261 results match your criteria administering influenza


Inhibitory effects of epigallocatechin gallate (EGCG) combined with zinc sulfate and silver nanoparticles on avian influenza A virus subtype H5N1.

Eur Rev Med Pharmacol Sci 2021 Mar;25(6):2630-2636

Pharmacy, Middle East University, Amman, Jordan.

Objective: Even though antiviral drugs against H5N1 flu infection are accessible, they are still limited by antiviral drug resistance and unfavorable side effects. Thus, this work tested the action of epigallocatechin gallate (EGCG) co-administered with both zinc (II) ions and silver nanoparticles (AgNPs).

Materials And Methods: EGCG was used with both zinc sulfate (zinc II) and silver nanoparticles to test their antiviral activities against avian flu subtype H5N1 in embryonated SPF eggs. Read More

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Musculoskeletal Corticosteroid Injection during COVID-19 Pandemic in Sabah: Is It Safe?

Adv Orthop 2021 27;2021:8863210. Epub 2021 Mar 27.

Sports Medicine Department, University Malaya Medical Centre, Kuala Lumpur, Malaysia.

Musculoskeletal corticosteroid injection is commonly used as an adjunct to help patients in pain management. In this current COVID-19 pandemic, many clinicians would differ from this treatment as steroid is considered an immunosuppressive drug and could risk the patient of developing severe adverse effects if contracting COVID-19. This is a retrospective study based in Sabah, Malaysia, examining the prevalence of COVID-19 infection following musculoskeletal corticosteroid injection from 1 December 2019 until 30 June 2020 in the sports medicine clinic and the orthopedic clinic. Read More

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An Assessment of Pharmacy School Curricula in Florida and Inactivated Influenza Vaccine (IIV) Administration to Pregnant Women.

Pharmacy (Basel) 2021 Mar 18;9(1). Epub 2021 Mar 18.

College of Public Health, University of South Florida, Tampa, FL 33612, USA.

There is a high risk for morbidity and mortality in pregnant women associated with influenza virus illness. Vaccine uptake rates in pregnant women remain lower than the targeted Healthy People 2020 goals despite recommendations from the Centers for Disease Control (CDC). Few studies have examined the role of the pharmacist in providing immunization services to pregnant women, fewer still have directly examined the PharmD curricula and the perspectives of pharmacy students on how they perceive their role in providing influenza inactivated vaccine (IIV) to pregnant women. Read More

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Pharmacists' views and desires regarding pharmacist administration of vaccines in New Zealand.

Int J Pharm Pract 2021 Mar;29(2):126-133

Pharmaceutical Society of New Zealand, Wellington, New Zealand.

Objectives: To explore pharmacists' views and experiences of pharmacist-administered vaccinations, motivators and barriers to pharmacists administering vaccinations and their preferences for expansions to such services.

Methods: All practising pharmacist members (n = 3400) of the Pharmaceutical Society of New Zealand were invited to participate in an online survey in 2017.

Key Findings: A total of 468 pharmacists completed the survey (14%). Read More

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A new candidate vaccine for human brucellosis based on influenza viral vectors: a preliminary investigation for the development of an immunization schedule in a guinea pig model.

Infect Dis Poverty 2021 Feb 16;10(1):13. Epub 2021 Feb 16.

Kazakh National Agrarian University, 8 Abay Avenue, Almaty, 050010, Kazakhstan.

Background: A new candidate vector vaccine against human brucellosis based on recombinant influenza viral vectors (rIVV) subtypes H5N1 expressing Brucella outer membrane protein (Omp) 16, L7/L12, Omp19 or Cu-Zn SOD proteins has been developed. This paper presents the results of the study of protection of the vaccine using on guinea pigs, including various options of administering, dose and frequency. Provided data of the novel vaccine candidate will contribute to its further movement into the preclinical stage study. Read More

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February 2021

Prevention of influenza during mismatched seasons in older adults with an MF59-adjuvanted quadrivalent influenza vaccine: a randomised, controlled, multicentre, phase 3 efficacy study.

Lancet Infect Dis 2021 Feb 9. Epub 2021 Feb 9.

Seqirus, Cambridge, MA, USA.

Background: The absolute degree of protection from influenza vaccines in older adults has not been studied since 2001. This study aimed to show the clinical efficacy of an MF59-adjuvanted quadrivalent influenza vaccine (aQIV) in adults 65 years or older compared with adults not vaccinated to prevent influenza.

Methods: We did a randomised, stratified, observer-blind, controlled, multicentre, phase 3 study at 89 sites in 12 countries in 2016-17 northern hemisphere and 2017 southern hemisphere influenza seasons. Read More

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February 2021

Combination of Microneedles and MF59 Adjuvant as a Simple Approach to Enhance Transcutaneous Immunization.

J Biomed Nanotechnol 2020 Dec;16(12):1776-1786

MF59, an oil-in-water nanoemulsion, has been used in licensed seasonal influenza vaccines for many years. Administration of such vaccines by injection is associated with pain and safety issues. Here, we evaluated the potential of administering MF59 via a transcutaneous route with antigen loading (either encapsulated into or mixed with MF59) to intact or microneedle-pretreated skin. Read More

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December 2020

The state of infection prevention and control at home health agencies in the United States prior to COVID-19: A cross-sectional study.

Int J Nurs Stud 2021 Mar 19;115:103841. Epub 2021 Jan 19.

Center for Health Policy, Columbia University School of Nursing, 560 West 168th Street, Mail Code 6, New York 10032, NY, USA.

Background: Home health care is a rapidly growing healthcare sector worldwide. Home health professionals face unique challenges related to preventing and controlling infections, which are likely to amplify during an infectious disease outbreak (e.g. Read More

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Strengthening pandemic preparedness through pharmacy and public health collaborations: Findings from a facilitated discussion exercise.

J Am Pharm Assoc (2003) 2021 Jan 18. Epub 2021 Jan 18.

Background: Community pharmacists are key partners to public health agencies during pandemics and other emergencies. Community pharmacy and public health agencies can establish memoranda of understanding (MOUs) for dispensing and administering medical countermeasures and providing related services to affected population(s) during a public health incident.

Objective: The objective of this facilitated discussion exercise was to identify the strengths and opportunities associated with the activation of a statewide pharmacy-public health agencies MOU with community pharmacists on the basis of a simulated pandemic influenza event. Read More

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January 2021

Association between C-reactive protein response to influenza vaccine during pregnancy and birth outcomes.

Am J Hum Biol 2021 Jan 20. Epub 2021 Jan 20.

Department of Anthropology and Institute for Policy Research, Northwestern University, Evanston, Illinois, USA.

Objective: A growing body of evidence suggests inflammatory markers can help predict poor outcomes in pregnancy. We evaluated C-reactive protein (CRP)-a key biomarker of inflammation-before and after a safe immune provocation (the seasonal influenza vaccine) during pregnancy. We evaluated predictors of the magnitude of response, as well as the association between CRP response and birth outcomes. Read More

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January 2021

Pneumococcal conjugate vaccines for preventing acute otitis media in children.

Cochrane Database Syst Rev 2020 11 24;11:CD001480. Epub 2020 Nov 24.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

Background: Prior to introducing pneumococcal conjugate vaccines (PCVs), Streptococcus pneumoniae was most commonly isolated from the middle ear fluid of children with acute otitis media (AOM). Reducing nasopharyngeal colonisation of this bacterium by PCVs may lead to a decline in AOM. The effects of PCVs deserve ongoing monitoring since studies from the post-PCV era report a shift in causative otopathogens towards non-vaccine serotypes and other bacteria. Read More

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November 2020

EFFICACY OF SPECIFIC PREVENTION OF INFLUENZA IN INDIVIDUALS WITH POLYMORPHISMS ARG753GLN OF TLR-2, LEU412PHE OF TLR-3, ASP299GLY OF TLR-4 GENES.

Wiad Lek 2020 ;73(9 cz. 2):1944-1949

UKRAINIAN MEDICAL STOMATOLOGICAL ACADEMY, POLTAVA, UKRAINE.

Objective: The aim: Is to study the efficacy of influenza vaccination for individuals with polymorphism Arg753Gln of TLR-2 gene, Leu412Phe of TLR-3 gene, and Asp299Gly of TLR-4 gene.

Patients And Methods: Materials and methods: 66 people with mutant genotypes and normal distribution of alleles of TLR-2, TLR-3, TLR-4 genes, aged 18-63, were inoculated with anti-influenza vaccine. The genotyping of Arg753Gln polymorphic site of TLR-2, Asp299Gly of TLR-4, and Leu412Phe of TLR-3 gene was carried out by polymerase chain reaction with oligonucleotide primers usage. Read More

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November 2020

Pharmacists' Perspectives on Providing the Influenza Vaccine in Community Pharmacies: A Qualitative Study.

Risk Manag Healthc Policy 2020 16;13:2179-2187. Epub 2020 Oct 16.

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.

Purpose: The objective of this study was to explore community pharmacists' views on providing influenza vaccine administration services in community pharmacies in Jordan.

Methods: The current study is a cross-sectional exploratory study conducted using semi-structured telephone interviews. The semi-structured interview schedule was developed by the researchers and comprised open-ended questions aligned with the study objectives. Read More

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October 2020

The incidence and clinical effects of Bordetella pertussis in children hospitalized with acute bronchiolitis.

Turk J Pediatr 2020 ;62(5):726-733

Division of Pediatric Infectious Diseases, Ankara University Faculty of Medicine, Ankara, Turkey.

Background: Pertussis is a disease leading to high morbidity and mortality in neonates and infants. Bronchiolitis is the most common cause of hospitalization especially in children < 2 year-old. Although the clinical findings are different in these two diseases, it is sometimes difficult to make this distinction in partially or fully vaccinated children. Read More

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November 2020

Effectiveness of a Simultaneous rHVT-F(ND) and rHVT-H5(AI) Vaccination of Day-Old Chickens and the Influence of NDV- and AIV-Specific MDA on Immune Response and Conferred Protection.

Vaccines (Basel) 2020 Sep 16;8(3). Epub 2020 Sep 16.

Sciensano, Avian Virology and Immunology Service, Groeselenberg 99, 1180 Brussels, Belgium.

The recombinant herpesvirus of turkey (rHVT) vaccines targeting Newcastle disease (ND) and H5Nx avian influenza (AI) have been demonstrated efficient in chickens when used individually at day-old. Given the practical field constraints associated with administering two vaccines separately and in the absence of a currently available bivalent rHVT vector vaccine expressing both F(ND) and H5(AI) antigens, the aim of this study was to investigate whether interference occurs between the two vaccines when simultaneously administered in a single shot. The studies have been designed to determine (i) the ND and AI-specific protection and antibody response conferred by these vaccines inoculated alone or in combination at day-old, (ii) the influence of maternally-derived antibodies (MDA), and (iii) the potential interference between the two vaccine. Read More

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September 2020

Airway Delivery of Anti-influenza Monoclonal Antibodies Results in Enhanced Antiviral Activities and Enables Broad-Coverage Combination Therapies.

J Virol 2020 10 27;94(22). Epub 2020 Oct 27.

ContraFect Corporation, Yonkers, New York, USA

Effective and reliable anti-influenza treatments are acutely needed and passive immunizations using broadly neutralizing anti-influenza monoclonal antibodies (bNAbs) are a promising emerging approach. Because influenza infections are initiated in and localized to the pulmonary tract, and newly formed viral particles egress from the apical side of the lung epithelium, we compared the effectiveness of hemagglutinin (HA) stalk-binding bNAbs administered through the airway (intranasal or via nebulization) versus the systemic route (intraperitoneal or intravenous). Airway deliveries of various bNAbs were 10- to 50-fold more effective than systemic deliveries of the same bNAbs in treating H1N1, H3N2, B/Victoria-, and B/Yamagata-lineage influenza viral infections in mouse models. Read More

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October 2020

Not Throwing Away My Shot: Leveraging a Peer Vaccination Workshop to Increase Residents' Immunization Skills.

Acad Pediatr 2020 Nov - Dec;20(8):1054-1058. Epub 2020 Jul 25.

Department of Pediatrics, Section of Hospital Medicine, Children's Corporate Center, Medical College of Wisconsin, Milwaukee, Wis.

Objective: The Accreditation Council for Graduate Medical Education (ACGME) requires that pediatric residents demonstrate competence administering immunizations. Despite mandatory simulation training, less than half our residents reported immunization competence. All residents need to receive their influenza vaccination, but schedule restrictions present logistical challenges. Read More

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A global agenda for older adult immunization in the COVID-19 era: A roadmap for action.

Vaccine 2020 Jul 3. Epub 2020 Jul 3.

Department of Health Sciences, University of Florence, Florence, Italy.

Given our global interconnectedness, the COVID-19 pandemic highlights the urgency of building a global system that can support both routine and pandemic/epidemic adult immunization. As such, a framework to recommend vaccines and build robust platforms to deliver them to protect the rapidly expanding demographic of older adults is needed. Adult immunization as a strategy has the broad potential to preserve and improve medical, social, and economic outcomes, including maintaining functional ability that benefits older adults, their families, communities, and countries. Read More

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Rapid Point-of-Care Influenza Testing for Patients in German Emergency Rooms - A Cost-Benefit Analysis.

J Health Econ Outcomes Res 2019 26;6(3):203-212. Epub 2019 Dec 26.

Institution for Statutory Accident Insurance and Prevention in the Health and Welfare Services (BGW), Hamburg 22089, Germany.

Background: Each year, influenza causes significant morbidity and death worldwide and produces significant economic losses at the expense of the healthcare system.

Objective: To assess the cost-benefit relationship of implementing a rapid point-of-care (POC) influenza test in emergency rooms (ERs) of German hospitals.

Methods: A deterministic decision-analytic model simulated the incremental costs of using the Sofia Influenza A+B test compared to those of using clinical judgement alone to confirm or exclude influenza in adult ILI (influenza-like illness) patients in German ERs prior to hospitalization. Read More

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December 2019

The Practice Guideline for Vaccinating Korean Patients with Autoimmune Inflammatory Rheumatic Disease.

Infect Chemother 2020 Jun;52(2):252-280

Department of Rheumatology, Chonnam National University Medical School & Hospital, Gwangju, Korea.

To develop a clinical practice guideline for vaccination in patients with autoimmune inflammatory rheumatic disease (AIIRD), the Korean College of Rheumatology and the Korean Society of Infectious Diseases developed a clinical practice guideline according to the clinical practice guideline development manual. Since vaccination is unlikely to cause AIIRD or worsen disease activities, required vaccinations are recommended. Once patients are diagnosed with AIIRD, treatment strategies should be established and, at the same time, monitor their vaccination history. Read More

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Evaluation of a vaccination training program for pharmacy graduands in Australia.

Curr Pharm Teach Learn 2020 07 18;12(7):850-857. Epub 2020 Mar 18.

Sydney Pharmacy School, Faculty of Medicine and Health, University of Sydney, NSW 2006, Australia. Electronic address:

Introduction: The University of Sydney School of Pharmacy offered provisionally registered pharmacy graduands the opportunity to complete the Pharmacy Guild of Australia (PGA) vaccination training course. This study evaluated participant perceptions of the vaccination training course and their experiences in administering the vaccines.

Methods: Graduands' perceived knowledge of influenza vaccinations and skills and confidence in administering vaccinations were assessed using anonymous, 17-item, pre- and post-course surveys (5-point Likert items, 1 = strongly disagree to 5 = strongly agree). Read More

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Modeling mitigation of influenza epidemics by baloxavir.

Nat Commun 2020 06 2;11(1):2750. Epub 2020 Jun 2.

Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA.

Influenza viruses annually kill 290,000-650,000 people worldwide. Antivirals can reduce death tolls. Baloxavir, the recently approved influenza antiviral, inhibits initiation of viral mRNA synthesis, whereas oseltamivir, an older drug, inhibits release of virus progeny. Read More

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The difficulties experienced during the preparation and administration of oral drugs by parents at home: a cross-sectional study from Palestine.

BMC Pediatr 2020 05 7;20(1):198. Epub 2020 May 7.

Poison Control and Drug Information Center (PCDIC), College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.

Background: Failure to properly administer drugs to children at home may cause adverse events, which makes it a challenging job for parents or caregivers. The main goal of this study was to investigate the problems and difficulties that parents or caregivers faced when administering oral drugs to their children at home.

Methods: A cross-sectional study was conducted using a questionnaire consisting of 'yes/no' and multiple-response questions to assess parents' experiences and problems with administering medication to their children at home. Read More

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Cost and reimbursement of providing routine vaccines in outpatient obstetrician/gynecologist settings.

Am J Obstet Gynecol 2020 10 13;223(4):562.e1-562.e8. Epub 2020 Mar 13.

Department of Pediatrics, University of Colorado Denver; Adult and Child Consortium for Outcomes Research and Delivery Science, University of Colorado Denver.

Objective: To determine the costs and reimbursement associated with running a vaccine program in 5 obstetrics/gynecology practices in Colorado that had participated in a 3-year randomized, controlled trial focused on increasing vaccination in this setting.

Materials And Methods: This was a secondary analysis on costs from 5 clinics participating in a cluster-randomized controlled trial that assessed the effectiveness of a multimodal intervention to improve vaccination rates in outpatient obstetrics/gynecology clinics in central Colorado. The intervention included designation of an immunization champion within the practice, purchasing recommended vaccines for the practice, guidance on storage and management, implementing practices for routine identification of eligible patients for vaccination using the medical record, implementation of standing orders for vaccination, and vaccine administration to patients. Read More

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October 2020

Fever After Influenza, Diphtheria-Tetanus-Acellular Pertussis, and Pneumococcal Vaccinations.

Pediatrics 2020 03 6;145(3). Epub 2020 Feb 6.

Immunization Safety Office, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Administering inactivated influenza vaccine (IIV), 13-valent pneumococcal conjugate vaccine (PCV13), and diphtheria-tetanus-acellular pertussis (DTaP) vaccine together has been associated with increased risk for febrile seizure after vaccination. We assessed the effect of administering IIV at a separate visit from PCV13 and DTaP on postvaccination fever.

Methods: In 2017-2018, children aged 12 to 16 months were randomly assigned to receive study vaccines simultaneously or sequentially. Read More

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Therapeutic efficacy of arginine-rich exenatide on diabetic neuropathy in rats.

Eur J Pharmacol 2020 Jan 30;866:172835. Epub 2019 Nov 30.

RMC "HOME OF PHARMACY", The Leningrad Region, Vsevolozhskiy District, 188663, Russia.

Diabetes mellitus is characterized by metabolic dysregulation associated with a number of health complications. More than 50% of patients with diabetes mellitus suffer from diabetic polyneuropathy, which involves the presence of peripheral nerve dysfunction symptoms. The aim of this study was to evaluate the potential of a new synthetic arginine-rich exendin-4 (Peptide D) in the treatment of complications caused by diabetes, including peripheral neuropathy, in rats. Read More

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January 2020

Shoulder Injury Related to Vaccine Administration (SIRVA): Petitioner claims to the National Vaccine Injury Compensation Program, 2010-2016.

Vaccine 2020 01 23;38(5):1076-1083. Epub 2019 Nov 23.

National Vaccine Injury Compensation Program, Health Resources and Services Administration, U.S. Department of Health and Human Services, 5600 Fishers Lane, Rockville, MD 20857, United States.

Background: Since 2010, petitioner claims of shoulder injury related to vaccine administration (SIRVA) to the National Vaccine Injury Compensation Program (VICP) have been increasing.

Objective: To conduct a scientific review of clinical characteristics of SIRVA petitions to the VICP.

Methods: We queried the VICP's Injury Compensation System database for medical reports of alleged SIRVA and SIRVA-like injuries. Read More

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January 2020

Update: Interim Guidance for Health Care Providers for Managing Patients with Suspected E-cigarette, or Vaping, Product Use-Associated Lung Injury - United States, November 2019.

MMWR Morb Mortal Wkly Rep 2019 Nov 22;68(46):1081-1086. Epub 2019 Nov 22.

CDC, the Food and Drug Administration (FDA), state and local health departments, and public health and clinical stakeholders are investigating a nationwide outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI) (1). CDC has published recommendations for health care providers regarding EVALI (2-4). Recently, researchers from Utah and New York published proposed diagnosis and treatment algorithms for EVALI (5,6). Read More

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November 2019

Characteristics of vaccinating providers reported through Medicare claims in office-based settings: Volume of influenza and pneumococcal vaccinations.

Vaccine 2020 01 1;38(1):15-19. Epub 2019 Nov 1.

Center for Medicare, Centers for Medicare & Medicaid Services, Baltimore, MD, United States.

Vaccination coverage among older adults is low in the United States. A recommendation from a provider is a strong predictor of vaccine receipt. Using Medicare Fee-For-Service data (2015-2017) this study characterized providers by the number of influenza and pneumococcal vaccines administered in physician offices, age, gender, and professional specialty to determine the volume of vaccines provided by individual providers and characteristics of these providers. Read More

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January 2020

Microprojection arrays applied to skin generate mechanical stress, induce an inflammatory transcriptome and cell death, and improve vaccine-induced immune responses.

NPJ Vaccines 2019 11;4:41. Epub 2019 Oct 11.

1Delivery of Drugs and Genes Group (D2G2), Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072 Australia.

Chemical adjuvants are typically used to improve immune responses induced by immunisation with protein antigens. Here we demonstrate an approach to enhance immune responses that does not require chemical adjuvants. We applied microprojection arrays to the skin, producing a range of controlled mechanical energy to invoke localised inflammation, while administering influenza split virus protein antigen. Read More

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October 2019