7,612,993 results match your criteria adult human

Transgenerational effects of selenomethionine on behaviour, social cognition, and the expression of genes in the serotonergic pathway in zebrafish.

Environ Pollut 2021 May 3;286:117289. Epub 2021 May 3.

Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, Saskatchewan, S7N 5E2, Canada; Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon, Saskatchewan, S7N 5B3, Canada.

Elevated levels of contaminants from human activities have become a major threat to animals, particularly within aquatic ecosystems. Selenium (Se) is a naturally occurring element with a narrow range of safe intake, but excessive Se has toxicological effects, as it can bioaccumulate and cause cognitive and behavioural impairments. In this study, we investigated whether exposure to Se would also have transgenerational effects, causing changes in the descendants of exposed individuals. Read More

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Hepatology 2021 May 10. Epub 2021 May 10.

Institute of Liver Studies, MowatLabs, Department of Inflammation Biology, School of Immunology & Microbial Sciences, Faculty of Liver Sciences and Medicine, King's College London, London, UK.

Background And Aims: Genetic predisposition to autoimmune hepatitis (AIH) in adults is associated with possession of HLA class I (A*01, B*08) and class II alleles (DRB1*03, -04, -07 or -13), depending on geographic regions. Juvenile autoimmune liver disease (AILD) comprises AIH-1, AIH-2 and autoimmune sclerosing cholangitis (ASC), which are phenotypically different from their adult counterparts. We aimed to define the relationship between HLA profile and disease course, severity and outcome in juvenile AILD. Read More

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The immune protection induced by a serine protease from the Trichinella spiralis adult against Trichinella spiralis infection in pigs.

PLoS Negl Trop Dis 2021 May 10;15(5):e0009408. Epub 2021 May 10.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.

Trichinellosis is a major foodborne parasitosis caused by Trichinella spiralis. In the present study, a serine protease gene from an adult T. spiralis (Ts-Adsp) cDNA library was cloned, expressed in Escherichia coli and purified by Ni-affinity chromatography. Read More

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A clinical study protocol for COVID-19 rehabilitation with herbal medicine and cardiorespiratory exercise.

JMIR Res Protoc 2021 Apr 12. Epub 2021 Apr 12.

Centre for Health and Exercise Science Research, Hong Kong Baptist University, Hong Kong Baptist UniversityKowloon Tong, Kowloon, HK.

Background: Recent studies revealed that most discharged patients with COVID-19 suffered ongoing symptoms months later. Rehabilitation interventions can help address the consequences of COVID-19. These include medically, physically, cognitively and psychologically related problems. Read More

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Dynamic changes occur in the DNA gut virome of female cynomolgus macaques during aging.

Microbiologyopen 2021 Mar;10(2):e1186

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Aging is a critical factor affecting physical health and disease in mammals. Emerging evidence indicates that aging may affect the gut bacteriome in cynomolgus macaques, but little is known about whether or how the gut virome changes with age. Here, we compared the DNA gut viral composition of 16 female cynomolgus monkeys (Macaca fascicularis) at three life stages (young, adult, and old) using the shotgun metagenome sequencing method. Read More

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Resuscitative Effect of Centhaquine (Lyfaquin) in Hypovolemic Shock Patients: A Randomized, Multicentric, Controlled Trial.

Adv Ther 2021 May 10. Epub 2021 May 10.

Pharmazz India Private Limited, Greater Noida, India.

Introduction: Centhaquine (Lyfaquin) showed significant efficacy as a resuscitative agent in animal models of haemorrhagic shock. Its safety and tolerability were confirmed in healthy human volunteers. In this study, our primary objective was to determine the safety, and the secondary objective was to assess the efficacy of centhaquine in patients with hypovolemic shock. Read More

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Therapeutic Potential of Cytokines in Demyelinating Lesions After Stroke.

J Mol Neurosci 2021 May 10. Epub 2021 May 10.

Department of Rehabilitation Medicine, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China.

White matter damage is a component of most human stroke and usually accounts for at least half of the lesion volume. Subcortical white matter stroke (WMS) accounts for 25% of all strokes and causes severe motor and cognitive dysfunction. The adult brain has a very limited ability to repair white matter damage. Read More

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Intraspecific and Interspecific Attachment Between Cohabitant Dogs and Human Caregivers.

Integr Comp Biol 2021 May 10. Epub 2021 May 10.

Department of Animal & Rangeland Sciences, Oregon State University, Corvallis Oregon, 97331, USA.

In recent years there has been growing interest in uncovering evolutionary and lifetime factors that may contribute to the domestic dog's (Canis lupus familiaris) success in anthropogenic environments. The readiness with which dogs form social attachments, their hyper-social focus, and social flexibility have all been areas of investigation. Prior research has demonstrated that many pet dogs form infant-caregiver type attachments towards human caretakers, even into adulthood. Read More

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Right aortic arch forming a true vascular ring: a clinical review.

Eur J Cardiothorac Surg 2021 May 10. Epub 2021 May 10.

Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, Netherlands.

Objectives: This review aims at presenting and summarizing the current state of literature on the presentation and surgical management of a right-sided aortic arch with a left-sided ligamentum forming a complete vascular ring around the oesophagus and trachea.

Methods: A systematic database search for appropriate literature was conducted on PubMed/MEDLINE. Articles were considered relevant when providing details on the presentation, diagnosis and surgical treatment of this specific congenital arch anomaly in human beings. Read More

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Unconscious Bias Is a Human Condition.

Mihal Emberton

Perm J 2021 May;25

Permanente Medical Group, Adult and Family Medicine, San Francisco, CA.

None: The unconscious bias that plagues our police departments is the same unconscious bias that plagues business in the form of employee oppression and burnout, that plagues academia in the form of social promotion and fixed mindset, that plagues law in the form of poetic injustice and that plagues politics in the form of disenfranchisement and voter suppression. Each industry has also attempted to correct the negative effects of unconscious bias with leadership development in business, Montessori method and active learning in academia, restorative justice in law, and voter participation and town halls in politics. The reason that each of these efforts is still in its infancy is that our understanding of the rules of unconscious bias and the behaviors that stem from that unconscious bias have been incompletely understood until now. Read More

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Exploring the association of early life physical activity and risk of dementia: a systematic review.

Minerva Med 2021 May 10. Epub 2021 May 10.

NESMOS Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.

Introduction: Physical activity has been included in the list of twelve modifiable risk factors for dementia, despite conflicting results from observational and controlled studies. In particular it is not clear whether physical inactivity near the time of dementia diagnosis is a consequence or cause of dementia. We review all available studies reporting the possible association between having engaged in PA before 60 years of age and the risk of dementia. Read More

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Weight teasing experienced during adolescence and young adulthood: Cross-sectional and longitudinal associations with disordered eating behaviors in an ethnically/racially and socioeconomically diverse sample.

Int J Eat Disord 2021 May 10. Epub 2021 May 10.

Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.

Objective: This study assessed cross-sectional and longitudinal relationships between weight teasing and disordered eating in an ethnically/racially and socioeconomically diverse sample of young people and examined these relationships across sociodemographic characteristics.

Method: The EAT 2010-2018 study surveyed adolescents (n = 1,534) in the Minneapolis/St. Paul public schools (mean age = 14. Read More

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Real-Time Video Scan Method for Community Partner Use to Inform Play Streets Implementation.

Health Promot Pract 2021 May 10:15248399211009789. Epub 2021 May 10.

Johns Hopkins University, Baltimore, MD, USA.

System for Observing Play and Recreation in Communities (SOPARC) can provide accurate assessment of physical activity; however, the skills, time, and human resources necessary to collect/interpret SOPARC data can be challenging for community organizations. This article describes a more accessible adaptation of SOPARC using video recordings for community organizations to obtain physical activity feedback at Play Streets. Narrated panoramic video scans occurred every 30 minutes at each Play Street using an iPad. Read More

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HTLV-1-Associated Lymphoma Presented as Massive Lymphadenopathy.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211013235

Brookdale University Hospital Medical Center, Brooklyn, NY, USA.

Adult T-cell leukemia/lymphoma is an aggressive T-cell malignancy caused by the long-term infection of human T-cell lymphotropic virus type 1 (HTLV-1). Our understanding of clinical features still largely relies on the Shimoyama classification developed 30 years ago, which described the 4 clinical subtypes (the smoldering, chronic, lymphoma, and acute types) based on the manifestations of lymphocytosis, elevated lactate dehydrogenase, hypercalcemia, lymphadenopathy, and involvement of the skin, lung, liver, spleen, central nervous system, bone, ascites, pleural effusion, and gastrointestinal tract. HTLV-1-associated lymphoma has a variety of presentations but the presentation of massive lymphadenopathy and compression symptoms is rare and has not been emphasized in the literature. Read More

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Which factors influence Demodex proliferation? A retrospective pilot study highlighting a possible role of subtle immune variations and sebaceous gland status.

J Dermatol 2021 May 9. Epub 2021 May 9.

Institut de Recherche Interdisciplinaire en Biologie humaine et moléculaire (IRIBHM), Université libre de Bruxelles (ULB), Brussels, Belgium.

Demodex folliculorum and brevis are commensal mites that live in low densities in human pilosebaceous follicles as part of the normal adult microbiota, but that give rise to demodicosis and, possibly, rosacea, when they proliferate excessively. This proliferation is favored by various factors, including age, marked immunosuppression, sebaceous gland hyperplasia, and hypervascularization-related factors. To study possible factors influencing mite proliferation, we explored the effects of different variables on Demodex densities (Dd) in a retrospective study of two groups of subjects selected on the basis of their clinical diagnosis: Demodex+, consisting of subjects with demodicosis or with centro-facial papulopustules suggesting rosacea (n = 844, mean Dd 263. Read More

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A review on the motivations, decision-making factors, attitudes and experiences of couples using pre-implantation genetic testing for inherited conditions.

Hum Reprod Update 2021 May 10. Epub 2021 May 10.

Division of Surgery and Cancer, Institute of Developmental Reproductive & Developmental Biology, Imperial College London, Chelsea and Westminster Hospital Campus, London, UK.

Background: In pre-implantation genetic testing (PGT), fertile couples undergo IVF with genetic testing of embryos to avoid conceptions with a genetic condition. There is an exponentially increasing uptake with over 600 applications listed by the Human Fertilisation and Embryology Authority in the UK. The psychological aspects of the decision-making process and the experience of PGT, however, are relatively underevaluated, with the potential to leave patients unsupported in their journeys. Read More

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The Psychological Impact of COVID-19 Among Pakistani Adults in Lahore.

Front Public Health 2021 21;9:578366. Epub 2021 Apr 21.

Department of Psychology, Forman Christian College: A Chartered University, Lahore, Pakistan.

In the wake of the worldwide spread of the novel coronavirus and the resultant restrictive measures, mental health has become a crucial issue. Physical health is not the only aspect of humans that is at risk. Globally, the rates and severity of mental illness are being significantly impacted by this pandemic. Read More

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Quality of life in patients with Marfan syndrome: a cross-sectional study of 102 adult patients.

Cardiovasc Diagn Ther 2021 Apr;11(2):602-610

Department of Sport and Health Sciences, Chair of Sport Psychology, Technical University Munich, Munich, Germany.

Background: Marfan syndrome (MFS) is a genetically determined multiorgan disease that leads to severe physiological and psychological impairments in adult life. Little consensus exists regarding quality of life (QOL) in individuals with MFS. The present study sought to investigate QOL in a representative cohort of adults with MFS. Read More

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Adult Perfomance on the Sustained Auditory Attention Skill Test.

Int Arch Otorhinolaryngol 2021 Apr 23;25(2):e249-e254. Epub 2020 Jun 23.

Postgraduate Program in Speech Therapy, Faculdade de Odontologia de Bauru, Universidade de São Paulo, Bauru, SP, Brazil.

 The Sustained Auditory Attention Ability Test (SAAAT) is an instrument used to assess sustained auditory attention in children. Difficulties related to this ability are not unique to children alone, as adults have been observed to present with the same deficits. Therefore, there is a need to adapt instruments like the SAAAT and provide reference values for adults. Read More

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Cardiac tissue engineering using human stem cell-derived cardiomyocytes for disease modeling and drug discovery.

Drug Discov Today Dis Models 2012 21;9(4):e219-e227. Epub 2012 Dec 21.

Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY.

Cardiovascular disease (CVD) is the most prevalent health problem in the world, and the high mortality rate associated with irreversibly injured heart muscle motivates an urgent need for the development of novel therapies to treat damaged myocardium. Recently, human engineered cardiac tissues (hECT) have been created using cardiomyocytes derived from human embryonic stem cells and human induced pluripotent stem cells. Although a healthy adult phenotype remains elusive, such hECT display structural and functional properties that recapitulate key aspects of natural human myocardium, including dose related responses to compounds with known chronotropic, inotropic and arrhythmogenic effects. Read More

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December 2012

Host-Specific Serum Factors Control the Development and Survival of .

Front Immunol 2021 23;12:635622. Epub 2021 Apr 23.

Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.

Introduction: Schistosomiasis is a neglected tropical disease (NTD) caused by blood-dwelling flatworms which develop from skin-penetrating cercariae, the freely swimming water-borne infective stage of , into adult worms. This natural course of infection can be mimicked in experimental mouse models of schistosomiasis. However, only a maximum of 20-30% of penetrated cercariae mature into fecund adults. Read More

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The Incidence of Stroke in Indigenous Populations of Countries With a Very High Human Development Index: A Systematic Review Protocol.

Front Neurol 2021 22;12:661570. Epub 2021 Apr 22.

School of Population and Global Health, University of Western Australia, Perth, WA, Australia.

Despite known Indigenous health and socioeconomic disadvantage in countries with a Very High Human Development Index, data on the incidence of stroke in these populations are sparse. With oversight from an Indigenous Advisory Board, we will undertake a systematic review of the incidence of stroke in Indigenous populations of developed countries or regions, with comparisons between Indigenous and non-Indigenous populations of the same region, though not between different Indigenous populations. Using PubMed, OVID-EMBASE, and Global Health databases, we will examine population-based incidence studies of stroke in Indigenous adult populations of developed countries published 1990-current, without language restriction. Read More

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Functional Connectivity of the Human Paraventricular Thalamic Nucleus: Insights From High Field Functional MRI.

Front Integr Neurosci 2021 21;15:662293. Epub 2021 Apr 21.

Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA, United States.

The paraventricular thalamic nucleus (PVT) is a small but highly connected nucleus of the dorsal midline thalamus. The PVT has garnered recent attention as a context-sensitive node within the thalamocortical arousal system that modulates state-dependent motivated behaviors. Once considered related to generalized arousal responses with non-specific impacts on behavior, accumulating evidence bolsters the contemporary view that discrete midline thalamic subnuclei belong to specialized corticolimbic and corticostriatal circuits related to attention, emotions, and cognition. Read More

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Dopaminergic Neuromodulation of Spike Timing Dependent Plasticity in Mature Adult Rodent and Human Cortical Neurons.

Front Cell Neurosci 2021 22;15:668980. Epub 2021 Apr 22.

Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Synapses in the cerebral cortex constantly change and this dynamic property regulated by the action of neuromodulators such as dopamine (DA), is essential for reward learning and memory. DA modulates spike-timing-dependent plasticity (STDP), a cellular model of learning and memory, in juvenile rodent cortical neurons. However, it is unknown whether this neuromodulation also occurs at excitatory synapses of cortical neurons in mature adult mice or in humans. Read More

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Aging-Related Neural Disruption Might Predispose to Postoperative Cognitive Impairment Following Surgical Trauma.

J Alzheimers Dis 2021 May 3. Epub 2021 May 3.

Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Accumulating evidence has demonstrated that aging is associated with an exaggerated response to surgical trauma together with cognitive impairments. This has significant implications for the development of clinical phenotype such as perioperative neurocognitive disorders (PND), which is a common complication following surgery, especially for the elderly. However, the mechanism by which aging brain is vulnerable to surgical trauma remains to be elucidated. Read More

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Relationship Between the Borg Scale Rating of Perceived Exertion and Leg-Muscle Deoxygenation During Incremental Exercise in Healthy Adults.

Adv Exp Med Biol 2021 ;1269:95-99

Institute for Human Movement and Medical Science, Niigata University of Health and Welfare, Niigata, Japan.

Introduction: The Borg scale rating of perceived exertion is a reliable indicator and widely used to monitor and guide exercise intensity. We aimed to evaluate the relationships between the Borg scale score and oxygenated hemoglobin (O2Hb) and deoxygenated hemoglobin (HHb) concentrations in the leg muscle as measured by near-infrared spectroscopy (NIRS) during cardiopulmonary exercise testing (CPET) in healthy adult men. We also investigated the relationships between the Borg scale score and the work rate (WR), heart rate (HR), oxygen uptake (VO), and minute ventilation (VE). Read More

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January 2021

Effect of interaction between obesity-promoting genetic variants and behavioral factors on the risk of obese phenotypes.

Mol Genet Genomics 2021 May 9. Epub 2021 May 9.

Molecular Biology and Human Genetics Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, 75270, Pakistan.

The studies investigating gene-gene and gene-environment (or gene-behavior) interactions provide valuable insight into the pathomechanisms underlying obese phenotypes. The Pakistani population due to its unique characteristics offers numerous advantages for conducting such studies. In this view, the current study was undertaken to examine the effects of gene-gene and gene-environment/behavior interactions on the risk of obesity in a sample of Pakistani population. Read More

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Effects of 20-Minute Intensive Exercise on Subjects with Different Working Memory Bases.

Adv Exp Med Biol 2021 ;1269:289-294

Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan.

Continuous moderate-intensity aerobic exercise improves cognitive function including working memory (WM). We aimed to determine the differences in the effects of exercise on WM based on pre-exercise WM function and oxyhemoglobin (OHb) changes. We enrolled 12 healthy adult males who, after a 4-min rest and warm-up, performed a 20-min exercise regime at a workload corresponding to 50% of maximal oxygen consumption. Read More

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January 2021

Cerebral Oxygenation Dynamics During Incremental Exercise: Comparison of Arm Cranking and Leg Cycling.

Adv Exp Med Biol 2021 ;1269:125-130

Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan.

This study aimed to compare cerebral oxyhemoglobin (OHb) levels during incremental exercise by cycling vs. arm cranking in 12 healthy adult men aged 20.8 ± 0. Read More

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January 2021

Community Participation Comparison Between Adults on the Autism Spectrum and Adults in the General Population.

J Autism Dev Disord 2021 May 9. Epub 2021 May 9.

Temple University Collaborative On Community Inclusion of Individuals With Psychiatric Disabilities, 1700 N. Broad St., Suite 304, Philadelphia, PA, 19122, USA.

Little research has examined the full-range of participation among adults on the autism spectrum. The current study addresses this knowledge gap by comparing the frequency, importance, breadth, and sufficiency of participation between autistic adults and adults in the general population. Autistic adults participated less, had fewer areas that were important to them, participated in fewer areas that were important to them, and were less satisfied with their participation even after controlling for demographic characteristics. Read More

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