6,314 results match your criteria adjusted power

Effectiveness of antimicrobial photodynamic therapy with indocyanine green against the standard and fluconazole-resistant Candida albicans.

Lasers Med Sci 2021 Jul 31. Epub 2021 Jul 31.

Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Antimicrobial photodynamic therapy (aPDT) is an alternative approach. The current study aimed to investigate the efficacy of aPDT with indocyanine green (ICG) against two Candida albicans (C. albicans) strains. Read More

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Improving the predictive potential of diffusion MRI in schizophrenia using normative models-Towards subject-level classification.

Hum Brain Mapp 2021 Jul 29. Epub 2021 Jul 29.

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Diffusion MRI studies consistently report group differences in white matter between individuals diagnosed with schizophrenia and healthy controls. Nevertheless, the abnormalities found at the group-level are often not observed at the individual level. Among the different approaches aiming to study white matter abnormalities at the subject level, normative modeling analysis takes a step towards subject-level predictions by identifying affected brain locations in individual subjects based on extreme deviations from a normative range. Read More

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Overcoming the problems caused by collinearity in mixed-effects logistic model: determining the contribution of various types of violence on depression in pregnant women.

BMC Med Res Methodol 2021 Jul 28;21(1):154. Epub 2021 Jul 28.

Health Education and Promotion, Department of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: Collinearity is a common and problematic phenomenon in studies on public health. It leads to inflation in variance of estimator and reduces test power. This phenomenon can occur in any model. Read More

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Venous access devices for the delivery of long-term chemotherapy: the CAVA three-arm RCT.

Health Technol Assess 2021 Jul;25(47):1-126

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

Background: Venous access devices are used for patients receiving long-term chemotherapy. These include centrally inserted tunnelled catheters or Hickman-type devices (Hickman), peripherally inserted central catheters (PICCs) and centrally inserted totally implantable venous access devices (PORTs).

Objectives: To evaluate the clinical effectiveness, safety, cost-effectiveness and acceptability of these devices for the central delivery of chemotherapy. Read More

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Application of Automated Hand Ultrasound Scanning and a Simplified Three-Joint Scoring System for Assessment of Rheumatoid Arthritis Activity.

Ultrasound Med Biol 2021 Jul 24. Epub 2021 Jul 24.

Department of Rheumatology and Immunology, Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:

Ultrasound can be used to objectively diagnose and evaluate disease activity in patients with rheumatoid arthritis (RA). We aimed to determine the value of a new automated hand ultrasound (AHUS) scanning device and a simplified 3-joint ultrasound scoring system (US3) in detecting synovitis in RA. We compared AHUS and traditional ultrasound (US) scanning in detecting synovial hyperplasia (SH), joint effusion, bone erosion and power Doppler (PD) synovitis in 49 patients. Read More

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Differential DNA methylation by early versus late parenteral nutrition in the PICU: a biological basis for its impact on emotional and behavioral problems documented 4 years later.

Clin Epigenetics 2021 Jul 27;13(1):146. Epub 2021 Jul 27.

Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Background: The PEPaNIC multicenter randomized controlled trial (RCT) has shown that early administration of supplemental parenteral nutrition (early-PN) as compared with withholding PN for 1 week (late-PN) induced long-term internalizing, externalizing and total emotional/behavioral problems in critically ill children, as observed 4 years later. Early-PN was further shown to alter the methylation status of 37 CpG-sites in leukocyte DNA between admission and discharge from the pediatric intensive care unit (PICU). In a preplanned subanalysis of the PEPaNIC trial, we now investigated whether the altered methylation of these CpG-sites could statistically explain the negative impact of early-PN on emotion/behavior documented 4 years after PICU admission. Read More

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Large self-insured employers lack power to effectively negotiate hospital prices.

Am J Manag Care 2021 Jul;27(7):290-296

Bloomberg School of Public Health, Johns Hopkins University, 624 N Broadway, Rm 406, Baltimore, MD 21205. Email:

Objectives: Self-insured employers cover more people than Medicare, Medicaid, or direct purchasers of private insurance.This study examined the ability of self-insured employers to negotiate hospital prices and the relationship between hospital prices and employer market power in the United States.

Study Design: Repeated cross-section analysis of commercial claims. Read More

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Reliability of the ASA Physical Status Classification System in Predicting Surgical Morbidity: a Retrospective Analysis.

J Med Syst 2021 Jul 22;45(9):83. Epub 2021 Jul 22.

Department of Anesthesiology, Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.

The American Society of Anesthesiologists (ASA) Physical Status Classification System has been used to assess pre-anesthesia comorbid conditions for over 60 years. However, the ASA Physical Status Classification System has been criticized for its subjective nature. In this study, we aimed to assess the correlation between the ASA physical status assignment and more objective measures of overall illness. Read More

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Laser conversion of biomass into porous carbon composite under ambient condition for pH-Universal electrochemical hydrogen evolution reaction.

J Colloid Interface Sci 2021 Jul 16;604:885-893. Epub 2021 Jul 16.

Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, National & Local United Engineering Laboratory for Power Batteries, Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Analysis and Testing Center, Department of Chemistry, Northeast Normal University, Changchun, Jilin Province 130024, China. Electronic address:

It is highly desirable to develop durable and advanced electrocatalysts for pH-universal hydrogen evolution reaction (HER). While it makes much progress so far, the development of an environmental-friendly and cost-effective method to upgrade earth-abundant biomass into high value-added products still remains a major challenge. Thermal pyrolysis method which requires high pyrolysis temperature and long synthesis period is considered as a general method for preparation of carbon-based electrocatalysts. Read More

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Determinants of Performance in Paced and Maximal 800-m Running Time Trials.

Med Sci Sports Exerc 2021 Jul 23. Epub 2021 Jul 23.

Griffith Sports Science, Griffith University, Gold Coast, Queensland, Australia. Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium Mermaid Beach Radiology, Queensland, Australia Qscan Radiology Clinics, Australia.

Purpose: We aimed to identify the underpinning physiological and speed/mechanical determinants of different types of 800-m running time trials (i.e., with a positive or negative pacing strategy) and key components within each 800-m time trial (i. Read More

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Non-surgical correction of gummy smile using temporary skeletal mini-screw anchorage devices: A systematic review.

J Clin Exp Dent 2021 Jul 1;13(7):e717-e723. Epub 2021 Jul 1.

Dental Students, College of Dentistry, Riyadh Elm University, Saudi Arabia.

Background: There are no studies that have systematically reviewed randomized control trials and/or prospective cohort studies that have assessed the significance of temporary skeletal mini-screw anchorage devices (TSAD) for the correction of gummy-smile. The aim of the present systematic review was to assess the significance of non-surgical correction of gummy smile using TSAD.

Material And Methods: The addressed focused question was "Are temporary skeletal mini-screw anchorage devices effective for the correction of gummy smile?" Indexed databases were searched up to and including May 2020. Read More

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Power and Radio Resource Management in Femtocell Networks for Interference Mitigation.

Sensors (Basel) 2021 Jul 15;21(14). Epub 2021 Jul 15.

Department of Computer Science, Umm Al-Qura University, Makkah City 24381, Saudi Arabia.

The growth of mobile traffic volume has been exploded because of the rapid improvement of mobile devices and their applications. Heterogeneous networks (HetNets) can be an attractive solution in order to adopt the exponential growth of wireless data. Femtocell networks are accommodated within the concept of HetNets. Read More

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What is the best anthropometric predictor for identifying higher risk for cardiovascular diseases in afro-descendant Brazilian women? A cross-sectional population-based study.

Am J Hum Biol 2021 Jul 22:e23652. Epub 2021 Jul 22.

Department of Social Nutrition and Nutritional Sciences Graduate Program, Fluminense Federal University, Rio de Janeiro, Brazil.

Objectives: Excessive adiposity is associated with cardiovascular disease (CVD). Anthropometric indices are useful in screening individuals at higher risk for these diseases. However, there are no studies that show which of these indices has the best discriminatory power among Afro-descendant Brazilian women. Read More

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Exploiting the power of information in medical education.

Med Teach 2021 07;43(sup2):S17-S24

Department of Medical Education Outcomes, American Medical Association, Chicago, IL, USA.

The explosion of medical information demands a thorough reconsideration of medical education, including what we teach and assess, how we educate, and whom we educate. Physicians of the future will need to be self-aware, self-directed, resource-effective team players who can synthesize and apply summarized information and communicate clearly. Training in metacognition, data science, informatics, and artificial intelligence is needed. Read More

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A true face of Indian married couples: Effect of age and education on control over own sexuality and sexual violence.

PLoS One 2021 21;16(7):e0254005. Epub 2021 Jul 21.

International Institute for Population Sciences, Deonar, Mumbai, Maharashtra, India.

Introduction: Though there are several interventions evaluated over the past 25 years, significant knowledge gaps continue to exist regarding the effective prevention of sexual violence. This study explored the socio-economic and context-specific distinctive characteristics of husbands and wives on sexual autonomy and unwanted sexual experiences of currently married women in India.

Methodology: We have utilized the recent round of National Family Health Survey (NFHS-4, 2015-16) data for this exploration. Read More

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Intraocular lens power calculation using adjusted corneal power in eyes with prior myopic laser vision correction.

Graefes Arch Clin Exp Ophthalmol 2021 Jul 21. Epub 2021 Jul 21.

Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea.

Purpose: To evaluate the prediction accuracy of the intraocular lens (IOL) power calculation using adjusted corneal power according to the posterior/anterior corneal curvature radii ratio in the Haigis formula (Haigis-E) in patients with a history of prior myopic laser vision correction.

Methods: Seventy eyes from 70 cataract patients who underwent cataract surgery and had a history of myopic laser vision correction were enrolled. The adjusted corneal power obtained with conventional keratometry (K) was calculated using the posterior/anterior corneal curvature radii ratio measured by a single Scheimpflug camera. Read More

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The histamine H receptor antagonist hydroxyzine enhances sevoflurane and propofol anesthesia: A quantitative EEG study.

Clin Neurophysiol 2021 Jun 24;132(9):2054-2061. Epub 2021 Jun 24.

Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, Japan.

Objective: The aim of this study was to determine the anesthesia-promoting effects of hydroxyzine on electroencephalograms during sevoflurane anesthesia and during propofol anesthesia.

Methods: We analyzed 40 patients scheduled for elective surgery under sevoflurane anesthesia (n = 20) or propofol anesthesia (n = 20). Anesthesia was adjusted at a bispectral index value of 50-60, and then 0. Read More

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The Incidence and Treatment Response of Double Expression of MYC and BCL2 in Patients with Diffuse Large B-Cell Lymphoma: A Systematic Review and Meta-Analysis.

Cancers (Basel) 2021 Jul 5;13(13). Epub 2021 Jul 5.

Division of Neuroradiology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

MYC/BCL2 protein co-expression (i.e., double expressor) has been shown to be a negative predictor of outcome in diffuse large B-cell lymphoma (DLBCL). Read More

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The role of external genital lesions in HIV seroconversion among men participating in a multinational study.

Sex Transm Dis 2021 Jul 17. Epub 2021 Jul 17.

Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA Center for AIDS Intervention Research, Medical College of Wisconsin, Milwaukee, WI, USA Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center & Research Institute, Tampa, FL, USA Centro de Referência e Treinamento DST/AIDS and Centro Universitário FAM, São Paulo, Brazil Instituto do Cancer do Estado de São Paulo, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil Instituto Nacional de Salud Pública, Cuernavaca, México.

Background: Studies in women have shown an increased risk of HIV acquisition with prior HPV infection; however, few studies have been conducted among men. Our objective was to assess whether HPV-related external genital lesions (EGLs) increase risk of HIV seroconversion among men.

Methods: A total of 1379 HIV-negative men aged 18-70 years from the US, Mexico, and Brazil were followed for up to seven years and underwent clinical examination for EGLs and blood draws every six-months. Read More

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Improving Care Management in Attention-Deficit/Hyperactivity Disorder: An RCT.

Pediatrics 2021 Jul 19. Epub 2021 Jul 19.

Departments of Pediatrics.

Objectives: To compare the effectiveness of care management combined with a patient portal versus a portal alone for communication among children with attention-deficit/hyperactivity disorder (ADHD).

Methods: Randomized controlled trial conducted at 11 primary care practices. Children aged 5 to 12 years old with ADHD were randomly assigned to care management + portal or portal alone. Read More

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Development of a health behavior scale for older adults living alone receiving public assistance.

BMC Public Health 2021 Jul 19;21(1):1428. Epub 2021 Jul 19.

Department of Community and Public Health Nursing, Graduate School of Health Sciences and Faculty of Medicine, Hokkaido University, N12-W5, Kita-ku, Sapporo, 060-0812, Japan.

Background: To reduce health disparities, prevention of non-communicable diseases (NCD) by performing desirable health behavior in older adults living alone with low socioeconomic status is an essential strategy in public health. Self-perception of personal power and practical skills for daily health are key elements of desirable health behavior. However, methods for measuring these concepts have not been established. Read More

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Brief Exercise at Work ([email protected]): A Mixed-Methods Pilot Trial of a Workplace High-Intensity Interval Training Intervention.

Front Sports Act Living 2021 2;3:699608. Epub 2021 Jul 2.

School of Applied Sciences, Edinburgh Napier University, Edinburgh, United Kingdom.

The efficacy of high-intensity interval training (HIIT) for improving markers of physical fitness and cardiometabolic health is promising. The workplace is one non-laboratory setting where the effectiveness of HIIT could be explored. The aim of this study was to undertake a mixed-methods exploratory pilot trial of a workplace HIIT intervention named Brief Exercise at Work ([email protected]). Read More

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Functional Mitral Regurgitation Outcome and Grading in Heart Failure With Reduced Ejection Fraction.

JACC Cardiovasc Imaging 2021 Jul 7. Epub 2021 Jul 7.

Department of Cardiovascular Diseases, Mayo Clinic, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Objectives: This study aims to define excess-mortality linked to functional mitral regurgitation (FMR) quantified in routine-practice.

Background: Appraisal of FMR in heart failure with reduced ejection fraction (HFrEF) is challenging because risks of excess mortality remain uncertain and guidelines diverge.

Methods: Cases of HFrEF (ejection-fraction <50%) Stage B-C that were diagnosed between 2003 and 2011 and had routine-practice FMR quantitation (FMR cohort, n = 6,381) were analyzed for excess mortality thresholds/rates within the cohort and in comparison to the general population. Read More

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Association between high-density lipoprotein cholesterol and type 2 diabetes mellitus among Chinese: the Beijing longitudinal study of aging.

Lipids Health Dis 2021 Jul 17;20(1):71. Epub 2021 Jul 17.

Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, 100069, China.

Background: Some previous studies on different populations have yielded inconsistent findings with respect to the relationship between levels of high-density lipoprotein cholesterol (HDL-C) and future type 2 diabetes mellitus (T2DM) incidence. This study was designed to gain further insight into this relationship through a cohort study with a 25-year follow-up duration.

Methods: In total, 1462 individuals that were 55 years of age or older and were free of T2DM at baseline were enrolled in the present study. Read More

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Covariate adjustment in subgroup analyses of randomized clinical trials: A propensity score approach.

Clin Trials 2021 Jul 16:17407745211028588. Epub 2021 Jul 16.

Department of Biostatistics, Yale University School of Public Health, New Haven, CT, USA.

Background: Subgroup analyses are frequently conducted in randomized clinical trials to assess evidence of heterogeneous treatment effect across patient subpopulations. Although randomization balances covariates within subgroups in expectation, chance imbalance may be amplified in small subgroups and adversely impact the precision of subgroup analyses. Covariate adjustment in overall analysis of randomized clinical trial is often conducted, via either analysis of covariance or propensity score weighting, but covariate adjustment for subgroup analysis has been rarely discussed. Read More

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Determinants of drug prices: a systematic review of comparison studies.

BMJ Open 2021 Jul 15;11(7):e046917. Epub 2021 Jul 15.

Department of Pharmacy, Sint Maartenskliniek, Nijmegen, The Netherlands.

Objective: In this systematic review on drug price comparison studies, we report on recent determinants of drug prices in a national and international context to facilitate regulation of drug prices by purchasers and policymakers worldwide. Determinants of drug prices were divided into non-modifiable and modifiable and were categorised as pertaining to a country's income level, pharmaceutical market system and its policies and government.

Primary Outcome: Determinants of drug prices or price variance. Read More

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Optically controlled THz power tuning based on interference at transmission line.

Opt Express 2021 Jun;29(13):20034-20044

We have proposed an optically controlled THz power tuning method based on THz wave interference. Through interfered THz waves at the T-junction transmission line, adjustment of the THz power is achieved, and tuning control is attained by varying the optical time delay of the beat-note lightwaves. To demonstrate and verify THz power tuning with an optical delay line, we have also fabricated a monolithic chip on an InP substrate, which integrates arrayed uni-traveling-carrier photodiodes and a planar slot antenna array for 300GHz wave generation. Read More

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Two-Layer Compared With One-Layer Vaginal Cuff Closure at the Time of Total Laparoscopic Hysterectomy to Reduce Complications.

Obstet Gynecol 2021 Jul;138(1):59-65

Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania; Obstetrics and Gynecology, Mercy Medical Center, Baltimore, Maryland; IVF and Minimally Invasive Gynecological Surgery, Moulana Hospital, Perinthalmanna, India; the Uniformed Services University, Bethesda, Maryland; and the Clinical and Translational Science Institute, Office of Clinical Research, University of Pittsburgh, Pittsburgh, Pennsylvania.

Objective: To explore whether two-layer laparoscopic vaginal cuff closure at the time of laparoscopic hysterectomy is associated with a lower rate of postoperative complications compared with a standard one-layer cuff closure.

Methods: A retrospective cohort study of total laparoscopic hysterectomies performed by fellowship-trained minimally invasive gynecologic surgeons between 2011 and 2017 was performed. Surgeons sutured the vaginal cuff laparoscopically, either in a two- or one-layer closure. Read More

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Validation of the Acute Physiology and Chronic Health Evaluation (APACHE) II and IV Score in COVID-19 Patients.

Crit Care Res Pract 2021 19;2021:5443083. Epub 2021 Jun 19.

Department of Intensive Care and Anesthesiology, Jessa Hospital, Hasselt, Belgium.

Background: Severity scoring systems are inherent to ICU practice for multiple purposes. Acute Physiology and Chronic Health Evaluation (APACHE) scoring systems are designed for ICU mortality prediction. This study aims to validate APACHE IV in COVID-19 patients admitted to the ICU. Read More

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