7,937,970 results match your criteria adult cancer


Radiation-Induced Lens Opacity and Cataractogenesis: A Lifetime Study Using Mice of Varying Genetic Backgrounds.

Radiat Res 2021 May 13. Epub 2021 May 13.

Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, United Kingdom.

Recent epidemiological findings and reanalysis of historical data suggest lens opacities resulting from ionizing radiation exposures are likely induced at lower doses than previously thought. These observations have led to ICRP recommendations for a reduction in the occupational dose limits for the eye lens, as well as subsequent implementation in EU member states. The EU CONCERT LDLensRad project was initiated to further understand the effects of ionizing radiation on the lens and identify the mechanism(s) involved in radiation-induced cataract, as well as the impact of dose and dose-rate. Read More

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Direct reprogramming with Sendai virus vectors repaired infarct hearts at the chronic stage.

Biochem Biophys Res Commun 2021 May 10;560:87-92. Epub 2021 May 10.

Department of Cardiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba City, Ibaraki, 305-8575, Japan. Electronic address:

Adult hearts have limited regenerative capacity. Hence, after acute myocardial infarction (MI), dead myocardial tissues are digested by immune cells and replaced by fibrosis, leading to ventricular remodeling and heart failure at the chronic stage. Direct reprogramming of the cardiac fibroblasts (CFs) into induced cardiomyocytes (iCMs) with cardiac transcription factors, including Gata4, Mef2c, and Tbx5 (GMT), may have significant potential for cardiac repair. Read More

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Inflammatory Biomarkers Correlate with Time Evolution in Cerebral Venous Thrombosis.

J Stroke Cerebrovasc Dis 2021 May 10;30(7):105844. Epub 2021 May 10.

Department of Neurology, Centro Hospitalar Universitário de São João, EPE, Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of University of Porto.

Objectives: We aimed to analyse the relationship between specific inflammatory biomarkers' levels and the temporal pattern of cerebral venous thrombosis (CVT) symptoms.

Materials And Methods: We performed a retrospective study of adult CVT patients admitted between Jan 01 2006 and Dec 31 2019. We excluded patients with infection at admission, autoimmune, inflammatory or haematological disorders. Read More

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Impact of processing demands at encoding, maintenance and retrieval in visual working memory.

Cognition 2021 May 10;214:104758. Epub 2021 May 10.

Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK; Department of Experimental Psychology, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK; Wellcome Centre for Integrative Neuroimaging, Oxford, UK.

There has been surprisingly little examination of how recall performance is affected by processing demands induced by retrieval cues, how manipulations at encoding interact with processing demands during maintenance or due to the retrieval cue, and how these are affected with aging. Here, we investigate these relationships by examining the fidelity of working memory recall across two delayed reproduction tasks with a continuous measure of report across the adult lifespan. Participants were asked to remember and subsequently reproduce from memory the identity and location of a probed item from the encoding display. Read More

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Mortality After Elective Surgery: The Potential Role for Preoperative Palliative Care.

J Surg Res 2021 May 10;266:44-53. Epub 2021 May 10.

Department of Surgery, University of Minnesota Medical School, Minneapolis, MN.

Background: Preoperative optimization is increasingly emphasized for high-risk surgical patients. One critical component of this includes preoperative advanced care planning to promote goal-concordant care. We aimed to define a subset of patients that might benefit from preoperative palliative care consult for advanced care planning. Read More

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Partnership and mortality in mid and late life: Protection or selection?

Soc Sci Med 2021 May 7;279:113971. Epub 2021 May 7.

(Universidad Complutense de Madrid & GEPS), Spain. Electronic address:

The main goal of this paper is to address how different partnership statuses impact the likelihood of death among mature adults and elderly persons in Spain circa 2012 using a massive new dataset of administrative registers linked to census data. First, gross and net effects of having a partner on mortality risks of partnered and non-partnered persons are evaluated; then the characteristics and the importance of selection and protection effects of marriage and partnership with regard to the likelihood of death are assessed. We make use of exact matching methods in order to avoid the selection bias associated with the non-random assignment of persons to different partnership statuses. Read More

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Blood lead levels and their associated risk factors in Chinese adults from 1980 to 2018.

Ecotoxicol Environ Saf 2021 May 10;218:112294. Epub 2021 May 10.

School of Public Health, Qingdao University, Qingdao 266000, China. Electronic address:

In China, studies on lead exposure to grownup are scarce compared to children, although relevant disease burdens for adults are much severe than that in developed countries. The present study evaluated blood lead levels (BLLs) in Chinese adults by data mining using Monte Carlo simulation. A total of 115 scientific studies published between January 1980 and March 2021 reflecting 45,514 Chinese adults were included in the study. Read More

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Functional brain networks underlying automatic and controlled handwriting in Chinese.

Brain Lang 2021 May 10;219:104962. Epub 2021 May 10.

CAS Key Laboratory of Behavioral Science, Center for Brain Science and Learning Difficulties, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

This study aimed to identify the functional brain networks underlying the distinctions between automatic and controlled handwriting in Chinese. Network-based analysis was applied to functional magnetic resonance imaging data collected while adult participants performed a copying task under automatic and speed-controlled conditions. We found significant differences between automatic and speed-controlled handwriting in functional connectivity within and between the frontoparietal network, default mode network, dorsal attention network, somatomotor network and visual network; these differences reflect the variations in general attentional control and task-relevant visuomotor operations. Read More

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Do computed tomography findings agree with traditional osteological examination? The case of porous cranial lesions.

Int J Paleopathol 2021 May 10;33:209-219. Epub 2021 May 10.

Department of Anthropology, University of California Santa Barbara, Santa Barbara, CA, 93106, USA.

Objective: The current study evaluates the feasibility of using clinical cranial computed tomography (CT) scans for assessing the presence and morphology of porous cranial lesions (cribra orbitalia, porotic hyperostosis).

Methods: Observers (n = 4) conducted three independent evaluations of porous cranial lesions based on photographs, 2-D CT, and 3-D CT scans of archaeological crania. Evaluations of the crania from each viewing scenario were compared to findings from direct macroscopic observation. Read More

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Thundering hoofbeats and dazzling zebras: A model integrating current rare disease perspectives in paleopathology.

Int J Paleopathol 2021 May 10;33:196-208. Epub 2021 May 10.

School of Human Evolution and Social Change, Arizona State University, PO Box 872402, Tempe, AZ, 85287-2402, USA. Electronic address:

Objective: The article reviews the study of rare diseases and their nomenclature, emerging government policies and initiatives, and the concerns voiced by the modern rare disease communities. An interpretive model is then presented for the bioarchaeological interpretations of individuals with paleopathological evidence of rare diseases.

Materials: In demonstration of the application of the proposed framework, we evaluate the skeletal remains of an adult female (EZ 3-7-1) excavated in the 1980s from the Middle Woodland (50BCE-CE400) context of the Elizabeth site (11PK512) in the lower Illinois Valley, USA. Read More

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Providing a nurse-led complex nursing INtervention FOcused on quality of life assessment on advanced cancer patients: The INFO-QoL pilot trial.

Eur J Oncol Nurs 2021 Apr 18;52:101961. Epub 2021 Apr 18.

Department of Health Sciences, University of Genoa, Via Antonio Pastore, 1, 16132, Genoa, Italy. Electronic address:

Purpose: Unmet needs for advanced-disease cancer patients are fatigue, pain, and emotional support. Little information is available about the feasibility of interventions focused on patient-reported outcome measurement developed according to the Medical Research Council (MRC) Framework in advanced-disease cancer patients. We aimed to pilot a nurse-led complex intervention focused on QoL assessment in advanced-disease cancer patients. Read More

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Quality of life after sepsis and its association with mortality among sepsis survivors in South Korea: A population level cohort study.

J Crit Care 2021 May 3;64:193-198. Epub 2021 May 3.

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Electronic address:

Purpose: This study aimed to investigate the incidence and effect of quality of life (QOL) change in Korean sepsis survivors.

Materials And Methods: Using the National Health Insurance claim database of South Korea, we included adult sepsis survivors who were primarily diagnosed with sepsis between 2010 and 2018 and survived for more than 1 year after diagnosis. QOL change was defined using three criteria: decrease in annual income level, newly acquired disability, and increase in underlying comorbidities after sepsis. Read More

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First report of fatal baylisascariasis-induced acute pancreatitis in a giant panda.

Parasitol Int 2021 May 10:102380. Epub 2021 May 10.

Sichuan Key Laboratory of Conservation Biology for Endangered Wildlife, Chengdu Research Base of Giant Panda Breeding, Sich3uan Academy of Giant Panda, Chengdu, Sichuan, China.

A wild adult male giant panda that was rescued from a nature reserve in Sichuan Province, China, has died. The panda had been in poor physical condition: it was wheezing and had increased serum amylase. A pathological examination was performed in order to determine the cause of death. Read More

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Differences between the child and adult brain in the local functional structure of the cerebral cortex.

Neuroimage 2021 May 10:118150. Epub 2021 May 10.

ISGlobal, Barcelona, Spain; Pompeu Fabra University, Barcelona, Catalonia, Spain; Ciber on Epidemiology and Public Health (CIBERESP), Madrid, Spain.

Imaging studies on neuronal network formation provide relevant information as to how the brain matures during adolescence. We used a novel imaging approach combining well-established MRI measures of local functional connectivity that jointly provide qualitatively different information relating to the functional structure of the cerebral cortex. To investigate the adolescent transition into adulthood, we comparatively assessed 169 preadolescents aged 8-12 years and 121 healthy adults. Read More

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Sarcopenia is independently associated with parietal atrophy in older adults.

Exp Gerontol 2021 May 10:111402. Epub 2021 May 10.

Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Division of Neurology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Pharmacy, Tajen University, Pingtung, Taiwan. Electronic address:

Introduction: As populations age, sarcopenia becomes a major health problem among adults aged 65 years and older. However, little information is available about the relationship between sarcopenia and brain structure abnormalities. The objective of this study was to investigate associations between sarcopenia and brain atrophy in older adults and relationships with regional brain areas. Read More

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Nandrolone decanoate causes uterine injury by changing hormone levels and sex steroid receptors in a dose- and time-dependent manner.

Reprod Toxicol 2021 May 10. Epub 2021 May 10.

Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, IBB/UNESP, 16618-689, SP, Brazil. Electronic address:

Different doses of nandrolone decanoate (ND) were used to investigate the expression of uterine sex steroid receptors (AR, ER-α, and ER-β) and the levels of serum sex hormones after treatment and recovery periods in adult rats. ND doses of 1.87, 3. Read More

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Smiling Faces on Food Packages Can Increase Adults' Purchase Likelihood for Children.

Appetite 2021 May 10:105301. Epub 2021 May 10.

Courtney Szocs is the Piccadilly Inc., Business Partnership Professor and Assistant Professor of Marketing, Louisiana State University, Baton Rouge, LA 70808. Electronic address:

Manufacturers often include smiling faces on food packages, especially those targeted towards children. Prior research suggests that anthropomorphized images in general, and smiling faces in particular, are an effective marketing tool that encourage food choice and consumption among children. However, it is not clear how adult consumers, who often make food purchases for children, respond to smiling faces on packaging when making decisions for a child recipient. Read More

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The anxiolytic sertraline reduces the impact of psychological stress on bladder function in mice.

Life Sci 2021 May 10:119598. Epub 2021 May 10.

Centre for Urology Research, Faculty of Health Sciences and Medicine, Bond University, Robina, QLD 4229, Australia. Electronic address:

Aims: To determine if treatment with the selective serotonin reuptake inhibitor (SSRI) sertraline reduces the bladder dysfunction caused by water avoidance stress in mice.

Main Methods: Adult female mice were randomly allocated to (1) Unstressed, (2) Stressed or (3) Stress + Sertraline experimental groups. Stressed mice were subjected to water avoidance for 1 h/day for 10 days and received sertraline or vehicle in drinking water, starting 10-days prior to the first stress exposure. Read More

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Evolution of life cycle dimorphism: an example of sacoglossan sea slugs.

J Theor Biol 2021 May 10:110760. Epub 2021 May 10.

Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda-shi, Hyogo 669-1337, Japan.

Many sea slugs of Sacoglossa (Mollusca: Heterobranchia) are sometimes called "solar-powered sea slugs" because they keep chloroplasts obtained from their food algae and receive photosynthetic products (termed kleptoplasty). Some species show life cycle dimorphism, in which a single species has some individuals with a complex life cycle (the mother produces planktotrophic larvae, which later settle in the adult habitat) and others with a simple life cycle (mothers produce benthic offspring by direct development or short-term nonfeeding larvae in which feeding planktonic stages are skipped). Life cycle dimorphism is not common among marine species. Read More

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Nephrogenic syndrome of inappropriate antidiuresis - an ethnically, genetically and phenotypically diverse disorder: First report in a Chinese adult and review of published cases.

Clin Chim Acta 2021 May 10. Epub 2021 May 10.

Department of Pathology, Queen Elizabeth Hospital, Hong Kong.

Background: Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a rare inherited disorder characterised by hyponatraemia. To date, most reported cases are Caucasians with gain-of-function variants in AVPR2, an X-linked gene which encodes the vasopressin V2 receptor (V2R). Recently, germline gain-of-function variants in the stimulatory G protein α-subunit (Gsα) were reported to cause dominantly inherited NSIAD. Read More

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Ouabain worsens diastolic sarcomere length in myocytes from a cardiomyopathy mouse model.

Eur J Pharmacol 2021 May 10:174170. Epub 2021 May 10.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany. Electronic address:

Diastolic dysfunction is a major feature of hypertrophic cardiomyopathy (HCM). Data from patient tissue and animal models associate increased Ca sensitivity of myofilaments with altered Na and Ca ion homeostasis in cardiomyocytes with diastolic dysfunction. In this study, we tested the acute effects of ouabain on ventricular myocytes of an HCM mouse model. Read More

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Variation in 30-Day Readmission Rates from Inpatient Rehabilitation Facilities to Acute Care Hospitals.

J Am Med Dir Assoc 2021 May 10. Epub 2021 May 10.

Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Research Institute, Charlestown, MA, USA. Electronic address:

Objectives: To quantify the rate of readmission from inpatient rehabilitation facilities (IRFs) to acute care hospitals (ACHs) during the first 30 days of rehabilitation stay. To measure variation in 30-day readmission rate across IRFs, and the extent that patient and facility characteristics contribute to this variation.

Design: Retrospective analysis of an administrative database. Read More

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Two-photon live imaging of single corneal stem cells reveals compartmentalized organization of the limbal niche.

Cell Stem Cell 2021 May 3. Epub 2021 May 3.

Department of Dermatology, Department of Cell and Developmental Biology, Institute for Regenerative Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

The functional heterogeneity of resident stem cells that support adult organs is incompletely understood. Here, we directly visualize the corneal limbus in the eyes of live mice and identify discrete stem cell niche compartments. By recording the life cycle of individual stem cells and their progeny, we directly analyze their fates and show that their location within the tissue can predict their differentiation status. Read More

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A comparative study of the NAART and WRAT4 Word Reading subtest to estimate reading level.

Appl Neuropsychol Adult 2021 May 13:1-6. Epub 2021 May 13.

Department of Social Work, Wright State University, Dayton, OH, USA.

Patients are often asked to fill out paperwork in medical settings, but varying reading levels can affect the ability to self-report. By screening for reading level, clinicians can prevent potential patient confusion, frustration, and embarrassment. Clinicians can also avoid problems leading to misdiagnosis and providing materials that patients will not understand. Read More

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Effects of Short-Term Air Pollution Exposure on Venous Thromboembolism: A Case-Crossover Study.

Ann Am Thorac Soc 2021 May 13. Epub 2021 May 13.

University of Utah, Pulmonary and Critical Care Medicine, Salt Lake City, Utah, United States.

Rationale: Exposure to outdoor air pollution is associated with increased cardiovascular disease, respiratory illness, and mortality. The effect of air pollution on venous thromboembolism (VTE) is less certain.

Objectives: To test for associations between short-term exposure to air pollution and VTE. Read More

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Toulouse-Piéron Cancellation Test: Normative scores for the portuguese population.

Appl Neuropsychol Adult 2021 May 13:1-7. Epub 2021 May 13.

Neurology Department, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal.

The Toulouse-Piéron Cancelation Test (TP) is a classic psychometric tool for the assessment of selective/sustained attention, processing speed and visuo-perceptual abilities. It is commonly used in neurological disorders such as epilepsy, multiple sclerosis or Alzheimer's disease. It encompasses two main indexes: Work-Efficiency (WE) and Dispersion-Index (DI). Read More

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Identifying Childhood Expressive Language Features That Best Predict Adult Language and Communication Outcome in Individuals With Autism Spectrum Disorder.

J Speech Lang Hear Res 2021 May 13:1-15. Epub 2021 May 13.

Department of Communication Sciences and Disorders, Emerson College, Boston, MA.

Purpose Several studies have reported that "useful speech" at 5 years of age predicts outcomes in individuals with autism spectrum disorder (ASD), but this skill has been vaguely defined. This study investigates which specific aspects of expressive language in children with ASD best predict adult language and communication outcomes. Method Language samples from 29 children (ages 47-72 months) enrolled in a longitudinal project (e. Read More

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Nonsurgical maxillary expansion in a 60-year-old patient with gingival recession and crowding.

Korean J Orthod 2021 May;51(3):217-227

Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, Korea.

Maxillary transverse deficiency often manifests as a posterior crossbite or edge-to-edge bite and anterior crowding. However, arbitrary arch expansion in mature patients has been considered to be challenging due to the possible periodontal adverse effects such as alveolar bone dehiscence and gingival recession. To overcome these limitations, nonsurgical maxillary expansion of the basal bone has been demonstrated in young adults. Read More

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Projected lifetime cancer risk from cone-beam computed tomography for orthodontic treatment.

Korean J Orthod 2021 May;51(3):189-198

Department of Orthodontics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Objective: To estimate the projected cancer risk attributable to diagnostic cone-beam computed tomography (CBCT) performed under different exposure settings for orthodontic purposes in children and adults.

Methods: We collected a list of CBCT machines and their specifications from 38 orthodontists. Organ doses were estimated using median and maximum exposure settings of 105 kVp/156. Read More

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Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort.

Alzheimers Dement 2021 May 13. Epub 2021 May 13.

Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.

Introduction: To examine the independent association of body mass index (BMI) in early adulthood with dementia incidence among men and women.

Methods: We studied 5104 older adults from the Cardiovascular Health Study (CHS) and the Health, Aging, and Body Composition (Health ABC) study. We imputed early adulthood and midlife BMI using a pooled parent cohort with complete adult lifespan coverage and previously established methods. Read More

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