Colloids Surf B Biointerfaces 2021 Apr 24;204:111782. Epub 2021 Apr 24.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China; College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China; Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201301, China; Shandong International Biotechnology Park Development Co. Ltd, 39, Keji Avenue, Yantai High-Tech Zone, 264670, Shandong Province, China. Electronic address:
Hydrogel adhesives with high tissue adhesion, biodegradability and biocompatibility are benefit for promoting surgical procedures and minimizing the pain and post-surgical complications of patients. In this paper, an injectable mussel inspired double cross-linked hydrogel adhesive composed of thiolated mussel inspired chitosan (CSDS) and tetra-succinimidyl carbonate polyethylene glycol (PEG-4S) was designed and developed. CSDS was synthesized with thiol and catechol groups inspired by the synergistic effect of mussel foot proteins (mfps). Read More