332,878 results match your criteria adult livers


Bisphenol A disrupts apolipoprotein E expression through estrogen-related receptor gamma and DNA methlylation in the liver of male rare minnow Gobiocypris rarus.

Ecotoxicol Environ Saf 2021 Dec 1;228:113041. Epub 2021 Dec 1.

College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.

An increasing number of studies show that bisphenol A (BPA) can cause lipid metabolism disorder. However, few studies focused on the effect of BPA on lipid transport. Apolipoprotein E (ApoE) plays important roles in triglyceride (TG) transportation. Read More

View Article and Full-Text PDF
December 2021

Wnt signaling in biliary development, proliferation, and fibrosis.

Exp Biol Med (Maywood) 2021 Dec 3:15353702211061376. Epub 2021 Dec 3.

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Biliary fibrosis is an important pathological indicator of hepatobiliary damage. Cholangiocyte is the key cell type involved in this process. To reveal the pathogenesis of biliary fibrosis, it is essential to understand the normal development as well as the aberrant generation and proliferation of cholangiocytes. Read More

View Article and Full-Text PDF
December 2021

Intact Preparation of the Lymph Gland for a Comprehensive Analysis of Larval Hematopoiesis.

Bio Protoc 2021 Nov 5;11(21):e4204. Epub 2021 Nov 5.

Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India.

Blood cells have a limited lifespan and are replenished by a small number of hematopoietic stem and progenitor cells (HSPCs). Adult vertebrate hematopoiesis occurs in the bone marrow, liver, and spleen, rendering a comprehensive analysis of the entire HSPC pool nearly impossible. The blood system is well studied and has developmental, molecular, and functional parallels with that of vertebrates. Read More

View Article and Full-Text PDF
November 2021

Generation of in situ CRISPR-mediated primary and metastatic cancer from monkey liver.

Signal Transduct Target Ther 2021 Dec 3;6(1):411. Epub 2021 Dec 3.

National Center for International Research of Biotargeting Theranostics, Guangxi Key Laboratory of Biotargeting Theranostics, Guangxi Medical University, Nanning, Guangxi, 530021, China.

Non-human primates (NHPs) represent the most valuable animals for drug discovery. However, the current main challenge remains that the NHP has not yet been used to develop an efficient translational medicine platform simulating human diseases, such as cancer. This study generated an in situ gene-editing approach to induce efficient loss-of-function mutations of Pten and p53 genes for rapid modeling primary and metastatic liver tumors using the CRISPR/Cas9 in the adult cynomolgus monkey. Read More

View Article and Full-Text PDF
December 2021

Protocol for a prospective double-blind, randomised, placebo-controlled feasibility trial of octreotide infusion during liver transplantation.

BMJ Open 2021 Dec 2;11(12):e055864. Epub 2021 Dec 2.

Division of Surgery & Interventional Science, University College London, London, UK.

Introduction: Liver transplantation is a complex operation that can provide significant improvements in quality of life and survival to the recipients. However, serious complications are common and include major haemorrhage, hypotension and renal failure. Blood transfusion and the development of acute kidney injury lead to both short-term and long-term poor patient outcomes, including an increased risk of death, graft failure, length of stay and reduced quality of life. Read More

View Article and Full-Text PDF
December 2021

Perceived acceptability of partial enteral nutrition (PEN) using oral nutritional supplement drinks in adolescent and adult Crohn's disease outpatients: A feasibility study.

Clin Nutr ESPEN 2021 Dec 12;46:276-287. Epub 2021 Oct 12.

University College London Hospital NHS Foundation Trust, Department of Nutrition and Dietetics, 3rd Floor East, 250 Euston Road, London, NW1 2PG, UK. Electronic address:

Background And Aims: Studies, mainly in Japanese cohorts, have shown that partial enteral nutrition (PEN) including oral nutritional supplement (ONS) drinks can prolong disease remission and increase drug effectiveness in Crohn's disease (CD). Acceptability is a key feasibility parameter to determine whether PEN is a viable treatment option in UK CD patients. We report the results of a single centre cross-sectional feasibility study carried out to investigate perceived acceptability of PEN using ONS drinks and whether ONS preference varies with sex, nutritional status or phenylthiocarbamide (PTC) sensitivity. Read More

View Article and Full-Text PDF
December 2021

Novel screening model of obstructive sleep apnea for snorers with suspected NAFLD undergoing liver sonography.

BMC Pulm Med 2021 Nov 26;21(1):387. Epub 2021 Nov 26.

Department of Otolaryngology-Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, No. 6, Sec. W., Jiapu Rd., Puzi City, 613, Chiayi County, Taiwan.

Background/aims: Given the increased incidence of obstructive sleep apnea (OSA) among patients with nonalcoholic fatty liver disease (NAFLD), noninvasive screening methods are urgently needed to screen for OSA risk in these patients when conducting an office-based assessment of hepatic steatosis. Therefore, we investigated the controlled attenuation parameter (CAP) and hepatic steatosis index (HSI) in patients with and without OSA and developed screening models to detect OSA.

Methods: We retrospectively reviewed the medical records of all adult snorers with suspected NAFLD undergoing liver sonography between June 2017 and June 2020. Read More

View Article and Full-Text PDF
November 2021

Tissue distribution and endocrine disruption effects of chronic exposure to pharmaceuticals and personal care products mixture at environmentally relevant concentrations in zebrafish.

Aquat Toxicol 2021 Nov 24;242:106040. Epub 2021 Nov 24.

School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China. Electronic address:

Pharmaceuticals and personal care products (PPCPs) as emerging contaminants are ubiquitously present in the aquatic environment. Using in vivo and in silico techniques, this study aims to elucidate tissue distribution and endocrine disruption effects of chronic exposure (120 days) to PPCP mixture at environmentally relevant concentrations (ERCs) in adult zebrafish. Results from UHPLC-MS/MS analyses showed elevated distribution of PPCPs in zebrafish tissues in the order of liver > gonad > brain. Read More

View Article and Full-Text PDF
November 2021

Hepatobiliary Findings in Nigerian Children with Sickle Cell Anaemia.

West Afr J Med 2021 Oct;Vol. 38(10):917-923

Department of Medicine, College of Medicine/ Lagos University Teaching Hospital, Lagos.

Introduction: Hepatobiliary abnormalities occur commonly in sickle cell anaemia and these have been extensively reported in the adult patients. However, complications have been sparsely reported in children especially in the sub-Saharan African continent. This study aimed to highlight the hepatobiliary complications in this group of children using clinical examination, laboratory testing and abdominal ultrasonography. Read More

View Article and Full-Text PDF
October 2021

Disparities in Unmet Needs in Indigenous and Non-Indigenous Australians with Cirrhosis: An Exploratory Study.

Patient Prefer Adherence 2021 24;15:2649-2658. Epub 2021 Nov 24.

QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.

Purpose: Understanding and responding to the supportive care needs of people with cirrhosis is essential to quality care. Indigenous Australians, Aboriginal and Torres Strait Islander people, are overrepresented amongst patients with cirrhosis. This study documented the nature and extent of supportive care needs of Indigenous Australians with cirrhosis, in comparison with non-Indigenous Australians. Read More

View Article and Full-Text PDF
November 2021

Treatment outcomes among patients admitted to hospital with antiretroviral and/or antituberculosis drug-induced liver injury.

S Afr Med J 2021 Apr 30;111(5):474-481. Epub 2021 Apr 30.

Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: South Africa (SA) has among the highest rates of HIV and tuberculosis (TB) in the world. Antituberculosis and antiretroviral treatment (ART) can cause drug-induced liver injury (DILI), consequences of which are disease relapse, treatment failure and drug resistance.

Objectives: To: (i) determine the demographics of patients with DILI and the proportion of patients on antituberculosis drugs v. Read More

View Article and Full-Text PDF

Hepatitis E virus infection increases the risk of diabetes and severity of liver disease in patients with chronic hepatitis C virus infection.

Clinics (Sao Paulo) 2021 26;76:e3270. Epub 2021 Nov 26.

Divisao de Gastroenterologia e Hepatologia Clinica, Departamento de Gastroenterologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: Co-infection with hepatitis A or B viruses may aggravate liver injury in patients infected with hepatitis C virus (HCV). However, few studies have assessed co-infection with hepatitis E virus (HEV) and HCV. Therefore, this study aimed to assess the prevalence and impact of HEV infection among Brazilian patients with chronic HCV infection. Read More

View Article and Full-Text PDF
November 2021

Afamin predicts the prevalence and incidence of nonalcoholic fatty liver disease.

Clin Chem Lab Med 2021 Dec 2. Epub 2021 Dec 2.

Department of Genetics and Pharmacology, Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.

Objectives: In the general population, increased afamin concentrations are associated with the prevalence and incidence of metabolic syndrome as well as type 2 diabetes. Although metabolic syndrome is commonly associated with nonalcoholic fatty liver disease (NAFLD), there exist no information on afamin and NAFLD.

Methods: Afamin concentrations were cross-sectionally measured in 146 Austrian patients with NAFLD, in 45 patients without NAFLD, and in 292 age- and sex-matched healthy controls. Read More

View Article and Full-Text PDF
December 2021

Middle hepatic vein reconstruction in adult living donor liver transplantation: a randomized clinical trial.

Br J Surg 2021 Nov 25. Epub 2021 Nov 25.

Department of Gastrointestinal Surgery & Solid Organ Transplant, Amrita Institute of Medical Sciences & Research Centre, Amrita University, Kochi, India.

Background: In adult right lobe living donor liver transplantation (LDLT), venous drainage of the anterior sector is usually reconstructed on the bench to form a neo-middle hepatic vein (MHV). Reconstruction of the MHV for drainage of the anterior sector is crucial for optimal graft function. The conduits used for reconstruction include cryopreserved allografts, synthetic grafts, or the recipient portal vein. Read More

View Article and Full-Text PDF
November 2021

Blood test assessment of liver ultrasound findings in patients with Fontan surgery.

Am J Cardiovasc Dis 2021 25;11(5):611-617. Epub 2021 Oct 25.

Ophthalmology Service, Hospital Universitario de Gran Canaria Dr. Negrín Las Palmas de Gran Canaria, Spain.

Hepatic complications are common in patients with Fontan surgery. The objective of this observational study is to compare demographic, clinical and blood test data in patients older than 14 years old with a Fontan procedure (cases) and asymptomatic patients with single non-operated restrictive ventricular septal defect (VSD) (controls) and to determine whether there are differences in blood collection and liver disease scores according to the liver ultrasound findings in the group of Fontan patients. The liver findings were classified as mild (normal or heterogeneous echogenicity) and significant (nodular surface, small hyperechoic nodules or hepatocarcinoma). Read More

View Article and Full-Text PDF
October 2021

Alpha-1 antitrypsin deficiency: a re-surfacing adult liver disorder.

J Hepatol 2021 Nov 27. Epub 2021 Nov 27.

Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Health Care Provider of the European Reference Network on Rare Liver Disorders (ERN RARE LIVER), Aachen, Germany. Electronic address:

Alpha-1 antitrypsin deficiency (AATD) arises from mutations in the SERPINA1 gene encoding alpha-1 antitrypsin (AAT) that lead to AAT retention in the endoplasmic reticulum of hepatocytes, causing proteotoxic liver injury and loss-of-function lung disease. The homozygous Pi*Z mutation (Pi*ZZ genotype) is responsible for the majority of severe AATD cases and can precipitate both pediatric and adult liver diseases, while the heterozygous Pi*Z mutation (Pi*MZ genotype) is an established modifier of liver disease. We review genotype-related hepatic phenotypes/disease predispositions. Read More

View Article and Full-Text PDF
November 2021

Chronic Liver Disease in Homeless Individuals and Performance of Non-Invasive Liver Fibrosis and Injury Markers: VALID Study.

Liver Int 2021 Nov 30. Epub 2021 Nov 30.

Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, Brighton, UK.

Background/aims: Community-based assessment and management of chronic liver disease (CLD) in people who are homeless (PWAH) remains poorly described. We aimed to determine prevalence/predictors of chronic liver disease (CLD) in PWAH and assess performance of non-invasive hepatocyte fibrosis and injury markers.

Methods: The Vulnerable Adult LIver Disease (VALID) study provided a "one-stop" liver service based at homeless hostels. Read More

View Article and Full-Text PDF
November 2021

Giant liver teratoma with gliosis peritonei treated by right extended hepatectomy: Overview and case report.

Ann Hepatobiliary Pancreat Surg 2021 Nov;25(4):544-550

Department of Surgical Oncology, Soft Tissue, Bone Tumors and Digestive Tract Tumors, Oncology Hospital, XXI Century National Medical Center, Mexican Institute of Social Security, Mexico City, Mexico.

Germ cell tumors (GCTs) are considered as extragonadal if there is no evidence of a primary tumor in the testes or ovaries. GCTs can be classified as seminomas, non-seminomatous, mature teratomas, and immature teratomas based upon histology. Mature teratomas are generally found in prepuberal children. Read More

View Article and Full-Text PDF
November 2021

Acquired diaphragmatic hernia after hepatectomy and liver transplantation in adults and children: A case series and literature review.

Ann Hepatobiliary Pancreat Surg 2021 Nov;25(4):462-471

Department of Digestive Diseases, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.

Backgrounds/aims: Acquired diaphragmatic hernia is a rare complication following liver surgery in adult and pediatric patients. This study aims to describe main features occurring in adult and pediatric patients after liver surgery and report an up-date review of the literature.

Methods: All adult and pediatric patients who were diagnosed with postoperative acquired diaphragmatic hernia in Lyon and Marseille University Hospitals were included in this study. Read More

View Article and Full-Text PDF
November 2021

The presence of polystyrene nanoplastics enhances the MCLR uptake in zebrafish leading to the exacerbation of oxidative liver damage.

Sci Total Environ 2021 Nov 26:151749. Epub 2021 Nov 26.

College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China; Hubei Provincial Engineering Laboratory for Pond Aquaculture, Wuhan 430070, China. Electronic address:

The accumulation of diminutive plastic waste in the environment, including microplastics and nanoplastics, has threatened the health of multiple species. Nanoplastics can adsorb the pollutants from the immediate environment, and may be used as carriers for pollutants to enter organisms and bring serious ecological risk. To evaluate the toxic effects of microcystin-LR (MCLR) on the liver of adult zebrafish (Danio rerio) in the presence of 70 nm polystyrene nanoplastics (PSNPs), zebrafish were exposed to MCLR alone (0, 0. Read More

View Article and Full-Text PDF
November 2021

Primary Hyperoxaluria Type 1 (PH1) Presenting With End-Stage Kidney Disease and Cutaneous Manifestations in Adulthood: A Case Report.

Can J Kidney Health Dis 2021 22;8:20543581211058931. Epub 2021 Nov 22.

Department of Medicine, Dalhousie University, Halifax, NS, Canada.

Rationale: Primary hyperoxaluria (PH) is a rare autosomal recessive disorder more commonly diagnosed in children or adolescents. Owing to its rarity and heterogeneous phenotype, it is often underrecognized, resulting in delayed diagnosis, including diagnosis after end-stage kidney disease (ESKD) has occurred or recurrence after kidney-only transplantation.

Case Presentation: A 40-year-old Caucasian Canadian woman with a history of recurrent nephrolithiasis since age 19 presented with ESKD and cutaneous symptoms. Read More

View Article and Full-Text PDF
November 2021

Efficacy of bilateral erector spinae block for post-operative analgesia in liver hydatid surgery.

Br J Pain 2021 Nov 22;15(4):376-379. Epub 2020 Oct 22.

Department of Anesthesia, Habib Thameur Hospital, Tunis, Tunisia.

Background: Erector spinae plane (ESP) block is a recently described interfacial block, and since 2016, studies have shown that it is a safe technique related to the lower risk of neurovascular and pleural injury comparing to epidural or paravertebral blockade. The application of ESP block in abdominal surgery is relatively limited to case reports and small population studies, which is why we believe every new case of its application should be a valuable contribution.

Case Presentation: With this present case, we explored the efficacy of bilateral ESP block as a post-operative analgesia technique for liver hydatid surgery on a 56-year-old patient. Read More

View Article and Full-Text PDF
November 2021

"Eh - What type of cells are these - flourishing in the liver?" Cancer patients' disclosure of existential concerns in routine hospital consultations.

Patient Educ Couns 2021 Nov 23. Epub 2021 Nov 23.

Centre for Medical Ethics, University of Oslo, Oslo, Norway. Electronic address:

Objective: Advanced cancer poses a threat to all aspects of being, potentially causing existential suffering. We explore what kind of existential concerns patients with advanced cancer disclose during a routine hospital consultation, and how they communicate such concerns.

Methods: We analyzed thirteen video-recorded hospital consultations involving adult patients with advanced cancer. Read More

View Article and Full-Text PDF
November 2021

Virtual Monoenergetic Spectral Detector CT for Preoperative CT Angiography in Liver Donors.

Curr Probl Diagn Radiol 2021 Nov 2. Epub 2021 Nov 2.

Department of Radiology, Lahey Hospital and Medical Center, Burlington, MA.

Objective: The purpose of this study was to evaluate the use of virtual monoenergetic images (VMI) in pre-operative CT angiography of potential donors for living donor adult liver transplantation (LDALT), and to determine the optimal energy level to maximize vascular signal-to-noise and contrast-to-noise ratios (SNR and CNR, respectively).

Materials And Methods: We retrospectively evaluated 29 CT angiography studies performed preoperatively in potential liver donors on a spectral detector CT scanner. All studies included arterial, early venous, and delayed venous phase imaging. Read More

View Article and Full-Text PDF
November 2021

Prevalence of HIV infection and high-risk behaviors in truck and bus drivers in Kurdistan province.

BMC Infect Dis 2021 Nov 28;21(1):1198. Epub 2021 Nov 28.

Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Background: Truck, bus, transit drivers, and men with mobile jobs are at high risk for HIV/AIDS. The purpose of this study was to investigate the prevalence of HIV and risky behaviors among truck and bus drivers in Kurdistan province.

Methods: This cross-sectional study was conducted on 601 bus and truck drivers in Kurdistan province during 2018-2019. Read More

View Article and Full-Text PDF
November 2021

Studying the electrolyte changes in ileal urine at the time of radical cystectomy and ileal conduit diversion.

Arch Ital Urol Androl 2021 Oct 4;93(3):375-378. Epub 2021 Oct 4.

Urology Department, Alexandria University, Alexandria, Egypt; Urology Department, Northern Ontario School of Medicine, Thunder Bay, ON.

To the Editor, Radical cystectomy (RC) for bladder cancer is a life-changing surgery, associated with high morbidity and mortality rate. Ileal neobladder seems as an attractive way for urine management post cystectomy but would carry the risk of retaining urine in the ileal pouch for a long time, resulting in serum electrolyte changes, that may add to the patients' morbidity. EAU guidelines recommend against ileal neobladder for patients with liver and renal disorders, as well as for patients > 80 years old [. Read More

View Article and Full-Text PDF
October 2021

HCV disease burden and population segments in Switzerland.

Liver Int 2021 Nov 27. Epub 2021 Nov 27.

CDA Foundation, Lafayette, Colorado, USA.

Background: Switzerland has made strides towards hepatitis C virus elimination, but as of 2019, elimination was not guaranteed. However, political interest in viral hepatitis has been increasing. We sought to develop a better understanding of Switzerland's progress toward HCV elimination and the profile of remaining HCV-RNA positive patients. Read More

View Article and Full-Text PDF
November 2021

Acute Fatty Liver of Pregnancy.

Am J Case Rep 2021 Nov 28;22:e933252. Epub 2021 Nov 28.

Graduate Medical Education Intarnal Medicine, Piedmont Athens Regional Medical Center, Athens, GA, USA.

BACKGROUND Acute fatty liver of pregnancy (AFLP) is a rare obstetric emergency resulting from microvesicular infiltration of the liver by fat, leading to liver failure. It usually presents at 36 weeks of gestation, and risk factors include twin pregnancy and low BMI. The presentation of AFLP is nonspecific, requiring a high index of suspicion. Read More

View Article and Full-Text PDF
November 2021

Transient congenital hyperinsulinism and hemolytic disease of a newborn despite rhesus D prophylaxis: a case report.

J Med Case Rep 2021 Nov 26;15(1):573. Epub 2021 Nov 26.

Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.

Background: In neonates, rhesus D alloimmunization despite anti-D immunoglobulin prophylaxis is rare and often unexplained. Rhesus D alloimmunization can lead to hemolytic disease of the newborn with anemia and unconjugated hyperbilirubinemia. In past reports, transient congenital hyperinsulinism has been described as a rare complication of rhesus D alloimmunization. Read More

View Article and Full-Text PDF
November 2021

Long noncoding RNAs associated with nonalcoholic fatty liver disease in a high cholesterol diet adult zebrafish model.

Sci Rep 2021 Nov 26;11(1):23005. Epub 2021 Nov 26.

Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea.

The mechanism of nonalcoholic fatty liver disease (NAFLD) has not been completely revealed. In this study, we investigated the association of liver histological changes and long noncoding RNAs (lncRNAs) in the NAFLD zebrafish model. Forty zebrafish were fed a high-cholesterol diet (1. Read More

View Article and Full-Text PDF
November 2021