14,612 results match your criteria adults pre-existing


Molecular pathogenesis of pediatric thyroid carcinoma.

J Radiat Res 2021 May;62(Supplement_1):i71-i77

Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.

There has been little understanding of the molecular pathogenesis of pediatric thyroid cancers. Most of them are histologically classified as papillary thyroid carcinoma (PTC). Ionizing radiation is the most important environmental factor to induce PTC, especially in children. Read More

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CBR3 V244M is associated with LVEF reduction in breast cancer patients treated with doxorubicin.

Cardiooncology 2021 May 11;7(1):17. Epub 2021 May 11.

Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA.

Background: The CBR3 V244M single nucleotide polymorphism has been linked to the risk of anthracycline-related cardiomyopathy in survivors of childhood cancer. There have been limited prospective studies examining the impact of CBR3 V244M on the risk for anthracycline-related cardiotoxicity in adult cohorts.

Objectives: This study evaluated the presence of associations between CBR3 V244M genotype status and changes in echocardiographic parameters in breast cancer patients undergoing doxorubicin treatment. Read More

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Disordered eating and self-harm as risk factors for poorer mental health during the COVID-19 pandemic: A population-based cohort study.

medRxiv 2021 May 4. Epub 2021 May 4.

Background: Young adults and especially those with pre-existing mental health conditions, such as disordered eating and self-harm, appear to be at greater risk of developing metal health problems during the COVID-19 pandemic. However, it is unclear whether this increased risk is affected by any changes in lockdown restrictions, and whether any lifestyle changes could moderate this increased risk.

Methods: In a longitudinal UK population-based cohort (The Avon Longitudinal Study of Parents and Children, ALSPAC) we assessed the relationship between pre-pandemic measures of disordered eating and self-harm and mental health during the COVID-19 pandemic in 2,657 young adults. Read More

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Sensitisation patterns and allergy outcomes in pregnant women living in the urban area.

Allergy Asthma Clin Immunol 2021 May 10;17(1):46. Epub 2021 May 10.

1st Department of Pediatrics, Allergology and Cardiology, Wroclaw Medical University, ul. Chalubinskiego 2a, 50-368, Wroclaw, Poland.

Background: Worldwide, allergy affects more than one billion people, with particularly rising prevalence in industrialised areas. Specifically, young adults appear to be predominantly targeted for an allergy diagnosis. Allergic diseases in pregnancy are mainly pre-existing but could also occur de novo. Read More

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Association of metabolic-bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174 772 participants.

Lancet 2021 May 6. Epub 2021 May 6.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Surgery, University Surgical Cluster, National University Health System, Singapore. Electronic address:

Background: Metabolic-bariatric surgery delivers substantial weight loss and can induce remission or improvement of obesity-related risks and complications. However, more robust estimates of its effect on long-term mortality and life expectancy-especially stratified by pre-existing diabetes status-are needed to guide policy and facilitate patient counselling. We compared long-term survival outcomes of severely obese patients who received metabolic-bariatric surgery versus usual care. Read More

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Mental health responses to the COVID-19 pandemic: a latent class trajectory analysis using longitudinal UK data.

Lancet Psychiatry 2021 May 6. Epub 2021 May 6.

Centre for Women's Mental Health, University of Manchester, Manchester, UK; Division of Psychology and Mental Health, University of Manchester, Manchester, UK; Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK.

Background: The mental health of the UK population declined at the onset of the COVID-19 pandemic. Convenience sample surveys indicate that recovery began soon after. Using a probability sample, we tracked mental health during the pandemic to characterise mental health trajectories and identify predictors of deterioration. Read More

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A UK nationwide study of people with type 1 diabetes admitted to hospital with COVID-19 infection.

Diabetologia 2021 May 8. Epub 2021 May 8.

Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Aims/hypothesis: The aim of this work was to describe the clinical characteristics of adults with type 1 diabetes admitted to hospital and the risk factors associated with severe coronavirus disease-2019 (COVID-19) in the UK.

Methods: A retrospective cohort study was performed using data collected through a nationwide audit of people admitted to hospital with diabetes and COVID-19, conducted by the Association of British Clinical Diabetologists from March to October 2020. Prespecified demographic, clinical, medication and laboratory data were collected from the electronic and paper medical record systems of the participating hospitals by local clinicians. Read More

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The COVID-19 Disease Burden in Germany in 2020.

Dtsch Arztebl Int 2021 03;118(9):145-151

Department 2, Epidemiology and Health Monitoring, Robert Koch Institute, Berlin; Department 3, Infectious Disease Epidemiology, Robert Koch Institute, Berlin; Department II 1 Environmental Hygiene, German Environment Agency, Berlin.

Background: The SARS-CoV-2 pandemic presented major challenges to the health sector in 2020. The burden of disease arising from COVID-19 can be expressed as the number of years of life lost to disease or death. For example, death at age 40 involves a loss of far more years of life than death at age 80. Read More

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Effects of khat use on response to antipsychotic medications in patients with newly diagnosed schizophrenia: a retrospective study.

East Mediterr Health J 2021 Apr 27;27(4):353-360. Epub 2021 Apr 27.

The Faculty of Medicine, Jazan University, Jazan, Saudi Arabia.

Background: Khat contains the amphetamine-like cathinone, and can trigger onset of schizophrenia and exacerbate pre-existing psychosis. However, it remains unknown whether the use of khat complicates the outcome of schizophrenia treatment.

Aims: We tested the hypothesis that patients with schizophrenia who are using khat will fail to respond to standard antipsychotic treatment. Read More

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Bilateral simultaneous non-arteritic ischaemic optic neuropathy: a rare complication of idiopathic systemic capillary leak syndrome (SCLS).

BMJ Case Rep 2021 May 4;14(5). Epub 2021 May 4.

Ophthalmology Department, Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.

We report a case of bilateral symmetrical superior visual field defects in a 72-year-old man first reported during the recovery from systemic capillary leak syndrome (SCLS). During the acute illness, he required extensive and prolonged fluid replacement and mechanical ventilation for severe hypotension, shock and multiorgan dysfunction. His visual field defect and optic nerve changes were consistent with a diagnosis of ischaemic optic neuropathy. Read More

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Improving forensics: Characterizing injuries among community-dwelling physically abused older adults.

J Am Geriatr Soc 2021 May 4. Epub 2021 May 4.

Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.

Background: Physical elder abuse affects a substantial number of older adults, leaving victims at increased risk for negative health outcomes. Improved detection of abuse-related injuries may increase victim access to professional support, but providers report difficulties distinguishing between accidental and abuse-related injuries, due in part to victims' pre-existing health conditions and medication use.

Objectives: To describe the spectrum and characteristics of injuries among physically abused older adults and identify injury characteristics associated with abuse. Read More

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Predictors of fatal outcomes of hospitalized COVID-19 patients with pre-existing hypertension in China.

Clin Respir J 2021 May 3. Epub 2021 May 3.

State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Background: Coronavirus disease 2019 (COVID-19) is an emerging, rapidly evolving pandemic, hypertension is one of the most common co-existing chronic conditions and a risk factor for mortality. Nearly one third of the adult population are hypertensive worldwide, it is urgent to identify the factors that determine the clinical course and outcomes of COVID-19 patients with hypertension.

Methods And Results: 148 COVID-19 patients with pre-existing hypertension with clarified outcomes (discharge or deceased) from a national cohort in China were included in this study, of whom 103 were discharged and 45 died in hospital. Read More

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Climate change, environment pollution, COVID-19 pandemic and mental health.

Sci Total Environ 2021 Jun 21;773:145182. Epub 2021 Jan 21.

Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, Italy. Electronic address:

Converging data would indicate the existence of possible relationships between climate change, environmental pollution and epidemics/pandemics, such as the current one due to SARS-CoV-2 virus. Each of these phenomena has been supposed to provoke detrimental effects on mental health. Therefore, the purpose of this paper was to review the available scientific literature on these variables in order to suggest and comment on their eventual synergistic effects on mental health. Read More

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Lifestyle risk factors and infectious disease mortality, including COVID-19, among middle aged and older adults: Evidence from a community-based cohort study in the United Kingdom.

Brain Behav Immun 2021 Apr 30. Epub 2021 Apr 30.

Charles Perkins Centre, School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, NSW, Australia.

In this community-based cohort study, we investigated the relationship between combinations of modifiable lifestyle risk factors and infectious disease mortality. Participants were 468,569 men and women (56.5 ± 8. Read More

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Treatment of Pediatric Alopecia Areata: A Systematic Review.

J Am Acad Dermatol 2021 Apr 30. Epub 2021 Apr 30.

Department of Dermatology, University of California Davis, Sacramento, CA, USA; Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento, CA, USA. Electronic address:

Background: Alopecia areata (AA) is an autoimmune, non-scarring hair loss disorder with slightly greater prevalence in children than adults. Various treatment modalities exist; however, their evidence in pediatric AA patients is lacking.

Methods: We conducted a systematic review on the PubMed database in October 2019 for all published articles involving patients <18 years old. Read More

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Monitoring of human coronaviruses in Belgian primary care and hospitals, 2015-20: a surveillance study.

Lancet Microbe 2021 Mar 27;2(3):e105-e114. Epub 2021 Jan 27.

National Influenza Centre, Sciensano, Brussels, Belgium.

Background: Seasonal human coronaviruses (hCoVs) broadly circulate in humans. Their epidemiology and effect on the spread of emerging coronaviruses has been neglected thus far. We aimed to elucidate the epidemiology and burden of disease of seasonal hCoVs OC43, NL63, and 229E in patients in primary care and hospitals in Belgium between 2015 and 2020. Read More

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Ischaemic bowel perforation secondary to a gravid uterus in a patient with treated inflammatory bowel disease and an ileoanal pouch: a case report.

Ann R Coll Surg Engl 2021 May;103(5):e151-e155

Musgrove Park Hospital, Taunton, UK.

The diagnosis of visceral perforation during pregnancy is often delayed and the management complex. A 32-year-old primigravid woman in her second trimester presented with abdominal pain and a pre-existing ileoanal pouch. Initial imaging was negative but later imaging was suggestive of serious pathology. Read More

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Deployment of the consultation-liaison model in adult and child-adolescent psychiatry and its impact on improving mental health treatment.

BMC Fam Pract 2021 Apr 29;22(1):82. Epub 2021 Apr 29.

Department of Family Medicine and Emergency Medicine, University of Sherbrooke, Sherbrooke, QC, Canada.

Background: Little information exists on the perceptions of psychiatrists regarding the implementation and various impacts of the consultation-liaison model. This model has been used in Quebec (Canada) through the function of specialist respondent-psychiatrists (SRP) since 2009. This study assessed the main activities, barriers or facilitators, and impact of SRP in adult and child-adolescent psychiatry on the capacity of service providers in primary care and youth centers to treat patients with mental health disorders (MHD). Read More

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The Impact of Monitoring Depth of Anesthesia and Nociception on Postoperative Cognitive Function in Adult Multiple Trauma Patients.

Medicina (Kaunas) 2021 Apr 23;57(5). Epub 2021 Apr 23.

Anaesthesia and Intensive Care Clinic, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania.

: Patients with traumatic injuries have often been excluded from studies that have attempted to pinpoint modifiable factors to predict the transient disturbance of the cognitive function in the postoperative settings. Anesthetists must be aware of the high risk of developing postoperative delirium and cognitive dysfunction (POCD) in patients undergoing emergency surgery. Monitoring the depth of anesthesia in order to tailor anesthetic delivery may reduce this risk. Read More

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Emotional Reasoning and Psychopathology.

Brain Sci 2021 Apr 8;11(4). Epub 2021 Apr 8.

Department of Psychology, Telematic University of Rome "Guglielmo Marconi", Via Plinio 44, 00193 Rome, Italy.

One of the several ways in which affect may influence cognition is when people use affect as a source of information about external events. Emotional reasoning, ex-consequentia reasoning, and affect-as-information are terms referring to the mechanism that can lead people to take their emotions as information about the external world, even when the emotion is not generated by the situation to be evaluated. Pre-existing emotions may thus bias evaluative judgments of unrelated events or topics. Read More

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Transition to adult care: Exploring factors associated with transition readiness among adolescents and young people in adolescent ART clinics in Uganda.

PLoS One 2021 29;16(4):e0249971. Epub 2021 Apr 29.

Department of Obstetrics and Gynaecology, College of Health Science, Makerere University, Kampala, Uganda.

Background: Transition readiness refers to a client who knows about his/her illness and oriented towards future goals and hopes, shows skills needed to negotiate healthcare, and can assume responsibility for his/ her treatment, and participate in decision-making that ensures uninterrupted care during and after the care transition to adult HIV care. There is a paucity of research on effective transition strategies. This study explored factors associated with adolescent readiness for the transition into adult care in Uganda. Read More

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Normative tensions in filial caring for a mother with dementia: A narrative perspective.

Dementia (London) 2021 Apr 29:14713012211014003. Epub 2021 Apr 29.

Zorggroep Elde Maasduinen, The Netherlands.

This article aims to gain insight in the normative struggles of adult children caring for their ageing mother living with dementia. Two Dutch autobiographical books written by siblings recording their own caregiving experience were analysed using a narrative design. Children appear to understand their normative concerns through six fields of tension. Read More

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Risk of early failure of VP shunts implanted for hydrocephalus after craniotomies for brain tumors in adults.

Neurosurg Rev 2021 Apr 27. Epub 2021 Apr 27.

Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Risks and survival times of ventriculoperitoneal (VP) shunts implanted due to hydrocephalus after craniotomies for brain tumors are largely unknown. The purpose of this study was to determine the overall timing of VP shunting and its failure after craniotomy for brain tumors in adults. The authors also wished to explore risk factors for early VP shunt failure (within 90 days). Read More

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Pre-existing and machine learning-based models for cardiovascular risk prediction.

Sci Rep 2021 Apr 26;11(1):8886. Epub 2021 Apr 26.

Cardiovascular Center, Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-Ro 173 Beon-Gil, Bundang-Gu, Seongnam-si, 13620, Gyeonggi-Do, Korea.

Predicting the risk of cardiovascular disease is the key to primary prevention. Machine learning has attracted attention in analyzing increasingly large, complex healthcare data. We assessed discrimination and calibration of pre-existing cardiovascular risk prediction models and developed machine learning-based prediction algorithms. Read More

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A systematic scoping review of interventions to optimise medication prescribing and adherence in older adults with cancer.

Res Social Adm Pharm 2021 Apr 17. Epub 2021 Apr 17.

School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland. Electronic address:

Background: Older adults with cancer often require multiple medications (polypharmacy) comprising cancer-specific treatments, supportive care medications (e.g. analgesics), and medications for pre-existing health conditions. Read More

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Implications of cardiac markers in risk-stratification and management for COVID-19 patients.

Crit Care 2021 04 26;25(1):158. Epub 2021 Apr 26.

Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, China.

Background: COVID-19 has resulted in high mortality worldwide. Information regarding cardiac markers for precise risk-stratification is limited. We aim to discover sensitive and reliable early-warning biomarkers for optimizing management and improving the prognosis of COVID-19 patients. Read More

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Levels and predictors of fear and health anxiety during the current outbreak of COVID-19 in immunocompromised and chronic disease patients in Saudi Arabia: A cross-sectional correlational study.

PLoS One 2021 26;16(4):e0250554. Epub 2021 Apr 26.

Department of Biology, College of Science and Arts, King Abdulaziz University, Rabigh, Kingdom of Saudi Arabia.

Coronavirus disease 2019 (COVID-19) infection has become a clinical threat to healthy people as well as immunocompromised patients and those with pre-existing chronic diseases around the world. This study, which used a cross-sectional correlational design, aimed to assess the levels of fear and health anxiety and to investigate their predictors during the current outbreak of COVID-19 in immunocompromised and chronic disease patients in Saudi Arabia. Sociodemographic and clinical data, fear of COVID-19, and health anxiety measurements were collected by online surveys from June 15 to July 15, 2020. Read More

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Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 Multi-Parameter Detection.

Front Immunol 2021 9;12:614676. Epub 2021 Apr 9.

Department of Microbiology, Boston University School of Medicine, Boston, MA, United States.

The COVID-19 pandemic has drastically impacted work, economy, and way of life. Sensitive measurement of SARS-CoV-2 specific antibodies would provide new insight into pre-existing immunity, virus transmission dynamics, and the nuances of SARS-CoV-2 pathogenesis. To date, existing SARS-CoV-2 serology tests have limited utility due to insufficient reliable detection of antibody levels lower than what is typically present after several days of symptoms. Read More

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MSF experiences of providing multidisciplinary primary level NCD care for Syrian refugees and the host population in Jordan: an implementation study guided by the RE-AIM framework.

BMC Health Serv Res 2021 Apr 26;21(1):381. Epub 2021 Apr 26.

Médecins sans Frontières, London, UK.

Background: In response to the rising global NCD burden, humanitarian actors have rapidly scaled-up NCD services in crisis-affected low-and-middle income countries. Using the RE-AIM implementation framework, we evaluated a multidisciplinary, primary level model of NCD care for Syrian refugees and vulnerable Jordanians delivered by MSF in Irbid, Jordan. We examined the programme's Reach, Effectiveness, Adoption and acceptance, Implementation and Maintenance over time. Read More

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