121,196 results match your criteria adults dementia


On the prevention and treatment of Alzheimer's disease: Control the promoters and look beyond the brain.

Med Hypotheses 2021 Jul 19;154:110645. Epub 2021 Jul 19.

Harvard Medical School Multi-Campus Geriatric Fellowship, Boston, Massachusetts, USA. Electronic address:

Alzheimer's disease (AD) is a progressive incurable neurodegenerative disease of the brain afflicting a third of the population aged 85 and older. Pathologic hallmarks include extracellular plaques of amyloid-beta (Aß), intraneuronal neurofibrillary tangles of hyperphosphorylated tau protein, synaptic destruction, neuronal death, and brain atrophy. Neuroinflammation, mediated by microglia, is a central component of the disease, and is intricately connected with peripheral inflammation. Read More

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Speech Understanding in Modulated Noise and Speech Maskers as a Function of Cognitive Status in Older Adults.

Am J Audiol 2021 Jul 27:1-13. Epub 2021 Jul 27.

Department of Communication Disorders, University of Massachusetts Amherst.

Objectives The purpose of this study was to investigate the impact of different types of maskers on speech understanding as a function of cognitive status in older adults. The hypothesis tested was that individuals with a diagnosis of mild cognitive impairment (MCI) or mild dementia would perform like their age- and hearing status-matched control counterparts in modulated noise but would perform more poorly in the presence of competing speech. Design Participants ( = 39; age range: 55-77 years old) performed a speech-in-noise task and completed two cognitive screening tests and a measure of working memory. Read More

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Self-rated health and incident dementia over two decades: Replication across two cohorts.

J Psychiatr Res 2021 Jun 18. Epub 2021 Jun 18.

College of Medicine, Florida State University, USA.

This prospective study examined the association between self-rated health and incident dementia in two large cohorts of middle-aged and older adults. Participants were drawn from the Health and Retirement Study (HRS, N = 13,839, Mean Age = 64.32, SD = 9. Read More

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The value of deprescribing in older adults with dementia: a narrative review.

Expert Rev Clin Pharmacol 2021 Jul 26. Epub 2021 Jul 26.

School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.

: Mitigating the burden of unnecessary polypharmacy or multiple medication use in people living with dementia has been recognized as a key priority internationally. One approach to reducing inappropriate polypharmacy is through medication withdrawal or deprescribing. The aim of this narrative review is to appraise current evidence on the safety and efficacy of deprescribing in older people with dementia. Read More

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Behavioral variations among vascular cognitive impairment subtypes - A comparative study.

Appl Neuropsychol Adult 2021 Jul 22:1-8. Epub 2021 Jul 22.

Department of Neurology, Institute of Postgraduate Medical Education and Research Bangur Institute of Neurology, Kolkata, India.

Dementia of vascular origin is a distinct variety with a heterogeneous neuropsychological profile. Very few studies have compared the behavioral dysfunction in the large vessel and small vessel vascular dementia (VaD) and studied the association between executive dysfunction and behavioral dysfunction documented in these patients, between the white matter load in small vessel disease (SVD) and the behavioral dysfunction. 76 patients having a modified Hachinski Ischemic Scale score of ≥ 4 were recruited and categorized into a small vessel and large vessel VaD. Read More

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Physical Activity and its Influencing Factors in Community-Dwelling Older Adults With Dementia: A Path Analysis.

Clin Nurs Res 2021 Jul 22:10547738211033928. Epub 2021 Jul 22.

Peking University First Hospital, Beijing, China.

Dementia is prevalent in worldwide, and increases the care burden and potential costs. Physical activity (PA) has been increasingly shown to be beneficial for them. This was a cross-sectional observational study aiming to investigate the status of PA among community-dwelling older adults with dementia in Beijing or Hangzhou, China, and verify the relationships between neuropsychiatric symptoms, activities of daily living (ADL), caregivers' fear of patients' falling and their PA using a path analysis approach. Read More

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Resting-state brain connectivity in healthy young and middle-aged adults at risk of progressive Alzheimer's disease.

Neurosci Biobehav Rev 2021 Jul 23. Epub 2021 Jul 23.

Edinburgh Dementia Prevention and Centre for Clinical Brain Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom.

Functional brain connectivity of the resting-state networks has gained recent attention as a possible biomarker of Alzheimer's Disease (AD). In this paper, we review the literature of functional connectivity differences in young adults and middle-aged cognitively intact individuals with non-modifiable risk factors of AD (n = 17). We focus on three main intrinsic resting-state networks: The Default Mode network, Executive network, and the Salience network. Read More

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Disrupted anterior and posterior hippocampal structural networks correlate impaired verbal memory and spatial memory in different subtypes of MCI.

Eur J Neurol 2021 Jul 26. Epub 2021 Jul 26.

State Key Laboratory of Cognitive Neuroscience and Learning & IDG, McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.

Background And Purpose: The anterior and posterior hippocampal networks represent verbal and spatial memory respectively, and may play different roles in the pathological mechanism of amnestic mild cognitive impairment (aMCI) and non-amnestic MCI (naMCI), which hasn't been explored.

Methods: A total of 990 older adults with 791 normal control (NC, 65 ± 6 years, 502 women), 140 aMCI (66 ± 7 years, 84 women) and 59 naMCI (66 ± 7 years, 38 women) were included. We used a multivariate method, partial least squares, to assessed the structural covariance network of anterior hippocampus (aHC) and posterior hippocampus (pHC), and their relationships with verbal memory and spatial memory in the three groups. Read More

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Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study.

Alzheimers Dement 2021 Jul 26. Epub 2021 Jul 26.

Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.

Introduction: No large-scale characterizations of neurofilament light chain (NfL) have been conducted in diverse populations.

Methods: Baseline data were analyzed among n = 890 Mexican Americans and n = 813 non-Hispanic Whites from the multi-ethnic Health & Aging Brain among Latino Elders (HABLE) study. Plasma NfL was measured on the Simoa platform. Read More

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Metabolite signature of Alzheimer's disease in adults with Down syndrome.

Ann Neurol 2021 Jul 26. Epub 2021 Jul 26.

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Objective: To examine the Alzheimer's Disease metabolite signature through magnetic resonance spectroscopy in adults with Down syndrome and its relation with Alzheimer's Disease biomarkers and cortical thickness.

Methods: We included 118 adults with Down syndrome from the Down Alzheimer Barcelona Imaging Initiative and 71 euploid healthy controls from the Sant Pau Initiative on Neurodegeneration cohort. We measured the levels of myo-inositol (a marker of neuroinflammation) and N-acetyl-aspartate (a marker of neuronal integrity) in the precuneus using magnetic resonance spectroscopy. Read More

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[Analysis of brain perfusion single-photon emission tomography images using an easy Zscore imaging system for early diagnosis of Alzheimer's disease].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jul;41(7):1093-1100

Department of Nuclear Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To analyze single-photon emission tomography (SPECT) images of cerebral blood flow perfusion using an easy Z-score imaging system (eZIS) and explore the value of SPECT and eZIS in early diagnosis of Alzheimer's disease (AD).

Methods: We retrospectively analyzed the clinical data of 71 subjects undergoing brain perfusion SPECT examination in our department from September, 2018 to September, 2020 and identified 31 eligible subjects for this study. Among these subjects, according to the NIA-AA criteria (2011 edition), 12 were diagnosed with mild cognitive impairment due to AD (MCI) and 11 with AD dementia stage (AD); 8 elderly subjects were healthy without cognitive impairment (NC). Read More

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Multiple Cognitive and Behavioral Factors Link Association Between Brain Structure and Functional Impairment of Daily Instrumental Activities in Older Adults.

J Int Neuropsychol Soc 2021 Jul 26:1-14. Epub 2021 Jul 26.

Department of Psychiatry, Seoul Metropolitan Government-Seoul National University College Boramae Medical Center, Seoul, Republic of Korea.

Objective: Functional impairment in daily activity is a cornerstone in distinguishing the clinical progression of dementia. Multiple indicators based on neuroimaging and neuropsychological instruments are used to assess the levels of impairment and disease severity; however, it remains unclear how multivariate patterns of predictors uniquely predict the functional ability and how the relative importance of various predictors differs.

Method: In this study, 881 older adults with subjective cognitive complaints, mild cognitive impairment (MCI), and dementia with Alzheimer's type completed brain structural magnetic resonance imaging (MRI), neuropsychological assessment, and a survey of instrumental activities of daily living (IADL). Read More

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Centrally-acting anticholinergic drugs- associations with mortality, hospitalisation and cognitive decline following dementia diagnosis in people receiving antidepressant and antipsychotic drugs.

Aging Ment Health 2021 Jul 26:1-9. Epub 2021 Jul 26.

Mental Health for Older Adults and Dementia Clinical Academic Group, South London and Maudsley NHS Foundation Trust, London, UK.

Objectives: Long-term use of anticholinergic medication in older people is associated with increased risk of cognitive decline and mortality, but this relationship could be confounded by the underlying illness the drugs are treating. To investigate associations between central anticholinergic antidepressants or antipsychotics and mortality, hospitalisation and cognitive decline in people with dementia.

Method: In cohorts of patients with a dementia diagnosis receiving antidepressant and/or antipsychotic medication ( = 4,380 and  = 2,335 respectively), assembled from a large healthcare database, central anticholinergic burden scores were estimated using the Anticholinergic Effect on Cognition (AEC) scale. Read More

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Neither Blood Culture Positivity nor Time to Positivity Is Associated With Mortality Among Patients Presenting With Severe Manifestations of Sepsis: The FABLED Cohort Study.

Open Forum Infect Dis 2021 Jul 17;8(7):ofab321. Epub 2021 Jun 17.

Division of Infectious Diseases, McGill University Health Center, McGill University, Montreal, Quebec, Canada.

Background: Sepsis is a leading cause of morbidity, mortality, and health care costs worldwide.

Methods: We conducted a multicenter, prospective cohort study evaluating the yield of blood cultures drawn before and after empiric antimicrobial administration among adults presenting to the emergency department with severe manifestations of sepsis. Enrolled patients who had the requisite blood cultures drawn were followed for 90 days. Read More

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Alpha-Synuclein Pathology Coincides With Increased Number of Early Stage Neural Progenitors in the Adult Hippocampus.

Front Cell Dev Biol 2021 7;9:691560. Epub 2021 Jul 7.

Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Hanover, Germany.

Alpha-synuclein pathology driven impairment in adult neurogenesis was proposed as a potential cause of, or at least contributor to, memory impairment observed in both patients and animal models of Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB). Mice overexpressing wild-type alpha-synuclein under the Thy-1 promoter (Thy1-aSyn, line 61) uniquely replicate early cognitive deficits together with multiple other characteristic motor and non-motor symptoms, alpha-synuclein pathology and dopamine loss. Here we report overt intracellular accumulation of phosphorylated alpha-synuclein in the hippocampus of these transgenic mice. Read More

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Performance of the Rowland Universal Dementia Assessment Scale for the Detection of Mild Cognitive Impairment and Dementia in a Diverse Cohort of Illiterate Persons From Rural Communities in Peru.

Front Neurol 2021 7;12:629325. Epub 2021 Jul 7.

Department of Neurology, University of California, San Francisco, San Francisco, CA, United States.

The accurate diagnosis of neurocognitive disorders in illiterate Peruvian populations is challenging, largely owing to scarcity of brief cognitive screening tools (BCST) validated in these diverse populations. The Peruvian version of the Rowland Universal Dementia Assessment Scale (RUDAS-PE) is a BCST that relies minimally on educational attainment and has shown good diagnostic accuracy in an urban illiterate population in Peru, yet its psychometric properties in illiterate populations in rural settings of the country have not been previously investigated. To establish the diagnostic accuracy of the RUDAS-PE compared to expert clinical diagnosis using the Clinical Dementia Rating (CDR) Scale in healthy and cognitively impaired illiterate persons living in two culturally and geographically distinct rural communities of Peru. Read More

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Hearing Loss and Dementia: A Meta-Analysis of Prospective Cohort Studies.

Front Aging Neurosci 2021 8;13:695117. Epub 2021 Jul 8.

Jiangsu Provincial Key Medical Discipline (Laboratory), Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

Consensus is lacking with regard to whether hearing loss is an independent risk factor for dementia. We therefore conducted a meta-analysis to clarify the relationship of hearing loss and dementia. Prospective cohort studies investigating the association between hearing loss and the incidence of dementia in a community-derived population were included by searching electronic databases that included PubMed, Embase, and Cochrane's Library. Read More

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[The efficacy of modified mini-mental state examination in patients with severe to profound hearing loss].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Jul;35(7):577-581

Department of Otolaryngology Head and Neck Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Ear Institute,Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases(14DZ2260300.

To evaluate the efficacy of modified mini-mental state examination(MMSE) in elderly patients with severe to profound hearing loss. A total of 24 elderly patients with severe to profound hearing loss from April to June 2019 were involved. Severe to profound hearing loss was defined by a pure-tone average of hearing thresholds at 0. Read More

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Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study.

Lancet Neurol 2021 Aug;20(8):615-626

Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Background: Due to trisomy of chromosome 21 and the resultant extra copy of the amyloid precursor protein gene, nearly all adults with Down syndrome develop Alzheimer's disease pathology by the age of 40 years and are at high risk for dementia given their increased life expectancy compared with adults with Down syndrome in the past. We aimed to compare CSF biomarker patterns in Down syndrome with those of carriers of autosomal dominant Alzheimer's disease mutations to enhance our understanding of disease mechanisms in these two genetic groups at high risk for Alzheimer's disease.

Methods: We did a cross-sectional study using data from adults enrolled in the Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study, a multisite longitudinal study of Alzheimer's disease in Down syndrome, as well as a cohort of carriers of autosomal dominant Alzheimer's disease mutations and non-carrier sibling controls enrolled in the Dominantly Inherited Alzheimer Network (DIAN) study. Read More

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Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study.

Lancet Neurol 2021 Aug;20(8):605-614

Sant Pau Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Madrid, Spain; Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain; Horizon 21 Consortium, Paris, France. Electronic address:

Background: Adults with Down syndrome are at an ultra-high risk of Alzheimer's disease, but diagnosis of Alzheimer's disease in this population is challenging. We aimed to validate the clinical utility of plasma neurofilament light chain (NfL) for the diagnosis of symptomatic Alzheimer's disease in Down syndrome, assess its prognostic value, and establish longitudinal changes in adults with Down syndrome.

Methods: We did a multicentre cohort study, including adults with Down syndrome (≥18 years), recruited from six hospitals and university medical centres in France, Germany, Spain, the UK, and the USA, who had been assessed, followed up, and provided at least two plasma samples. Read More

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Undiagnosed Endoscopy Capsule Retention Causing Delayed Intestinal Obstruction in a Patient with a Small Bowel Neuroendocrine Tumor.

Am J Case Rep 2021 Jul 24;22:e932419. Epub 2021 Jul 24.

2nd Propaedeutic Department of Surgery, Aristotle University School of Medicine, Hippokration General Hospital, Thessaloniki, Greece.

BACKGROUND Capsule endoscopy has played a significant role in small bowel investigation, providing the opportunity of detecting neoplastic lesions to a greater degree and at an earlier stage than other diagnostic procedures. Failure to excrete the capsule with the feces within 48 h can lead to capsule retention with increased risk of further complications such as bowel obstruction and perforation. Capsule retention can remain undetected in case of incomplete follow-up and poor patient compliance. Read More

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Sociodemographic aspects and health care-related outcomes: a latent class analysis of informal dementia care dyads.

BMC Health Serv Res 2021 Jul 23;21(1):727. Epub 2021 Jul 23.

Department of Social Services, Centre for Participation Research, Catholic University of Applied Sciences of North Rhine-Westphalia, Cologne, Germany.

Background: Studies revealed the importance to assess dementia care dyads, composed of persons with dementia and their primary informal caregivers, in a differentiated way and to tailor support services to particular living and care circumstances. Therefore, this study aims first to identify classes of dementia care dyads that differ according to sociodemographic, care-related and dementia-specific characteristics and second, to compare these classes with regard to healthcare-related outcomes.

Methods: We used data from the cross-sectional German DemNet-D study (n = 551) and conducted a latent class analysis to investigate different classes of dementia care dyads. Read More

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Effects of 1 Year of Lifestyle Intervention on Institutionalized Older Adults.

Int J Environ Res Public Health 2021 Jul 17;18(14). Epub 2021 Jul 17.

Polo Universitario Asti Studi Superiori (Uni-Astiss), 14100 Asti, Italy.

The socio-economic and health consequences of our ageing population are well documented, with older adults living in long-term care facilities amongst the frailest possessing specific and significant healthcare and social care needs. These needs may be exacerbated through the sedentary behaviour which is prevalent within care home settings. Reducing sedentary time can reduce the risk of many diseases and improve functional health, implying that improvements in health may be gained by simply helping older adults substitute time spent sitting with time spent standing or in light-intensity ambulation. Read More

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The Association between Physical Activity and Selected Parameters of Psychological Status and Dementia in Older Women.

Int J Environ Res Public Health 2021 Jul 15;18(14). Epub 2021 Jul 15.

Department of Clinical Psychology, Poznan University of Medical Sciences, 60-535 Poznan, Poland.

Physical activity has an unquestionable impact on broadly understood human health. One interesting issue related to this is the importance of movement on mental health and cognitive functioning. Research shows that regular physical activity improves the cognitive functioning of adults and people with mental disorders. Read More

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The effect of dance interventions on cognition, neuroplasticity, physical function, depression, and quality of life for older adults with mild cognitive impairment: A systematic review and meta-analysis.

Int J Nurs Stud 2021 Jun 30;122:104025. Epub 2021 Jun 30.

Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Level 2, Clinical Research Centre, Block MD 11,10 Medical Drive, Singapore 117597, Singapore. Electronic address:

Background: Mild cognitive impairment is an age-related cognitive disorder which is associated with frequent memory lapses, impaired judgement, and progressive functional decline. If untreated early, 39.2% of people with mild cognitive impairment could progress to develop dementia. Read More

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Clinical characteristics of COVID-19 in older adults. A retrospective study in long-term nursing homes in Catalonia.

PLoS One 2021 23;16(7):e0255141. Epub 2021 Jul 23.

Infectious Diseases Department, Hospital Universitari Vall d´Hebron, Barcelona, Spain.

The natural history of COVID-19 and predictors of mortality in older adults need to be investigated to inform clinical operations and healthcare policy planning. A retrospective study took place in 80 long-term nursing homes in Catalonia, Spain collecting data from March 1st to May 31st, 2020. Demographic and clinical data from 2,092 RT-PCR confirmed cases of SARS-CoV-2 infection were registered, including structural characteristics of the facilities. Read More

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Association of Sleep and β-Amyloid Pathology Among Older Cognitively Unimpaired Adults.

JAMA Netw Open 2021 Jul 1;4(7):e2117573. Epub 2021 Jul 1.

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco.

Importance: Disrupted sleep commonly occurs with progressing neurodegenerative disease. Large, well-characterized neuroimaging studies of cognitively unimpaired adults are warranted to clarify the magnitude and onset of the association between sleep and emerging β-amyloid (Aβ) pathology.

Objective: To evaluate the associations between daytime and nighttime sleep duration with regional Aβ pathology in older cognitively unimpaired adults. Read More

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Current advances in digital cognitive assessment for preclinical Alzheimer's disease.

Alzheimers Dement (Amst) 2021 20;13(1):e12217. Epub 2021 Jul 20.

Center for Alzheimer Research and Treatment Department of Neurology, Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA.

There is a pressing need to capture and track subtle cognitive change at the preclinical stage of Alzheimer's disease (AD) rapidly, cost-effectively, and with high sensitivity. Concurrently, the landscape of digital cognitive assessment is rapidly evolving as technology advances, older adult tech-adoption increases, and external events (i.e. Read More

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Person-centered dementia care in home care services - highly recommended but still challenging to obtain: a qualitative interview study.

BMC Health Serv Res 2021 Jul 22;21(1):723. Epub 2021 Jul 22.

The Research Centre for Age-related Functional Decline and Disease, Innlandet Hospital Trust, Brumunddal, Norway.

Background: Dementia is one of the main causes of disability and dependence in older people, and people with dementia need comprehensive healthcare services, preferably in their own homes. A well-organized home care service designed for people with dementia is necessary to meet their needs for health- and social care. Therefore, it is important to gain knowledge about how people with dementia experience the home care service and if the service responds to their wishes and needs. Read More

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