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A comprehensive overview of social network measures for older adults: A systematic review.

Arch Gerontol Geriatr 2021 Sep 11;97:104525. Epub 2021 Sep 11.

Centre for Health Systems and Safety Research, Australian Institute of Health Innovation, Macquarie University, NSW, Australia. Electronic address:

Objectives: The size and type of older adults' social networks is associated with health, mental and social outcomes. Investigators within many disciplines are now measuring social networks, but it is not always clear what they are assessing, or which measures may best meet their objectives. To undertake a systematic review to identify (i) social network measures used for older adults, (ii) variety of social network dimensions and (iii) how measures have developed over time. Read More

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September 2021

Inhibition of DNA methylation in newborns reprograms ischemia-sensitive biomarkers resulting in development of a heart ischemia-sensitive phenotype late in life.

Reprod Toxicol 2021 Sep 15. Epub 2021 Sep 15.

Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States. Electronic address:

Adverse environmental stress exposure at critical perinatal stages can alter cardiovascular development, which could persist into adulthood and develop a cardiovascular dysfunctional phenotype late in life. However, the underlying molecular mechanisms remain largely unknown. The present study provided a direct evidence that DNA methylation is a key epigenetic mechanism contributing to the developmental origins of adult cardiovascular disease. Read More

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September 2021

Reexamining the Neural Network Involved in Perception of Facial Expression: A Meta-analysis.

Neurosci Biobehav Rev 2021 Sep 15. Epub 2021 Sep 15.

State Key Laboratory of Brain and Cognitive Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

Perception of facial expression is essential for social interactions. Although a few competing models have enjoyed some success to map brain regions, they are also facing difficult challenges. The current study used an updated activation likelihood estimation (ALE) method of meta-analysis to explore the involvement of brain regions in facial expression processing. Read More

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September 2021

The Society of Thoracic Surgeons Adult Cardiac Surgery Database: 2021 Update on Echocardiography.

Ann Thorac Surg 2021 Sep 15. Epub 2021 Sep 15.

Department of Anesthesiology; Vanderbilt University, Nashville, TN. Electronic address:

The Society of Thoracic Surgeons (STS) Adult Cardiac Surgery Database (ACSD) is the world's premier clinical outcomes registry for adult cardiac surgery and a driving force for quality improvement in cardiac surgery. Echocardiographic data provide a wealth of hemodynamic, structural, and functional data and have been part of STS ACSD data collection since its inception. An increasing body of evidence suggests that the use of echocardiography in patients undergoing cardiac surgery has a positive impact on postoperative outcomes. Read More

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September 2021

Association between Diabetes Mellitus and the Risk of Herpes Zoster: A Systematic Review and Meta-analysis.

J Clin Endocrinol Metab 2021 Sep 18. Epub 2021 Sep 18.

Department of Endocrinology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei City, Taiwan.

Context: Individuals with diabetes mellitus (DM) are susceptible to various infections.

Objective: We estimated the risk of herpes zoster (HZ) among individuals with DM compared to individuals in the general population.

Data Sources: We searched the PubMed, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trails, Cumulative Index to Nursing and Allied Health Literature and PerioPath databases from their inception to January 30, 2021 for studies on the risk of HZ in individuals with DM. Read More

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September 2021

Sight-threatening retinopathy in 9 adolescents with early-onset type 1 diabetes.

Pediatr Diabetes 2021 Sep 18. Epub 2021 Sep 18.

Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Westmead, NSW.

In adults, there has been a decline in the incidence of diabetic retinopathy associated with improvements in diabetes management. Data on incident severe diabetic retinopathy in adolescents are sparse. In our established diabetes complications assessment service, we recorded nine cases of sight-threatening retinopathy in youth aged 15-17. Read More

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September 2021

Demographic and clinical characteristics of a population-based paediatric cohort of type 1 and type 2 diabetes in Western Australia (1999-2019).

Pediatr Diabetes 2021 Sep 18. Epub 2021 Sep 18.

Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, Western Australia.

Objectives: To determine demographic and clinical characteristics of youth diagnosed with type 1 (T1D) or type 2 (T2D) diabetes aged ≤15 years from 1999-2019 in Western Australia, and examine time to first diagnosis of diabetes complications.

Methods: A retrospective cohort study was conducted of patients identified from the population-based, prospective Western Australian Children's Diabetes Database and longitudinal data extracted for available demographic and clinical variables. Patients were followed from diagnosis to transition to adult services, death or 31 December 2019. Read More

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September 2021

The Effect of Resistance Training in Healthy Adults on Body Fat Percentage, Fat Mass and Visceral Fat: A Systematic Review and Meta-Analysis.

Sports Med 2021 Sep 18. Epub 2021 Sep 18.

Department of Exercise Physiology, School of Health Sciences, Faculty of Medicine and Health, University of New South Wales, Room 202, Wallace Wurth Building, Sydney, NSW, Australia.

Background: Resistance training is the gold standard exercise mode for accrual of lean muscle mass, but the isolated effect of resistance training on body fat is unknown.

Objectives: This systematic review and meta-analysis evaluated resistance training for body composition outcomes in healthy adults. Our primary outcome was body fat percentage; secondary outcomes were body fat mass and visceral fat. Read More

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September 2021

Efficacy and safety of closed-loop insulin delivery versus sensor-augmented pump in the treatment of adults with type 1 diabetes: a systematic review and meta-analysis of randomized-controlled trials.

J Endocrinol Invest 2021 Sep 17. Epub 2021 Sep 17.

Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, 1 Minde Road, Nanchang, 330006, China.

Background: Controversy remains regarding whether closed-loop (CL) insulin delivery or insulin sensor-augmented pump (SAP) delivery is more efficient for clinical treatment. Therefore, we aimed to compare the efficacy and safety of CL insulin delivery systems versus insulin SAP delivery for adults with type 1 diabetes (T1D).

Methods: Embase, Ovid MEDLINE, PubMed, ScienceDirect, Scopus, the Cochrane Library, and other databases were searched for related articles, and we analyzed the average blood glucose (BG), time in range (TIR), and adverse effects (AEs) as primary endpoints to evaluate efficacy and safety. Read More

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September 2021

Accounts of health risk assessment survey administration in the Catch a Break Program: the social construction of osteoporosis risk identification and need for intervention.

Arch Osteoporos 2021 Sep 17;16(1):136. Epub 2021 Sep 17.

Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, 2J2.00 WC Mackenzie Health Sciences Centre, 8440 112 St. NW, Edmonton, AB, T6G 2R7, Canada.

Catch a Break staff conducting the organizational work of delivering secondary fracture prevention screening conversations drew on cultural and organizational resources to determine eligibility of individuals. They encountered and navigated their way through interactional troubles as they requested participation, assessed trauma risk, and provided lifestyle information.

Purpose: We investigated delivery of a population-based type C fracture liaison service for non-hip fractures. Read More

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September 2021

Shugosin 2 is a biomarker for pathological grading and survival prediction in patients with gliomas.

Sci Rep 2021 Sep 17;11(1):18541. Epub 2021 Sep 17.

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.

Glioblastomas are the most common type of adult primary brain neoplasms. Clinically, it is helpful to identify biomarkers to predict the survival of patients with gliomas due to its poor outcome. Shugoshin 2 (SGO2) is critical in cell division and cell cycle progression in eukaryotes. Read More

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September 2021

Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals.

Sci Rep 2021 Sep 17;11(1):18557. Epub 2021 Sep 17.

Sanquin Research, Department of Hematopoiesis, Amsterdam, The Netherlands, and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Beta-hemoglobinopathies become prominent after birth due to a switch from γ-globin to the mutated β-globin. Haploinsufficiency for the erythroid specific indispensable transcription factor Krueppel-like factor 1 (KLF1) is associated with high persistence of fetal hemoglobin (HPFH). The In(Lu) phenotype, characterized by low to undetectable Lutheran blood group expression is caused by mutations within KLF1 gene. Read More

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September 2021

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions.

Nat Commun 2021 Sep 17;12(1):5501. Epub 2021 Sep 17.

Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.

Fibrotic scar tissue limits central nervous system regeneration in adult mammals. The extent of fibrotic tissue generation and distribution of stromal cells across different lesions in the brain and spinal cord has not been systematically investigated in mice and humans. Furthermore, it is unknown whether scar-forming stromal cells have the same origin throughout the central nervous system and in different types of lesions. Read More

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September 2021

Monitoring New Symptoms After COVID-19 Infection Among Primary Care Patients in New York City.

J Am Board Fam Med 2021 Sep-Oct;34(5):1014-1016

From the Department of Population Health, NYU Grossman School of Medicine, New York, NY (KT); Internal Medicine, NYU Langone Health, New York, NY (EK); Department of Child and Adolescent Psychiatry, New York University Grossman School of Medicine, New York, NY (YY).

Introduction: COVID-19 affects multiple organ systems causing substantial long-term morbidity. The implications of the Post-Acute Sequelae of SARS-CoV-2 infection, particularly for primary care, remain unknown. This cross-sectional study examines new symptoms reported at primary care encounters during three post-acute follow-up intervals after initial SARS-CoV-2 infection. Read More

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Yoga for Substance Use: A Systematic Review.

J Am Board Fam Med 2021 Sep-Oct;34(5):964-973

From the Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX (NW, JM, SG, RZ); West Virginia University Health Sciences Center, Morgantown, WV (AT).

Introduction: Substance use disorders (SUDs) are complex interactions between various genetic, environmental, developmental, and social factors. Yoga is recommended as a nonmainstream treatment for many health conditions, including SUDs.

Methods: Five databases were searched for randomized controlled trials (RCTs) that evaluated yoga as an intervention in adults with any type of substance use disorder. Read More

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Characteristics of older adults with back pain associated with choice of first primary care provider: a cross-sectional analysis from the BACE-N cohort study.

BMJ Open 2021 Sep 17;11(9):e053229. Epub 2021 Sep 17.

Department of Physiotherapy, Oslo Metropolitan University, Oslo, Norway.

Objectives: To describe characteristics of older adults with back pain in primary care, and to assess associations between patient characteristics and type of first primary care provider (general practitioner (GP), physiotherapist (PT) or chiropractor).

Design: Cross-sectional analysis from the Back Complaints in the Elders-Norway cohort study.

Setting: Norwegian GP, PT and chiropractic primary care centres. Read More

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September 2021

Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study.

BMJ 2021 Sep 17;374:n2244. Epub 2021 Sep 17.

Division of Primary Care, School of Medicine, University of Nottingham, Nottingham, UK.

Objectives: To derive and validate risk prediction algorithms to estimate the risk of covid-19 related mortality and hospital admission in UK adults after one or two doses of covid-19 vaccination.

Design: Prospective, population based cohort study using the QResearch database linked to data on covid-19 vaccination, SARS-CoV-2 results, hospital admissions, systemic anticancer treatment, radiotherapy, and the national death and cancer registries.

Settings: Adults aged 19-100 years with one or two doses of covid-19 vaccination between 8 December 2020 and 15 June 2021. Read More

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September 2021

Safety Matters: A Meta-analysis of Interhospital Transport Adverse Events in Critically Ill Patients.

Air Med J 2021 Sep-Oct;40(5):350-358. Epub 2021 May 24.

Research Associate Program, Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD; Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD; Program in Trauma, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD. Electronic address:

Objective: Interhospital transport (IHT) is common among critically ill patients. Our meta-analysis investigated the prevalence and possible factors associated with adverse events (AEs) during IHT.

Methods: Searching PubMed, Embase, and Scopus databases until February 12, 2021, we included studies that a priori defined AEs for adult medical patients. Read More

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Effects of physical exercise on working memory in older adults: a systematic and meta-analytic review.

Eur Rev Aging Phys Act 2021 Sep 17;18(1):18. Epub 2021 Sep 17.

School of Physical Education and Health, Shanghai Lixin University of Accounting and Finance, 2800 Wenxiang Road, Shanghai, 201620, China.

Background: This systematic and meta-analytic review aimed to investigate the effects of physical exercise on the working memory of older adults, and to identify the moderators of these effects.

Methods: We searched six electronic databases for randomized controlled trials on the effects of physical exercise on working memory that were published before or on May 15, 2020. The PEDro scale was used to evaluate the methodological quality of the included studies. Read More

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September 2021

Host genetics of pediatric SARS-CoV-2 COVID-19 and multisystem inflammatory syndrome in children.

Curr Opin Pediatr 2021 Sep 15. Epub 2021 Sep 15.

Division of Rheumatology, Cincinnati Children's Hospital Medical Center Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio Division of Rheumatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Purpose Of Review: This review is meant to describe the genetic associations with pediatric severe COVID-19 pneumonia and the postinfectious complication of the multisystem inflammatory syndrome in children (MIS-C). Multiple genetic approaches have been carried out, primarily in adults with extrapolation to children, including genome-wide association studies (GWAS), whole exome and whole genome sequencing (WES/WGS), and target gene analyses.

Recent Findings: Data from adults with severe COVID-19 have identified genomic regions (human leukocyte antigen locus and 3p21. Read More

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September 2021

Pediatric Home Parenteral Nutrition in France: A six years national survey.

Clin Nutr 2021 Aug 14;40(10):5278-5287. Epub 2021 Aug 14.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Necker-Enfants Malades University of Paris-UFR Paris Descartes, Certified Center for Home Parenteral Nutrition, Reference Center for Rare Digestive Diseases in Children, Paris, France. Electronic address:

Background And Aims: Home Parenteral Nutrition (HPN) is the cornerstone management for children suffering from chronic intestinal failure (CIF). In France, HPN is organized from a network of 7 certified centers located in University Hospitals spread across the national territory. This study aims to review the data involving children on HPN over a 6-years period in France to outline the global and continuous improvement in care. Read More

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Anti-Müllerian hormone, testosterone, and insulin-like peptide 3 as biomarkers of Sertoli and Leydig cell function during deslorelin-induced testicular downregulation in the dog.

Theriogenology 2021 Aug 15;175:100-110. Epub 2021 Aug 15.

Department of Obstetrics and Food Animal Medicine Clinic, University of Veterinary Medicine Budapest, Hungary; ATRC Aurigon Ltd., Dunakeszi, Hungary.

The role of anti-Müllerian hormone (AMH) and insulin-like peptide 3 (INSL3) in male infertility is not fully understood. We used the downregulated testis as a model of gonadotropin-dependent infertility. Serum testosterone and AMH concentrations were studied in five adult male Beagles implanted (day 0) with 4. Read More

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Help when you need it: Perspectives of adults with T1D on the support and training they would have wanted when starting CGM.

Diabetes Res Clin Pract 2021 Sep 14:109048. Epub 2021 Sep 14.

Division of Endocrinology and Diabetes, Department of Pediatrics, Stanford University, School of Medicine, Stanford, CA; Stanford Diabetes Research Center, Stanford, CA. Electronic address:

Aims: The purpose of this study was to explore preferences that adults with type 1 diabetes (T1D) have for training and support to initiate and sustain optimal use of continuous glucose monitoring (CGM) technology.

Methods: Twenty-two adults with T1D (M age 30.95±8. Read More

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September 2021

Relationship between time in range, glycemic variability, HbA1c and complications in adults with type 1 diabetes mellitus.

J Clin Endocrinol Metab 2021 Sep 17. Epub 2021 Sep 17.

Endocrinology-Diabetology, University Hospital Antwerp, Edegem, Belgium.

Purpose: Real-time continuous glucose monitoring (RT-CGM) provides information on glycaemic variability (GV), time in range (TIR) and guidance to avoid hypoglycemia, thereby complimenting HbA1c for diabetes management. We investigated whether GV and TIR were independently associated with chronic and acute diabetes complications.

Methods: Between September 2014 and January 2017 515 subjects with type 1 diabetes using sensor-augmented pump therapy were followed for 24 months. Read More

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September 2021

Age-related prescription medication utilization for the -management of sickle cell disease among Texas Medicaid patients.

J Opioid Manag 2021 Jul-Aug;17(4):301-310

College of Pharmacy, The University of Texas at Austin, Austin, Texas.

Introduction: Sickle cell disease (SCD) is associated with recurrent complications and healthcare burden. Although SCD management guidelines differ based on age groups, little is known regarding actual utilization of preventative (hydroxyurea) and palliative therapies (opioid and nonopioid analgesics) to manage complications. This study assessed whether there were agerelated differences in SCD index therapy type and SCD-related medication utilization. Read More

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September 2021

Pulmonary vasculitis in Hughes-Stovin syndrome (HSS): a reference atlas and computed tomography pulmonary angiography guide-a report by the HSS International Study Group.

Clin Rheumatol 2021 Sep 17. Epub 2021 Sep 17.

Serviço de Reumatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Introduction: Hughes-Stovin syndrome (HSS) is a systemic vasculitis characterized by widespread venous/arterial thrombosis and pulmonary artery aneurysms (PAAs), which is associated with serious morbidity and mortality. All fatalities reported in HSS resulted from unpredictable fatal suffocating hemoptysis. Therefore, it is necessary to recognize pulmonary complications at an early stage of the disease. Read More

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September 2021

Characteristic phenotype of Chinese patients with adult-onset diabetes who are autoantibody positive by 3-Screen ICA™ ELISA.

Acta Diabetol 2021 Sep 17. Epub 2021 Sep 17.

NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.

Aims: To assess the prevalence of diabetes-associated autoantibodies in Chinese patients recently diagnosed with adult-onset diabetes and to evaluate the potential role of the autoantibody markers for characterization of disease phenotype in the patient population.

Methods: The study included 1273 recent-onset adult patients with phenotypic type 2 diabetes mellitus (T2DM). Serum samples were tested using the 3-Screen ICA™ ELISA (3-Screen) designed for combined measurement of GADAb and/or IA-2Ab and/or ZnT8Ab. Read More

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September 2021

It is time for TEG in pediatric trauma: unveiling meaningful alterations in children who undergo massive transfusion.

Pediatr Surg Int 2021 Sep 17. Epub 2021 Sep 17.

Division of Pediatric Surgery, Children's Hospital Colorado, Aurora, CO, USA.

Background: Hemorrhage is the leading cause of preventable death in pediatric trauma patients. In adults, goal-directed thrombelastography (TEG) has been shown to reduce mortality when used to guide massive transfusion (MT) resuscitation. There remains a paucity of data on the utility of TEG in directing resuscitation of pediatric trauma patients. Read More

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September 2021

Perceptions of older adults? Measuring positive, negative, and physical descriptors using the stereotype content and strength survey.

J Gerontol Soc Work 2021 Sep 17:1-13. Epub 2021 Sep 17.

Department of Mathematics and Statistics, Utah State University, Logan, UT, USA.

The COVID-19 pandemic has disproportionately impacted the health of older adults. In addition to a higher risk for serious illness and death, the societal value of senescent adults was challenged. There have been conflicting results reported in the research literature regarding positive and negative stereotypes of older adults, and areliable and valid assessment tool to measure content (existence of astereotype) and strength (intensity of astereotype) is unavailable. Read More

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September 2021

Occupational therapy intervention for cancer patients following hospital discharge: How and when should we intervene? A systematic review.

Aust Occup Ther J 2021 Sep 17. Epub 2021 Sep 17.

Occupational Therapy Department, Sir Charles Gairdner Hospital, North Metropolitan Health Service, Perth, Western Australia, Australia.

Introduction: Advances in cancer treatment over the last decade have led to increased survival rates. As a result, survivors are living longer with and beyond cancer, often with greater levels of morbidity. Occupational therapists, with their focus on remedial and compensatory strategies to improve function and participation, are well suited to assess and intervene with this population. Read More

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September 2021