361,641 results match your criteria adjuvant

Evaluation of a Cooperia oncophora double-domain ASP-based vaccine against Cooperia spp. infections in cattle and sheep.

Vet Parasitol 2021 Sep 17;299:109578. Epub 2021 Sep 17.

Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.

A double-domain activation-associated secreted protein (dd-Co-ASP) isolated from the bovine small intestinal parasite Cooperia oncophora was previously shown to be an effective vaccine candidate to protect calves against a homologous challenge infection. The aim of this study was to investigate whether the dd-Co-ASP protein, purified from a Belgian C. oncophora isolate, would offer protection against a C. Read More

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September 2021

Association of a vaccine adjuvant with endogenous HDL increases lymph uptake and dendritic cell activation.

Eur J Pharm Biopharm 2021 Sep 24. Epub 2021 Sep 24.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Australia. Electronic address:

Vaccines are a powerful health intervention but there is still an unmet need for effective preventative and therapeutic vaccines for many diseases such as cancer and infections. Interstitial (e.g. Read More

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September 2021

Statin in combination with cisplatin makes favorable tumor-immune microenvironment for immunotherapy of head and neck squamous cell carcinoma.

Cancer Lett 2021 Sep 24. Epub 2021 Sep 24.

KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02456, Republic of Korea; Center for Theragnosis, Biomedical Research Institute, Korea Institute Science and Technology (KIST), Seoul, 02456, Republic of Korea. Electronic address:

The purpose of this study was to determine whether statins can enhance anticancer effects in head and neck squamous cell carcinoma (HNSCC) when used with cisplatin and act as immunogenic cell death (ICD) inducers that can be used in cancer immunotherapy. Statins alone showed both in vitro and in vivo inhibitory effects against HNSCC, and synergistic antitumor effects were observed when combined with cisplatin in a syngeneic murine HNSCC model. Statins increased calreticulin exposure and endoplasmic reticulum stress-related signals in HNSCC cells. Read More

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September 2021

The Association of Bullous Pemphigoid With Atopic Dermatitis and Allergic Rhinitis-A Population-Based Study.

Dermatitis 2021 Sep 27. Epub 2021 Sep 27.

From the Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany Azrieli Faculty of Medicine, Bar-Ilan University, Safed Unit of Dermatology, Baruch Padeh Poria Medical Center, Tiberias Clalit Health Services, Tel-Aviv Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences Otolaryngology Department, Barzilai University Medical Center, Ben-Gurion University of the Negev, Beer Sheva Department of Behavioral Sciences, Ariel University Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Background: Although bullous pemphigoid (BP), atopic dermatitis (AD), and allergic rhinitis (AR) are associated with shared pathogenic mechanisms the epidemiological relationship between these conditions remains to be investigated.

Objective: To evaluate the bidirectional association of BP with AD and AR.

Methods: A population-based retrospective cohort study was performed comparing BP patients (n = 3924) with age-, sex-, and ethnicity-matched control subjects (n = 19,280), with respect to incident cases of AD and AR. Read More

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September 2021

Potential benefits of using hydrogen sulfide, vitamin E and necrostatin-1 to counteract acetaminophen‑induced hepatotoxicity in rats.

Bratisl Lek Listy 2021 ;122(10):732-738

Background: The use of acetaminophen (APAP) is increasing recently, especially with COVID-19 outbreaks. APAP is safe at therapeutic levels, however, an overdose can cause severe liver injury. This study aims to explore possible mechanisms involved in APAP‑induced hepatotoxicity and compare different hepatoprotective agents, namely vitamin E, hydrogen sulfide (H2S) and necrostatin-1 (NEC-1). Read More

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January 2021

Pure Laparoscopic Right Hemicolectomy plus Pancreaticoduodenectomy via Caudal Approach for Hepatic Flexure Colon Cancer Invading Pancreaticoduodenum after Translational Therapy.

Colorectal Dis 2021 Sep 27. Epub 2021 Sep 27.

Division of Colorectal & Anal Surgery, Department of Gastrointestinal Surgery, Guangxi Medical University Cancer Hospital, Guangxi Zhuang Autonomous Region, the People's Republic of China, Nanning.

Background: Laparoscopic-assisted or open extended right hemicolectomy (RC) plus pancreaticoduodenectomy (PD) has recently been reported.(1, 2) A less invasive alternative with better surgical outcomes is pure laparoscopic surgery,(3) which is expected to resolve impaired wound healing caused by targeted drugs that can delay subsequent systemic therapies.

Methods: This video presents the first case of pure laparoscopic RC+PD via caudal approach after chemotherapy and targeted drug translational treatment. Read More

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September 2021

Endothelial dysfunction after androgen deprivation therapy and the possible underlying mechanisms.

Prostate 2021 Sep 27. Epub 2021 Sep 27.

S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.

Introduction: Androgen deprivation therapy (ADT) is a key treatment modality in the management of prostate cancer (PCa), especially for patients with metastatic disease. Increasing evidences suggest that patients who received ADT have increased incidence of diabetes, myocardial infarction, stroke, and even mortality. It is important to understand the pathophysiological mechanisms on how ADT increases cardiovascular risk and induces cardiovascular events, which would provide important information for potential implementation of preventive measures. Read More

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September 2021

Impact of systemic adjuvant therapy and CYP2D6 activity on mammographic density in a cohort of tamoxifen-treated breast cancer patients.

Breast Cancer Res Treat 2021 Sep 27. Epub 2021 Sep 27.

Department of Clinical Science and Education at Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.

Purpose: Change in mammographic density has been suggested to be a proxy of tamoxifen response. We investigated the effect of additional adjuvant systemic therapy and CYP2D6 activity on MD change in a cohort of tamoxifen-treated pre- and postmenopausal breast cancer patients.

Methods: Swedish breast cancer patients (n = 699)  operated 2006-2014, genotyped for CYP2D6, having at least three months postoperative tamoxifen treatment, a baseline, and at least one follow-up digital mammogram were included in the study. Read More

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September 2021

Left Upper Lobectomy for Lung Cancer as a Risk Factor for Cerebral Infarction: A Systematic Review and Meta-Analysis.

Lung 2021 Sep 27. Epub 2021 Sep 27.

British Columbia Centre for Excellence in HIV/AIDS, 608-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.

Background: There is limited evidence on the role of the type of lobectomy after primary lung cancer with postoperative cerebral infarction (CI). The purpose of this review was to evaluate the role of left upper lobectomy (LUL) in pulmonary vein thrombosis (PVT) and eventual CI.

Methods: A search was performed on MEDLINE, Embase, and Web of Science from inception to January 2021. Read More

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September 2021

A novel prognostic biomarker for cutaneous malignant melanoma: red cell distribution width (RDW) to lymphocyte ratio.

Melanoma Res 2021 Sep 23. Epub 2021 Sep 23.

Department of Medical Oncology, Atatürk University Faculty of Medicine, Erzurum, Turkey.

It is well-known that inflammation plays a significant role in cancer formation and prognosis. Both lymphocyte count and red cell distribution width (RDW) has been used to predict prognosis in various cancers as an indicator of inflammation. Yet, the role of RDW-lymphocyte ratio (RLR) in determining prognosis is still unknown. Read More

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September 2021

"Neuroendocrine Tumor Grade 3 (NET G3)" of the Uterine Cervix: A Report of 2 Cases.

Int J Gynecol Pathol 2021 Sep 27. Epub 2021 Sep 27.

Department of Diagnostic Pathology, Kumamoto University Hospital (T.K., F.K., Y.M.) Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University (Y.I., F.S.), Kumamoto, Japan.

In the fifth edition of the World Health Organization classification of female genital tumors, neuroendocrine neoplasms are subcategorized as neuroendocrine tumors (NETs) of grade 1 (G1) and G2, and neuroendocrine carcinoma. NET G3 is not included, as it is for classification of pancreas tumors. Herein, we report 2 cases of "NET G3" of the uterine cervix with long-term follow-up. Read More

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September 2021

Effects of exercise training on bone mineral density in adults living with HIV: a retrospective study.

HIV Res Clin Pract 2021 Sep 25:1-10. Epub 2021 Sep 25.

Laboratory of Physical Activity and Health Promotion, Institute of Physical Education and Sports, University of Rio de Janeiro State, Rio de Janeiro, RJ, Brazil.

Evidence on the effects of exercise training on the bone health of men and women living with HIV (MLHIV and WLHIV) is limited. To investigate the effects of a long-term multimodal exercise program on the bone mineral density (BMD) of MLHIV and WLHIV. A retrospective cohort of 39 patients (13 women; 48. Read More

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September 2021

Antiproliferative activity of aqueous and polyphenol-rich extracts of Cav. on a melanoma cell line.

Nat Prod Res 2021 Sep 27:1-4. Epub 2021 Sep 27.

Facultad de Farmacia y Bioquímica, Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad de Buenos Aires, Buenos Aires, Argentina.

Most of the deaths from skin cancer are caused by melanoma, a malignancy in which STAT3 plays a crucial role. The inhibition of STAT3 is considered a potential target to induce cell death, tumor regression and metastasis inhibition. The objective of this work was to evaluate the activity of the aqueous extract of (Aq), a fraction rich in polyphenols (EA),and the isolated compound quercetin-3-methyl ether (Q3ME) on B16F10 melanoma cells. Read More

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September 2021

Outcomes of organ-sparing surgery for adult testicular tumors: A systematic review of the literature.

BJUI Compass 2021 Sep 23;2(5):306-321. Epub 2021 Feb 23.

Department of Urology, Miller School of Medicine, University of Miami, Miami, FL, USA.

Objective: To perform a systematic review on the effects of testicular sparing surgery (TSS) on the oncological, functional, and hormonal outcomes of adults with testicular tumors.

Methods: A literature search was performed after PROSPERO registration (CRD42020200842) and reported in compliance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methods. We conducted a systematic search of Medline (Ovid), Embase, Cochrane CENTRAL, CINAHL, Scopus, Web of Science, ClinicalTrials. Read More

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September 2021

Interferon gamma immunotherapy in five critically ill COVID-19 patients with impaired cellular immunity: a case series.

Med (N Y) 2021 Sep 21. Epub 2021 Sep 21.

Department of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.

Background: Prolonged SARS-CoV-2 shedding has been described in immunocompromised COVID-19 patients, resulting in protracted disease and poor outcome. Specific therapy to improve viral clearance and outcome for this group of patients is currently unavailable.

Methods: Five critically ill COVID-19 patients with severe defects in cellular immune responses, high SARS-CoV-2 viral RNA loads, and no respiratory improvement were treated with interferon gamma, 100 μg subcutaneously, thrice weekly. Read More

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September 2021

Lactic Acid Bacteria Strains Differently Modulate Gut Microbiota and Metabolic and Immunological Parameters in High-Fat Diet-Fed Mice.

Front Nutr 2021 9;8:718564. Epub 2021 Sep 9.

Centro de Referencia para Lactobacilos -CONICET, Tucumán, Argentina.

Dietary strategies, including the use of probiotics as preventive agents that modulate the gut microbiota and regulate the function of adipose tissue, are suitable tools for the prevention or amelioration of obesity and its comorbidities. We aimed to evaluate the effect of lactic acid bacteria (LAB) with different adipo- and immuno-modulatory capacities on metabolic and immunological parameters and intestinal composition microbiota in high-fat-diet-induced in mice fed a high-fat diet Balb/c weaning male mice were fed a standard (SD) or high-fat diet (HFD) with or without supplementation with CRL1446 (CRL1446) CRL1434 (CRL1434), or CRL431 (CRL431) for 45 days. Biochemical and immunological parameters, white-adipose tissue histology, gut microbiota composition, and cellular functionality (adipocytes and macrophages) were evaluated in SD and HFD mice. Read More

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September 2021

Changes in the Gut Microbiome Contribute to the Development of Behcet's Disease Adjuvant Effects.

Front Cell Dev Biol 2021 8;9:716760. Epub 2021 Sep 8.

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, China.

Behcet's disease (BD) is associated with considerable gut microbiome changes. However, it still remains unknown how the composition of the gut microbiome exactly affects the development of this disease. In this study, transplantation of stool samples from patients with active ocular BD to mice oral gavage was performed. Read More

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September 2021

Gut Microbiota-Mediated Modulation of Cancer Progression and Therapy Efficacy.

Front Cell Dev Biol 2021 8;9:626045. Epub 2021 Sep 8.

Jiangsu Key Laboratory for Pharmacolgy and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.

The role of gut microbiota in the development of various tumors has been a rising topic of public interest, and in recent years, many studies have reported a close relationship between microbial groups and tumor development. Gut microbiota play a role in host metabolism, and the positive and negative alterations of these microbiota have an effect on tumor treatment. The microbiota directly promote, eliminate, and coordinate the efficacy of chemotherapy drugs and the toxicity of adjuvant drugs, and enhance the ability of patients to respond to tumors in adjuvant immunotherapy. Read More

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September 2021

Long-Term Survivors of Metastatic Colorectal Cancer: A Tertiary Care Centre Experience.

South Asian J Cancer 2021 Apr 23;10(2):87-91. Epub 2021 Sep 23.

Department of Radiation Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.

Prognosis of metastatic colorectal cancer (mCRC) is poor and goal of treatment is mainly palliative unless there is limited metastatic disease which is surgically resectable. Here, we report a case series of long-term survivors treated predominantly with chemotherapy. This is a single-center retrospective analysis of patients of mCRC. Read More

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Real-World Experience of Immunotherapy from India in Recurrent Squamous Cell Carcinoma of Head and Neck Cancer.

South Asian J Cancer 2021 Apr 20;10(2):72-75. Epub 2021 Aug 20.

Department of Oncology, Max Super Speciality Hospital, Delhi, India.

Recurrent metastatic head and neck squamous cell carcinoma (HNSCC) patients carry a poor prognosis and have limited therapeutic options. In the randomized phase-3 trial CheckMate 141, nivolumab showed benefit in overall survival (OS) with manageable toxicity. Nivolumab is available for clinical practice since 2017 in India. Read More

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A Multicentric Randomized Trial to Evaluate the ROle of Uterine MANipulator on Laparoscopic/Robotic HYsterectomy for the Treatment of Early-Stage Endometrial Cancer: The ROMANHY Trial.

Front Oncol 2021 10;11:720894. Epub 2021 Sep 10.

Division of Gynecologic Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Objective: This prospective randomized trial aimed to assess the impact of the uterine manipulator in terms of lymph vascular space invasion (LVSI) in patients undergoing minimally invasive staging for early-stage endometrial cancer.

Methods: In this multicentric randomized trial, enrolled patients were randomly allocated in two groups according to the no use (arm A) or the use (arm B) of the uterine manipulator. Inclusion criteria were G1-G2 early-stage endometrial cancer at preoperative evaluation. Read More

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September 2021

Azoximer Bromide: Mystery, Serendipity, and Promise.

Front Oncol 2021 10;11:699546. Epub 2021 Sep 10.

Laboratory of Immunology of Hematopoiesis, N.N. Blokhin Cancer Research Center (RCRC), Moscow, Russia.

Azoximer bromide (AZB) was identified as an immunomodulator, and was initially developed and currently successfully indicated as one of several natural polyelectrolytes, a vaccine adjuvant, and an effective agent for the treatment of infectious and inflammatory diseases of viral, bacterial, and fungal origin. AZB has the potential to increase an individual's resistance to local and general infection and is indicated for the treatment of viral infections, and has also demonstrated clinical efficacy in the treatment of a variety of secondary immunodeficiencies. However, AZB may offer long-term promise beyond use against infection. Read More

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September 2021

Primary Renal Synovial Sarcoma Presenting as Haemorrhagic Shock: A Rare Presentation.

J Kidney Cancer VHL 2021 3;8(3):1-4. Epub 2021 Sep 3.

Division of Urology, Department of Surgery, Ministry of the National Guard - Health Affairs, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Primary synovial sarcoma (PSS) of the kidney is considered the rarest type of all renal sarcomas with specific chromosomal translocation t (X; 18) (p11.2; q11.2). Read More

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September 2021

Hepatectomy and immune checkpoint inhibitor treatment for liver metastasis originating from non-cutaneous melanoma: a report of three cases.

Int Cancer Conf J 2021 Oct 15;10(4):274-279. Epub 2021 Jun 15.

Department of Gastroenterological Surgery I, Hokkaido University Hospital, Kita-ku, Kita 15, Nishi 7, Sapporo, Hokkaido 060-8638 Japan.

The outcomes of hepatectomy alone for liver metastasis derived from non-cutaneous melanoma are insufficient, and the outcomes of systemic therapy alone are also insufficient, even since the development of immune checkpoint inhibitors (ICIs). We report the cases of three patients, in whom liver metastasis derived from non-cutaneous melanoma was treated with hepatectomy combined with ICI therapy, which was administered in various settings. One patient received ICI treatment for recurrent melanoma and survived 107 months after the first hepatectomy, one patient received both preoperative and adjuvant ICI treatment and has been disease-free for 27 months, and another patient received postoperative ICI treatment after reduction hepatectomy and has been alive with disease for 47 months. Read More

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October 2021

Clinicopathological Analysis of Neuroendocrine Carcinoma of the Uterine Cervix: A Single-Institution Retrospective Review of 9 Cases.

Int J Surg Oncol 2021 16;2021:8290659. Epub 2021 Sep 16.

Akdeniz University, Department of Gynecology Obstetrics, Division of Gynecologic Oncology, Antalya, Turkey.

Aim: To evaluate the clinicopathological features affecting the recurrence and survival of 9 cases of neuroendocrine cancer of the cervix.

Method: We retrospectively analyzed 9 cervical neuroendocrine cancer cases identified among 453 cervical cancer patients between 2004 and 2021 at Akdeniz University Gynecological Oncology Outpatient Clinic. Kaplan-Meier survival analysis was used for progression-free survival (PFS) and overall survival (OS). Read More

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September 2021

Reverse Myocardial Remodeling in Hypertrophic Cardiomyopathy: Little Explored Benefit of Exercise.

Int J Exerc Sci 2021 1;14(2):1018-1026. Epub 2021 Aug 1.

Actus-Cordios, Cardiovascular and Metabolic Rehabilitation, Salvador, BA, BRAZIL.

Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease that causes myocardial remodeling. Physical exercise (PE) is a therapeutic resource used in Supervised Cardiac Rehabilitation (SCR) to improve Quality of Life (QL), reducing cardiovascular morbidity and mortality. Therefore, the aim of this study is to report how SCR using a personalized exercise prescription, promoted Reverse Myocardial Remodeling (RMR), improved functionality and QL of a patient with HCM. Read More

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Role of immunotherapy in localized muscle invasive urothelial cancer.

Ther Adv Med Oncol 2021 22;13:17588359211045858. Epub 2021 Sep 22.

Department of Hematology/Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

The standard treatment for non-metastatic muscle-invasive bladder cancer (MIBC) is cisplatin-based neoadjuvant chemotherapy followed by radical cystectomy or trimodality therapy with chemoradiation in select patients. Pathologic complete response (pCR) to neoadjuvant chemotherapy is a reliable predictor of overall and disease-specific survival in MIBC. A pCR rate of 35-40% is attained with neoadjuvant cisplatin-based chemotherapy. Read More

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September 2021

Comparative efficacy of modified FOLFIRINOX, gemcitabine plus capecitabine and gemcitabine plus nab-paclitaxel as adjuvant treatment for resected pancreatic cancer: a Bayesian network meta-analysis.

Ecancermedicalscience 2021 16;15:1276. Epub 2021 Aug 16.

Medical Oncology Department, A.C. Camargo Cancer Center, Rua Prof. Antônio Prudente 211, São Paulo SP 01509-010, Brazil.

Background: There are no head-to-head comparisons evaluating the efficacy of the main polychemotherapy regimens used for patients with pancreatic cancer in the adjuvant setting. We aimed to describe the relative efficacy of modified FOLFIRINOX (mFOLFIRINOX), gemcitabine plus capecitabine (GEM-CAP) and gemcitabine plus nab-paclitaxel (GEM-NAB) in this setting using a Bayesian network approach.

Methods: We collected data from the ESPAC-4, PRODIGE 24 and APACT trials. Read More

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Aspirin and cancer survival: a systematic review and meta-analyses of 118 observational studies of aspirin and 18 cancers.

Ecancermedicalscience 2021 2;15:1258. Epub 2021 Jul 2.

University Library Service, Cardiff University, Cardiff, UK.

Background: Despite the accumulation of research papers on aspirin and cancer, there is doubt as to whether or not aspirin is an acceptable and effective adjunct treatment of cancer. The results of several randomised trials are awaited, and these should give clear evidence on three common cancers: colon, breast and prostate. The biological effects of aspirin appear likely however to be of relevance to cancer generally, and to metastatic spread, rather than just to one or a few cancers, and there is already a lot of evidence, mainly from observational studies, on the association between aspirin and survival in a wide range of cancers. Read More

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