217,668 results match your criteria administration investigated

Characterization of Latilactobacillus curvatus MS2 isolated from Korean traditional fermented seafood and cholesterol reduction effect as synbiotics with isomalto-oligosaccharide in BALB/c mice.

Biochem Biophys Res Commun 2021 Jul 26;571:125-130. Epub 2021 Jul 26.

Biopharmaceutical Engineering Major, Division of Applied Bioengineering, Dong-Eui University, Busan, 47340, Republic of Korea. Electronic address:

This study investigated the properties of Latilactobacillus curvatus MS2 isolated from Korean traditional fermented seafood as probiotics and the effect of reducing cholesterol as a synbiotic with isomalto-oligosaccharide (IMO) in BALB/c mice. The isolated strain showed high resistance to acids and bile acids and exhibited a high DPPH scavenging capacity of 72.27 ± 0. Read More

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Survival of Hepatitis A Virus on Two-month Stored Freeze-dried Berries.

J Food Prot 2021 Jul 29. Epub 2021 Jul 29.

US Food and Drug Administration 6502 S Archer Rd UNITED STATES Bedford Park IL 60501 1-630-822-5484.

Imported berries have contributed to U.S. hepatitis A virus (HAV) infections. Read More

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Reducing mosquito-borne disease transmission to humans: A systematic review of cluster randomised controlled studies that assess interventions other than non-targeted insecticide.

PLoS Negl Trop Dis 2021 Jul 29;15(7):e0009601. Epub 2021 Jul 29.

The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.

Background: Mosquito control interventions are widely used to reduce mosquito-borne diseases. It is unclear what combination of interventions are most effective in reducing human disease. A novel intervention study for Buruli ulcer targeting mosquito vectors was proposed for a Buruli ulcer-endemic area of Victoria, Australia. Read More

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Serial administration of rhBMP-2 and alendronate enhances the differentiation of osteoblasts.

Int J Rheum Dis 2021 Jul 29. Epub 2021 Jul 29.

Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.

Aim: The incorporation of growth factors is an effective strategy to accelerate bone induction. Bone morphogenetic protein-2 (BMP-2) promotes osteoblast differentiation and induces bone formation. Alendronate (ALN) is an osteoclast deactivation drug. Read More

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Genetic evidence for the causal association between programmed death-ligand 1 and lung cancer.

J Cancer Res Clin Oncol 2021 Jul 29. Epub 2021 Jul 29.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Beijing, 100142, People's Republic of China.

PD-1/PD-L1 might have a causal role in operating lung cancer risk. However, such an association has not been investigated in the general population. We assessed whether PD-L1 has an independent effect on lung cancer risk using two-sample Mendelian randomization (MR) based on a proteomic genome-wide association study (3301 health participants) of European ancestry and the International Lung cancer Consortium (11,348 cases and 15,861 controls). Read More

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How Did the Lockdown Imposed Due to COVID-19 Affect Patients With Cerebral Palsy?

Pediatr Phys Ther 2021 Jul 27. Epub 2021 Jul 27.

Physical Medicine and Rehabilitation Clinic (Drs Dogruoz Karatekin, Sahin, Kacar, and Bayram), Istanbul Medeniyet University, Goztepe Prof Dr Suleyman Yalcin City Hospital, Istanbul, Turkey; Department of Physical Medicine and Rehabilitation (Dr İcagasioglu), Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkey.

Background: The novel coronavirus infection (SARS-CoV-2) caused disruption of the treatment and follow-up evaluations of children with cerebral palsy.

Aim: The change in mobility, pain, functional status, and spasticity was investigated who were followed in a pediatric rehabilitation unit after the lockdown.

Methods: One hundred ten children were evaluated. Read More

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Prognostic Role of Intragastric Cytopathology and Microbiota in Surgical Patients with Stomach Cancer.

J Cytol 2021 Apr-Jun;38(2):82-87. Epub 2021 May 11.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Background: In the last decade, analysis of malignant cells and flora in gastric lavage (GL) has provided interesting data on pathogenesis of gastric cancer (GC). For this study, combining such two aspects into one cyto-microbiologic category, we tested the prognostic role of the presence/absence of cancer cells (GL1/GL0) and bacterial microbiota (MB1/MB0) in our GC population.

Material And Methods: Between April 2012 and August 2019, 79 surgical patients with GC were prospectively investigated with the determination of GL MB. Read More

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Anemoside B4 inhibits enterovirus 71 propagation in mice through upregulating 14-3-3 expression and type I interferon responses.

Acta Pharmacol Sin 2021 Jul 28. Epub 2021 Jul 28.

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Enterovirus 71 (EV71) is the major pathogens of human hand, foot, and mouth disease (HFMD). EV71 efficiently escapes innate immunity responses of the host to cause infection. At present, no effective antiviral drugs for EV71 are available. Read More

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Nrf2 Depletion Sensitizes Pancreatic Cancer Cells to Gemcitabine via Aldehyde Dehydrogenase 3a1 Repression.

J Pharmacol Exp Ther 2021 Jul 28. Epub 2021 Jul 28.

Tohoku University Graduate School of Medicine, Japan

As the central regulator of the oxidative stress response, nuclear factor erythroid 2-related factor 2 (Nrf2) is attracting great interest as a therapeutic target for various cancers, and the possible clinical applications of novel Nrf2 inhibitors have been explored in Nrf2-activated cancers. In the present study, we specifically investigated halofuginone, which is derived from a natural plant alkaloid. We found that halofuginone administration decreased the number of pancreatic intraepithelial neoplasias in pancreas-specific and mutant (KPC) mice. Read More

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Intratumoral administration of astatine-211-labeled gold nanoparticle for alpha therapy.

J Nanobiotechnology 2021 Jul 28;19(1):223. Epub 2021 Jul 28.

Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan.

Background: At is a high-energy α-ray emitter with a relatively short half-life and a high cytotoxicity for cancer cells. Its dispersion can be imaged using clinical scanners, and it can be produced in cyclotrons without the use of nuclear fuel material. This study investigated the biodistribution and the antitumor effect of At-labeled gold nanoparticles (At-AuNP) administered intratumorally. Read More

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Orexin-2 receptor antagonism in the cornu ammonis 1 region of hippocampus prevented the antinociceptive responses induced by chemical stimulation of the lateral hypothalamus in the animal model of persistent pain.

Behav Pharmacol 2021 Jul 26. Epub 2021 Jul 26.

Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad university Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran Department of Physiology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr Department of Biology, Payame Noor University (PNU) Department of Animal Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran.

Orexins are excitatory neuropeptides, mainly produced by neurons located in the lateral hypothalamus, which project to many brain areas. The orexinergic system plays a fundamental role in arousal, sleep/wakefulness, feeding, energy homeostasis, motivation, reward, stress and pain modulation. As a prominent part of the limbic system, the hippocampus has been involved in formalin-induced nociception modulation. Read More

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Sophocarpine Attenuates Cognitive Impairment and Promotes Neurogenesis in a Mouse Model of Alzheimer's Disease.

Neuroimmunomodulation 2021 Jul 28:1-12. Epub 2021 Jul 28.

Neurobiology Laboratory, Institute of Basic Medicine, Hebei Medical University, Shijiazhang, China.

Introduction: Alzheimer's disease (AD), which is characterized by abnormal deposition of amyloid-β (Aβ) plaques and impaired neurogenesis and cognition, still lacks an optimally effective therapeutic agent for its management, and mounting evidence has shown that inflammatory processes are implicated in AD. Sophocarpine has been reported to exert inflammation-regulating effects in various diseases. However, whether sophocarpine can exert anti-neuroinflammatory and neuroprotective effects in AD remains unclear. Read More

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Caloric restriction alleviates radiation injuries in a sex-dependent fashion.

FASEB J 2021 Aug;35(8):e21787

Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.

Safe and effective regimens are still needed given the risk of radiation toxicity from iatrogenic irradiation. The gut microbiota plays an important role in radiation damage. Diet has emerged as a key determinant of the intestinal microbiome signature and function. Read More

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Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19.

PLoS One 2021 28;16(7):e0254453. Epub 2021 Jul 28.

Section of Infectious Diseases, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.

Background: Limited therapeutic options exist for coronavirus disease 2019 (COVID-19). COVID-19 convalescent plasma (CCP) is a potential therapeutic, but there is limited data for patients with moderate-to-severe disease.

Research Question: What are outcomes associated with administration of CCP in patients with moderate-to-severe COVID-19 infection?

Study Design And Methods: We conducted a propensity score-matched analysis of patients with moderate-to-severe COVID-19. Read More

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Absence of QTc Prolongation with Sodium N-(8-[2-Hydroxybenzoyl] Amino) Caprylate (SNAC), an Absorption Enhancer Co-Formulated with the GLP-1 Analogue Semaglutide for Oral Administration.

Diabetes Ther 2021 Jul 28. Epub 2021 Jul 28.

Novo Nordisk A/S, Søborg, Denmark.

Introduction: Oral delivery of proteins, including glucagon-like peptide 1 (GLP-1) receptor agonists, is impeded by low gastrointestinal permeation. Oral semaglutide has been developed for once-daily oral administration by co-formulation of the GLP-1 analogue semaglutide with an absorption enhancer, sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC, 300 mg). A randomised, partially double-blind, placebo-controlled thorough QT/corrected QT (QTc) trial was conducted to confirm the absence of unacceptable QTc interval prolongation with SNAC. Read More

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The effect of BNR17 on postmenopausal symptoms in ovariectomized rats.

J Microbiol Biotechnol 2021 Jul 19;31(9):1-10. Epub 2021 Jul 19.

AceBiome Inc., 511, Yeongdong-daero, Gangnam-gu, Seoul, 06164, Republic of Korea.

Clinical and preclinical studies have reported that BNR17, a probiotic bacterial strain isolated from human breast milk, reduces body weight and white adipose tissue volume. In order to further explore the actions of BNR17, we investigated the anti-menopausal effects of BNR17 in an ovariectomized (OVX) rat model. The serum alanine aminotransferase levels of the rats in the OVX-BNR17 group were lower than those of the rats in the OVX-vehicle only (OVX-Veh) group. Read More

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5α-reductase inhibitors: evaluation of their potential confounding effect on GC-C-IRMS doping analysis.

Drug Test Anal 2021 Jul 27. Epub 2021 Jul 27.

Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Rome, Italy.

5α-reductase inhibitors (5-ARIs) are considered by the World Anti-doping Agency as potential confounding factors in evaluating the athlete steroid profile, since they may interfere with the urinary excretion of several diagnostic compounds. We herein investigated 5α-reductase inhibitors from a different perspective, by verifying their influence on the carbon isotopic composition of 5α- and 5β- reduced testosterone and nandrolone metabolites. The GC-C-IRMS analysis was performed on a set of urine samples collected from three male Caucasian volunteers after the acute and chronic administration of finasteride in combination with the intake of 19-norandrostenedione, a nandrolone precursor. Read More

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Betaine downregulates microRNA 34a expression via a p53-dependent manner in cisplatin-induced nephrotoxicity in rats.

J Biochem Mol Toxicol 2021 Jul 28:e22856. Epub 2021 Jul 28.

Department of Pharmacology, Faculty of Medicine, Mutah University, Al-Karak, Jordan.

Cisplatin-induced nephrotoxicity limits its wide application as a chemotherapeutic drug. Betaine is a natural trimethylglycine compound involved in several biological reactions. In this study, the protective effect of betaine against cisplatin-induced nephrotoxicity through modulating the expression of microRNA 34a (miRNA 34a), p53, apoptosis, and inflammation was investigated. Read More

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Spatial-temporal variation, ecological risk, and source identification of nutrients and heavy metals in sediments in the peri-urban riverine system.

Environ Sci Pollut Res Int 2021 Jul 27. Epub 2021 Jul 27.

State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Institute of Soil and Water Conservation, Northwest A&F University, No.26, Xinong Road, Yangling, Shaanxi Province, 712100, People's Republic of China.

A great deal of attention has been directed to the toxicity, enrichment, and accumulation of urban river sediment pollution. To understand the spatial-temporal variation, ecological risk and source of nutrients, and heavy metals in sediments from the Weihe River, the concentrations of total nitrogen (TN), total phosphorus (TP), organic matter (OM), and 10 heavy metals (Cd, Sb, As, Co, Cu, Pb, Ni, Cr, Zn, and Mn) in sediments at 14 sampling sites along the river were investigated. The results showed that nutrients and heavy metals had an interannual decreasing trend, and that the high-value regions were concentrated in urban locations within the study area. Read More

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Repeated cocaine administration upregulates CB receptor expression in striatal medium-spiny neurons that express dopamine D receptors in mice.

Acta Pharmacol Sin 2021 Jul 27. Epub 2021 Jul 27.

Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.

Cannabinoid CB receptors (CBR) are importantly involved in drug reward and addiction. However, the cellular mechanisms underlying CBR action remain unclear. We have previously reported that cocaine self-administration upregulates CBR expression in midbrain dopamine (DA) neurons. Read More

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Differential DNA methylation by early versus late parenteral nutrition in the PICU: a biological basis for its impact on emotional and behavioral problems documented 4 years later.

Clin Epigenetics 2021 Jul 27;13(1):146. Epub 2021 Jul 27.

Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Background: The PEPaNIC multicenter randomized controlled trial (RCT) has shown that early administration of supplemental parenteral nutrition (early-PN) as compared with withholding PN for 1 week (late-PN) induced long-term internalizing, externalizing and total emotional/behavioral problems in critically ill children, as observed 4 years later. Early-PN was further shown to alter the methylation status of 37 CpG-sites in leukocyte DNA between admission and discharge from the pediatric intensive care unit (PICU). In a preplanned subanalysis of the PEPaNIC trial, we now investigated whether the altered methylation of these CpG-sites could statistically explain the negative impact of early-PN on emotion/behavior documented 4 years after PICU admission. Read More

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Effect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness.

Malar J 2021 Jul 27;20(1):326. Epub 2021 Jul 27.

Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.

Background: Seasonal malaria chemoprevention (SMC) consists of administration of sulfadoxine-pyrimethamine (SP) + amodiaquine (AQ) at monthly intervals to children during the malaria transmission period. Whether the addition of azithromycin (AZ) to SMC could potentiate the benefit of the intervention was tested through a double-blind, randomized, placebo-controlled trial. The effect of SMC and the addition of AZ, on malaria transmission and on the life history traits of Anopheles gambiae mosquitoes have been investigated. Read More

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One hundred and ten years of Allergen Immunotherapy: A journey from empiric observation to evidence.

Allergy 2021 Jul 27. Epub 2021 Jul 27.

Section of Allergology and Clinical Immunology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

One hundred and ten years after Noon's first clinical report of the subcutaneous application of allergen extracts, allergen immunotherapy (AIT) has evolved as the most important pillar of the treatment of allergic patients. It is the only disease-modifying treatment option available and the evidence for its clinical efficacy and safety is broad and undisputed. Throughout recent decades, more insights into the underlying mechanisms, in particular the modulation of innate and adaptive immune responses, have been described. Read More

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Rosmarinic acid attenuates lipopolysaccharide-induced neuroinflammation and cognitive impairment in rats.

J Chem Neuroanat 2021 Jul 24:102008. Epub 2021 Jul 24.

Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand 9717853577, Iran. Electronic address:

It has been recently demonstrated that rosmarinic acid (RA) through modulation in the amyloidogenic pathway exhibit neuroprotective potential in Alzheimer's disease. However, its effects on non-amyloidogenic pathways such as neuroinflammation (NI) and oxidative stress have not been elucidated carefully. Hence, this study aimed to investigate the effect of RA on cognitive function, cortical and hippocampal oxidant-antioxidant balance, and proinflammatory cytokines production in lipopolysaccharide (LPS)-induced NI in rats. Read More

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Prophylactic Administration of Diphenhydramine/Acetaminophen and Ondansetron Reduced Postoperative Nausea and Vomiting and Pain Following Laparoscopic Sleeve Gastrectomy: a Randomized Controlled Trial.

Obes Surg 2021 Jul 27. Epub 2021 Jul 27.

Department of Anesthesiology, Sina Hospital, Tehran University of Medical Sciences, Imam Khomeini St, Tehran, 11367-46911, Iran.

Purpose: Postoperative nausea and vomiting (PONV) and pain following bariatric surgery are problematic and affect the outcome of patients. Intraoperative multimodal antiemetic prophylaxis is essential to improve postoperative outcomes. This study investigated the effect of adding diphenhydramine to acetaminophen and ondansetron in reducing postoperative nausea and vomiting and pain following laparoscopic sleeve gastrectomy (LSG). Read More

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(R)-Ketamine attenuates LPS-induced endotoxin-derived delirium through inhibition of neuroinflammation.

Psychopharmacology (Berl) 2021 Jul 27. Epub 2021 Jul 27.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.

Rationale: (R)-Ketamine produced beneficial effects in a variety of models of inflammatory diseases, including low dose of bacterial lipopolysaccharide (LPS) (0.5-1.0 mg/kg)-induced endotoxemia. Read More

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Nanomedicines and microneedles: a guide to their analysis and application.

Anal Methods 2021 Jul 27. Epub 2021 Jul 27.

Medway School of Pharmacy, Universities of Greenwich and Kent, Anson Building, Central Avenue, Chatham, ME4 4TB, UK.

The fast-advancing progress in the research of nanomedicine and microneedle applications in the past two decades has suggested that the combination of the two concepts could help to overcome some of the challenges we are facing in healthcare. They include poor patient compliance with medication and the lack of appropriate administration forms that enable the optimal dose to reach the target site. Nanoparticles as drug vesicles can protect their cargo and deliver it to the target site, while evading the body's defence mechanisms. Read More

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Effect of Crude Leaves Extract of Bersama Abyssinica on Blood Glucose Level and Serum Lipid Level of Streptozotocin-Induced Diabetic Mice: Evidence for In vivo Antidiabetic Activity.

Cardiovasc Hematol Agents Med Chem 2021 Jul 25. Epub 2021 Jul 25.

Department of Human Anatomy, School of Medicine, College of Medicine and Health Sciences, Gondar. Ethiopia.

Background: Diabetes mellitus is one of the major and common metabolic, and chronic disorders in the world. Several medicinal plants have been used globally for the management of diabetes mellitus. The current study aimed to study the anti-hyperglycemic and anti-hyperlipidemic effects of Bersama abyssinica. Read More

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The Comparative Effects of Teacher Versus Peer-Scaffolding on EFL Learners' Incidental Vocabulary Learning and Reading Comprehension: A Socio-Cultural Perspective.

J Psycholinguist Res 2021 Jul 27. Epub 2021 Jul 27.

College of Health Sciences (STIKES), Mataram, Indonesia.

Drawing on sociocultural theory, and multiple empirical studies conducted on the effectiveness of scaffolding on second or foreign language learning, the authors investigated the application of various forms of scaffolding (i.e., teacher versus peer-scaffolding) on EFL learners' incidental vocabulary learning and reading comprehension performance through a sociocultural perspective. Read More

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Pain Relieving and Neuroprotective Effects of Non-opioid Compound, DDD-028, in the Rat Model of Paclitaxel-Induced Neuropathy.

Neurotherapeutics 2021 Jul 26. Epub 2021 Jul 26.

Department of Neuroscience, NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Psychology, Drug Research and Child HealthViale Pieraccini 6, 50139, Florence, Italy.

Chemotherapy-induced neuropathy (CIN) is a major dose-limiting side effect of anticancer therapy that can compel therapy discontinuation. Inadequate analgesic efficacy of current pharmacological approaches requires the identification of innovative therapeutics and, hence, the purpose of this study is to conduct a preclinical evaluation of the efficacy of DDD-028, a versatile pentacyclic pyridoindole derivative, against paclitaxel-induced neuropathic pain. In two separate experiments, DDD-028 was administered per os acutely (1-25 mg kg) or repeatedly (10 mg kg) in paclitaxel-treated rats. Read More

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