methods: ARROW is a multi-cohort, open-label, phase 1/2 study done at 71 sites (community and academic cancer centres) in 13 countries (Belgium, China, France, Germany, Hong Kong, Italy, Netherlands, Singapore, South Korea, Spain, Taiwan, the UK, and the USA). Read More

View Article and Full-Text PDF

Tracking elimination of HIV transmission in men who have sex with men in England: a modelling study.

Lancet HIV 2021 Jun 9. Epub 2021 Jun 9.

Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK. Electronic address:

Background: To manage the HIV epidemic among men who have sex with men (MSM) in England, treatment as prevention strategies based on test and treat were strengthened between 2011 and 2015, and supplemented from 2015 by scale-up of pre-exposure prophylaxis (PrEP). We examined the effect of these interventions on HIV incidence and investigated whether internationally agreed targets for HIV control and elimination of HIV transmission by 2030 might be within reach among MSM in England.

Methods: We used a novel, age-stratified, CD4-staged Bayesian back-calculation model to estimate HIV incidence and undiagnosed infections among adult MSM (age ≥15 years) during the 10-year period between 2009 and 2018. Read More

View Article and Full-Text PDF

Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury.

Aging Cell 2021 Jun 12:e13407. Epub 2021 Jun 12.

Department of Medicine, Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, USA.

The mechanism of kidney injury in aging are not well understood. In order to identify hitherto unknown pathways of aging-related kidney injury, we performed RNA-Seq on kidney extracts of young and aged mice. Expression of chloride (Cl) channel accessory 1 (CLCA1) mRNA and protein was increased in the kidneys of aged mice. Read More

View Article and Full-Text PDF

Nurse turnover: A longitudinal survival analysis of the Korea Nurses' Health Study.

J Adv Nurs 2021 Jun 12. Epub 2021 Jun 12.

College of Nursing, University of Illinois at Chicago, Chicago, IL, USA.

Aims: To identify factors influencing turnover among Korean female nurses from a longitudinal perspective.

Design: A national cohort study called the Korea Nurses' Health Study (2013-2020) was used.

Methods: A national sample of female nurses from module 1 (N = 20,613, 2013-2014), module 5 (N = 11,527, 2016-2017), module 7 (N = 8,658, 2018-2019) and module 8 (N = 10,253, 2019-2020) was used. Read More

View Article and Full-Text PDF

Indoor solid fuel use for heating and cooking with blood pressure and hypertension: A cross-sectional study among middle-aged and older adults in China.

Indoor Air 2021 Jun 12. Epub 2021 Jun 12.

School of Public Health, Sun Yat-sen University, Guangzhou, China.

A cross-sectional study was conducted to investigate the impact of solid fuel use for heating and cooking on blood pressure (BP) and hypertension, using data from the China Health and Retirement Longitudinal Study (CHARLS). The primary fuels used for indoor heating and cooking were collected by questionnaires, respectively. Hypertension was defined based on self-report of physician's diagnosis, and/or measured BP, and/or anti-hypertensive medication use. Read More

View Article and Full-Text PDF

Peripheral intravenous catheter management in childbirth (PICMIC): A multi-centre, prospective cohort study.

J Adv Nurs 2021 Jun 12. Epub 2021 Jun 12.

School of Nursing, Midwifery and Social Work, University of Queensland, Brisbane, QLD, Australia.

Background: Childbirth is a normal, physiological process, yet intervention is common. Arguably the most common intervention is the insertion of a peripheral intravenous catheter; however, there are few studies guiding best practice. This study aimed to describe current intravenous catheter insertion practice, explore clinician decision-making during insertion and perceptions of women. Read More

View Article and Full-Text PDF

Clinicopathological insight into self-reported hair loss with no findings: How do we manage this enigmatic condition?

J Dermatol 2021 Jun 12. Epub 2021 Jun 12.

Department of Dermatology, Faculty of Medicine, Kyorin University, Tokyo, Japan.

Patients who complain of hair loss without any supportive findings can be encountered in daily practice. To provide insight into this embarrassing condition, we retrospectively reviewed medical charts of eight cases with self-reported hair loss with no findings (SHLNOF). High frequency in middle aged women and concomitance of thyroid and gynecological problems were revealed. Read More

View Article and Full-Text PDF