29,060 results match your criteria administering

The use of high dose octreotide in management of neonatal chylothorax: Review.

M A Alhasoon

J Neonatal Perinatal Med 2021 Apr 7. Epub 2021 Apr 7.

Department of Pediatrics, Unaizah College of Medicine and Medical Sciences, Qassim University, Kingdom of Saudi Arabia.

Background: Being a rare condition, the incidence of chylothorax among neonates is low, but the mortality rate is high. In a dire effort to reduce the risk of death, octreotide treatment is used to effectively treat acquired and congenital chylothorax. Octreotide is proven to effectively treat chylothorax in pre-term and full-term neonates. Read More

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Method for detecting hemodynamic alterations following a single gavage in rats.

Exp Anim 2021 Apr 12. Epub 2021 Apr 12.

Functional Control Systems, Graduate School of Engineering and Science, Shibaura Institute of Technology.

It is known that administering a gavage to rodents evokes a cardiac reflex, due to gastrointestinal stimulation. Consequently, it is difficult to evaluate changes in hemodynamics after a single oral dose of a pungent or astringent, which alters the circulation by increasing sympathetic activity. In the present study, we developed a method for administering a gavage without significantly affecting hemodynamics measurements. Read More

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The treatment challenges and limitation in high-voltage pediatric electrical burn at rural area: A case report.

Int J Surg Case Rep 2021 Apr 1;82:105857. Epub 2021 Apr 1.

S. K. Lerik Public General Hospital, Kupang City, East Nusa Tenggara, Indonesia. Electronic address:

Introduction: Although rare, electrical injury in pediatrics is potentially life threatening and has significant and long-term impact in life. It is challenging to manage such cases in rural areas.

Presentation Of Case: A fully conscious 13-year-old boy was admitted to the emergency room after being electrocuted by high-voltage power cable, with superficial partial thickness burn over right arm, trunk, and left leg (26 % of total body surface area). Read More

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Development of X-ray contrast agents using single nanometer-sized gold nanoparticles and lactoferrin complex and their application in vascular imaging.

Colloids Surf B Biointerfaces 2021 Apr 1;203:111732. Epub 2021 Apr 1.

Department of Medical Physics, Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan; International Center for Synchrotron Radiation InnovationSmart (SRIS), Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai 980-8577, Japan. Electronic address:

The technology to accurately image the morphology of tumor vessels with X-ray contrast agents is important to clarify mechanisms underlying tumor progression and evaluate the efficacy of chemotherapy. However, in clinical practice, iodine-based contrast agents present problems such as short blood retention owing to a high clearance ability and insufficient X-ray absorption capacity when compared with other high atomic number elements. To resolve these issues, gold nanoparticles (AuNPs), with a high atomic number, have attracted a great deal of attention as contrast agents for angiography, and have been employed in small animal models. Read More

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Avelumab first-line maintenance in locally advanced or metastatic urothelial carcinoma: Applying clinical trial findings to clinical practice.

Cancer Treat Rev 2021 Mar 22;97:102187. Epub 2021 Mar 22.

Beth Israel Deaconess Medical Center and IMIM-PSMAR Lab, Harvard Medical School, Boston, MA, USA.

Although urothelial carcinoma (UC) is considered a chemotherapy-sensitive tumor, progression-free survival and overall survival (OS) are typically short following standard first-line (1L) platinum-containing chemotherapy in patients with locally advanced or metastatic disease. Immune checkpoint inhibitors (ICIs) have antitumor activity in UC and favorable safety profiles compared with chemotherapy; however, trials of 1L ICI monotherapy or chemotherapy + ICI combinations have not yet shown improved OS vs chemotherapy alone. In addition to direct cytotoxicity, chemotherapy has potential immunogenic effects, providing a rationale for assessing ICIs as switch-maintenance therapy. Read More

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Comparison of immediate hypersensitivity reactions to preoperative antibiotics in patients labeled as penicillin allergic.

Surgery 2021 Apr 8. Epub 2021 Apr 8.

University of Colorado Anschutz Medical Campus, Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO. Electronic address:

Background: Cefazolin is routinely recommended as the first-line agent for surgical antibiotic prophylaxis because it prevents more surgical site infections than second-line antibiotics. Clinicians often avoid administering cefazolin to patients who are labeled as penicillin allergic due to concerns of cross-reactivity. The aim of this study was to compare the incidence of hypersensitivity reactions between cefazolin and the second-line antibiotics vancomycin and clindamycin. Read More

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A mixed methods approach to determine the climate of interprofessional education among medical and health sciences students.

BMC Med Educ 2021 Apr 10;21(1):203. Epub 2021 Apr 10.

College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.

Background: High-quality patient care is a complex phenomenon that requires collaboration among healthcare professionals. Research has shown that Interprofessional Education (IPE) carries promise to improve collaborative work and patient care. So far, collaboration among various health professionals remains a challenge. Read More

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Diagnostic Accuracy of Ambulatory Devices in Detecting Atrial Fibrillation: Systematic Review and Meta-analysis.

JMIR Mhealth Uhealth 2021 Apr 9;9(4):e26167. Epub 2021 Apr 9.

Department of Family Medicine, Taipei Medical University Hospital, Taipei City, Taiwan.

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide. Early diagnosis of AF is crucial for preventing AF-related morbidity, mortality, and economic burden, yet the detection of the disease remains challenging. The 12-lead electrocardiogram (ECG) is the gold standard for the diagnosis of AF. Read More

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Reinforced electrospun nanofiber composites for drug delivery applications.

J Biomed Mater Res A 2021 Apr 9. Epub 2021 Apr 9.

Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Gandhinagar, India.

Electrospun technology becomes a valuable means of fabricating functional polymeric nanofibers with distinctive morphological properties for drug delivery applications. Nanofibers are prepared from the polymer solution, which allows the direct incorporation of therapeutics such as small drug molecules, genes, and proteins by merely mixing them into the polymeric solution. Due to their biocompatibility, adhesiveness, sterility, and efficiency in delivering diverse cargoes, electrospun nanofibers have gained much attention. Read More

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A Robust Percutaneous Myocardial Infarction Model in Pigs and Its Effect on Left Ventricular Function.

J Cardiovasc Transl Res 2021 Apr 8. Epub 2021 Apr 8.

Center for Clinical Research, Texas Heart Institute, 6770 Bertner Ave, Houston, TX, 77030, USA.

In this study, we created a reproducible myocardial infarction (MI) model in pigs characterized by a low mortality rate and significant changes in left ventricular function. After administering an arrhythmia prevention regimen, we created a 90-min balloon-induced percutaneous MI in 42 pigs below the first diagonal branch (D1) of the left anterior descending artery. Echocardiograms were performed before and 14 days after MI induction. Read More

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Undergraduate data science degrees emphasize computer science and statistics but fall short in ethics training and domain-specific context.

PeerJ Comput Sci 2021 25;7:e441. Epub 2021 Mar 25.

Office of Digital Innovation & Stewardship, University Libraries, University of Arizona, Tucson, AZ, USA.

The interdisciplinary field of data science, which applies techniques from computer science and statistics to address questions across domains, has enjoyed recent considerable growth and interest. This emergence also extends to undergraduate education, whereby a growing number of institutions now offer degree programs in data science. However, there is considerable variation in what the field actually entails and, by extension, differences in how undergraduate programs prepare students for data-intensive careers. Read More

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Primary Care Physicians' Perspective on Pharmacists Delivering Vaccines to Adults.

J Am Board Fam Med 2021 Mar-Apr;34(2):392-397

From the Department of Pharmacy, Children's Hospital Colorado, Aurora, (CEM); Adult and Child Consortium for Health Outcomes Research and Delivery Science, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora (LPH, STO, JRC, LAC, CG, MB, BLB, AK); Division of General Internal Medicine, Denver Health, Denver, CO (LPH); Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora (STO, JRC, MB, AK); Department of Community and Behavioral Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora (LAC).

Introduction: Since 2009, pharmacists in all 50 states have been authorized to provide vaccinations to adults. The objective of this study was to assess primary care physicians' (PCPs) experiences with and attitudes about pharmacists administering vaccinations.

Methods: Internet and mail survey of PCPs representative of American College of Physicians' and American Academy of Family Physicians' memberships. Read More

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September 2020

Evaluation of cytokines expression in the phytoflavonoids treated epileptic rats: An in vivo study.

Pak J Pharm Sci 2020 Sep;33(5(Supplementary)):2371-2377

Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan/Faculty of Pharmacy, University of Central Punjab, Lahore, Pakistan.

Seizure are basic characteristic of epilepsy; these initiate due to irregular, excessive and synchronous electrical discharges. We aimed to determine the antiepileptic potential of phyto-flavonoids on the evaluation of the mRNA expression of TNF-α, IL-6, IL-1 Beta, IL-10, IL-1Ra, IL 4 and NF-κB. We induced chronic epilepsy in rats by administering sub-convulsive dose of pentylenetetrazole (25 mg/kg/day for 28 days). Read More

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September 2020

Inhibitory effects of epigallocatechin gallate (EGCG) combined with zinc sulfate and silver nanoparticles on avian influenza A virus subtype H5N1.

Eur Rev Med Pharmacol Sci 2021 Mar;25(6):2630-2636

Pharmacy, Middle East University, Amman, Jordan.

Objective: Even though antiviral drugs against H5N1 flu infection are accessible, they are still limited by antiviral drug resistance and unfavorable side effects. Thus, this work tested the action of epigallocatechin gallate (EGCG) co-administered with both zinc (II) ions and silver nanoparticles (AgNPs).

Materials And Methods: EGCG was used with both zinc sulfate (zinc II) and silver nanoparticles to test their antiviral activities against avian flu subtype H5N1 in embryonated SPF eggs. Read More

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[Successful treatment with cyclosporine in a patient with rituximab-refractory thrombocytopenic purpura].

Rinsho Ketsueki 2021 ;62(3):176-179

Department of Hematology and Oncology, Mie University Hospital.

Acquired thrombotic thrombocytopenic purpura (aTTP) is a life-threatening systemic thrombotic microangiopathy characterized by the presence of anti-ADAMTS13 antibodies (inhibitor). Here we report the case of a patient with refractory aTTP successfully treated with cyclosporine. A 69-year-old man presenting with hematuria and petechiae was referred to our hospital; he was disoriented and febrile. Read More

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Musculoskeletal Corticosteroid Injection during COVID-19 Pandemic in Sabah: Is It Safe?

Adv Orthop 2021 27;2021:8863210. Epub 2021 Mar 27.

Sports Medicine Department, University Malaya Medical Centre, Kuala Lumpur, Malaysia.

Musculoskeletal corticosteroid injection is commonly used as an adjunct to help patients in pain management. In this current COVID-19 pandemic, many clinicians would differ from this treatment as steroid is considered an immunosuppressive drug and could risk the patient of developing severe adverse effects if contracting COVID-19. This is a retrospective study based in Sabah, Malaysia, examining the prevalence of COVID-19 infection following musculoskeletal corticosteroid injection from 1 December 2019 until 30 June 2020 in the sports medicine clinic and the orthopedic clinic. Read More

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Effect of M. chamomilla L. tea on chlorpromazine induced catalepsy: A neuroprotective study.

Pak J Pharm Sci 2020 Sep;33(5):1945-1953

Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan.

We determined anti-Parkinson's activity of M. chamomilla L. tea in chlorpromazine (CPZ) developed investigational animal model. Read More

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September 2020

Clinical effect of Brisson operation modified by Y-shaped incision for treatment of concealed penis in adolescents.

J Int Med Res 2021 Apr;49(4):3000605211005951

Department of Urology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.

Objective: To analyze the clinical effect of the Brisson operation modified by a Y-shaped incision in treating adolescent concealed penis.

Methods: We retrospectively analyzed clinical data of 27 adolescents with a concealed penis treated with the Brisson operation modified by a Y-shaped incision in our hospital from January 2017 to March 2020.

Results: The operation went smoothly in all 27 patients. Read More

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Vanillin exerts therapeutic effects against hyperglycemia-altered glucose metabolism and purinergic activities in testicular tissues of diabetic rats.

Reprod Toxicol 2021 Apr 3;102:24-34. Epub 2021 Apr 3.

Department of Biochemistry, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa. Electronic address:

Testicular dysfunctions leading to male infertility has been reported in type 2 diabetes (T2D), with glucose dysmetabolism, cholinergic and purinergic dysfunction being major contributors. In the present study, the effect of vanillin on glucose metabolism, purinergic and cholinergic dysfunctions were investigated in testicular tissues of T2D rats. Male Sprague-Dawley rats were divided into 6 groups containing 5 rats each. Read More

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Treatment results of radiotherapy to both the prostate and metastatic sites in patients with bone metastatic prostate cancer.

J Radiat Res 2021 Apr 5. Epub 2021 Apr 5.

Department of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

Although systemic therapy is the standard treatment for metastatic prostate cancer, a randomized controlled trial showed radiotherapy to the prostate improved overall survival of metastatic prostate cancer patients with the low metastatic burden. Additionally, a randomized phase II trial showed that metastasis-directed therapy for oligo-recurrent prostate cancer improved androgen-deprivation therapy (ADT)-free survival. Therefore, administering radiotherapy to both prostate and metastatic regions might result in better outcomes. Read More

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Boston Naming Test: Lose the Noose.

Arch Clin Neuropsychol 2021 Apr 5. Epub 2021 Apr 5.

Neuropsychology Program, Department of Psychiatry, Geisel School of Medicine at Dartmouth/DHMC, Lebanon, NH, USA.

Objective: Administering the noose item of the Boston Naming Test (BNT) has been questioned given the cultural, historical, and emotional salience of the noose in American culture. In response, some have modified the BNT by skipping/removing this item and giving the point as if the examinee responded correctly. It is unknown, however, whether modifying standardized administration and scoring in this manner affects clinical interpretation. Read More

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Limiting the priming dose of a SARS CoV-2 vaccine improves virus-specific immunity.

bioRxiv 2021 Apr 1. Epub 2021 Apr 1.

Since late 2019, SARS-CoV-2 has caused a global pandemic that has infected 128 million people worldwide. Although several vaccine candidates have received emergency use authorization (EUA), there are still a limited number of vaccine doses available. To increase the number of vaccinated individuals, there are ongoing discussions about administering partial vaccine doses, but there is still a paucity of data on how vaccine fractionation affects vaccine-elicited immunity. Read More

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targets host transcription factor NRF2 to activate anti-oxidant enzyme HO-1 and transcriptional repressor ATF3 for establishing infection.

Infect Immun 2021 Apr 5. Epub 2021 Apr 5.

Department of Biochemistry, University of Calcutta, Kolkata 700019, India.

In visceral leishmaniasis, we earlier showed that antioxidant enzyme heme oxygenase-1 (HO-1) is critical for survival. HO-1 inhibits host oxidative burst and inflammatory cytokine production leading to parasite persistence. In present study, screening of reported HO-1 transcription factors revealed that infection up-regulated (4. Read More

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Orbital abscess due to infection of a non-absorbable porous orbital implant after orbital wall fracture repair : An uncommon and delayed occurred case.

Eur J Ophthalmol 2021 Apr 5:11206721211008035. Epub 2021 Apr 5.

Department of Ophthalmology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.

We report a rare case of a patient who developed an orbital abscess several years after successful orbital medial wall fracture repair. A 37-year-old female patient who underwent orbital fracture repair with a titanium Medpor orbital implant two years prior visited the clinic for pain, conjunctival injection, discharge, and lid swelling of the right eye. Orbital CT revealed severe orbital cellulitis and sinusitis. Read More

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The Role of Neutrophil Extracellular Traps in Periodontitis.

Front Cell Infect Microbiol 2021 18;11:639144. Epub 2021 Mar 18.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.

Periodontitis is a chronic, destructive disease of periodontal tissues caused by multifaceted, dynamic interactions. Periodontal bacteria and host immunity jointly contribute to the pathological processes of the disease. The dysbiotic microbial communities elicit an excessive immune response, mainly by polymorphonuclear neutrophils (PMNs). Read More

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Hippocampal mu opioid receptors are modulated following cocaine self-administration in rat.

Eur J Neurosci 2021 Apr 3. Epub 2021 Apr 3.

Université de Strasbourg, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA UMR7364), Centre de la Recherche Nationale Scientifique, 12 rue Goethe, F-67000, Strasbourg, France.

Cocaine addiction is a complex pathology induced by long-term brain changes. Understanding the neurochemical changes underlying the reinforcing effects of this drug of abuse is critical for reducing the societal burden of drug addiction. The mu opioid receptor plays a major role in drug reward. Read More

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Injured recipients of low-titer group O whole blood have similar clinical outcomes compared to recipients of conventional component therapy: A single-center, retrospective study.

Transfusion 2021 Apr 3. Epub 2021 Apr 3.

Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Introduction: Low-titer group O whole blood (LTOWB) is being increasingly transfused to injured patients. This study evaluated a range of clinical outcomes to determine if receipt of LTOWB predisposed recipients to worse outcomes compared to recipients of conventional component therapy (CCT).

Methods: A retrospective analysis of trauma patients who received at least 3 units of LTOWB (LTOWB group) versus those that received at least 3 units of RBCs, 1 unit of plasma and 1 unit of platelets but no LTOWB (CCT group) during the first 24 h of their admission was performed. Read More

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In Vitro Assessment of the Antiviral Activity of Ketotifen, Indomethacin and Naproxen, Alone and in Combination, against SARS-CoV-2.

Viruses 2021 03 26;13(4). Epub 2021 Mar 26.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584CG Utrecht, The Netherlands.

The 2019 coronavirus infectious disease (COVID-19) is caused by infection with the new severe acute respiratory syndrome coronavirus (SARS-CoV-2). Currently, the treatment options for COVID-19 are limited. The purpose of the experiments presented here was to investigate the effectiveness of ketotifen, naproxen and indomethacin, alone or in combination, in reducing SARS-CoV-2 replication. Read More

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Inhibition of Soluble Epoxide Hydrolase Ameliorates Phenotype and Cognitive Abilities in a Murine Model of Niemann Pick Type C Disease.

Int J Mol Sci 2021 Mar 26;22(7). Epub 2021 Mar 26.

Pharmacology and Toxicology Section and Institute of Neuroscience, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.

Niemann-Pick type C (NPC) disease is a rare autosomal recessive inherited childhood neurodegenerative disease characterized by the accumulation of cholesterol and glycosphingolipids, involving the autophagy-lysosome system. Inhibition of soluble epoxide hydrolase (sEH), an enzyme that metabolizes epoxy fatty acids (EpFAs) to 12-diols, exerts beneficial effects in modulating inflammation and autophagy, critical features of the NPC disease. This study aims to evaluate the effects of UB-EV-52, an sEH inhibitor (sEHi), in an NPC mouse model (Npc) by administering it for 4 weeks (5 mg/kg/day). Read More

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