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Virtual crossmatch-prodigal saviour of cardiac transplants in India.

Indian J Thorac Cardiovasc Surg 2021 May 8;37(3):351-353. Epub 2021 Jan 8.

Division of Transfusion Medicine, P.D Hinduja Hospital and Research Centre, Mahim, Mumbai, Maharashtra 400016 India.

Positive anti-human leukocyte antigen (HLA) antibodies are considered a contraindication for cardiac transplantation in India, due to its negative impact on cardiac allograft survival and increased chances of rejection post-transplant. Single antigen bead (SAB) assay helps to further characterize these antibodies. Our case portrays India's first reported successful cardiac transplant utilizing a virtual crossmatch (VXM)-based approach in a patient with positive anti-HLA antibody screen and SAB assay. Read More

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A new regression model for overdispersed binomial data accounting for outliers and an excess of zeros.

Stat Med 2021 May 7. Epub 2021 May 7.

Department of Economics, Management and Statistics, University of Milano-Bicocca, Milan, Italy.

Binary outcomes are extremely common in biomedical research. Despite its popularity, binomial regression often fails to model this kind of data accurately due to the overdispersion problem. Many alternatives can be found in the literature, the beta-binomial (BB) regression model being one of the most popular. Read More

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Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo.

Nat Commun 2021 05 4;12(1):2509. Epub 2021 May 4.

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Differential transcription of identical DNA sequences leads to distinct tissue lineages and then multiple cell types within a lineage, an epigenetic process central to progenitor and stem cell biology. The associated genome-wide changes, especially in native tissues, remain insufficiently understood, and are hereby addressed in the mouse lung, where the same lineage transcription factor NKX2-1 promotes the diametrically opposed alveolar type 1 (AT1) and AT2 cell fates. Here, we report that the cell-type-specific function of NKX2-1 is attributed to its differential chromatin binding that is acquired or retained during development in coordination with partner transcriptional factors. Read More

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Random Forest Modelling of Milk Yield of Dairy Cows under Heat Stress Conditions.

Animals (Basel) 2021 Apr 30;11(5). Epub 2021 Apr 30.

Department of Agricultural and Food Sciences-Agricultural Engineering (DISTAL), Alma Mater Studiorum University of Bologna, Viale Fanin 48, 40127 Bologna, Italy.

Precision Livestock Farming (PLF) relies on several technological approaches to acquire, in the most efficient way, precise and real-time data concerning production and welfare of individual animals. In this regard, in the dairy sector, PLF devices are being increasingly adopted, automatic milking systems (AMSs) are becoming increasingly widespread, and monitoring systems for animals and environmental conditions are becoming common tools in herd management. As a consequence, a great amount of daily recorded data concerning individual animals are available for the farmers and they could be used effectively for the calibration of numerical models to be used for the prediction of future animal production trends. Read More

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Sexual Minorities who Reject an LGB Identity: Who Are They and Why Does It Matter?

Issues Law Med 2021 ;36(1):27-43

Salt Lake City, Utah, United States.

Although some persons with minority sexual orientations do not identify as lesbian, gay, or bisexual (LGB), Minority Stress Theory (Meyer, 2003) has largely been developed utilizing LGB-identified samples. We examined a sample ( = 274) of sexual minorities with diverse religious and sexual identity labels to determine if those rejecting versus adopting an LGB identity were different in terms of religious, sexual, relational, and health characteristics. Results suggested those who reject an LGB identity are more likely to be religiously active, full members of their church, and highly intrinsic and theologically conservative in their religious viewpoint. Read More

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January 2021

CMV Status Drives Distinct Trajectories of CD4+ T Cell Differentiation.

Front Immunol 2021 15;12:620386. Epub 2021 Apr 15.

Emory Transplant Center, Department of Surgery, Emory University School of Medicine, Atlanta, GA, United States.

Cytomegalovirus (CMV) is one of the most commonly recognized opportunistic pathogens and remains the most influential known parameter in shaping an individual's immune system. As such, T cells induced by CMV infection could have a long-term impact on subsequent immune responses. Accumulating evidence indicates that memory T cells developed during past bacterial and viral infection can cross-react with unrelated pathogens, including transplant antigens, and can alter responses to infections, vaccines, cancers, or rejection. Read More

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Simultaneous transmission, detection, and energy harvesting.

Opt Lett 2021 May;46(9):2075-2078

Due to the electro-optic property of InGaN multiple quantum wells, a III-nitride diode can provide light transmission, photo detection, and energy harvesting under different bias conditions. Made of III-nitride diodes arrayed in a single chip, the combination allows the diodes to transmit, detect, and harvest visible light at the same time. Here, we monolithically integrate a III-nitride transmitter, receiver, and energy harvester using a compatible foundry process. Read More

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Comorbidities and Susceptibility to COVID-19: A Generalized Gene Set Data Mining Approach.

J Clin Med 2021 Apr 13;10(8). Epub 2021 Apr 13.

Department of Oral Medicine, Carolinas Medical Center, Atrium Health, Charlotte, NC 28203, USA.

The COVID-19 pandemic has led to over 2.26 million deaths for almost 104 million confirmed cases worldwide, as of 4 February 2021 (WHO). Risk factors include pre-existing conditions such as cancer, cardiovascular disease, diabetes, and obesity. Read More

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Node Centrality Measures Identify Relevant Structural MRI Features of Subjects with Autism.

Brain Sci 2021 Apr 14;11(4). Epub 2021 Apr 14.

National Institute for Nuclear Physics (INFN), Bologna Division, I-40127 Bologna, Italy.

Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental conditions characterized by impairments in social interaction and communication and restricted patterns of behavior, interests, and activities. Although the etiopathogenesis of idiopathic ASD has not been fully elucidated, compelling evidence suggests an interaction between genetic liability and environmental factors in producing early alterations of structural and functional brain development that are detectable by magnetic resonance imaging (MRI) at the group level. This work shows the results of a network-based approach to characterize not only variations in the values of the extracted features but also in their mutual relationships that might reflect underlying brain structural differences between autistic subjects and healthy controls. Read More

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Tunneling Spectroscopy for Electronic Bands in Multi-Walled Carbon Nanotubes with Van Der Waals Gap.

Molecules 2021 Apr 7;26(8). Epub 2021 Apr 7.

Department of Physics, Jeonbuk National University, Jeonju 54896, Korea.

Various intriguing quantum transport measurements for carbon nanotubes (CNTs) based on their unique electronic band structures have been performed adopting a field-effect transistor (FET), where the contact resistance represents the interaction between the one-dimensional and three-dimensional systems. Recently, van der Waals (vdW) gap tunneling spectroscopy for single-walled CNTs with indium-metal contacts was performed adopting an FET device, providing the direct assignment of the subband location in terms of the current-voltage characteristic. Here, we extend the vdW gap tunneling spectroscopy to multi-walled CNTs, which provides transport spectroscopy in a tunneling regime of ~1 eV, directly reflecting the electronic density of states. Read More

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Protein -Fucosyltransferase 1 Undergoes Interdomain Flexibility in Solution.

Molecules 2021 Apr 7;26(8). Epub 2021 Apr 7.

Institute of Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, 50018 Zaragoza, Spain.

Protein -fucosyltransferase 1 (PoFUT1) is a GT-B fold enzyme that fucosylates proteins containing EGF-like repeats. GT-B glycosyltransferases have shown a remarkable grade of plasticity adopting closed and open conformations as a way of tuning their catalytic cycle, a feature that has not been observed for PoFUT1. Here, we analyzed PoFUT1 (PoFUT1) conformational behavior in solution by atomic force microscopy (AFM) and single-molecule fluorescence resonance energy transfer (SMF-FRET). Read More

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Does Delayed Cord Clamping Improve Long-Term (≥4 Months) Neurodevelopment in Term Babies? A Systematic Review and a Meta-Analysis of Randomized Clinical Trials.

Front Pediatr 2021 12;9:651410. Epub 2021 Apr 12.

Clinic of Obstetrics and Gynecology, University Hospital of Udine, Udine, Italy.

Recently, the literature suggested that placental transfusion facilitated by delayed cord clamping (DCC), besides having benefits on hematological parameters, might improve the infants' brain development. The present review primarily evaluates the Ages and Stages Questionnaire (ASQ) total score mean difference (MD) at long-term follow-up (≥4 months) comparing DCC (>90 or >180 s) to early cord clamping (ECC). Secondary aims consisted of evaluating the ASQ domains' MD and the results obtained from other methods adopted to evaluate the infants' neurodevelopment. Read More

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Charge transport physics of a unique class of rigid-rod conjugated polymers with fused-ring conjugated units linked by double carbon-carbon bonds.

Sci Adv 2021 Apr 28;7(18). Epub 2021 Apr 28.

Optoelectronics Group, Cavendish Laboratory, JJ Thomson Avenue, Cambridge CB3 0HE, UK.

We investigate the charge transport physics of a previously unidentified class of electron-deficient conjugated polymers that do not contain any single bonds linking monomer units along the backbone but only double-bond linkages. Such polymers would be expected to behave as rigid rods, but little is known about their actual chain conformations and electronic structure. Here, we present a detailed study of the structural and charge transport properties of a family of four such polymers. Read More

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Developing and validating a questionnaire to assess an individual's perceived risk of four major non-communicable diseases in Myanmar.

PLoS One 2021 27;16(4):e0234281. Epub 2021 Apr 27.

University of Public Health, Yangon, Myanmar.

Adopting healthy lifestyles is greatly influenced by an individual's perceived risk of developing non-communicable diseases (NCDs). This study aimed to develop and validate a questionnaire that can assess an individual's perceived risk of developing four major NCDs. We used the exploratory sequential mixed methods design. Read More

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Validity and Diagnosis in Physical and Rehabilitation Medicine: Critical View and Future Perspectives.

Am J Phys Med Rehabil 2021 Apr 14. Epub 2021 Apr 14.

Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario, Canada Department of Medicine, Division of Physical Medicine and Rehabilitation, University of Toronto, Toronto, Ontario, Canada.

Abstract: Obtaining a diagnosis is an essential and integral part of physical and rehabilitation medicine (PRM) in practice and research. Standardized psychometric properties are required of any classifications, diagnostic criteria and diagnostic rules used. Physicians and researchers, inPRM, need to understand these properties to determine the accuracy and consistency of their diagnosis. Read More

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Brolucizumab: a novel anti-VEGF humanized single-chain antibody fragment for treating w-AMD.

Expert Opin Biol Ther 2021 May 24;21(5):553-561. Epub 2021 Apr 24.

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (Dinogmi), University of Genoa, Italy.

Introduction: Wet age-related macular degeneration (w-AMD) represents the leading cause of visual impairment in the elderly in the developed countries. Intravitreal antivascular endothelial growth factor (VEGF) drugs are currently considered as the first-line treatment option for treating w-AMD; however, the frequent injection intervals have lit the way to investigate novel anti-VEGF agents allowing a more extended treatment regimen. Brolucizumab is a single-chain antibody fragment targeting all the isoforms of VEGF-A. Read More

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Enhancing the odds of adopting e-learning or community-focused experiential learning as a teaching practice amongst university faculty.

Heliyon 2021 Apr 16;7(4):e06704. Epub 2021 Apr 16.

Office of the Associate Vice-President, Teaching & Learning, York University, Canada.

Identifying the optimal approach for motivating faculty to adopt teaching innovation is important, given that broad-scale initiatives can utilize an inordinate amount of time and resources. Using a quantitative approach, we evaluate policy actions that are most strongly associated with the adoption of either e-learning or community-focused experiential learning, over a five-year period in a single institution. Comparisons between adopters and non-adopters affirm the relevance of previously documented facilitators and barriers. Read More

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Combined Endonasal-Transorbital Approach to Manage the Far Lateral Frontal Sinus: Surgical Technique.

World Neurosurg 2021 Apr 17;151. Epub 2021 Apr 17.

Department of Otorhinolaryngology-Head and Neck Surgery, ASST Sette Laghi, Varese, Italy.

In recent decades, the ever-expanding use of endoscopes and development of dedicated instrumentation have reshaped the panorama of surgical approaches to the frontal sinus. Nonetheless, the far lateral portion of the sinus might still represent a concern, especially in cases with unfavorable or distorted anatomy. We report the case of a 52-year-old man, referred to our department for recurrent episodes of left orbital swelling and supraorbital headache, 3 months after Draf III frontal sinusotomy for marsupialization of multiple frontal mucoceles. Read More

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Bit-Related Lesions in Event Horses After a Cross-Country Test.

Front Vet Sci 2021 31;8:651160. Epub 2021 Mar 31.

Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.

Bit-related oral lesions are common and may impair horse welfare. The aim of this study was to investigate the prevalence of oral lesions and their risk factors in a sample of Finnish event horses. The rostral part of the oral cavity (the bit area) of 208 event horses (127 warmbloods, 52 coldbloods, and 29 ponies) was examined in a voluntary inspection after the last competition phase, i. Read More

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Localizing confined epileptic foci in patients with an unclear focus or presumed multifocality using a component-based EEG-fMRI method.

Cogn Neurodyn 2021 Apr 10;15(2):207-222. Epub 2020 Jul 10.

CIPCE, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, North Kargar Ave., Tehran, Iran.

Precise localization of epileptic foci is an unavoidable prerequisite in epilepsy surgery. Simultaneous EEG-fMRI recording has recently created new horizons to locate foci in patients with epilepsy and, in comparison with single-modality methods, has yielded more promising results although it is still subject to limitations such as lack of access to information between interictal events. This study assesses its potential added value in the presurgical evaluation of patients with complex source localization. Read More

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Leadership for a climate resilient, net-zero health system: Transforming supply chains to the circular economy.

Authors:
Neil H Ritchie

Healthc Manage Forum 2021 Apr 15:8404704211003610. Epub 2021 Apr 15.

482659Canadian Coalition for Green Health Care, Halifax, Nova Scotia, Canada.

The global pandemic has taught us that we can focus the attention of the healthcare system on a clear intention when there is a looming threat. Climate action is required from multiple stakeholders particularly private sector suppliers in order to achieve the net-zero carbon emission by 2050 goal established by the Canadian government. Also building climate resilience among healthcare institutions and their supply chains is urgently needed, as they are already affected by a changing climate. Read More

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A device category economic model of electrosurgery technologies across procedure types: a U.S. hospital budget impact analysis.

J Med Econ 2021 Jan-Dec;24(1):524-535

Johnson & Johnson Medical Devices Companies, Cincinnati, OH, USA.

Aims: The electrosurgical technology category is used widely, with a diverse spectrum of devices designed for different surgical needs. Historically, hospitals are supplied with electrosurgical devices from several manufacturers, and those devices are often evaluated separately; it may be more efficient to evaluate the category holistically. This study assessed the health economic impact of adopting an electrosurgical device-category from a single manufacturer. Read More

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What Is the State of Compassion Education? A Systematic Review of Compassion Training in Health Care.

Acad Med 2021 Apr 6. Epub 2021 Apr 6.

S. Sinclair is associate professor and director, Compassion Research Lab, Faculty of Nursing, University of Calgary, Calgary, Alberta, Canada. J. Kondejewski is research assistant, Compassion Research Lab, Faculty of Nursing, University of Calgary, Calgary, Alberta, Canada. P. Jaggi is research coordinator, Compassion Research Lab, Faculty of Nursing, University of Calgary, Calgary, Alberta, Canada. L. Dennett is librarian, Scott Health Sciences Library, University of Alberta, Edmonton, Alberta, Canada. A.L. Roze des Ordons is clinical associate professor, Department of Critical Care Medicine and Division of Palliative Medicine, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. T.F. Hack is professor, College of Nursing, Rady Faculty of Health Sciences, University of Manitoba, and director, Psychosocial Oncology & Cancer Nursing Research, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada.

Purpose: To investigate the current state and quality of compassion education interventions offered to health care providers during training or practice, determine how the components of each education intervention map onto the domains of an empirically based clinical model of compassion, and identify the most common approaches to compassion education.

Method: The MEDLINE, Embase, CINAHL Plus with Full Text, Sociological Abstracts, Web of Science, ERIC, and Education Research Complete databases were searched from inception to March 2020 in this systematic review. Studies that evaluated a compassion education intervention for health care providers or those in training to enhance compassion toward patients and/or families were included. Read More

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Prokaryotic taxonomy and nomenclature in the age of big sequence data.

ISME J 2021 Apr 6. Epub 2021 Apr 6.

Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.

The classification of life forms into a hierarchical system (taxonomy) and the application of names to this hierarchy (nomenclature) is at a turning point in microbiology. The unprecedented availability of genome sequences means that a taxonomy can be built upon a comprehensive evolutionary framework, a longstanding goal of taxonomists. However, there is resistance to adopting a single framework to preserve taxonomic freedom, and ever increasing numbers of genomes derived from uncultured prokaryotes threaten to overwhelm current nomenclatural practices, which are based on characterised isolates. Read More

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Growth, spectral, optical, electrical and computational analysis of sodium oxalate single crystals.

Heliyon 2021 Mar 21;7(3):e06527. Epub 2021 Mar 21.

Department of Chemistry, St Berchmans College (Autonomous), Changanassery, 686101, Kerala, India.

Single crystals of Sodium Oxalate (SO) were grown by adopting the slow evaporation solution growth approach from aqueous solution. The prominent functional groups seen in the SO crystal were distinctly detected with Fourier transform infrared and FT-Raman spectral analysis. The cut-off wavelength of 230 nm was measured using Ultraviolet -visible spectral analysis. Read More

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Combined Systemic and Hepatic Artery Infusion Pump Chemo-Therapy as a Liver-Directed Therapy for Colorectal Liver Metastasis-Review of Literature and Case Discussion.

Cancers (Basel) 2021 Mar 13;13(6). Epub 2021 Mar 13.

Comprehensive Cancer Center, Division of Oncology, Department of Internal Medicine, Barnes-Jewish Hospital and The Alvin J. Siteman, Washington University School of Medicine, St. Louis, MO 63110, USA.

Colorectal cancer (CRC) is the third most prevalent malignancy and the second most common cause of death in the US. Liver is the most common site of colorectal metastases. About 13% of patients with colorectal cancer have liver metastasis on initial presentation and 50% develop them during the disease course. Read More

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Synthesis, Polymorphism and Thermal Decomposition Process of (n-CH)N(BH) for = Ho, Tm and Yb.

Materials (Basel) 2021 Mar 10;14(6). Epub 2021 Mar 10.

Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland.

In total, three novel organic derivatives of lanthanide borohydrides, n-ButN(BH) (TBAB), = Ho, Tm, Yb, have been prepared utilizing mechanochemical synthesis and purified via solvent extraction. Studies by single crystal and powder X-ray diffraction (SC-XRD and PXRD) revealed that they crystalize in two polymorphic forms, α- and β-TBAB, adopting monoclinic (2/c) and orthorhombic (nna) unit cells, previously found in TBAYB and TBAScB, respectively. Thermal decomposition of these compounds has been investigated using thermogravimetric analysis and differential scanning calorimetry (TGA/DSC) measurements, along with the analysis of the gaseous products with mass spectrometry (MS) and with analysis of the solid decomposition products with PXRD. Read More

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Computer-aided diagnosis of masses in breast computed tomography imaging: deep learning model with combined handcrafted and convolutional radiomic features.

J Med Imaging (Bellingham) 2021 Mar 29;8(2):024501. Epub 2021 Mar 29.

Radboud University Medical Center, Department of Medical Imaging, Nijmegen, The Netherlands.

A computer-aided diagnosis (CADx) system for breast masses is proposed, which incorporates both handcrafted and convolutional radiomic features embedded into a single deep learning model. The model combines handcrafted and convolutional radiomic signatures into a multi-view architecture, which retrieves three-dimensional (3D) image information by simultaneously processing multiple two-dimensional mass patches extracted along different planes through the 3D mass volume. Each patch is processed by a stream composed of two concatenated parallel branches: a multi-layer perceptron fed with automatically extracted handcrafted radiomic features, and a convolutional neural network, for which discriminant features are learned from the input patches. Read More

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Veganism: Are future pharmacists ready to provide advice?

Curr Pharm Teach Learn 2021 May 22;13(5):512-519. Epub 2021 Jan 22.

Queen's University Belfast Management School, 185 Stranmillis Road, Belfast BT9 5EE, United Kingdom. Electronic address:

Introduction: In addition to advising about diets, nutritional deficiencies, and supplements, pharmacists should be confident discussing medicine-related issues that may arise from people adopting veganism, including checking about animal-derived pharmaceutical product excipients, formulation processes, and determining whether vegan-friendly alternatives exist. Thus, this study aimed to investigate pharmacy students' knowledge and views about veganism.

Methods: Given veganism's increasing popularity and relevance to pharmacy practice, students enrolled in their last year of the undergraduate master of pharmacy degree program at Queen's University Belfast participated in this voluntary study. Read More

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Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study.

Lancet Oncol 2021 04;22(4):548-557

Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK; Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK; West London Gynaecological Cancer Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK. Electronic address:

Background: Most uterine cervical high-risk human papillomavirus (HPV) infections are transient, with only a small fraction developing into cervical cancer. Family aggregation studies and heritability estimates suggest a significant inherited genetic component. Candidate gene studies and previous genome-wide association studies (GWASs) report associations between the HLA region and cervical cancer. Read More

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