42 results match your criteria administrated exosomes


Bone marrow mesenchymal stem cell derived exosomal miR-455-5p protects against spinal cord ischemia reperfusion injury.

Tissue Cell 2021 Nov 22;74:101678. Epub 2021 Nov 22.

Department of Cardiac Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China. Electronic address:

At present, much more studies have focused on the therapeutic effect of exosome-delivered microRNAs on diseases. Previous study has shown that miR-455-5p is downregulated in ischemic stroke, but little is known about the role of exosome-delivered miR-455-5p in spinal cord ischemia reperfusion (SCIR) injury. Herein, we isolated exosomes from bone marrow mesenchymal stem cells (BMSCs) transfected with lentivirus vectors containing miR-455-5p. Read More

View Article and Full-Text PDF
November 2021

Exosomes derived from miR-129-5p modified bone marrow mesenchymal stem cells represses ventricular remolding of mice with myocardial infarction.

J Tissue Eng Regen Med 2021 Nov 23. Epub 2021 Nov 23.

Department of cardiology, Shijiazhuang People's Hospital, 5 Fangbei Road, Shijiazhuang, Hebei, 050011, China.

Background: Myocardial infraction (MI) is a severe disease with great mortality. Mesenchymal stem cells (MSCs)-derived exosomes display protection against MI. MicroRNA-129-5p was reported to exert anti-inflammation activity by targeting high mobility group box 1 (HMGB1). Read More

View Article and Full-Text PDF
November 2021

Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-inflammation and macrophage polarization via NF-κB signaling pathway and Nrf2/HO-1 axis.

Stem Cell Res Ther 2021 09 28;12(1):519. Epub 2021 Sep 28.

PLA Rocket Force Characteristic Medical Center, Beijing, 100088, China.

Background: Exosomes are considered a substitute for stem cell-based therapy for myocardial infarction (MI). FNDC5, a transmembrane protein located in the cytoplasm, plays a crucial role in inflammation diseases and MI repair. Furthermore, our previous study found that FNDC5 pre-conditioning bone marrow-derived mesenchymal stem cells (BMMSCs) could secrete more exosomes, but little was known on MI repair. Read More

View Article and Full-Text PDF
September 2021

Therapeutic effects of bone marrow mesenchymal stem cells-derived exosomes on osteoarthritis.

J Cell Mol Med 2021 10 27;25(19):9281-9294. Epub 2021 Aug 27.

Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong, China.

Mesenchymal stem cells (MSCs) have shown chondroprotective effects in clinical models of osteoarthritis (OA). However, effects of MSC-derived exosomes on OA remain unclear. The study aimed to investigate the therapeutic potential of exosomes from human bone marrow MSCs (BM-MSCs) in alleviating OA. Read More

View Article and Full-Text PDF
October 2021

Extracellular vesicles derived from small intestinal lamina propria reduce antigen-specific immune response.

Korean J Intern Med 2021 Aug 25. Epub 2021 Aug 25.

Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.

Background/aims: Extracellular vesicles (EVs) are secreted from various types of cells and have specific functions related to their origin. EVs are observed in the small intestinal lamina propria (lpEVs), but their function remains unclear. This study aimed to investigate the role of lpEVs. Read More

View Article and Full-Text PDF

Mesenchymal stem cell-derived exosomal miR-146a reverses diabetic β-cell dedifferentiation.

Stem Cell Res Ther 2021 08 11;12(1):449. Epub 2021 Aug 11.

Department of Endocrinology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 Wenhua Xi Road, Jinan, 250012, Shandong, China.

Background: Mesenchymal stem cells (MSCs) show promising therapeutic potential in treating type 2 diabetes mellitus (T2DM) in clinical studies. Accumulating evidence has suggested that the therapeutic effects of MSCs are not due to their direct differentiation into functional β-cells but are instead mediated by their paracrine functions. Among them, exosomes, nano-sized extracellular vesicles, are important substances that exert paracrine functions. Read More

View Article and Full-Text PDF

hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis.

Stem Cell Res Ther 2021 07 22;12(1):416. Epub 2021 Jul 22.

Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.

Background: Human umbilical cord mesenchymal stem cell (hucMSC)-derived exosomes are recognized as novel cell-free therapeutic agents for inflammatory bowel disease (IBD), a condition caused by dysregulated intestinal mucosal immunity. In this event, macrophage pyroptosis, a process of cell death following the activation of NLRP3 (NOD-like receptor family, pyrin domain-containing 3) inflammasomes, is believed to partially account for inflammatory reactions. However, the role of macrophage pyroptosis in the process of hucMSC-derived exosomes alleviating colitis remains unknown. Read More

View Article and Full-Text PDF

Dental pulp stem cell-derived exosomes alleviate cerebral ischaemia-reperfusion injury through suppressing inflammatory response.

Cell Prolif 2021 Aug 7;54(8):e13093. Epub 2021 Jul 7.

School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.

Objectives: The study aimed to determine whether dental pulp stem cell-derived exosomes (DPSC-Exos) exert protective effects against cerebral ischaemia-reperfusion (I/R) injury and explore its underlying mechanism.

Materials And Methods: Exosomes were isolated from the culture medium of human DPSC. Adult male C57BL/6 mice were subjected to 2 hours transient middle cerebral artery occlusion (tMCAO) injury followed by 2 hours reperfusion, after which singular injection of DPSC-Exos via tail vein was administrated. Read More

View Article and Full-Text PDF

Mesenchymal stem cell-derived exosomal miR-143-3p suppresses myocardial ischemia-reperfusion injury by regulating autophagy.

Life Sci 2021 Sep 22;280:119742. Epub 2021 Jun 22.

Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing Jiangsu Province 210009, China. Electronic address:

Aims: Myocardial ischemia-reperfusion (I/R) injury is considered as a major obstacle of myocardial perfusion to save acute myocardial infarction, and causes a serious threat to human health. An extensive body of evidence has unveiled that mesenchymal stem cells (MSCs) as adult stem cells play a vital role in the field of damaged myocardial regeneration and repair. However, the biological role of MSCs derived-exosomes in the protection of myocardial I/R injury has not been elucidated. Read More

View Article and Full-Text PDF
September 2021

Exosomes derived from cochlear spiral ganglion progenitor cells prevent cochlea damage from ischemia-reperfusion injury via inhibiting the inflammatory process.

Cell Tissue Res 2021 Nov 22;386(2):239-247. Epub 2021 Jun 22.

Department of Otolaryngology and Head & Neck Surgery, the Second Xiangya Hospital, Central South University, Hunan, 410011, Changsha, China.

Ischemia-reperfusion injury (I/R)-induced inflammatory process can mediate cochlea damage-related hearing loss; whether cochlear spiral ganglion progenitor cell-derived exosomes (CSGPC-exos) play a protective role by carrying functional microRNAs into recipient cells is unknown. Different doses of CSGPC-exos (0.1 μg/μl, 0. Read More

View Article and Full-Text PDF
November 2021

Exosomes derived from human amniotic fluid mesenchymal stem cells alleviate cardiac fibrosis via enhancing angiogenesis and .

Cardiovasc Diagn Ther 2021 Apr;11(2):348-361

Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, Changsha, China.

Background: Cardiac fibrosis is a pathological process characterized by excess extracellular matrix (ECM) deposition and plays a critical role in nearly all types of heart disease. The mechanism of cardiac fibrosis is still unclear and no effective medication treatment of cardiac fibrosis. Research showed that mesenchymal stem cell (MSC) derived exosomes may play a critical role in cardiac fibrosis. Read More

View Article and Full-Text PDF

Adipose-Derived Mesenchymal Stem Cells-Derived Exosomes Carry MicroRNA-671 to Alleviate Myocardial Infarction Through Inactivating the TGFBR2/Smad2 Axis.

Inflammation 2021 Oct 21;44(5):1815-1830. Epub 2021 Apr 21.

Department of Cardiology, Tianjin Medical University General Hospital, NO. 154, Anshan Street, Heping District, Tianjin, 300052, People's Republic of China.

Mesenchymal stem cells (MSCs) and their derived extracellular vesicles have been reported as promising tools for the management of heart disease. The aim of this study was to explore the function of adipose-derived MSCs (adMSCs)-derived exosomes (Exo) in the progression of myocardial infarction (MI) and the molecules involved. Mouse cardiomyocytes were treated with oxygen-glucose deprivation (OGD) to mimic an MI condition in vitro. Read More

View Article and Full-Text PDF
October 2021

Intercellular transfer of exosomal wild type EGFR triggers osimertinib resistance in non-small cell lung cancer.

Mol Cancer 2021 01 18;20(1):17. Epub 2021 Jan 18.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine; Guangdong Esophageal Cancer Institute; Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China.

Background: Epidermal growth factor receptor (EGFR)-mutated lung cancer constitutes a major subgroup of non-small cell lung cancer (NSCLC) and osimertinib is administrated as first-line treatment. However, most patients with osimertinib treatment eventually relapse within one year. The underlying mechanisms of osimertinib resistance remain largely unexplored. Read More

View Article and Full-Text PDF
January 2021

Engineering exosomes for pulmonary delivery of peptides and drugs to inflammatory lung cells by inhalation.

J Control Release 2021 02 1;330:684-695. Epub 2021 Jan 1.

Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea. Electronic address:

Exosomes have been investigated as delivery vesicles for various drugs. However, exosome-mediated peptide delivery into the lungs has not been studied. In this study, exosomes were engineered for the pulmonary delivery of RAGE-binding peptide (RBP), an anti-inflammatory peptide. Read More

View Article and Full-Text PDF
February 2021

Lysosomal-associated transmembrane protein 4B regulates ceramide-induced exosome release.

FASEB J 2020 12 8;34(12):16022-16033. Epub 2020 Oct 8.

Lipid Biofunction Section, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.

Exosomes are extracellular vesicles that mediate the transport of intracellular molecules, including neurodegenerative agents. Exogenously administrated ceramides have been implicated in the acceleration of exosome production by neurons; however, the molecular machinery involved in this process is unknown. Here, we found that ceramides, especially those consisting of long fatty acids, were internalized into the endocytic pathway in neuroblastoma SH-SY5Y cells to induce exosome secretion through lysosome-associated protein transmembrane 4B (LAPTM4B). Read More

View Article and Full-Text PDF
December 2020

Adipose Mesenchymal Stem Cell-Derived Exosomal microRNA-1236 Reduces Resistance of Breast Cancer Cells to Cisplatin by Suppressing SLC9A1 and the Wnt/β-Catenin Signaling.

Cancer Manag Res 2020 22;12:8733-8744. Epub 2020 Sep 22.

Department of Thyroid and Breast Surgery, Affiliated Hospital of Binzhou Medical University, Binzhou 256603, Shandong, People's Republic of China.

Background: Emerging evidence has noted the versatile functions of mesenchymal stem cell-derived exosomes (MSC-Exos) in cancer control. This work aims to probe to function of adipose MSC-Exos (adMSC-Exos) in drug-resistance of breast cancer (BC) cells to cisplatin (DDP) and the molecules involved.

Methods: Parental and DDP-resistant BC cell lines MCF-7 and MDA-MB-231 were used. Read More

View Article and Full-Text PDF
September 2020

Exosomes from miRNA-126-modified endothelial progenitor cells alleviate brain injury and promote functional recovery after stroke.

CNS Neurosci Ther 2020 12 3;26(12):1255-1265. Epub 2020 Oct 3.

Department of Pharmacology & Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.

Aims: We previously showed that the protective effects of endothelial progenitor cells (EPCs)-released exosomes (EPC-EXs) on endothelium in diabetes. However, whether EPC-EXs are protective in diabetic ischemic stroke is unknown. Here, we investigated the effects of EPC-EXs on diabetic stroke mice and tested whether miR-126 enriched EPC-EXs (EPC-EXs ) have enhanced efficacy. Read More

View Article and Full-Text PDF
December 2020

Low-dose rituximab lowers serum Exosomal miR-150-5p in AChR-positive refractory myasthenia gravis patients.

J Neuroimmunol 2020 11 15;348:577383. Epub 2020 Sep 15.

Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, China; Department of Neurology, Jing'an District Centre Hospital of Shanghai, Fudan University, China. Electronic address:

Two potentially related microRNAs (miRNAs; miR-150-5p and miR-146a-5p) were examined after low-dose rituximab (RTX) treatment in patients with acetylcholine receptor antibody (AChR)-positive refractory myasthenia gravis (MG). In this prospective, open-label, and self-controlled pilot trial, 12 AChR-positive refractory MG patients were administrated a single, low dose of RTX and followed up at six months. Results showed that RTX decreased the serum exosomal miR-150-5p, scores on three clinical indices (MGFA, MMT, ADL), and patients' prednisolone requirement. Read More

View Article and Full-Text PDF
November 2020

Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease .

J Extracell Vesicles 2020 Aug 7;9(1):1795362. Epub 2020 Aug 7.

Department of Periodontics, Dental College of Georgia at Augusta University, GA, USA.

Chronic bone degenerative diseases represent a major threat to the health and well-being of the population, particularly those with advanced age. This study isolated exosomes (EXO), natural nano-particles, from dendritic cells, the "directors" of the immune response, to examine the immunobiology of DC EXO in mice, and their ability to reprogram immune cells responsible for experimental alveolar bone loss . Distinct DC EXO subtypes including immune-regulatory (regDC EXO), loaded with TGFB1 and IL10 after purification, along with immune stimulatory (stimDC EXO) and immune "null" immature (iDCs EXO) unmodified after purification, were delivered via I. Read More

View Article and Full-Text PDF

A review on the stem cell therapy and an introduction to exosomes as a new tool in reproductive medicine.

Reprod Biol 2020 Dec 6;20(4):447-459. Epub 2020 Sep 6.

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Stem cell therapy and exosome therapy are the two experimental methods that are now at the center of attention. Various types of stem cells, especially mesenchymal stem cells and spermatogonial stem cells have been widely administrated in reproductive medicine. However, due to the limitation of injecting living cells, using their paracrine secretions such as exosomes seems to be a better option. Read More

View Article and Full-Text PDF
December 2020

Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization.

Drug Des Devel Ther 2020 5;14:3143-3158. Epub 2020 Aug 5.

Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, People's Republic of China.

Introduction: Intracerebral hemorrhage (ICH) is a devastating type of stroke with high mortality, and the effective therapies for ICH remain to be explored. Exosomes (Exos) have been found to play important roles in cell communication by transferring molecules, including microRNAs (miRNAs/miRs). MiRNAs are critical regulators of genes involved in many various biological processes and have been demonstrated to aggravate or alleviate brain damages induced by ICH. Read More

View Article and Full-Text PDF

miR-210 transferred by lung cancer cell-derived exosomes may act as proangiogenic factor in cancer-associated fibroblasts by modulating JAK2/STAT3 pathway.

Clin Sci (Lond) 2020 04;134(7):807-825

Thoracic Surgery Department, The Second Affiliated of Zhejiang University, School of Medicine, Hangzhou, China.

It has been generally believed that cancer-associated fibroblasts (CAFs) have the ability to increase the process of tumor angiogenesis. However, the potential mechanisms by which cancer-derived exosomes in lung cancer (LC) remains to be investigated. LC-derived exosomes were administrated to NIH/3T3 cells. Read More

View Article and Full-Text PDF

Altered biodistribution of deglycosylated extracellular vesicles through enhanced cellular uptake.

J Extracell Vesicles 2020 13;9(1):1713527. Epub 2020 Jan 13.

Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.

Extracellular vesicles (EVs) from cancer are delivered both proximal and distal organs. EVs are highly glycosylated at the surface where EVs interact with cells and therefore has an impact on their properties and biological functions. Aberrant glycosylation in cancer is associated with cancer progression and metastasis. Read More

View Article and Full-Text PDF
January 2020

Delivery of High Mobility Group Box-1 siRNA Using Brain-Targeting Exosomes for Ischemic Stroke Therapy.

J Biomed Nanotechnol 2019 Dec;15(12):2401-2412

Ischemic strokes are caused by decreased blood flow into the brain, due to narrowed cerebral arteries. In the ischemic brain, high-mobility group box 1 (HMGB1) is released into extracellular spaces and induces inflammatory reactions. In this study, HMGB1 small interfering RNA (siRNA) was delivered into ischemic brains by intravenous administration using rabies virus glycoprotein (RVG) peptide-decorated exosomes. Read More

View Article and Full-Text PDF
December 2019

Exosomes derived from human umbilical cord blood mesenchymal stem cells improve hepatic ischemia reperfusion injury via delivering miR-1246.

Cell Cycle 2019 Dec 10;18(24):3491-3501. Epub 2019 Nov 10.

Department of Hepatopancreatobiliary Surgery, The first Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

The purpose of this study was to explore the associated mechanism by which MSCs-derived exosomes exerted protective effect in hepatic ischemia/reperfusion injury (IRI). Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs)-derived exosomes were administrated into LO2 cells exposed to hypoxia/reoxygenation (H/R) and mice subjected to IRI. Cell viability was assessed by CCK-8 assay. Read More

View Article and Full-Text PDF
December 2019

ASCs-Exosomes Recover Coupling Efficiency and Mitochondrial Membrane Potential in an Model of ALS.

Front Neurosci 2019 17;13:1070. Epub 2019 Oct 17.

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

The amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by motoneurons death. Mutations in the superoxide dismutase 1 (SOD1) protein have been identified to be related to the disease. Beyond the different altered pathways, the mitochondrial dysfunction is one of the major features that leads to the selective death of motoneurons in ALS. Read More

View Article and Full-Text PDF
October 2019

Exosomal miR-199a-5p derived from endothelial cells attenuates apoptosis and inflammation in neural cells by inhibiting endoplasmic reticulum stress.

Brain Res 2020 01 18;1726:146515. Epub 2019 Oct 18.

Clinical Research Center for Neurological Disease, the People's Hospital of HongHuaGang District of ZunYi, China.

Remote ischemic post-conditioning (RIPostC) is a technique that can protect vital organs in an indirect manner, the effects of which are exerted by the long-distance exosome-mediated transfer of functional factors. In the current study, the possible mechanism driving the function of RIPostC was explored using an in vitro system by focusing on miR-199a-5p and its downstream effectors involved in endoplasmic reticulum (ER) stress. Human umbilical vein endothelial cells (HUVECs) were administrated with hypoxia/re-oxygenation (H/R) process and exosomes were collected from the H/R-treated HUVECs. Read More

View Article and Full-Text PDF
January 2020

Exosomal miR-1246 derived from human umbilical cord blood mesenchymal stem cells attenuates hepatic ischemia reperfusion injury by modulating T helper 17/regulatory T balance.

IUBMB Life 2019 12 21;71(12):2020-2030. Epub 2019 Aug 21.

Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

The purpose of this study was to explore the mechanism by which human umbilical cord blood mesenchymal stem cells (hUCB-MSCs)-derived exosomes exerted protective effect in hepatic ischemia/reperfusion injury (IRI). hUCB-MSCs-derived exosomes were administrated into hepatic IRI mice or cocultured with naïve CD4 T cells exposed to hepatic hypoxia/reoxygenation microenvironment. Hepatic function was assessed by determining serum transaminases. Read More

View Article and Full-Text PDF
December 2019

High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer.

J Hematol Oncol 2019 06 10;12(1):56. Epub 2019 Jun 10.

Division of Hematology/Oncology, Department of Internal Medicine, University of California Davis School of Medicine, University of California Davis Comprehensive Cancer Center, 4501 X Street, Suite 3016, Sacramento, CA, 95817, USA.

Background: α3β1 integrin is a promising cancer biomarker and drug target. We previously identified a 9-amino-acid cyclic peptide LXY30 for detecting α3β1 integrin on the surface of live tumor cells. This study was undertaken to characterize LXY30 in the detection, cellular function, imaging, and targeted delivery of in vitro and in vivo non-small cell lung cancer (NSCLC) models. Read More

View Article and Full-Text PDF

Golden Exosomes Selectively Target Brain Pathologies in Neurodegenerative and Neurodevelopmental Disorders.

Nano Lett 2019 06 27;19(6):3422-3431. Epub 2019 Feb 27.

Sagol School of Neuroscience , Tel Aviv University , Tel Aviv 6997801 , Israel.

Exosomes, nanovesicles that are secreted by different cell types, enable intercellular communication at local or distant sites. Alhough they have been found to cross the blood brain barrier, their migration and homing abilities within the brain remain unstudied. We have recently developed a method for longitudinal and quantitative in vivo neuroimaging of exosomes based on the superior visualization abilities of classical X-ray computed tomography (CT), combined with gold nanoparticles as labeling agents. Read More

View Article and Full-Text PDF