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Wu-Zi-Yan-Zong-Wan protects mouse blood-testis barrier from Tripterygium wilfordii Hook. f. multiglycoside-induced disruption by regulating proinflammatory cytokines.

J Ethnopharmacol 2021 Jul 19;280:114440. Epub 2021 Jul 19.

Department of Gynecology, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China. Electronic address:

Ethnopharmacological Relevance: Wu-Zi-Yan-Zong-Wan (WZYZW) is a classical traditonal Chinese herbal formula and a Chinese patent medicine used to treat male infertility. However, the chemical components of WZYZW and its mechanism are not yet fully clarified.

Aim Of The Study: The purpose of this study is to observe the effect and underlying mechanism of WZYZW on ameliorating blood-testis barrier (BTB) dysfunction in mice with spermatogenic dysfunction induced by administration of Tripterygium wilfordii Hook. Read More

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Application of in vitro data in physiologically-based kinetic models for quantitative in vitro-in vivo extrapolation: A case-study for baclofen.

Toxicol In Vitro 2021 Jul 19:105223. Epub 2021 Jul 19.

Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.177, 3508TD Utrecht, the Netherlands. Electronic address:

Physiologically-based kinetic (PBK) models can simulate concentrations of chemicals in tissues over time without animal experiments. Nevertheless, in vivo data are often used to parameterise PBK models. This study aims to illustrate that a combination of kinetic and dynamic readouts from in vitro assays can be used to parameterise PBK models simulating neurologically-active concentrations of xenobiotics. Read More

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Neonatal Fournier's Gangrene: Avoiding Extensive Debridement.

Pediatr Infect Dis J 2021 Jul 20. Epub 2021 Jul 20.

From the Division of Plastic Pediatric Surgery, Pediatric Surgery Department Neonatology Department Pediatric Surgery Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Fournier's gangrene is a necrotizing fasciitis of the scrotal and inguinal region, associating high mortality and complication rates. It is extremely rare in the neonatal period and may be life threatening. We present an exceptional case of a 24-day-old boy who consulted to the emergency department for fever (39 °C) and an indurated, fluctuating and painful erythema in both groins, left hemiscrotum, left anterior femoral region and perineum for the last 6 hours. Read More

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Persistence of Immunity Following 2-Dose Priming with a 10-Valent Pneumococcal Conjugate Vaccine at 6 and 10 Weeks or 6 and 14 Weeks of Age in Nepalese Toddlers.

Pediatr Infect Dis J 2021 Jul 20. Epub 2021 Jul 20.

From the Paediatric Research Unit, Patan Academy of Health Sciences, Kathmandu, Nepal; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom; Department of Pathology, University of Otago, Christchurch, New Zealand; NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom; International Vaccine Access Centre, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; and Great Ormond Street Institute of Child Health Biomedical Research Centre, University College London, London, United Kingdom.

Background: The pneumococcal conjugate vaccine has had a substantial impact on invasive pneumococcal disease. Previously, we compared immunity following vaccination with the 10-valent pneumococcal conjugate vaccine (PCV10) administered at 2 slightly different schedules: at 6 and 10 weeks of age, and at 6 and 14 weeks of age, both followed by a 9-month booster. In this study, we followed up those participants to evaluate the medium-term persistence of serotype-specific pneumococcal immunity at 2-3 years of age. Read More

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Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through Sirt1 in MCAO rats.

J Asian Nat Prod Res 2021 Jul 22:1-12. Epub 2021 Jul 22.

Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

The purpose of the present study was to examine the protective action and mechanisms of quercetin on the blood-brain barrier (BBB) in rats subjected to transient middle cerebral artery occlusion (tMCAO) and reperfusion. Quercetin (10, 30, 50 mg/kg) was intraperitoneally administered at the onset of reperfusion. The results showed that quercetin significantly reduced cerebral infarct volume, neurological deficit, BBB permeability and ROS generation via Sirt1/Nrf2/HO-1 signaling pathway. Read More

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Prevalence of anemia and associated factors among the elderly population in South Khorasan, Birjand, 2019.

Med J Islam Repub Iran 2021 5;35:86. Epub 2021 Jul 5.

Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran.

Anemia is a multifactorial and common public health problem in geriatric age groups, especially in developing countries. Therefore, this study was designed to study the prevalence of anemia and associated factors among the elderly population in Birjand, Iran, in 2019. This was a cross-sectional approach to the baseline data of the Birjand longitudinal aging study (BLAS) in which 1396 people aged ≥ 60 years were screened for the presence of anemia based on the World Health Organization (WHO) criteria. Read More

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Osmotic Demyelination Syndrome Associated with Hypernatremia Caused by Lactulose Enema in a Patient with Chronic Alcoholism.

Electrolyte Blood Press 2021 Jun 30;19(1):15-18. Epub 2021 Jun 30.

Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.

A 44-year-old man with chronic alcoholism presented with seizure and loss of consciousness. He was diagnosed with alcoholic hepatic encephalopathy, and his neurologic symptoms recovered after lactulose enema treatment. His initial serum sodium level was 141mEq/L. Read More

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The effects of auricular acupressure on stress, anxiety, and depression of outpatient nurses in South Korea.

Complement Ther Clin Pract 2021 Jul 16;44:101447. Epub 2021 Jul 16.

College of Nursing, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, South Korea. Electronic address:

Background And Purpose: Outpatient nursing is an occupation with high emotional labor and job stress. The purpose of this study was to examine the effects of auricular acupressure on stress, anxiety, and depression of outpatient nurses.

Materials And Methods: The study design was a randomized controlled trial. Read More

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Effects of cannabinoid (CBD) on blood brain barrier permeability after brain injury in rats.

Brain Res 2021 Jul 18:147586. Epub 2021 Jul 18.

Department of Anatomy and Histology/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China. Electronic address:

Cannabidiol is a natural herbal medicine known to protect the brain from traumatic brain injury (TBI). Here, a TBI rat model was established, with cannabidiol administered intraperitoneally at doses of 5, 10, or 20 mg/kg, 30 min before surgery and 6 h after surgery until sacrifice. Brain water content, body weight, and modified neurological severity scores were determined, and enzyme-linked immunosorbent assay, immunofluorescence staining, hematoxylin and eosin staining, Nissl staining, Evans-blue dye extravasation, and western blotting were performed. Read More

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Competitive blocking of salivary gland [F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study.

EJNMMI Res 2021 Jul 21;11(1):66. Epub 2021 Jul 21.

Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, NCI/NIH, Building 10, Room # B3B69F, Bethesda, MD, 20892, USA.

Background: PSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa), but dose-limiting xerostomia can severely limit its clinical adaptation, especially when using alpha-emitting radionuclides. With [F]DCFPyL as a surrogate for PSMA-TRT, we report a novel method to selectively reduce salivary gland (SG) uptake of systemically administered [F]DCFPyL by immediate prior infusion of non-radioactive standard of [F]DCFPyL (DCFPyL) directly into the SG via retrograde cannulation.

Methods: A dose-finding cohort using athymic nude mice demonstrated proof of principle that SG uptake can be selectively blocked by DCFPyL administered either locally via cannulation (CAN group) or systemically (SYS group). Read More

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Daily rhythms of both host and parasite affect antimalarial drug efficacy.

Evol Med Public Health 2021 26;9(1):208-219. Epub 2021 Apr 26.

Institute of Evolutionary Biology & Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Charlotte Auerbach Road, Edinburgh EH9 3FL, UK.

Background And Objectives: Circadian rhythms contribute to treatment efficacy in several non-communicable diseases. However, chronotherapy (administering drugs at a particular time-of-day) against infectious diseases has been overlooked. Yet, the daily rhythms of both hosts and disease-causing agents can impact the efficacy of drug treatment. Read More

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Liver Protection Mechanism and Absorption Promotion Technology of Silybin Based on Intelligent Medical Analysis.

J Healthc Eng 2021 3;2021:9968016. Epub 2021 Jul 3.

Zhucheng People's Hospital, Zhucheng 262200, Shandong, China.

With the continuous popularization of smart medicine, the protective effect of silibinin in the liver has attracted much attention. This study mainly explores the liver protection mechanism and absorption promotion technology of silybin based on intelligent medical analysis. Refining of silibinin: accurately weigh 1. Read More

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Antihypertensive Effects of the Methanol Extract and the Ethyl Acetate Fraction from (Amaryllidaceae) Leaves in L-NAME-Treated Rat.

Evid Based Complement Alternat Med 2021 3;2021:2656249. Epub 2021 Jul 3.

Research Unit of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.

Arterial hypertension (AHT) is a leading cardiovascular disease, with a high negative impact on the quality of life. () leaves extract is used in the West region of Cameroon to treat AHT and heart problems. This study aimed to investigate the antihypertensive effect of extract in -nitro-L-arginine methyl ester- (L-NAME-) induced hypertensive rats. Read More

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Qihu Preparation Ameliorates Diabetes by Activating the AMPK Signaling Pathway in db/db Mice.

Diabetes Metab Syndr Obes 2021 14;14:3229-3241. Epub 2021 Jul 14.

Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, People's Republic of China.

Purpose: To examine the pharmacological effects of Qihu on type 2 diabetes mellitus using db/db mice.

Materials And Methods: Thirty-seven db/db mice were randomly divided into the following 5 groups: diabetes model control group (DM group; n = 7), administered with the adjuvant 0.3% carboxymethyl cellulose-Na; positive control group (Met group; n = 8), administered with metformin (0. Read More

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20p11.23-p11.21 deletion in a child with hyperinsulinemic hypoglycemia and GH deficiency: A case report.

Clin Pediatr Endocrinol 2021 10;30(3):133-137. Epub 2021 Jul 10.

Department of Pediatrics, Saitama Medical Center Jichi Medical University, Saitama, Japan.

Some neonatal hypoglycemias have genetic origins. For instance, mutation in forkhead box protein A2 (), located on chromosome 20p11.21, has recently been reported to cause hyperinsulinemic hypoglycemia and hypopituitarism. Read More

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GD2-directed bispecific trifunctional antibody outperforms dinutuximab beta in a murine model for aggressive metastasized neuroblastoma.

J Immunother Cancer 2021 Jul;9(7)

Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Background: Neuroblastoma is the most common extracranial solid tumor of childhood. Patients with high-risk disease undergo extremely aggressive therapy and nonetheless have cure rates below 50%. Treatment with the ch14. Read More

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Impact of IgG response to malaria-specific antigens and immunity against malaria in pre-school children in Ghana. A cluster randomized, placebo-controlled trial.

PLoS One 2021 20;16(7):e0253544. Epub 2021 Jul 20.

Kintampo Health Research Centre, Kintampo-North, Ghana.

Background: Iron fortification and micronutrient initiatives, specifically, vitamin A, and zinc supplementation are the most cost-effective developmental strategies against malnutrition and health emergencies in pre-school children. Iron-deficiency among pre-school children have been documented, however, studies evaluating the impact of immunoglobulin G (IgG) isotype responses among iron-fortified pre-school children in malaria endemic communities has not been assessed. We evaluated the impact of iron fortification on the IgG responses to GLURP R0, GLURP R2 and MSP3 FVO malaria-specific antigens among pre-school children in malaria endemic areas. Read More

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Toxicity studies of Aspergillus fumigatus administered by inhalation to B6C3F1/N mice.

Authors:

Toxic Rep Ser 2021 Jul(100)

Aspergillus fumigatus is a thermotolerant, soil-borne fungal species that is ubiquitous in the environment. Mold was nominated to the National Toxicology Program (NTP) by a private individual due to suspected adverse health effects associated with personal exposure in indoor and occupational settings. A. Read More

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Music in the Wound Care Center: Effects on Anxiety Levels and Blood Pressure Measurements in Patients Receiving Standard Care.

Wound Manag Prev 2021 Apr;67(4):16-22

Department of Surgery, JFK University Medical Center, Hackensack Meridian Health, Edison, New Jersey.

Background: Chronic wounds require frequent assessment, minor procedures, and dressing changes. Discomfort, anxiety, and stress are commonly reported during treatment procedures.

Purpose: To examine the effect of music during treatment on post-wound care treatment anxiety levels and blood pressure measurements in patients with chronic wounds. Read More

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Pharmacokinetics and tissue distribution of hydrazinocurcumin in rats.

Pharmacol Rep 2021 Jul 20. Epub 2021 Jul 20.

Department of Pharmaceutical Sciences, M. M. College of Pharmacy, M. M. Deemed To Be University, Mullana, Ambala, Haryana, India.

Background: Curcumin, a natural polyphenol from Curcuma longa, is known to possess diversified pharmacological roles including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic properties; however, its bioavailability is severely limited due to its poor solubility, poor absorption, rapid metabolism, and significant elimination. Hydrazinocurcumin (HZC), a novel analogue of curcumin has been reported to overcome the limitations of curcumin and also possesses multiple pharmacological activities. The present study aimed to evaluate the unexplored pharmacokinetic profile of this agent in experimental rats. Read More

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Cerebral venous thrombosis in a child with inflammatory bowel disease.

Iran J Child Neurol 2021 ;15(3):159-166

Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Shahid Beheshti Shahid Beheshti University of Medical Sciences.

Background: Inflammatory bowel disease (IBD) has both intestinal and extraintestinal manifestations. Inflammatory bowel disease is a known risk factor for cerebral venous thrombosis (CVT) in adults and children. The precise mechanism of the thrombotic event is unclear in IBD patients. Read More

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January 2021

Blood glutamate scavengers increase pro-apoptotic signaling and reduce metastatic melanoma growth in-vivo.

Sci Rep 2021 Jul 19;11(1):14644. Epub 2021 Jul 19.

Steyer School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, P.O. Box 39040, 6997801, Tel Aviv, Israel.

Inhibition of extracellular glutamate (Glu) release decreases proliferation and invasion, induces apoptosis, and inhibits melanoma metastatic abilities. Previous studies have shown that Blood-glutamate scavenging (BGS), a novel treatment approach, has been found to be beneficial in attenuating glioblastoma progression by reducing brain Glu levels. Therefore, in this study we evaluated the ability of BGS treatment to inhibit brain metastatic melanoma progression in-vivo. Read More

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Incidence of bleeding in patients on different anticoagulants and antiplatelet therapies undergoing thoracentesis.

BMJ Open Respir Res 2021 Jul;8(1)

Pulmonary, Critical Care and Sleep Medicine, Ascension St John Hospital, Detroit, Michigan, USA.

Introduction: Thoracentesis is one of the most commonly performed procedures in the inpatient setting. Although coagulation profile is usually evaluated prior to thoracentesis, bleeding is a rare complication, occurring in less than 1% of the cases. Several society guidelines recommend holding antiplatelet medications and anticoagulants prior to thoracentesis. Read More

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Oral Administration of Lipopolysaccharide Prevents Cognitive Impairment in Streptozotocin-induced Diabetic Mice in a Blood Glucose-independent Manner.

Anticancer Res 2021 Aug;41(8):4053-4059

Control of Innate Immunity, Collaborative Innovation Partnership, Kagawa, Japan

Background/aim: Diabetes is a risk factor for dementia. However, no radical preventive method for diabetes-associated dementia has yet been developed. Our previous study revealed that oral administration of lipopolysaccharide (LPS) prevents high-fat diet-induced cognitive impairment. Read More

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Artificial Long Estrus Protocols Administered Prior to Progesterone Increase Endometrial Uterocalin Expression in Anestrous Mares.

J Equine Vet Sci 2021 Aug 6;103:103669. Epub 2021 Jun 6.

Letur, Albacete, Spain. Electronic address:

Uterocalin (P19) is a lipocalin protein that has binding activity for the provisioning of the embryo with lipids, including those essential for morphogenesis and pattern formation. Therefore, it is thought that P19 plays an important role in supporting the survival of the early embryo. Previous research has shown that the endometrium from acyclic mares expressed more P19 following a simulated long estrus: treatment of 8 mg of estradiol benzoate (EB) split over five consecutive days, followed by long-acting progesterone administration (LA-P4) 72 hours later, when compared to a single 2. Read More

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Pharmacokinetics of Single-Dose Intramuscular and Subcutaneous Injections of Buprenorphine in Common Marmosets (Callithrix jacchus).

J Am Assoc Lab Anim Sci 2021 Jul 19. Epub 2021 Jul 19.

Although buprenorphine is the most frequently used opioid analgesic in common marmosets (Callithrix jacchus), thereis limited information in the literature supporting current dosing regimens used for this species. The purpose of this study was to determine the pharmacokinetic profiles of single-dose buprenorphine HCl administered intramuscularly (IM) at 0.01 mg/kg in 6 adult marmosets (1. Read More

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Efficacy and safety of Suxiao Jiuxin Pill in the treatment of stable angina (Qi stagnation and blood stasis syndrome): study protocol of a randomized, double-blind, placebo-controlled, multi-center clinical trial.

Trials 2021 Jul 19;22(1):466. Epub 2021 Jul 19.

Cardiovascular Department, Shuguang Hospital of Shanghai University of Traditional Chinese Medicine, No. 528 Zhangheng Road, Pudong New Area, Shanghai, 201203, China.

Background: Coronary heart disease (CHD) has become one of the biggest health problems in the world. Stable angina is a common clinical type of CHD with poor prognosis and high mortality. Although there are various interventions for stable angina, none of them can significantly reduce mortality. Read More

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Transcriptomic changes in peripheral blood mononuclear cells with weight loss: systematic literature review and primary data synthesis.

Genes Nutr 2021 Jul 19;16(1):12. Epub 2021 Jul 19.

School of Agriculture and Food, The University of Melbourne, Melbourne, Australia.

Background And Objectives: Peripheral blood mononuclear cells (PBMCs) have shown promise as a tissue sensitive to subtle and possibly systemic transcriptomic changes, and as such may be useful in identifying responses to weight loss interventions. The primary aim was to comprehensively evaluate the transcriptomic changes that may occur during weight loss and to determine if there is a consistent response across intervention types in human populations of all ages.

Methods: Included studies were randomised control trials or cohort studies that administered an intervention primarily designed to decrease weight in any overweight or obese human population. Read More

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Effects of Atorvastatin on Sevoflurane Postconditioning in in vivo Rabbit Hearts.

J Oral Biosci 2021 Jul 16. Epub 2021 Jul 16.

Department of Dental Anesthesiology, Kanagawa Dental University, 1-23 Ogawa-Cho, Yokosuka, Kanagawa 238-8570, Japan.

Objectives: Myocardial ischemia-reperfusion injury is a phenomenon that promotes myocardial damage when the blood supply returns to the tissue after a period of ischemia. Anesthetic postconditioning involves myocardial protection against myocardial I/R injury. The effects of atorvastatin (ATV) on sevoflurane postconditioning against myocardial ischemia-reperfusion injury have not been thoroughly studied. Read More

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Clinical history and gastrointestinal bleeding in patients taking oral anticoagulants.

Int J Cardiol 2021 Jul 17. Epub 2021 Jul 17.

Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

Background: Common risk factors for gastrointestinal bleeding (GIB) are advanced age and the use of antiplatelet or anticoagulants drugs for the prevention of cardiovascular diseases.

Methods: In this prospective real-world observational study, oral anticoagulated patients were recruited and followed between June 2013 and December 2019. The primary end-point was to evaluate a possible relationship between bleeding events and patients' clinical history of gastrointestinal disease prior to the start of the therapy. Read More

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