138,391 results match your criteria adipose tissue

Chicken C/EBPζ gene: Expression profiles, association analysis, and identification of functional variants for abdominal fat.

Domest Anim Endocrinol 2021 Apr 15;76:106631. Epub 2021 Apr 15.

Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China; College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China. Electronic address:

CCAAT enhancer binding protein ζ (C/EBPζ) plays an important role in adipose proliferation and differentiation in humans. However, very little is known about the effect of C/EBPζ on the growth and development of adipose tissues in domesticated animals. The present study attempted to investigate the mRNA expression profiles of chicken C/EBPζ in a variety of tissues; analyze the association of its variants with abdominal fat; and identify the functional variants for abdominal fat. Read More

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Systemic manifestation and contribution of peripheral tissues to Huntington's disease pathogenesis.

Ageing Res Rev 2021 May 9:101358. Epub 2021 May 9.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. Electronic address:

Huntington disease (HD) is an autosomal dominant neurodegenerative disease that is caused by expansion of cytosine/adenosine/guanine repeats in the huntingtin (HTT) gene, which leads to a toxic, aggregation-prone, mutant HTT-polyQ protein. Beyond the well-established mechanisms of HD progression in the central nervous system, growing evidence indicates that also peripheral tissues are affected in HD and that systemic signaling originating from peripheral tissues can influence the progression of HD in the brain. Herein, we review the systemic manifestation of HD in peripheral tissues, and the impact of systemic signaling on HD pathogenesis. Read More

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Putting ATM to BED: How Adipose Tissue Macrophages Are Affected by Bariatric Surgery, Exercise, and Dietary Fatty Acids.

Adv Nutr 2021 May 12. Epub 2021 May 12.

Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, Quebec, Canada.

With increasing adiposity in obesity, adipose tissue macrophages contribute to adipose tissue malfunction and increased circulating proinflammatory cytokines. The chronic low-grade inflammation that occurs in obesity ultimately gives rise to a state of metainflammation that increases the risk of metabolic disease. To date, only lifestyle and surgical interventions have been shown to be somewhat effective at reversing the negative consequences of obesity and restoring adipose tissue homeostasis. Read More

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The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures.

PLoS Biol 2021 May 12;19(5):e3000988. Epub 2021 May 12.

Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.

Although visceral adipocytes located within the body's central core are maintained at approximately 37°C, adipocytes within bone marrow, subcutaneous, and dermal depots are found primarily within the peripheral shell and generally exist at cooler temperatures. Responses of brown and beige/brite adipocytes to cold stress are well studied; however, comparatively little is known about mechanisms by which white adipocytes adapt to temperatures below 37°C. Here, we report that adaptation of cultured adipocytes to 31°C, the temperature at which distal marrow adipose tissues and subcutaneous adipose tissues often reside, increases anabolic and catabolic lipid metabolism, and elevates oxygen consumption. Read More

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Epigenetic Regulation of m6A Modifications in Obesity.

J Diabetes Investig 2021 May 12. Epub 2021 May 12.

School of Kinesiology, Shenyang Sport University, Shenyang, 110102, China.

Obesity is a serious health issue in the world and is related to a higher risk of suffering metabolic diseases. Understanding the molecular basis of obesity is critical to identify new targets to treat obesity and obesity-associated metabolic diseases. N6-methyladenosine (m6A) modification is the most common form of RNA modification which has attracted the increasing interest of researchers in recent years, as it is reported that m6A has vital functions in diseases and everyday life activities. Read More

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Role of Exosomes in Mediating the Cross-Talk Between Adipose Tissue and the Brain.

Neuromolecular Med 2021 May 12. Epub 2021 May 12.

Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, 25755, USA.

Adipose tissue is recognized as the largest endocrine organ by releasing secretory factors to exert systemic function on the brain. Exosomes are one type of extracellular vesicles that transport bioactive molecules between cells and organs. The cargo delivered by exosomes can alter a wide range of cellular responses in recipient cells and play an important pathophysiological role in human diseases. Read More

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Coronary artery calcification and epicardial adipose tissue as independent predictors of mortality in COVID-19.

Int J Cardiovasc Imaging 2021 May 12. Epub 2021 May 12.

Cardiology Division, Montefiore Medical Center, 111 E 210th, Bronx, NY, 10467, USA.

Recent epidemiological studies have demonstrated that common cardiovascular risk factors are strongly associated with adverse outcomes in COVID-19. Coronary artery calcium (CAC) and epicardial fat (EAT) have shown to outperform traditional risk factors in predicting cardiovascular events in the general population. We aim to determine if CAC and EAT determined by Computed Tomographic (CT) scanning can predict all-cause mortality in patients admitted with COVID-19 disease. Read More

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The impact of epicardial adipose tissue in patients with acute myocardial infarction.

Clin Res Cardiol 2021 May 12. Epub 2021 May 12.

Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.

Aims: Epicardial adipose tissue (EAT) has been linked to impaired reperfusion success after percutaneous coronary intervention (PCI). Whether EAT predicts myocardial damage in the early phase after acute myocardial infarction (MI) is unclear. Therefore, we investigated whether EAT in patients with acute MI is associated with more microvascular obstruction (MVO), greater ST-deviation, larger infarct size and reduced myocardial salvage index (MSI). Read More

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Intercostal Brown Adipose Tissue on FDG PET/CT.

AJR Am J Roentgenol 2021 May 12. Epub 2021 May 12.

Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, 75 Francis St, Brigham and Women's Hospital, Boston, MA 02115.

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Emerging roles for kisspeptin in metabolism.

J Physiol 2021 May 11. Epub 2021 May 11.

Section of Endocrinology & Investigative Medicine, Imperial College London, London, UK.

Kisspeptin, a neuropeptide hormone, has been firmly established to be a key regulator of the hypothalamic-pituitary-gonadal axis and mammalian reproductive behaviour. In recent years, a growing body of evidence has emerged suggesting a role for kisspeptin in regulating metabolic processes. This data suggests that kisspeptin exerts its metabolic effects indirectly via gonadal hormones and/or directly via the kisspeptin receptor in the brain, pancreas and brown adipose tissue. Read More

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Mice lacking endogenous TRPV1 express reduced levels of thermogenic proteins and are susceptible to diet-induced obesity and metabolic dysfunction.

FEBS Lett 2021 May 11. Epub 2021 May 11.

Molecular Signaling Laboratory, School of Pharmacy, University of Wyoming, Laramie, 82072, USA.

Transient receptor potential vanilloid subfamily 1 (TRPV1) is a non-selective cation channel protein expressed in neuronal and non-neuronal cells. Although TRPV1 is implicated in thermogenesis and diet-induced obesity (DIO), its precise role remains controversial. TRPV1 mice are protected from DIO, while TRPV1 activation enhances thermogenesis to prevent obesity. Read More

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Studying Metabolic Abnormalities in the Costello Syndrome HRAS G12V Mouse Model: Isolation of Mouse Embryonic Fibroblasts and Their In Vitro Adipocyte Differentiation.

Methods Mol Biol 2021 ;2262:397-409

Institute of Comparative Molecular Endocrinology, Ulm University, Ulm, Germany.

Costello syndrome (CS), characterized by a developmental delay and a failure to thrive, is also associated with an impaired lipid and energy metabolism. White adipose tissue is a central sensor of whole-body energy homeostasis, and HRAS hyperactivation may affect adipocyte differentiation and mature adipocyte homeostasis. An extremely useful tool for delineating in vitro intrinsic cellular signaling leading to metabolic alterations during adipogenesis is mouse embryonic fibroblasts, known to differentiate into adipocytes in response to adipogenesis-stimulating factors. Read More

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January 2021

Insulin-like growth factor-1 short-period therapy stimulates bone marrow cells in obese swiss mice.

Cell Tissue Res 2021 May 11. Epub 2021 May 11.

Laboratory of Stem Cell Research, Department of Histology and Embryology, Institute of Biology, University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.

Bone marrow cells (BMCs) from obese Swiss mice fed with Western diet show mitochondrial dysfunction. Obesity interferes with BMCs disrupting energetic metabolism, stimulating apoptosis, and reducing cell proliferation since adipose tissue releases inflammatory adipokines into the medullar microenvironment. These changes lead to reduction of BMC differentiation capacity and hematopoiesis impairment, a process responsible for blood cell continuous production through hematopoietic stem cells (HSCs). Read More

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Adipotropic effects of heavy metals and their potential role in obesity.

Fac Rev 2021 26;10:32. Epub 2021 Mar 26.

IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Epidemiological studies demonstrated an association between heavy metal exposure and the incidence of obesity and metabolic syndrome. However, the particular effects of metal toxicity on adipose tissue functioning are unclear. Therefore, recent findings of direct influence of heavy metals (mercury, cadmium, and lead) and metalloid (arsenic) on adipose tissue physiology are discussed while considering existing gaps and contradictions. Read More

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Subgaleal Lipoma: Imaging Findings.

J Belg Soc Radiol 2021 Apr 20;105(1):23. Epub 2021 Apr 20.

Université catholique de Louvain, CHU UCL Namur, Department of Radiology, 1 Avenue Dr G Thérasse, 5530, Yvoir, BE.

Subgaleal lipoma is a benign tumor of adipose tissue. It should be suspected when a semi-spherical avascular mass with well-defined margins, iso- or hyperechoic in most cases, with thin internal echogenic lines parallel to the long axis of the tumor, is observed between the galea aponeurosis and periosteum of the cranial bone. We report a series of cases of three patients who underwent surgical lesion excision and whose histopathological examination findings confirmed the diagnosis of lipoma. Read More

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Deletion of in Preosteoblasts Reveals a Role for the Mammalian Target of Rapamycin Complex 1 (mTORC1) Complex in Dietary-Induced Changes to Bone Mass and Glucose Homeostasis in Female Mice.

JBMR Plus 2021 May 24;5(5):e10486. Epub 2021 Mar 24.

Adelaide Medical School, Faculty of Health and Medical Science University of Adelaide Adelaide South Australia Australia.

The mammalian target of rapamycin complex 1 (mTORC1) complex is the major nutrient sensor in mammalian cells that responds to amino acids, energy levels, growth factors, and hormones, such as insulin, to control anabolic and catabolic processes. We have recently shown that suppression of the mTORC1 complex in bone-forming osteoblasts (OBs) improved glucose handling in male mice fed a normal or obesogenic diet. Mechanistically, this occurs, at least in part, by increasing OB insulin sensitivity leading to upregulation of glucose uptake and glycolysis. Read More

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Parietal peritoneal lipomas: a first case report of two lipomas of the parietal peritoneum.

Yagan Pillay

J Surg Case Rep 2021 May 4;2021(5):rjab162. Epub 2021 May 4.

Department of General Surgery, University of Saskatchewan, Saskatchewan, Canada.

Parietal peritoneal lipomas are a rare surgical entity with seven case reports in the published literature. Their aetiology remains nebulous and includes theories such as misplaced embryonic tissue, adipose hyperproliferation, trauma and fat herniation or excessive obesity. This is the first case report in the literature with two parietal peritoneal lipomas incarcerated in an umbilical hernia. Read More

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Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity.

Nat Commun 2021 May 11;12(1):2622. Epub 2021 May 11.

Neuroscience Division, Garvan Institute of Medical Research, St Vincent's Hospital, Sydney, NSW, Australia.

Obesity is caused by an imbalance between food intake and energy expenditure (EE). Here we identify a conserved pathway that links signalling through peripheral Y1 receptors (Y1R) to the control of EE. Selective antagonism of peripheral Y1R, via the non-brain penetrable antagonist BIBO3304, leads to a significant reduction in body weight gain due to enhanced EE thereby reducing fat mass. Read More

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Association of the new visceral adiposity index with coronary artery calcification and arterial stiffness in Korean population.

Nutr Metab Cardiovasc Dis 2021 Mar 23. Epub 2021 Mar 23.

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background And Aims: The new visceral adiposity index (NVAI) is an indirect marker of visceral adipose tissue recently developed using a Korean population. Here we examined the association of NVAI with coronary artery calcification and arterial stiffness in asymptomatic Korean patients.

Methods And Results: We analyzed data from 60,938 asymptomatic Korean adults. Read More

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Transcriptomics analysis of differentially expressed genes in subcutaneous and perirenal adipose tissue of sheep as affected by their pre- and early postnatal malnutrition histories.

BMC Genomics 2021 May 11;22(1):338. Epub 2021 May 11.

Nutrition Research Unit, Department of Animal Science, Aarhus University, Blichers Alle 20, 8830, Tjele, Denmark.

Background: Early life malnutrition is known to target adipose tissue with varying impact depending on timing of the insult. This study aimed to identify differentially expressed genes in subcutaneous (SUB) and perirenal (PER) adipose tissue of 2.5-years old sheep to elucidate the biology underlying differential impacts of late gestation versus early postnatal malnutrition on functional development of adipose tissues. Read More

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The characterization of metabolites alterations in white adipose tissue of diabetic GK Rats after ileal transposition surgery by an untargeted metabolomics approach.

Adipocyte 2021 Dec;10(1):275-284

Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Dysfunction of adipose tissue could lead to insulin resistance, obesity and type 2 diabetes. Thus, our present study aimed to investigate metabolites alterations in white adipose tissue (WAT) of diabetic GK rats after IT surgery. Ten-week-old male diabetic GK rats were randomly subjected to IT and Sham-IT surgery. Read More

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December 2021

Differential expression of insulin receptor substrate-1(IRS-1) in visceral and subcutaneous adipose depots of morbidly obese subjects undergoing bariatric surgery in a tertiary care center in north India; SNP analysis and correlation with metabolic profile.

Diabetes Metab Syndr 2021 May 5;15(3):981-986. Epub 2021 May 5.

Department of Biochemistry, All India Institute of Medical Sciences, Delhi, India. Electronic address:

Background: /aim: Abdominal obesity and associated metabolic consequences are a burgeoning problem in Asian Indians and studying their genetic predisposition is important. This study is aimed at assessing variations in Insulin receptor substrate-1 (IRS-1), its expression at regional fat-depots (visceral and subcutaneous) in morbidly obese patients, and correlation with genotype-phenotype traits.

Methods: Gene expression of IRS-1 in paired adipose tissue from 35 morbidly obese subjects (BMI) > 40 kg/m) with co-morbidities and 15 controls (BMI<25 kg/m), undergoing bariatric/elective abdominal surgery, respectively was determined by quantitative real time PCR. Read More

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Curcumin improves insulin sensitivity and increases energy expenditure in high-fat-diet-induced obese mice associated with activation of FNDC5/irisin.

Nutrition 2021 Apr 7;90:111263. Epub 2021 Apr 7.

Jiangxi Province Key Laboratory of Animal Nutrition, Jiangxi Agricultural University, Jiangxi, China. Electronic address:

Objective: Curcumin (Cur) has a beneficial role in preventing metabolic dysfunctions; however, the underlying mechanism are not yet fully understood. The aim of this study was to evaluate whether the beneficial metabolic effects of curcumin are associated with the regulation of energy metabolism and activation of fibronectin type 3 domain-containing protein 5 (FNDC5)/irisin.

Methods: We used cellular and molecular techniques to investigate the effects of Cur on C57 BL/6 mice that were fed either a control diet or a high-fat diet (HFD) with or without 0. Read More

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Effects of astaxanthin in animal models of obesity-associated diseases: a systematic review and meta-analysis.

Free Radic Biol Med 2021 May 8. Epub 2021 May 8.

Centre for Obesity Research and Education (CORE), School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, UK. Electronic address:

Background And Aim: Obesity is a major risk factor for several diseases, including metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). The use of natural products, such as astaxanthin (ASX), a potent antioxidant compound produced by the freshwater green microalga Haematococcus pluvialis, has gained particular interest to reduce oxidative stress and inflammation, and to improve redox status, often associated with obesity. A systematic review and meta-analysis was performed to comprehensively examine the effects of ASX in animal models of diet induced obesity-associated diseases in order to inform the design of future human clinical studies for ASX use as supplement or nutraceutical. Read More

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The dynamics of human bone marrow adipose tissue in response to feeding and fasting.

JCI Insight 2021 May 11. Epub 2021 May 11.

Neuroendocrine Unit, Massachusetts General Hospital, Boston, United States of America.

Adipocytes were long considered to be inert components of the bone marrow niche, but both mouse and human models suggest that bone marrow adipose tissue (BMAT) is dynamic and responsive to hormonal and nutrient cues. In this study of healthy volunteers, we investigated how BMAT responds to acute nutrient changes, including analyses of endocrine determinants and paracrine factors from marrow aspirates. Study participants underwent a 10-day high-calorie protocol followed by a 10-day fast. Read More

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Correction to: Developmental programming of offspring adipose tissue biology and obesity risk.

Int J Obes (Lond) 2021 May 10. Epub 2021 May 10.

Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, Downing Street, University of Cambridge, Cambridge, UK.

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Human adipose tissue-derived mesenchymal stem cells and their extracellular vesicles modulate lipopolysaccharide activated human microglia.

Cell Death Discov 2021 May 10;7(1):98. Epub 2021 May 10.

Interventional Regenerative Medicine and Imaging Laboratory, Department of Radiology, Stanford University, Palo Alto, CA, 94304, USA.

Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), are driven by neuroinflammation triggered by activated microglial cells; hence, the phenotypic regulation of these cells is an appealing target for intervention. Human adipose tissue-derived mesenchymal stem cells (hAD-MSCs) may be a potential therapeutic candidate to treat NDs given their immunomodulatory properties. Evidence suggests that the mechanism of action of hAD-MSCs is through their secretome, which includes secreted factors such as cytokines, chemokines, or growth factors as well as extracellular vesicles (EVs). Read More

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Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction.

Elife 2021 May 11;10. Epub 2021 May 11.

Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.

Myocardial infarction (MI) promotes a range of systemic effects, many of which are unknown. Here, we investigated the alterations associated with MI progression in heart and other metabolically active tissues (liver, skeletal muscle, and adipose) in a mouse model of MI (induced by ligating the left ascending coronary artery) and sham-operated mice. We performed a genome-wide transcriptomic analysis on tissue samples obtained 6- and 24-hours post MI or sham operation. Read More

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Mulberry leaf activates brown adipose tissue and induces browning of inguinal white adipose tissue in type 2 diabetic rats through regulating AMPK signaling pathway.

Br J Nutr 2021 May 11:1-31. Epub 2021 May 11.

Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.

The current epidemic of type 2 diabetes mellitus (T2DM) significantly affects human health worldwide. Activation of brown adipocytes and browning of white adipocytes are considered as a promising molecular target for T2DM treatment. Mulberry leaf, a traditional Chinese medicine, has been demonstrated to have multi-biological activities, including anti-diabetic and anti-inflammatory effects. Read More

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Oxidant therapy improves adipogenic differentiation of adipose-derived stem cells in human wound healing.

Stem Cell Res Ther 2021 May 10;12(1):280. Epub 2021 May 10.

Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.

Background: Adipose-derived stem cells (ASC) and adipocytes are involved in numerous physiological and pathophysiological conditions, which have been extensively described in subcutaneous and visceral fat depots over the past two decades. However, much less is known about ASC and adipocytes outside classical fat tissue depots and their necessity in tissue remodeling after injury. Therefore, we investigated the etiology of adipocytes in human granulation tissue and define their possible role wound healing. Read More

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