137,392 results match your criteria adults fetal


Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG.

J Mol Cell Cardiol 2021 Jun 9. Epub 2021 Jun 9.

Department of Biomedical Engineering, Case School of Engineering, Case Western Reserve University, Cleveland, OH, USA. Electronic address:

Controlling fibrosis is an essential part of regenerating the post-ischemic heart. In the post-ischemic heart, fibroblasts differentiate to myofibroblasts that produce collagen-rich matrix to physically stabilize the infarct area. Infarct models in adult mice result in permanent scarring unlike newborn animals which fully regenerate. Read More

View Article and Full-Text PDF

Human induced pluripotent stem cell derived hepatocytes provide insights on parenteral nutrition associated cholestasis in the immature liver.

Sci Rep 2021 Jun 11;11(1):12386. Epub 2021 Jun 11.

Department of Pediatrics, Medical College of Wisconsin, 999 N. 92 Street, PO Box 1997, Milwaukee, WI, 53226, USA.

Parenteral nutrition-associated cholestasis (PNAC) significantly limits the safety of intravenous parenteral nutrition (PN). Critically ill infants are highly vulnerable to PNAC-related morbidity and mortality, however the impact of hepatic immaturity on PNAC is poorly understood. We examined developmental differences between fetal/infant and adult livers, and used human induced pluripotent stem cell-derived hepatocyte-like cells (iHLC) to gain insights into the contribution of development to altered sterol metabolism and PNAC. Read More

View Article and Full-Text PDF

Predictive factors for premature birth and respiratory exacerbation in pregnancies of women with cystic fibrosis.

J Pediatr (Rio J) 2021 Jun 8. Epub 2021 Jun 8.

Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pós-Graduação em Ciências Pulmonares, Porto Alegre, RS, Brazil; Hospital de Clínicas de Porto Alegre (HCPA), Serviço de Fisioterapia, Porto Alegre, RS, Brazil. Electronic address:

Objective: In this present study, the authors evaluated the predictive factors for adverse maternal-fetal outcomes in pregnancies of women with cystic fibrosis (CF). Patients were followed up by a referral center for adults in southern Brazil.

Methods: This is a retrospective cohort study that used data from electronic medical records regarding pregnancies of women diagnosed with CF. Read More

View Article and Full-Text PDF

Prostatic alterations associated to early weaning and its relation with cocoa powder supplementation. Experimental study in adult wistar rats.

Int Braz J Urol 2021 May 20;47. Epub 2021 May 20.

Departamento de Anatomia, Unidade de Pesquisa Urogenital, Universidade do Estado do Rio de Janeiro, UERJ, Rio de Janeiro, RJ, Brasil.

Early weaning can predispose the offspring to greater risk of developing chronic diseases in adulthood. It is believed that the consumption of functional foods is able to prevent these effects. The aim of this study is to evaluate the effects of maternal and postnatal cocoa powder supplementation on body mass, metabolism, and morphology of the prostate of early weaned Wistar rats. Read More

View Article and Full-Text PDF

Overexpression of DAZL, STRA8, and BOULE Genes and Treatment With BMP4 or Retinoic Acid Modulate the Expression of MSC Overexpressing Germ Cell Genes.

Front Vet Sci 2021 25;8:667547. Epub 2021 May 25.

Department of Animal Production Sciences, Faculty of Veterinary and Animal Sciences, University of Chile, Santiago, Chile.

gamete derivation from stem cells has potential applications in animal reproduction as an alternative method for the dissemination of elite animal genetics, production of transgenic animals, and conservation of endangered species. Mesenchymal stem cells (MSCs) may be suitable candidates for gamete derivation considering their differentiative capacity and their potential for cell therapy. Due to its relevance in gametogenesis, it has been reported that retinoic acid (RA) and bone morphogenetic protein (BMP) 4 are able to upregulate the expression of specific markers associated to the early stages of germ cell (GCs) differentiation in bovine fetal MSCs (bfMSCs). Read More

View Article and Full-Text PDF

Maternal and Neonatal Factors Affecting Bone Mineral Content of Indonesian Term Newborns.

Front Pediatr 2021 25;9:680869. Epub 2021 May 25.

Department of Neonatology, Amsterdam University Medical Center Location VU University Medical Center, Emma Children's Hospital, VU University Amsterdam, Amsterdam, Netherlands.

Interactions between the genome and intrauterine environment can affect bone mineralization in newborns and even in adult life. Several studies show that intrauterine fetal bone mineralization or early postnatal bone condition influences the risk of osteoporosis in later life. To determine whole body bone mineral content (WB BMC) and factors that influence neonatal WB BMC in Indonesian term newborns. Read More

View Article and Full-Text PDF

Evidence of Zika virus circulation in asymptomatic pregnant women in Northeast, Brazil.

PLoS Negl Trop Dis 2021 Jun 10;15(6):e0009412. Epub 2021 Jun 10.

Post-Graduate Program in Adult Health, Federal University of Maranhão, São Luís, Maranhão, Brazil.

Background: Zika virus (ZIKV) is a flavivirus associated with microcephaly and other fetal anormalities. However, evidence of asymptomatic ZIKV infection in pregnant women is still scarce. This study investigated the prevalence of Zika infection in asymptomatic pregnant women attending two public maternities in Maranhão state, Northeast Brazil. Read More

View Article and Full-Text PDF

Progress Toward Rubella Elimination - World Health Organization European Region, 2005-2019.

MMWR Morb Mortal Wkly Rep 2021 Jun 11;70(23):833-839. Epub 2021 Jun 11.

In 2005, the Regional Committee of the World Health Organization (WHO) European Region (EUR) passed a resolution calling for the regional elimination of measles, rubella, and congenital rubella syndrome (CRS) (1). In 2010, all 53 countries in EUR* reaffirmed their commitment to eliminating measles, rubella, and CRS (2); this goal was included in the European Vaccine Action Plan 2015-2020 (3,4). Rubella, which typically manifests as a mild febrile rash illness, is the leading vaccine-preventable cause of birth defects. Read More

View Article and Full-Text PDF

Developmental Programming and Aging of Male Reproductive Function.

Eur J Clin Invest 2021 Jun 9:e13637. Epub 2021 Jun 9.

Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México.

Developmental programming predisposes offspring to metabolic, behavioral, and reproductive dysfunction in adult life. Evidence is accumulating that aging phenotype and longevity are in part developmentally programmed in each individual. Unfortunately, there are few studies addressing the effects of developmental programming by maternal nutrition on the rate of aging of the male reproductive system. Read More

View Article and Full-Text PDF

Exposure of human fetal kidneys to mild analgesics interferes with early nephrogenesis.

FASEB J 2021 Jul;35(7):e21718

Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.

Acetaminophen, aspirin, and ibuprofen are mild analgesics commonly used by pregnant women, the sole current recommendation being to avoid ibuprofen from the fifth month of gestation. The nephrotoxicity of these three analgesics is well documented in adults, as is their interference with prostaglandins biosynthesis. Here we investigated the effect of these analgesics on human first trimester kidneys ex vivo. Read More

View Article and Full-Text PDF

Birth weight is positively associated with adult osteoporosis risk: observational and Mendelian randomization studies.

J Bone Miner Res 2021 Jun 9. Epub 2021 Jun 9.

Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Suzhou, China.

The relationship between birth weight and osteoporosis was inconsistent in previous observational studies. Therefore, we performed a systematic evaluation to determine the inconsistent relationship and further make causal inference based on the UK Biobank datasets (~500,000 individuals) and individual/summary-level genetic datasets. Observational analyses found consistent negative associations either between birth weight and estimated bone mineral density (eBMD) or between genetic risk score (GRS) of birth weight and eBMD in total subjects, and sex-stratified subgroups. Read More

View Article and Full-Text PDF

Reproductive diseases in captive Agoutis (Dasyprocta leporina).

Braz J Biol 2021 4;82:e237869. Epub 2021 Jun 4.

The University of the West Indies - UWI, Faculty of Food and Agriculture - FFA, Department of Food Production - DFP, The Open Tropical Forage-Animal Production Laboratory - OTF-APL, St. Augustine, Trinidad and Tobago.

Reproductive diseases have been well documented in domestic livestock such as sheep, goat, cattle and pigs. However, there is very little information on these diseases in the agouti (Dasyprocta leporina). The agouti is used for its meat in South America and the Caribbean. Read More

View Article and Full-Text PDF

Predictability of Macrosomic Birth based on Maternal Factors and Fetal Aneuploidy Screening Biochemical Markers in Hyperglycemic Mothers.

Int J Med Sci 2021 13;18(12):2653-2660. Epub 2021 May 13.

Department of Obstetrics and Gynecology, Korea University Medicine, Seoul 02841, Korea.

Macrosomic birth weight has been implicated as a significant risk factor for developing various adult metabolic diseases such as diabetes mellitus and coronary heart diseases; it has also been associated with higher incidences of complicated births. This study aimed to examine the predictability of macrosomic births in hyperglycemic pregnant women using maternal clinical characteristics and serum biomarkers of aneuploidy screening performed in the first half of pregnancy. A retrospective observational study was performed on a cohort of 1,668 pregnant women who 1) had positive outcomes after undergoing 50-g oral glucose challenge test (OGCT) at two university-based hospitals and 2) underwent any one of the following maternal biomarker screening tests for fetal aneuploidy: triple test, quadruple test, and integrated test. Read More

View Article and Full-Text PDF

Diagnostic performance of cerebroplacental and umbilicocerebral ratio in appropriate for gestational age and late growth restricted fetuses attempting vaginal delivery: a multicenter, retrospective study.

J Matern Fetal Neonatal Med 2021 Jun 8:1-7. Epub 2021 Jun 8.

Fetal Medicine Unit, Maternal and Child Health and Development Network, Department of Obstetrics and Gynecology, University Hospital 12 de Octubre, Complutense University of Madrid, Madrid, Spain.

Background: Cerebroplacental Doppler studies have been advocated to predict the risk of adverse perinatal outcome (APO) irrespective of fetal weight.

Objective: To report the diagnostic performance of cerebroplacental (CPR) and umbilicocerebral (UCR) ratios in predicting APO in appropriate for gestational age (AGA) fetuses and in those affected by late fetal growth restriction (FGR) attempting vaginal delivery.

Study Design: Multicenter, retrospective, nested case-control study between 1 January 2017 and January 2020 involving five referral centers in Italy and Spain. Read More

View Article and Full-Text PDF

Early life antibiotics influence in vivo and in vitro mouse intestinal epithelium maturation and functioning.

Cell Mol Gastroenterol Hepatol 2021 Jun 5. Epub 2021 Jun 5.

Department of Pediatrics, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands; Danone Nutricia Research, 3584 CT Utrecht, The Netherlands.

Background & Aims: The use of antibiotics (AB) is a common practice during the first months of life. AB can perturb the intestinal microbiota, indirectly influencing the intestinal epithelial cells (IECs), but also directly affect IECs, independent of the microbiota. Previous studies have mostly focused on the impact of AB treatment during adulthood. Read More

View Article and Full-Text PDF

Parvovirus B19 in Pregnancy: A Case Review.

J Midwifery Womens Health 2021 Jun 8. Epub 2021 Jun 8.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Alpert Medical School of Brown University, Providence, Rhode Island.

Parvovirus B19 has been identified as the cause of erythema infectiosum, a common childhood illness. Also known as fifth disease, this virus is highly contagious among school-age children, especially during the winter months when outbreaks within classrooms are widespread. The majority of adults have had the infection in childhood and are immune to recurrence. Read More

View Article and Full-Text PDF

Placental endocrine insufficiency programs anxiety, deficits in cognition and atypical social behaviour in offspring.

Hum Mol Genet 2021 Jun 7. Epub 2021 Jun 7.

Biomedicine Division, School of Biosciences, Cardiff University, Cardiff, UK, CF10 3AX, UK.

Abnormally elevated expression of the imprinted PHLDA2 gene has been reported in the placenta of human babies that are growth restricted in utero in several studies. We previously modelled this gene alteration in mice and found that just two-fold increased expression of Phlda2 resulted in placental endocrine insufficiency. In addition, elevated Phlda2 was found to drive fetal growth restriction (FGR) of transgenic offspring and impaired maternal care by their wild type mothers. Read More

View Article and Full-Text PDF

Mutations in were associated with growth traits in sheep ().

Anim Biotechnol 2021 Jun 7:1-7. Epub 2021 Jun 7.

College of Agriculture and Animal Husbandry, Qinghai University, Xining, People's Republic of China.

For its role in the mediation of myoblast proliferation, fibroblast growth factor receptor 1 () was considered a functional candidate gene for growth performance in Tibetan sheep. Via the polymerase chain reaction-restriction fragment length polymorphism (PCR-PFLP) approach, four single nucleotide polymorphisms (SNPs) including g.14752C > T (intron 1), g. Read More

View Article and Full-Text PDF

Research in Sickle Cell Disease: From Bedside to Bench to Bedside.

Hemasphere 2021 Jun 1;5(6):e584. Epub 2021 Jun 1.

Sickle Cell Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Sickle cell disease (SCD) is an exemplar of bidirectional translational research, starting with a remarkable astute observation of the abnormally shaped red blood cells that motivated decades of bench research that have now translated into new drugs and genetic therapies. Introduction of hydroxyurea (HU) therapy, the only SCD-modifying treatment for >30 years and now standard care, was initiated through another clinical observation by a pediatrician. While the clinical efficacy of HU is primarily due to its fetal hemoglobin (HbF) induction, the exact mechanism of how it increases HbF remains not fully understood. Read More

View Article and Full-Text PDF

Construction of a Human Cell Landscape of COVID-19 Infection at Single-cell Level.

Aging Dis 2021 Jun 1;12(3):705-709. Epub 2021 Jun 1.

1State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

COVID-19 is now causing a global pandemic, there is a demand to explain the different clinical patterns between children and adults. To clarify the organs/cell types vulnerable to COVID-19 infection and the potential age-depended expression patterns of five factors (, , , , ) associated with clinical symptoms. In this study, we analyzed expression levels of five COVID-19 host dependency factors in multiple adult and fetal human organs. Read More

View Article and Full-Text PDF

Enhanced HbF reactivation by multiplex mutagenesis of thalassemic CD34+ cells in vitro and in vivo.

Blood 2021 Jun 4. Epub 2021 Jun 4.

University of Washington, Seattle, Washington, United States.

Thalassemia or sickle cell patients with hereditary persistence of fetal hemoglobin (HPFH) have an ameliorated clinical phenotype and in some cases, can achieve transfusion independence. Inactivation via genome editing of γ-globin developmental suppressors, such as BCL11A or LRF/ZBTB7A, or of their binding sites have been shown to significantly increase expression of endogenous fetal hemoglobin (HbF). To broaden the therapeutic window beyond a single editing approach, we have explored combinations of cis and trans editing targets to enhance HbF reactivation. Read More

View Article and Full-Text PDF

Differentiation of Fetal Sertoli Cells in the Adult Testis.

Reproduction 2021 Jun 1. Epub 2021 Jun 1.

B Capel, Cell Biology, Duke University Medical Center, Durham, United States.

Sertoli cells proliferate and construct seminiferous tubules during fetal life, then undergo differentiation and maturation in the prepubertal testes. In the adult testes, mature Sertoli cells maintain spermatogonia and support spermatogenesis during the entire lifetime. Although Sertoli-like cells have been derived from iPS cells, they tend to remain immature. Read More

View Article and Full-Text PDF

Estimated glomerular filtration rate and cardiometabolic risk factors in a longitudinal cohort of children.

Sci Rep 2021 Jun 3;11(1):11702. Epub 2021 Jun 3.

Maternal-Fetal Metabolic Research Group, Girona Biomedical Research Institute (IDIBGI), Parc Hospitalari Martí I Julià, Edifici M2, 17190, Salt, Spain.

Associations between glomerular filtration rate (GFR) and cardiometabolic risk factors have been reported in adult and pediatric patients with renal disease. We aimed to assess the relationship between the estimated GFR (eGFR) and cardiometabolic risk factors in apparently healthy children. A longitudinal study in 401 asymptomatic Caucasian children (mean age 8 years) followed up after 4 years (mean age 12 years). Read More

View Article and Full-Text PDF

Early-life exposure to tris (1,3-dichloro-2-propyl) phosphate caused multigenerational neurodevelopmental toxicity in zebrafish via altering maternal thyroid hormones transfer and epigenetic modifications.

Environ Pollut 2021 May 28;285:117471. Epub 2021 May 28.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.

Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP), an alternative to brominated flame retardants, might pose an exposure risk to humans and wild animals during fetal development. Our recent study suggested that short-term TDCIPP exposure during early development caused sex-dependent behavioral alteration in adults. In the present study, multigenerational neurodevelopmental toxicity upon early-life exposure of parental zebrafish was evaluated, and the possible underlying mechanisms were further explored. Read More

View Article and Full-Text PDF

Intrauterine endogenous high glucocorticoids program ovarian dysfunction in female offspring secondary to prenatal caffeine exposure.

Sci Total Environ 2021 May 25;789:147691. Epub 2021 May 25.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China; Department of Gynaecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address:

Ovarian dysfunction has an intrauterine origin, and prenatal caffeine exposure (PCE) could lead to abnormal follicle counts in offspring after birth. However, the effect of PCE on offspring ovarian function and its mechanism of intrauterine programming have not been reported thus far. In this study, pregnant Wistar rats were intragastrically administered caffeine (30 and 120 mg/kg·d) at gestational days 9-20 (GD9-20). Read More

View Article and Full-Text PDF

Choroidal melanocytes: subpopulations of different origin?

Ann Anat 2021 May 31:151775. Epub 2021 May 31.

Center for Anatomy and Cell Biology, Institute of Anatomy and Cell Biology - Salzburg, Paracelsus Medical University, Salzburg, Austria. Electronic address:

Background: The human choroid derives from the mesectoderm, except the melanocytes originating from the neuroectoderm. To date, it is unclear whether all choroidal melanocytes share the same origin or might have different origins. The purpose of this study was to screen immunohistochemically for mesenchymal elements in the adult healthy human choroid, in the malignant melanoma of the choroid, as well as in the developing human fetal choroid. Read More

View Article and Full-Text PDF

Metabolic remodeling precedes mTORC1-mediated cardiac hypertrophy.

J Mol Cell Cardiol 2021 Jun 1;158:115-127. Epub 2021 Jun 1.

Division of Cardiology, Department of Internal Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address:

Rationale: The nutrient sensing mechanistic target of rapamycin complex 1 (mTORC1) and its primary inhibitor, tuberin (TSC2), are cues for the development of cardiac hypertrophy. The phenotype of mTORC1 induced hypertrophy is unknown.

Objective: To examine the impact of sustained mTORC1 activation on metabolism, function, and structure of the adult heart. Read More

View Article and Full-Text PDF

The role of demethylases in cardiac development and disease.

J Mol Cell Cardiol 2021 May 31;158:89-100. Epub 2021 May 31.

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, United States of America; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States of America. Electronic address:

Heart failure is a worldwide health condition that currently has limited noninvasive treatments. Heart disease includes both structural and molecular remodeling of the heart which is driven by alterations in gene expression in the cardiomyocyte. Therefore, understanding the regulatory mechanisms which instigate these changes in gene expression and constitute the foundation for pathological remodeling may be beneficial for developing new treatments for heart disease. Read More

View Article and Full-Text PDF

Copy Number Variations Analysis Identifies QPRT as a Candidate Gene Associated With Susceptibility for Solitary Functioning Kidney.

Front Genet 2021 17;12:575830. Epub 2021 May 17.

Department of Neurosurgery, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, China.

Background: The lack of understanding of molecular pathologies of the solitary functioning kidney makes improving and strengthening the continuity of care between pediatric and adult nephrological patients difficult. Copy number variations (CNVs) account for a molecular cause of solitary functioning kidney, but characterization of the pathogenic genes remains challenging.

Methods: In our prospective cohort study, 99 fetuses clinically diagnosed with a solitary functioning kidney were enrolled and evaluated using chromosomal microarray analysis (CMA). Read More

View Article and Full-Text PDF

Histological comparison of malignant epithelioid mesothelioma in young and adult cattle.

J Vet Med Sci 2021 Jun 3. Epub 2021 Jun 3.

Hokkaido Research Station, National Institute of Animal Health, National Agriculture and Food Research Organization.

The histology and immunohistochemistry of pleomorphic and conventional epithelioid mesotheliomas were examined. The former was detected in two young calves aged 2 and 4 months and was characterized by pleomorphic and atypical cells with decreased expression of cytokeratin 7 (CK7). In contrast, the latter was found in a 31-month-old heifer, consisting of tumor cells uniform in size and shape with CK7 expression in nearly all cells. Read More

View Article and Full-Text PDF