148,852 results match your criteria administered medical

Chemotherapy-Induced Peripheral Neurotoxicity in Cancer Survivors: Predictors of Long-Term Patient Outcomes.

J Natl Compr Canc Netw 2021 Jul 28;19(7):821-828. Epub 2021 Jul 28.

5Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia.

Background: Chemotherapy-induced peripheral neurotoxicity (CIPN) is a major adverse effect of cancer treatment. However, its impact remains poorly understood. This study aimed to investigate the impact associated with CIPN on the lives of cancer survivors. Read More

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Fibrin glue-induced eosinophilic pleural effusion after pulmonary resection: A case report.

Int J Surg Case Rep 2021 Jul 27;85:106239. Epub 2021 Jul 27.

Department of Thoracic Surgery, National Hospital Organization Yamaguchi Ube Medical Center, 685 Higashikiwa, Ube, Yamaguchi 755-0241, Japan.

Introduction And Importance: Prolonged air leakage after pulmonary resection is a common complication, and fibrin glue is used as a sealant to reduce this. Fibrin glue-induced adverse events are generally rare. Herein, we describe a rare case of fibrin glue-induced eosinophilic pleural effusion (EPE). Read More

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Immune checkpoint programmed death-1 mediates abdominal aortic aneurysm and pseudoaneurysm progression.

Biomed Pharmacother 2021 Jul 30;142:111955. Epub 2021 Jul 30.

Department of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, 450052 Henan, China; Key Vascular Physiology and Applied Research Laboratory of Zhengzhou City, 450002 Henan, China. Electronic address:

Purpose: The causes and pathogenetic mechanisms underlying abdominal aortic aneurysms (AAAs) and pseudoaneurysms are not fully understood. We hypothesized that inhibiting programmed death-1 (PD-1) can decrease AAA and pseudoaneurysm formation in mouse and rat models.

Methods: Human AAA samples were examined in conjunction with an adventitial calcium chloride (CaCl) application mouse model and an aortic patch angioplasty rat model. Read More

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Use of Oral Contraceptives in Women with Congenital Long QT Syndrome.

Heart Rhythm 2021 Jul 27. Epub 2021 Jul 27.

Clinical Cardiovascular Research Center, Division of Cardiology, University of Rochester Medical Center, Rochester, NY.

Background: Use of oral contraceptives (OC) may modulate the clinical course of women with congenital long QT syndrome (LQTS). The safety of OC use by sex hormone content has not been assessed in LQTS women.

Objective: We aimed to evaluate the association of OC with the risk of cardiac events (CE) in LQTS women. Read More

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Photodynamic Therapy Combined with Itraconazole Against A Case of Cutaneous Blastomycosis.

Photodiagnosis Photodyn Ther 2021 Jul 30:102436. Epub 2021 Jul 30.

Department of Dermatology, Daping Hospital, The Army Medical University, Chongqing 400042, China. Electronic address:

Cutaneous blastomycosis is endemic to North America and is often caused by dimorphic fungi with spores that are inhaled, inoculated spores, or hyphae that infect immunosuppressed and healthy people. It is sporadic and described as a universal imitator with morphological manifestations as erythema, nodules, and ulcers. Our case demonstrated a 69-year-old female bitten by her pet dog who was then diagnosed with cutaneous blastomycosis through social history and detailed laboratory examinations. Read More

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Evaluation of an Enhanced Recovery After Surgery Protocol (ERAS) for Same-Day discharge and Reduction of Opioid Use Following Bimaxillary Orthognathic Surgery.

J Oral Maxillofac Surg 2021 Jul 8. Epub 2021 Jul 8.

Partner, Southern California Permanente Medical Group; Attending Anesthesiologist, Department of Anesthesiology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA.

Purpose: This study sought to evaluate the impact of implementation of a comprehensive enhanced recovery after surgery (ERAS) protocol upon patients undergoing maxillary and mandibular osteotomy (MMO).

Methods: This study was a retrospective, observational study of patients undergoing MMO. The study intervention group consisted of patients who underwent MMO with utilization of ERAS protocol compared to control group without ERAS. Read More

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Kawasaki disease associated pulmonary involvement in infants.

Pediatr Pulmonol 2021 Aug 2. Epub 2021 Aug 2.

Department of Rheumatology and Immunology, Shenzhen Children's hospital, Shenzhen, China.

Objectives: Kawasaki disease (KD) is an acute, self-limited multisystemic vasculitis of unknown cause. Pulmonary involvement has been reported in case reports and limited small case series, which is not commonly recognized, especially in younger patients <1 year. Here, we describe clinical and radiological features of infants with KD-associated pulmonary involvement (KD-PI). Read More

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Efficacy of Delafloxacin against the Biothreat Pathogen .

Antimicrob Agents Chemother 2021 Aug 2:AAC0073621. Epub 2021 Aug 2.

U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID).

The in vitro activity and in vivo efficacy of delafloxacin were evaluated against the causative pathogen of melioidosis, . Delafloxacin MICs were determined by broth microdilution according to CLSI guidelines for 30 isolates of . The in vivo efficacy of delafloxacin was studied at a range of doses in a postexposure prophylaxis (PEP) murine model of melioidosis. Read More

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Systemic Contact Dermatitis: The Routes of Allergen Entry.

Clin Rev Allergy Immunol 2021 Aug 2. Epub 2021 Aug 2.

Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.

Systemic contact dermatitis (SCD) is a generalized reactivation of type IV hypersensitivity skin diseases in individuals with previous sensitization after a contact allergen is administered systemically. Patients with SCD may consider their dermatitis unpredictable and recalcitrant since the causative allergens are difficult to find. If a patient has a pattern of dermatitis suggestive of SCD but fails to improve with conventional treatment, SCD should be taken into consideration. Read More

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Effects Of Mixing Energy Drinks With Alcohol On Driving-Related Skills.

Int J Neuropsychopharmacol 2021 Aug 2. Epub 2021 Aug 2.

Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.

Background: Energy drinks (EDs) reduce sleepiness, fatigue and improve driving performance while alcohol does just the opposite. Although it is a trendy combination among young people, the effects of alcohol mixed with EDs on driving performance have been poorly studied. The aim was to assess if there is an interaction between the effects of both drinks on driving-related skills, as well as perceptions about driving ability. Read More

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The Development of as anti-SARS-CoV-2 nanobody drug candidates.

Elife 2021 Aug 2;10. Epub 2021 Aug 2.

Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, United States.

Combating the COVID-19 pandemic requires potent and low-cost therapeutics. We identified a series of single-domain antibodies (i.e. Read More

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Telemedicine in the era of coronavirus 19: Implications for postoperative care in cardiac surgery.

J Card Surg 2021 Aug 2. Epub 2021 Aug 2.

Department of Cardiothoracic Surgery, Yale University School of Medicine, New Haven, Connecticut, USA.

Background: The Coronavirus 19 (COVID-19) pandemic forced an unprecedented shift of postoperative care for cardiac surgery patients to telemedicine. How patients and surgeons perceive telemedicine is unknown. We examined patient and provider satisfaction with postoperative telehealth visits following cardiac surgery. Read More

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Synergistic deoxynucleoside and gene therapies for thymidine kinase 2 deficiency.

Ann Neurol 2021 Aug 2. Epub 2021 Aug 2.

H. Houston Merritt Neuromuscular Research Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY, 10032, USA.

Objective: Autosomal recessive human thymidine kinase 2 (TK2) mutations cause TK2 deficiency, which typically manifests as a progressive and fatal mitochondrial myopathy in infants and children. Treatment with pyrimidine deoxynucleosides deoxycytidine and thymidine ameliorates mitochondrial defects and extends the lifespan of Tk2 knock-in mouse (Tk2 ) and compassionate use deoxynucleoside therapy in TK2 deficient patients have shown promising indications of efficacy. To augment therapy for Tk2 deficiency, we assessed gene therapy alone and in combination with deoxynucleoside therapy in Tk2 mice. Read More

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Students' satisfaction and continued intention toward e-learning: a theory-based study.

Med Educ Online 2021 Dec;26(1):1961348

Department of Internal Medicine, College of Medicine, Taibah University, Almadinah Almunawwarah, Saudi Arabia.

Coronavirus disease (COVID-19) has forced the urgent lockdown of schools and colleges worldwide. To ensure the continuity of education a shift from traditional teaching to e-learning was required. This study aims to identify factors that affect students' satisfaction and continued intention towards e-learning. Read More

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December 2021

Myeloid specific deletion of ferroportin impairs macrophage bioenergetics but is disconnected from systemic insulin action in adult mice.

Am J Physiol Endocrinol Metab 2021 08 2. Epub 2021 Aug 2.

Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, Tennessee, United States.

Tissue iron overload is associated with insulin resistance and mitochondrial dysfunction in rodents and humans; however, the mechanisms or cell types that mediate this phenotype are not completely understood. Macrophages (Mɸ)s are known to contribute to iron handling; thus, we hypothesized that perturbed iron handling by Mɸs impairs mitochondrial energetics and evokes systemic insulin resistance in mice. Male and female mice with myeloid targeted (LysMCre) deletion of the canonical iron exporter, ferroportin (Fpn, encoded by Slc40a1), floxed littermates and C57BL/6J wild-type mice were used to test our hypotheses. Read More

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Optimal treatment sequence for targeted immune modulators for the treatment of moderate to severe ulcerative colitis.

J Manag Care Spec Pharm 2021 Aug;27(8):1046-1055

Comparative Health Outcomes, Policy & Economics (CHOICE) Institute, University of Washington School of Pharmacy, Seattle.

Ulcerative colitis is a chronic immune-mediated inflammatory condition of the large intestine and rectum. Several targeted immune modulators (TIMs) have demonstrated effectiveness for the treatment of moderate to severe ulcerative colitis and are approved by the FDA. Patients may try multiple TIMs, and currently there are no biomarkers or prognostic factors to guide choice of treatment sequence. Read More

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Perioperative sedation requirements of infants aged 0 to 3 months subjected to lower-body surgery under caudal blockade: a randomized controlled trial.

Minerva Anestesiol 2021 Aug 2. Epub 2021 Aug 2.

Department of Anesthesiology and Intensive Care, Hospital Hietzing, Vienna Hospital Association, Vienna, Austria.

Background: It remains unclear how much sedation is required for subumbilical surgery under caudal blockade, and sedatives may carry a poorly understood risk of late sequelae in infants. We designed a randomized controlled study to evaluate total propofol consumption and perioperative sedation quality with the avoidance of continuous perioperative sedation in infants undergoing surgery under caudal anesthesia.

Methods: Thirty-two infants (age: 0-3 months) were randomized to one of two groups in which perioperative administration of propofol was provided either "as needed" or by continuous infusion (5 mg kg-1 h-1). Read More

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One gut microbiota, Fusobacterium nucleatum aggravates Neonatal necrotizing enterocolitis by induction of IRF5 expression through lncRNA ENO1-IT1/miR-22-3p axis.

Eur Rev Med Pharmacol Sci 2021 Jul;25(14):4714-4728

Department of Neonatology, Affiliated Fuzhou Children Hospital of Fujian Medical University, Gulou District, Fuzhou, Fujian, China.

Objective: We explored the effects of Fusobacterium nucleatum (F. nucleatum) in Neonatal necrotizing enterocolitis (NEC) and its possible mechanism.

Materials And Methods: Patients with Neonatal NEC and normal healthy volunteers were collected for this study. Read More

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Postoperative Chemotherapy Bladder Instillation After Radical Nephroureterectomy: Results of a European Survey from the Young Academic Urologist Urothelial Cancer Group.

Eur Urol Open Sci 2020 Dec 6;22:45-50. Epub 2020 Nov 6.

Urology Department, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Paris University, Paris, France.

Background: Level 1 evidence supports the administration of single postoperative intravesical chemotherapy (pIVC) following radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC), in order to decrease intravesical recurrence risk.

Objective: The Young Academic Urologist Urothelial Cancer Group aimed to investigate the use of pIVC in daily practice among European colleagues.

Design Setting And Participants: An online survey was shared with European Association of Urology Section of Oncological Urology (ESOU) 2017 participants via e-mail. Read More

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December 2020

Cardiovascular Outcome in Patients Treated With SGLT2 Inhibitors for Heart Failure: A Meta-Analysis.

Front Cardiovasc Med 2021 14;8:691907. Epub 2021 Jul 14.

Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.

Sodium-glucose co-transporter 2 (SGLT2) inhibitors are an emerging class of glucose-lowering drugs that have become increasingly relevant for the treatment and prevention of heart failure (HF). Therefore, we aimed to investigate various SGLT2 inhibitors in patients with established HF at baseline and focused on the different types of HF. An extensive search of PubMed and Web of Science until January 2021 was done. Read More

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Acupuncture Treatment for Nocturnal Crying in Pediatric Patients: A Systematic Review of Clinical Studies.

Front Pediatr 2021 14;9:647098. Epub 2021 Jul 14.

Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.

Nocturnal crying is a common condition in which children intermittently or continuously cry and fuss during the night, at certain times or throughout the night. It is a common pediatric sleep disturbance for which medical assistance is highly sought by parents, and one of the non-pharmacologic treatments for nocturnal crying is pediatric acupuncture. This review aimed to review the literature about the effectiveness and safety of pediatric acupuncture for nocturnal crying. Read More

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Clinical Outcomes Among Patients With Metastatic Pancreatic Ductal Adenocarcinoma Treated With Liposomal Irinotecan.

Front Oncol 2021 15;11:678070. Epub 2021 Jul 15.

Department of Medical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.

Background: The NAPOLI-1 trial demonstrated that liposomal irinotecan in combination with fluorouracil (5-FU) and leucovorin (LV) prolonged survival with a manageable safety profile in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) previously treated with gemcitabine-based therapy. Real-world data on clinical outcomes associated with liposomal irinotecan in NAPOLI-1-based regimens is needed to further substantiate this.

Methods: This real-world, retrospective chart review study included patients with mPDAC who received NAPOLI-1-based regimens from six academic centers in the United States. Read More

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Perception of Non-Alcoholic Fatty Liver Disease: Real-Life Experience From Pakistan.

Cureus 2021 Jun 29;13(6):e16029. Epub 2021 Jun 29.

Internal Medicine, Dow University of Health Sciences, Karachi, PAK.

Introduction Non-alcoholic fatty liver disease (NALFD) has become one of the most pervasive causes of hepatic pathology. Because of its marked association with metabolic syndrome, type II diabetes and cardiovascular disease, NAFLD has gained substantial focus recently. Its prevalence and incidence are on the rise in Pakistan. Read More

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Chronic Alcohol Abuse-Induced Hypokalemia Might Lead to Delayed Diagnosis or Misdiagnosis of Thyrotoxic Periodic Paralysis.

Cureus 2021 Jun 23;13(6):e15880. Epub 2021 Jun 23.

School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei, TWN.

Thyrotoxic periodic paralysis is an uncommon and potentially life-threatening complication of thyrotoxicosis and hyperthyroidism characterized by acute and reversible episodes of muscle weakness and hypokalemia. Here is a 41-year-old Taiwanese male patient without any family history of hyperthyroidism presented to the emergency room of our institution with initial symptom of acute lower limb weakness. Laboratory analysis revealed uncommonly severe hypokalemia (<1. Read More

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Association of Antibiotics and Other Drugs with Clinical Outcomes in Metastatic Melanoma Patients Treated with Immunotherapy.

J Skin Cancer 2021 23;2021:9120162. Epub 2021 Jul 23.

Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Immune checkpoint inhibitors (ICIs) targeting the programmed cell death protein-1 (PD-1) and programmed cell death ligand-1 (PD-L1) have improved survival in many advanced cancers including advanced melanoma, renal cell, urothelial, and non-small-cell lung cancers. However, not all patients respond, and immune-related adverse events (irAEs) are common. Commensal gut bacteria may serve as an immunoregulatory link-mediating ICI response and toxicity. Read More

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Disparities in global COVID-19 vaccination rates & allocation of resources to countries in need.

Ann Med Surg (Lond) 2021 Jul 28:102620. Epub 2021 Jul 28.

Department of Surgery, Division of Trauma and Surgical Critical Care, Kendall Regional Medical Center, Miami, FL, USA.

As of July 20th, 2021, over 191 million confirmed COVID-related cases and 4.1 million COVID-related deaths have been documented across the globe. Vaccines were initially prioritized in healthcare workers (HCWs) and elderly populations to provide protection to high-risk individuals. Read More

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Trehalose Augments Neuron Survival and Improves Recovery from Spinal Cord Injury via mTOR-Independent Activation of Autophagy.

Oxid Med Cell Longev 2021 10;2021:8898996. Epub 2021 Jul 10.

Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Spinal cord injury (SCI) is a major cause of irreversible nerve injury and leads to serious tissue loss and neurological dysfunction. Thorough investigation of cellular mechanisms, such as autophagy, is crucial for developing novel and effective therapeutics. We administered trehalose, an mTOR-independent autophagy agonist, in SCI rats suffering from moderate compression injury to elucidate the relationship between autophagy and SCI and evaluate trehalose's therapeutic potential. Read More

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Adiponectin Treatment Attenuates Cerebral Ischemia-Reperfusion Injury through HIF-1-Mediated Antioxidation in Mice.

Oxid Med Cell Longev 2021 14;2021:5531048. Epub 2021 Jul 14.

Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China.

Adiponectin (ADPN) plays an important role in cerebral ischemia-reperfusion injury. Although previous studies have confirmed that ADPN pretreatment has a protective effect on ischemic stroke, the therapeutic effect of ADPN on ischemic stroke and the underlying mechanism are still unclear. In order to clarify these questions, focal transient cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in mice and ADPN was administered for three times at 6 h, 24 h, and 48 h after reperfusion. Read More

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A Clinical Monitoring Program of COVID-19 Outpatients: A Prospective Cohort Study.

Can J Infect Dis Med Microbiol 2021 20;2021:6644570. Epub 2021 Jul 20.

Department of Biostatistic, Ibne Sina Medical and Educational Center, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.

Purpose: Coronavirus disease 2019 (COVID-19) has been associated with a high rate of mortality and morbidity. While a high portion of COVID-19 patients have mild symptoms, a limited number of clinical trials have evaluated the clinical course of this large group of patients. This study was designed to investigate the demographics and clinical characteristics and comorbidity of nonhospitalized COVID-19 patients. Read More

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