290,874 results match your criteria adrenal hyperplasia

Socially unstable conditions experienced during development prime female Octodon degus to shape the phenotype of their own offspring.

Horm Behav 2021 Jun 12;134:105011. Epub 2021 Jun 12.

Department of Biology, Geology, and Environmental Sciences, University of Tennessee at Chattanooga, Chattanooga, TN 37403, USA.

Because residents and immigrants from group living species may experience fitness costs associated with permanent changes in group membership, we examined the hypothesis that females experiencing socially unstable or socially stable conditions during development compensate these costs by shaping the phenotype of their own offspring differently. Groups of adult females experiencing either socially stable or unstable conditions in the early social environment were assigned to either socially stable or unstable conditions in the social environment as adults. We quantified affiliative and agonistic interactions among the females during pregnancy and lactation of the focal female, maternal and allomaternal care, hypothalamic-anterior pituitary-adrenal axis (HPA) acute stress response, and early offspring growth. Read More

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UCP1 expression in the mouse adrenal gland is not upregulated by thermogenic conditions.

Biochem Biophys Res Commun 2021 Jun 12;566:184-189. Epub 2021 Jun 12.

Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan. Electronic address:

The uncoupling protein 1 (UCP1) gene is known to be highly expressed in brown adipose tissue (BAT) that functions in thermogenesis. It has been shown that UCP1 mRNA is localized to the mouse adrenal gland, but its significance remains elusive. To explore how UCP1 expression in the adrenal gland is regulated, we generated a reporter knock-in mouse in which the GFP gene was inserted into the UCP1 locus using CRISPR-Cas9 system. Read More

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Interactive regulation of laryngeal cancer and neuroscience.

Biochim Biophys Acta Rev Cancer 2021 Jun 12:188580. Epub 2021 Jun 12.

Department of Pathology, Harbin Medical University Cancer Hospital, Harbin 150081, China. Electronic address:

Nerve fibres are distributed throughout the body along with blood and lymphatic vessels. The intrinsic morphological characteristics of nerves and the general characteristics of secretions in the tumour microenvironment provide a solid theoretical basis for exploring how neuronal tissue can influence the progression of laryngeal cancer (LC). The central nervous system (CNS) and the peripheral nervous system (PNS) jointly control many aspects of cancer and have attracted widespread attention in the study of the progression, invasion and metastasis of tumour tissue banks. Read More

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Adrenalectomy During Radical Nephrectomy- Incidence and Oncologic Outcomes from the Canadian Kidney Cancer Information System (CKCis) -A Modern Era, Nationwide, Multicenter Cohort.

Urology 2021 Jun 12. Epub 2021 Jun 12.

Urology Division, Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. Electronic address:

Objective: To characterize proportion of patients receiving adrenalectomy, adrenal involvement prevalence and oncologic outcomes of routine adrenalectomy in contemporary practice. Ipsilateral adrenalectomy was once standard during radical nephrectomy. However, benefit of routine adrenalectomy has been questioned because adrenal involvement of renal cell carcinoma (RCC) is low. Read More

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Protection of laryngeal nerve palsy using amniotic membrane shield during thyroid surgery.

Tobias Carling

Endocrine 2021 Jun 15. Epub 2021 Jun 15.

Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.

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The discrepancy of aromatase expression in epicardial adipose tissue between CHD and non-CHD patients.

Cardiovasc J Afr 2021 Jun 7;32:1-4. Epub 2021 Jun 7.

Department of Cardiovascular Surgery, Shanxi Cardiovascular Hospital, Taiyuan, PR of China. Email:

Objectives: Epicardial adipose tissue (EAT) aromatase converts androstenedione and other adrenal androgens into oestrogens. The locally produced oestradiol (E) may have cardiovascular protective effects. Little is known about the relationship between EAT aromatase level and coronary heart disease (CHD). Read More

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Androgen receptor signalling inhibitors: post-chemotherapy, pre-chemotherapy and now in castration sensitive prostate cancer.

Endocr Relat Cancer 2021 Jun 1. Epub 2021 Jun 1.

S Kaochar, Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.

Based on pioneering work by Huggins, Hodges and others, hormonal therapies have been established as an effective approach for advanced prostate cancer (PC) for the past 8 decades. However, it quickly became evident that androgen deprivation therapy (ADT) via surgical or medical castration accomplishes inadequate inhibition of the androgen receptor (AR) axis, with clinical resistance inevitably emerging due to adrenal and intratumoral sources of androgens and other mechanisms. Early efforts to augment ADT by adding adrenal-targeting agents (aminoglutethimide, ketoconazole) or AR antagonists (flutamide, bicalutamide, nilutamide, cyproterone) failed to achieve overall survival (OS) benefits, although they did exhibit some evidence of limited clinical activity. Read More

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Clinical Characteristics of Patients with Adrenal Insufficiency and Fever.

J Korean Med Sci 2021 Jun 14;36(23):e152. Epub 2021 Jun 14.

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

Background: Because persistent fever often occurs in adrenal insufficiency, it might be confused with infectious diseases. This study aimed to identify clinical characteristics and risk factors of patients with adrenal insufficiency and fever.

Methods: All adult patients (n = 150) admitted to a tertiary care hospital in South Korea and diagnosed with adrenal insufficiency between 1 March 2018, and 30 June 2019, were recruited. Read More

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Early Adverse Experiences and Repeated Wheezing From 6 to 30 Months of Age: Investigating the Roles of Hypothalamic-Pituitary-Adrenal Axis Functioning, Child Sex, and Caregiving Sensitivity.

Child Dev 2021 Jun 15. Epub 2021 Jun 15.

Icahn School of Medicine at Mount Sinai.

This study examined associations among early adversity, diurnal cortisol, child sex, and caregiver sensitivity at age 6 months in relation to wheezing in children (47% male) followed to 30 months. Analyses included 676 mother-child dyads, 393 of whom completed an observational caregiver sensitivity measure. Participants were primarily ethnic minorities (42. Read More

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Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model.

Drugs R D 2021 Jun 14. Epub 2021 Jun 14.

Minase Research Institute of Ono Pharmaceutical, Osaka, Japan.

Background And Objective: Anaphylactic shock is a serious adverse drug reaction that can occur in response to contrast media used during coronary computed tomography angiography. The imaging quality of coronary computed tomography angiography is improved by β-blockers, which decrease heart rate. In this study, we sought to analyze anaphylactic shock treatment in patients receiving short-acting β1-blockers. Read More

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Pancreatic β-Cell Function Is Associated with Augmented Counterregulation to In-Exercise Hypoglycemia in Type 1 Diabetes.

Med Sci Sports Exerc 2021 Jul;53(7):1326-1333

Applied Sport, Technology, Exercise and Medicine Research Centre (A-STEM), College of Engineering, Swansea University, Swansea, UNITED KINGDOM.

Purpose: This study aimed to investigate the influence of residual β-cell function on counterregulatory hormonal responses to hypoglycemia during acute physical exercise in people with type 1 diabetes (T1D). A secondary aim was to explore relationships between biomarkers of pancreatic β-cell function and indices of glycemia following acute exercise including the nocturnal period.

Methods: This study involved an exploratory, secondary analysis of data from individuals with T1D who partook in a four-peroid, randomized, cross-over trial involving a bout of evening exercise followed by an overnight stay in a clinical laboratory facility. Read More

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[Decrease in the use of bronchodilators in the management of bronchiolitis after applying improvement initiatives].

An Pediatr (Barc) 2021 Jun 11. Epub 2021 Jun 11.

Servicio de Pediatría, Hospital Infantil Universitario Niño Jesús, Madrid, España.

Introduction: In the treatment of patients with acute bronchiolitis there is great variability in clinical practice. Treatments whose efficacy has not been demonstrated are frequently used despite the recommendations contained in the Clinical Practice Guidelines.

Material And Methods: A quality improvement strategy is implemented in the care of patients with acute bronchiolitis in the Emergency Department, which is maintained for five years and is periodically updated to be increasingly restrictive regarding the use of bronchodilators. Read More

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Single-port retroperitoneoscopic adrenalectomy: Initial experience and standardization of the technique.

Actas Urol Esp 2021 Jun 11. Epub 2021 Jun 11.

Servicio de Urología, Complejo Hospitalario Universitario A Coruña, A Coruña, España.

Introduction And Objective: The minimally invasive surgical approach to adrenal gland pathology is the most widely used nowadays, and retroperitoneoscopy occupies a relevant place. However, the evolution of these techniques towards even less invasive surgery through single-port access is anecdotal. The aim of this work is to describe our initial experience in single-port retroperitoneoscopic surgery (SPORS) of the adrenal gland focusing on perioperative data and postoperative pain. Read More

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Access Barriers to Epinephrine Autoinjectors for the Treatment of Anaphylaxis: A Survey of Practitioners.

J Allergy Clin Immunol Pract 2021 Jun 11. Epub 2021 Jun 11.

Division of Allergy and Immunology, Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, FL 33612.

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Improving the Dexamethasone Suppression Test.

Clin Chem 2021 Jun 14. Epub 2021 Jun 14.

Department of Clinical Biochemistry, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Centre, Manchester, UK.

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The evolution of the concept of stress and the framework of the stress system.

Cell Stress 2021 Apr 26;5(6):76-85. Epub 2021 Apr 26.

Center for Aging Biomedicine, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China.

Stress is a central concept in biology and has now been widely used in psychological, physiological, social, and even environmental fields. However, the concept of stress was cross-utilized to refer to different elements of the stress system including stressful stimulus, stressor, stress response, and stress effect. Here, we summarized the evolution of the concept of stress and the framework of the stress system. Read More

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Interventricular septum mass presenting as a late acute coronary syndrome with ST-segment elevation: a case report.

Eur Heart J Case Rep 2021 May 12;5(5):ytab164. Epub 2021 May 12.

Radiology Department, Hopital Saint-Joseph, 185 Rue Raymond Losserand, 75014 Paris, France.

Background: Intracardiac masses are relatively rare but the diagnosis can be challenging for the cardiologist and the clinical presentation can be misleading. While most of the cardiac masses are benign, malignant masses are mostly metastatic tumours.

Case Summary: An 81-year-old man was admitted to the cardiology department for congestive heart failure with the complaint of recent dyspnoea. Read More

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Bilateral Adrenal Haemorrhages Presenting as Adrenal Insufficiency.

Chonnam Med J 2021 May 24;57(2):152-153. Epub 2021 May 24.

Department of Diabetes and Endocrinology, Southend University Hospital NHS Trust, Westcliff-on-Sea, United Kingdom.

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Cardiogenic Shock and Guillain-Barré Syndrome as the First Manifestations of Pheochromocytoma.

Case Rep Endocrinol 2021 3;2021:6691095. Epub 2021 Jun 3.

Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Febrile congestive heart failure is a rare first manifestation of pheochromocytoma. Herein, the case of a 31-year-old female with febrile congestive heart failure and subsequent cardiogenic shock is presented. After intensive care unit (ICU) admission and further evaluating the right adrenal mass observed in abdominal ultrasonography, the diagnosis of pheochromocytoma was confirmed. Read More

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Voluntary Wheel Running Partially Attenuates Early Life Stress-Induced Neuroimmune Measures in the Dura and Evoked Migraine-Like Behaviors in Female Mice.

Front Physiol 2021 28;12:665732. Epub 2021 May 28.

Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, United States.

Migraine is a complex neurological disorder that affects three times more women than men and can be triggered by endogenous and exogenous factors. Stress is a common migraine trigger and exposure to early life stress increases the likelihood of developing chronic pain disorders later in life. Here, we used our neonatal maternal separation (NMS) model of early life stress to investigate whether female NMS mice have an increased susceptibility to evoked migraine-like behaviors and the potential therapeutic effect of voluntary wheel running. Read More

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Psychoactive Effects of Against Restraint Stress-Induced Memory Dysfunction in Mice Through Modulating Intestinal Inflammation and permeability-a Study Based on the Gut-Brain Axis Hypothesis.

Front Pharmacol 2021 26;12:662148. Epub 2021 May 26.

Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Though the underlying mechanism remains elusive, a close relationship between psychological stress and intestinal inflammation has been widely accepted. Such a link is very important to set the basis for our understanding of the critical role of gut-brain axis (GBA) in homeostatic processes in health and disease. Probiotics that could confer benefits to mental health through GBA are referred to as "psychobiotics". Read More

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Impact of Total Epinephrine Dose on Long Term Neurological Outcome for Cardiac Arrest Patients: A Cohort Study.

Front Pharmacol 2021 28;12:580234. Epub 2021 May 28.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Although epinephrine is universally acknowledged to increase return of spontaneous circulation (ROSC) after cardiac arrest, its balanced effects on later outcomes remain uncertain, causing potential harm during post-resuscitation phase. Recent studies have questioned the efficacy and potential deleterious effects of epinephrine on long-term survival and neurological outcomes, despite that the adverse relationship between epinephrine dose and outcome can be partially biased by longer CPR duration and underlying comorbidities. This study explored the long-term effect of epinephrine when used in a cohort of patients that underwent cardiac arrest during cardiopulmonary resuscitation. Read More

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Anhedonic Type Behavior and Anxiety Profile of Wistar-UIS Rats Subjected to Chronic Social Isolation.

Front Behav Neurosci 2021 28;15:663761. Epub 2021 May 28.

Neurosciences and Behavior, Universidad Pontificia Bolivariana Sectional Bucaramanga, Santander, Colombia.

Chronic Social Isolation (CSI) is a model of prolonged stress employed in a variety of studies to induce depression and anxious behavior in rats. The present study aims to evaluate the effect of CSI on male Wistar rats in terms of "anhedonic-type" behavior in the Sucrose Preference Test (SPT) and anxiogenic profile in the elevated-plus-maze (EPM) test, as well as evaluating the effect of resocialization upon sucrose consumption. A total of 24 adolescent male Wistar rats were evaluated. Read More

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Kaposi sarcoma of the adrenal gland: A report of two cases with a review of the literature.

J Cancer Res Ther 2021 Apr-Jun;17(2):606-608

Department of Pathology, Ibn Sina Teaching Hospital, Rabat, Morocco.

Kaposi sarcoma (KS) is a low-grade vascular neoplasm commonly involving mucocutaneous sites, while adrenal gland involvement is exceptional. The anaplastic variant is a rare entity characterized by marked cellular pleomorphism, increased mitosis, worse prognosis, and an increased metastatic potential. The diagnosis remains on histology and immunohistochemistry. Read More

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A Prospective Study of Diurnal Cortisol and Incident Dementia in Community-Dwelling Older Adults.

J Alzheimers Dis 2021 Jun 7. Epub 2021 Jun 7.

Biological Neuropsychiatry Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

Diurnal salivary cortisol was measured in 334 older adults without dementia, at four times on two separate days, under quiet and stressful conditions. In multivariate Cox proportional hazard models, higher global diurnal cortisol secretion was associated with incident dementia (HR = 1.09 [1. Read More

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Proton pump inhibitor therapy reverses endoscopic features of fibrosis in eosinophilic esophagitis.

Dig Liver Dis 2021 Jun 10. Epub 2021 Jun 10.

Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain; Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain. Electronic address:

Background: Long-standing inflammation leads to esophageal remodeling with stricture formation in patients with eosinophilic esophagitis (EoE). The ability of proton pump inhibitors (PPI) to reverse endoscopic features of fibrosis is still unknown.

Objective: To investigate the effect of a short course of PPI treatment in reducing endoscopic findings indicative of esophageal fibrosis in EoE patients. Read More

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Epinephrine dosing interval and neurological outcome in out-of-hospital cardiac arrest.

Perfusion 2021 Jun 12:2676591211025163. Epub 2021 Jun 12.

Department of Emergency and Critical Care Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

Objective: Current guidelines for cardiopulmonary resuscitation (CPR) recommend that standard-dose epinephrine be administered every 3-5 minutes during cardiac arrest. However, there is a knowledge gap regarding the optimal epinephrine dosing interval. This study aimed to examine the association between epinephrine dosing intervals and outcomes after out-of-hospital cardiac arrest (OHCA). Read More

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Comparison of MRI features in lipid-rich and lipid-poor adrenal adenomas using subjective and quantitative analysis.

Abdom Radiol (NY) 2021 Jun 12. Epub 2021 Jun 12.

Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.

Objective: To compare MR-imaging features in benign lipid-rich and lipid-poor adrenal adenomas.

Materials And Methods: With institutional review board approval, we compared 23 consecutive lipid-poor adenomas (chemical shift [CS] signal intensity [SI] index < 16.5%) imaged with MRI to 29 consecutive lipid-rich adenomas (CS-SI index ≥ 16. Read More

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Incidentally discovered myelolipomatous adrenal adenomas, including six cases presenting with hypercortisolism.

Pathol Res Pract 2021 Jun 6;224:153508. Epub 2021 Jun 6.

Department of Pathology, Indiana University, Indianapolis, IN, 46202, USA.

Most adrenal incidentalomas are non-functioning adenomas that require no treatment. The presence of a myelolipomatous component of adrenal incidentalomas is a rare, but well-known occurrence in both hyperplastic and neoplastic lesions of the adrenal cortex. Although the improvements in abdominal imaging have increased identification of myelolipomatous adrenal cortical adenomas radiologically, due to the rarity of this lesion, the clinical pathological features of these lesions are unclear and can sometimes cause diagnostic difficulty. Read More

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[Adenomatoid tumor of the adrenal gland: Clinicopathologic characteristics and differential diagnosis on two tumors of exceptional adrenal location].

Ann Pathol 2021 Jun 9. Epub 2021 Jun 9.

Service d'anatomie et cytologie pathologiques, hôpital Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France; Service de chirurgie digestive et endocrinienne, hôpital Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France; Cancer Research Center of Lyon, INSERM1052 CNRS5286, Lyon 1 University, France.

Adenomatoid tumors are benign tumors from mesothelial origin, usually occurring in the genital tract. Extragenital locations, especially in the adrenal gland are extremely rare. Here we are reporting two cases of a 28-year-old and 50-year-old men with an adenomatoid tumor of the right adrenal gland. Read More

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