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Weight Gain After Heart Transplantation in Adults: Systematic Review and Meta-Analysis.

ASAIO J 2021 Sep 20. Epub 2021 Sep 20.

From the Population Health Department, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia Transplant Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom Advanced Heart Failure and Cardiac Transplant Unit, The Prince Charles Hospital, Chermside, Queensland, Australia CRUK Manchester Institute and University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

Gain in weight is common after heart transplantation but the magnitude of usual weight gain and whether this varies by country is unknown. We systematically reviewed all relevant studies to quantify weight change among heart transplant recipients (HTRs) in the years after transplantation and assess variation with geographic location. We searched PubMed, Cumulative Index to Nursing and Allied Health Literature, and Excerpta Medica Database databases to September 2020. Read More

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September 2021

Is Foot Drop an Underreported Sequela of Extracorporeal Membrane Oxygenation?

ASAIO J 2021 Sep 20. Epub 2021 Sep 20.

From the Center for Advanced Heart Failure, Memorial Hermann Hospital-Texas Medical Center, Houston, Texas Department of Advanced Cardiopulmonary Therapies and Transplantation, University of Texas Health Science Center at Houston, Houston, Texas Rehabilitation Services, Memorial Hermann Hospital-Texas Medical Center, Houston, Texas.

Foot drop in the absence of limb ischemia is a chronic complication in peripheral venoarterial extracorporeal membrane oxygenation (V-A ECMO) survivors; however, there is little published regarding the incidence and functional outcomes of this condition. Common peroneal nerve is the most common cause of foot drop, a condition that leads to significant debility and requires extensive physical therapy and rehabilitation, thereby affecting the patient's quality of life. We completed a retrospective review of 153 patients who received femoral cannulation for V-A ECMO support for greater than 1 hour. Read More

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September 2021

Retrievable Inferior Vena Cava Filters - Use, Removal, and Removal Techniques.

Cardiol Rev 2021 Sep 15. Epub 2021 Sep 15.

From the Division of Vascular Surgery, and the Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY, USA.

The use of retrievable inferior vena cava (IVC) filters is on the rise but there is an inadequate number of these filters being removed even if their use as a prophylactic for venous thromboembolism is no longer indicated. Complications with retrievable filters that remain in the patient for an extended duration include examples such as filter tilt and embedding into the caval wall. This raises concerns for whether the filter is properly functioning and for consequent sequelae, including recurrent thrombosis, stenosis, or IVC perforation. Read More

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September 2021

Effect of Climbing Speed on Pulmonary Oxygen Uptake and Muscle Oxygen Saturation Dynamics in the Finger Flexors.

Int J Sports Physiol Perform 2021 Sep 24:1-9. Epub 2021 Sep 24.

Purpose: Although sport climbing is a self-paced whole-body activity, speed varies with climbing style, and the effect of this on systemic and localized oxygen responses is not well understood. Therefore, the aim of the present study was to determine muscle and pulmonary oxygen responses during submaximal climbing at differing speeds of ascent.

Methods: Thirty-two intermediate and advanced sport climbers completed three 4-minute-long ascents of the same route at 4, 6, and 9 m·min-1 on a motorized climbing ergometer (treadwall) on separate laboratory visits. Read More

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September 2021

Awake craniotomy with transcortical motor evoked potential monitoring for resection of gliomas within or close to motor-related areas: validation of utility for predicting motor function.

J Neurosurg 2021 Sep 24:1-10. Epub 2021 Sep 24.

1Department of Neurosurgery.

Objective: The authors previously showed that combined evaluation of changes in intraoperative voluntary movement (IVM) during awake craniotomy and transcortical motor evoked potentials (MEPs) was useful for predicting postoperative motor function in 30 patients with precentral gyrus glioma. However, the validity of the previous report is limited to precentral gyrus gliomas. Therefore, the current study aimed to validate whether the combined findings of IVM during awake craniotomy and transcortical MEPs were useful for predicting postoperative motor function of patients with a glioma within or close to motor-related areas and not limited to the precentral gyrus. Read More

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September 2021

The diagnostic accuracy of MRI and nonenhanced CT for high-risk vertebral artery anatomy for subaxial anterior cervical spine surgery safety.

J Neurosurg Spine 2021 Sep 24:1-8. Epub 2021 Sep 24.

1Spine Care Institute, Hospital for Special Surgery, New York, New York.

Objective: Medial migration of the vertebral artery (VA) can be a risk factor for injury during anterior procedures. CT angiography (CTA) has been considered the gold standard for the evaluation of various areas of the arterial anatomy. MRI and nonenhanced CT are more commonly used as routine preoperative imaging studies, but it is unclear if these modalities can safely exclude the anomalous course of the VA. Read More

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September 2021

Feasibility of robot-assisted neuroendovascular procedures.

J Neurosurg 2021 Sep 24:1-13. Epub 2021 Sep 24.

1Division of Neuroradiology, Department of Medical Imaging, Toronto Western Hospital, University Health Network, University of Toronto; and.

Objective: Geographic factors prevent equitable access to urgent advanced neuroendovascular treatments. Robotic technologies may enable remote endovascular procedures in the future. The authors performed a translational, benchtop-to-clinical study to evaluate the in vitro and clinical feasibility of the CorPath GRX Robotic System for robot-assisted endovascular neurointerventional procedures. Read More

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September 2021

Patient outcomes after circumferential minimally invasive surgery compared with those of open correction for adult spinal deformity: initial analysis of prospectively collected data.

J Neurosurg Spine 2021 Sep 24:1-12. Epub 2021 Sep 24.

1Department of Neurosurgery, University of California, San Francisco, San Francisco, California.

Objective: Circumferential minimally invasive spine surgery (cMIS) for adult scoliosis has become more advanced and powerful, but direct comparison with traditional open correction using prospectively collected data is limited. The authors performed a retrospective review of prospectively collected, multicenter adult spinal deformity data. The authors directly compared cMIS for adult scoliosis with open correction in propensity-matched cohorts using health-related quality-of-life (HRQOL) measures and surgical parameters. Read More

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September 2021

Advanced hybrid artificial pancreas system improves on unannounced meal response - In silico comparison to currently available system.

Comput Methods Programs Biomed 2021 Sep 13;211:106401. Epub 2021 Sep 13.

Center for Diabetes Technology, University of Virginia, Charlottesville, VA, USA. Electronic address:

Background And Objective: Glycemic control, especially meal-related disturbance rejection, has proven to be a major challenge for people with type 1 diabetes. In this manuscript, we introduce a novel, personalized, advanced hybrid insulin infusion system (a.k. Read More

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September 2021

Traffic-related air pollution and endurance exercise: Characterizing non-targeted serum metabolomics profiling.

Environ Pollut 2021 Sep 18;291:118204. Epub 2021 Sep 18.

Endurance Performance Research Group (GEDAE-USP), School of Physical Education and Sport, University of São Paulo, São Paulo, SP, Brazil. Electronic address:

Although the exposure to traffic-related air pollution (TRAP) has emerged as one of main problem worldwide to inhabitants' health in urban centers, its impact on metabolic responses during exercise is poorly understood. The aim of study was to characterize the profile of non-target serum metabolomics during prolonged exercise performed under TRAP conditions. Ten healthy men completed two 90 min constant-load cycling trials under conditions of either TRAP or filtered air. Read More

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September 2021

Quantitative analysis methods for studying fenestrations in liver sinusoidal endothelial cells. A comparative study.

Micron 2021 Jul 28;150:103121. Epub 2021 Jul 28.

Department of Medical Biology, Vascular Biology Research Group, University of Tromsø (UiT), The Arctic University of Norway, Norway.

Liver Sinusoidal Endothelial Cells (LSEC) line the hepatic vasculature providing blood filtration via transmembrane nanopores called fenestrations. These structures are 50-300 nm in diameter, which is below the resolution limit of a conventional light microscopy. To date, there is no standardized method of fenestration image analysis. Read More

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Techno-economic analysis of livestock urine and manure as a microalgal growth medium.

Waste Manag 2021 Sep 21;135:276-286. Epub 2021 Sep 21.

School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology, 50 UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan 44919, Republic of Korea. Electronic address:

Microalgae have the potential to utilize the nutrients in livestock urine and manure (LUM) for the production of useful biomass, which can be used as a source of bioindustry. This study aims to evaluate the economic benefits of LUM feedstock that have not been clearly discussed before. Two types of photobioreactors were designed with a capacity of 200 m d. Read More

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September 2021

Optimal start-up conditions for the efficient treatment of acid mine drainage using sulfate-reducing bioreactors based on physicochemical and microbiome analyses.

J Hazard Mater 2021 Sep 6;423(Pt B):127089. Epub 2021 Sep 6.

Environmental Management Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 16-1 Onogawa, Tsukuba, Ibaraki 305-8569, Japan. Electronic address:

Typically, sulfate-reducing bioreactors used to treat acid mine drainage (AMD) undergo an initial incubation period of a few weeks to acclimatize sulfate-reducing bacteria (SRB), although necessity of this preincubation has rarely been evaluated. To reduce time and economic cost, we developed an SRB acclimatization method using the continuous flow of AMD into bioreactors fed with rice bran, and compared with the conventional acclimatization method. We found that the SRB sufficiently acclimatized without the preincubation phase. Read More

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September 2021

Does large NGS panel analysed using exome tumour sequencing improve the management of advanced non-small-cell lung cancers?

Lung Cancer 2021 Aug 29;161:98-107. Epub 2021 Aug 29.

Department of Medical Oncology, Georges François Leclerc Cancer Center - UNICANCER, 1 rue du Professeur Marion, Dijon 21000, France; University of Burgundy-Franche Comté, Maison de l'université Esplanade Erasme, 21000 Dijon, France; Platform of Transfert in Biological Oncology, Georges François Leclerc Cancer Center - UNICANCER, 1 rue du Professeur Marion, Dijon 21000, France; Genomic and Immunotherapy Medical Institute, Dijon University Hospital, 14 rue Paul Gaffarel 21000 Dijon, France; UMR INSERM 1231, 7 Boulevard Jeanne d'Arc, 21000 Dijon, France. Electronic address:

Introduction: Non-small-cell lung cancer (NSCLC) is one of the most common and deadly cancers. Several molecular drivers of oncogene addiction are now known to be strong predictive biomarkers for target therapies. Advances in large Next Generation Sequencing (LNGS) have improved the ability to detect potentially targetable mutations. Read More

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Dual-high-frequency from single-piezoelectric crystal for ACE degradation by hybrid advanced oxidation UV-sonochemistry process.

Ultrason Sonochem 2021 Aug 19;78:105731. Epub 2021 Aug 19.

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, US. Electronic address:

This study investigates the combination of two waves emitted from a single-piezoelectric crystal by use of a dual-frequency generator in a sonochemical reactor. The dual-frequency configurations analyzed were the double-modulated fundamental frequency (376-376 kHz), resonant and second harmonic, termed 376D, 376R and 376H respectively. The effect of the phase shift (Φ) and the percentage of modulation between added waves were described by the total acoustic power distribution (P) measured inside the sonoreactor. Read More

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Quality of life in patients with locally advanced head and neck cancer treated with concurrent chemoradiation with cisplatin and nimotuzumab versus cisplatin alone - Additional data from a phase 3 trial.

Oral Oncol 2021 Sep 21;122:105517. Epub 2021 Sep 21.

Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, India. Electronic address:

Introduction: The addition of Nimotuzumab to radical chemoradiation (CRT) improved outcomes in patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC) undergoing radical CRT in a phase 3 randomized trial. The current study focuses on the quality of life (QoL) of patients in this trial.

Methods: In this phase III randomized trial, patients with newly diagnosed, nonmetastatic, stage III/IV LAHNSCC of the oral cavity, oropharynx, hypopharynx, or larynx were randomized to receive cisplatin 30 mg/m or cisplatin 30 mg/m with nimotuzumab once a week with curative radiotherapy. Read More

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September 2021

Prismatic 2.0 - Simulation software for scanning and high resolution transmission electron microscopy (STEM and HRTEM).

Micron 2021 Sep 10;151:103141. Epub 2021 Sep 10.

National Center for Electron Microscopy, Molecular Foundry, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA. Electronic address:

Scanning transmission electron microscopy (STEM), where a converged electron probe is scanned over a sample's surface and an imaging, diffraction, or spectroscopic signal is measured as a function of probe position, is an extremely powerful tool for materials characterization. The widespread adoption of hardware aberration correction, direct electron detectors, and computational imaging methods have made STEM one of the most important tools for atomic-resolution materials science. Many of these imaging methods rely on accurate imaging and diffraction simulations in order to interpret experimental results. Read More

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September 2021

Detection of transdermal biomarkers using gradient-based colorimetric array sensor.

Biosens Bioelectron 2021 Sep 20;195:113650. Epub 2021 Sep 20.

Center for Bioelectronics and Biosensors, The Biodesign Institute, Arizona State University, USA; Department of Electrical Engineering and Computer Science, South Dakota State University, Brookings, SD, 57007, USA. Electronic address:

Accurate assessment of dietary macronutrients intake is critical for the effective management of multiple diseases, such as obesity, diabetes, cardiovascular disease, metabolic disease, and cancer. Conventional self-reporting method is burdensome, inaccurate, and often biased. Though blood analysis and breath analysis can provide evidence-based information, they are either invasive or subject to human errors. Read More

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September 2021

Comments on the published Meta-Analysis of Prevalence of multidrug-resistant bacteria in Ethiopia: a systematic review and meta-analysis.

J Glob Antimicrob Resist 2021 Sep 21. Epub 2021 Sep 21.

Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

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September 2021

Machine-learning methods for ligand-protein molecular docking.

Drug Discov Today 2021 Sep 21. Epub 2021 Sep 21.

Université de Reims Champagne Ardenne, LICIIS - LRC CEA DIGIT, Reims, France. Electronic address:

Artificial intelligence (AI) is often presented as a new Industrial Revolution. Many domains use AI, including molecular simulation for drug discovery. In this review, we provide an overview of ligand-protein molecular docking and how machine learning (ML), especially deep learning (DL), a subset of ML, is transforming the field by tackling the associated challenges. Read More

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September 2021

Optimization strategies for expression of a novel bifunctional anti-PD-L1/TGFBR2-ECD fusion protein.

Protein Expr Purif 2021 Sep 21:105973. Epub 2021 Sep 21.

Hisun Biopharmaceutical Co., Ltd., Hangzhou, Zhejiang, 311404, China. Electronic address:

The novel anti-PD-L1/TGFBR2-ECD fusion protein (BR102) comprises an anti-PD-L1 antibody (HS636) which is fused at the C terminus of the heavy chain to a TGF-β1 receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment. In the expression of TGFBR2-ECD wild-type fused protein (BR102-WT), a 50 kDa clipped species was confirmed to be induced by proteolytic cleavage at a "QKS" site located in the N-terminus of the ectodomain, which resulted in the formation of IgG-like clipping. The matrix metalloproteinase-9 was determined to be associated with BR102-WT digestion. Read More

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September 2021

Evaluation of resveratrol-doped adhesive with advanced dentin bond durability.

J Dent 2021 Sep 21:103817. Epub 2021 Sep 21.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China. Electronic address:

Objectives: This paper aimed to evaluate the influence of resveratrol-doped adhesive on the durability and antibiofilm capability of dentin bonding.

Methods: Experimental adhesives were prepared by incorporating resveratrol into a universal adhesive at concentrations of 0 (control), 0.1, 1, and 10 mg/mL. Read More

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September 2021

Correlations between bone marrow radiation dose and hematologic toxicity in locally advanced cervical cancer patients receiving chemoradiation with cisplatin: a systematic review.

Radiother Oncol 2021 Sep 21. Epub 2021 Sep 21.

Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. Electronic address:

Patients with locally advanced cervical cancer (LACC) treated with chemoradiation often experience hematologic toxicity (HT), as chemoradiation can induce bone marrow (BM) suppression. Studies on the relationship between BM dosimetric parameters and clinically significant HT might provide relevant indices for developing BM-sparing (BMS) radiotherapy techniques. This systematic review studied the relationship between bone marrow dose and HT in LACC-patients treated with primary cisplatin-based chemoradiation. Read More

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September 2021

1α,25-Dihydroxyvitamin D3 promotes angiogenesis by alleviating AGEs-induced autophagy.

Arch Biochem Biophys 2021 Sep 21:109041. Epub 2021 Sep 21.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address:

Diabetes mellitus (DM) induces abnormal angiogenesis and results in multiple chronic vascular complications. Previous studies showed that advanced glycation end products (AGEs) up-regulated in diabetic patients and induced a series of cellular effects such as oxidative stress, inflammation, and autophagy. 1α,25-Dihydroxyvitamin D3 (1,25D), a hormonal form of vitamin D, proved to be beneficial for vascular diseases. Read More

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September 2021

Stacked Ensemble Machine Learning for Range-Separation Parameters.

J Phys Chem Lett 2021 Sep 24:9516-9524. Epub 2021 Sep 24.

Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, United States.

Density functional theory-based high-throughput materials and drug discovery has achieved tremendous success in recent decades, but its power on organic semiconducting molecules suffered catastrophically from the self-interaction error until the nonempirical but expensive optimally tuned range-separated hybrid (OT-RSH) functionals were developed. An OT-RSH transitions from a short-range (semi)local functional to a long-range Hartree-Fock exchange at a distance characterized by a molecule-specific range-separation parameter (ω). Herein, we propose a stacked ensemble machine learning model that provides an accelerated alternative of OT-RSH based on system-dependent structural and electronic configurations. Read More

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September 2021

Bioprinting of Human Liver-derived Epithelial Organoids for Toxicity Studies.

Macromol Biosci 2021 Sep 24:e2100327. Epub 2021 Sep 24.

Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Regenerative Medicine Center Utrecht, Uppsalalaan 8, Utrecht, 3584 CT, The Netherlands.

There is a need for long-lived hepatic in vitromodels to better predict drug induced liver injury (DILI). Human liver-derived epithelial organoids are a promising cell source for advanced in vitromodels. Here, organoid technology is combined with biofabrication techniques, which holds great potential for the design of in vitromodels with complex and customizable architectures. Read More

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September 2021

National disparities in use of minimally invasive surgery for rectal cancer in older adults.

J Am Geriatr Soc 2021 Sep 24. Epub 2021 Sep 24.

Division of Colorectal Surgery, Department of Surgery, The University of California at Davis Medical Center, Sacramento, California, USA.

Background: Minimally invasive surgery (MIS) is safe and improves outcomes in older persons with rectal cancer but may be underutilized. As older persons are the largest surgical population, investigation of the current use and factors impacting MIS use is warranted. Our goal is to investigate the trends and disparities that affect utilization of MIS in older persons with rectal cancer. Read More

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September 2021

The Active Hospital pilot: A qualitative study exploring the implementation of a Trust-wide Sport and Exercise Medicine-led physical activity intervention.

PLoS One 2021 24;16(9):e0257802. Epub 2021 Sep 24.

Advanced Wellbeing Research Centre, Sheffield Hallam University, Sheffield, United Kingdom.

Background: In 2017 Public Health England and Sport England commissioned a Consultant-led Sport and Exercise Medicine (SEM) pilot to test the feasibility and acceptability of embedding physical activity interventions in secondary care clinical pathways. The aim of this paper is to report qualitative findings exploring the experience of healthcare professionals (HCPs) and patients involved in the Active Hospital pilot.

Methods: Qualitative data was collected by semi-structured interviews with Active Hospital pilot SEM Consultants, and staff and patients involved in three clinical pathways. Read More

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September 2021

Mathematical model of a personalized neoantigen cancer vaccine and the human immune system.

PLoS Comput Biol 2021 Sep 24;17(9):e1009318. Epub 2021 Sep 24.

Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, United States of America.

Cancer vaccines are an important component of the cancer immunotherapy toolkit enhancing immune response to malignant cells by activating CD4+ and CD8+ T cells. Multiple successful clinical applications of cancer vaccines have shown good safety and efficacy. Despite the notable progress, significant challenges remain in obtaining consistent immune responses across heterogeneous patient populations, as well as various cancers. Read More

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September 2021