76 results match your criteria adhd-i adhd-combined


No support for white matter connectivity differences in the combined and inattentive ADHD presentations.

PLoS One 2021 5;16(5):e0245028. Epub 2021 May 5.

The Brain Dynamics Centre, Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.

Evidence from functional neuroimaging studies support neural differences between the Attention Deficit Hyperactivity Disorder (ADHD) presentation types. It remains unclear if these neural deficits also manifest at the structural level. We have previously shown that the ADHD combined, and ADHD inattentive types demonstrate differences in graph properties of structural covariance suggesting an underlying difference in neuroanatomical organization. Read More

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Disentangling ADHD's Presentation-Related Decision-Making-A Meta-Analytic Approach on Predominant Presentations.

Front Psychiatry 2021 18;12:519840. Epub 2021 Feb 18.

Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.

Deficient decision-making (DM) in attention deficit/hyperactivity disorder (ADHD) is marked by altered reward sensitivity, higher risk taking, and aberrant reinforcement learning. Previous meta-analysis aggregate findings for the ADHD combined presentation (ADHD-C) mostly, while the ADHD predominantly inattentive presentation (ADHD-I) and the predominantly hyperactive/impulsive presentation (ADHD-H) were not disentangled. The objectives of the current meta-analysis were to aggregate findings from DM for each presentation separately. Read More

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February 2021

Effects of the dopamine transporter gene on neuroimaging findings in different attention deficit hyperactivity disorder presentations.

Brain Imaging Behav 2021 Apr 20;15(2):1103-1114. Epub 2021 Jan 20.

Department of Child and Adolescent Psychiatry, Faculty of Medicine, Ege University, Izmir, Turkey.

Attention-Deficit/Hyperactivity Disorder (ADHD) is a phenotipically and neurobiologically heterogeneous disorder. Deficiencies at different levels in response inhibition, differences in dopamine transporter genotype (DAT1) and various symptomatic presentations contribute to ADHD heterogeneity. Integrating these three aspects into a functional neuroimaging research could help unreval specific neurobiological components of more phenotipically homogeneous groups of patients with ADHD. Read More

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Relationship between sluggish cognitive tempo and sleep, psychological, somatic, and cognitive problems and impairment in children with autism and children with ADHD.

Clin Child Psychol Psychiatry 2021 Apr 18;26(2):518-530. Epub 2020 Dec 18.

Department of Psychiatry, Penn State College of Medicine, Hershey, PA, USA.

Sluggish cognitive tempo SCT) is a topic of renewed interest. Much remains to be learned about its association with symptoms and diagnoses that have received little research attention, particularly sleep disturbance, somatic complaints, and autism. Our study is the first to explore the relationship between SCT and sleep, internalizing, externalizing, somatic, and cognitive problems, impairment, and demographics in large samples of children with autism, ADHD-Combined, and ADHD-Inattentive. Read More

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Efficacy and safety of guanfacine extended-release in Japanese adults with attention-deficit/hyperactivity disorder: Exploratory post hoc subgroup analyses of a randomized, double-blind, placebo-controlled study.

Neuropsychopharmacol Rep 2021 03 10;41(1):26-39. Epub 2020 Dec 10.

Department of Psychiatry, Showa University, School of Medicine, Tokyo, Japan.

Aim: Previously, we reported on the efficacy and safety of guanfacine extended-release (GXR) in Japanese adults with attention-deficit/hyperactivity disorder (ADHD) from a phase 3, double-blind, placebo-controlled, randomized trial. In this exploratory post hoc analysis, we assessed the efficacy and/or safety of GXR in the following subgroups: ADHD-combined (ADHD-C) and ADHD-predominantly inattentive (ADHD-I) subtypes, age (≥31, <31 years), sex (male, female), and body weight (≥50, <50 kg).

Methods: The primary efficacy endpoint was change from baseline in the Japanese version of the investigator-rated ADHD-Rating Scale-IV (ADHD-RS-IV) with adult prompts (total scores) at week 10. Read More

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Aberrant functional connectivity in resting state networks of ADHD patients revealed by independent component analysis.

BMC Neurosci 2020 09 18;21(1):39. Epub 2020 Sep 18.

Medical Engineering and Technology Research Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, 271016, China.

Background: ADHD is one of the most common psychiatric disorders in children and adolescents. Altered functional connectivity has been associated with ADHD symptoms. This study aimed to investigate abnormal changes in the functional connectivity of resting-state brain networks (RSNs) among adolescent patients with different subtypes of ADHD. Read More

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September 2020

Diagnostic Associations of Processing Speed in a Transdiagnostic, Pediatric Sample.

Sci Rep 2020 06 22;10(1):10114. Epub 2020 Jun 22.

Center for the Developing Brain, Child Mind Institute, New York, New York, USA.

Introduction: The present study examines the relationships between processing speed (PS), mental health disorders, and learning disorders. Prior work has tended to explore relationships between PS deficits and specific diagnoses in isolation of one another. Here, we simultaneously investigated PS associations with five diagnoses (i. Read More

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Spatiotemporal consistency analysis of attention-deficit/hyperactivity disorder children.

Neurosci Lett 2020 08 26;734:135099. Epub 2020 May 26.

Department of Internal Neurology, Children's Hospital of Chongqing Medical University, No.136 Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China. Electronic address:

Purpose: To identify the local spatiotemporal consistency of spontaneous brain activity of attention-deficit/hyperactivity disorder (ADHD) adolescents and its relation with clinical performance.

Materials And Methods: A cohort of 50 adolescents with ADHD-I or ADHD-C and a cohort of age- and gender- matched 46 typical development controls (TDC) were recruited from ADHD-200 dataset. FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) metric was used to analyze the local spatiotemporal consistency, which integrating local temporal homogeneity and regional stability of brain activity states. Read More

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Symptom Level Associations Between Attention-Deficit Hyperactivity Disorder and School Performance.

Clin Pediatr (Phila) 2020 09 22;59(9-10):874-884. Epub 2020 May 22.

Vermont Department of Health, Burlington, VT, USA.

Attention-deficit hyperactivity disorder (ADHD) is associated with reduced school performance. To determine which ADHD symptoms and subtypes have the strongest association, we used type and frequency of symptoms on the 2014 National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome (NS-DATA) to create symptom scores for inattention and hyperactivity-impulsivity and define subtypes (ADHD-Inattentive [ADHD-I], ADHD-Hyperactive-Impulsive, ADHD-Combined [ADHD-C]). Regression methods were used to examine associations between symptoms and subtype and a composite measure of school performance. Read More

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September 2020

Sleep among presentations of Attention-Deficit/Hyperactivity Disorder: Analysis of objective and subjective measures.

Int J Clin Health Psychol 2020 Jan-Apr;20(1):54-61. Epub 2019 Oct 18.

Laboratorio del Sueño y Promoción de la Salud; Centro de Investigación, Mente, Cerebro y Comportamiento (CIMCYC), Universidad de Granada, España.

To examine subjective and objective sleep patterns in children with different Attention-Deficit/Hyperactivity Disorder (ADHD) presentations.

Method: We assessed 92 children diagnosed with ADHD (29 ADHD-Inattentive [ADHD-I], 31 ADHD-Hyperactive/Impulsive [ADHD-H/I], and 32 ADHD-Combined [ADHD-C)]) aged 7-11 years. The Pediatric Sleep Questionnaire (PSQ), Pediatric Daytime Sleepiness Scale (PDSS), and a sleep diary were used as subjective sleep measures, and polysomnography was used to objectively assess sleep quantity, quality, and fragmentation. Read More

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October 2019

Sex and racial/ethnic differences in the association between childhood attention-deficit/hyperactivity disorder symptom subtypes and body mass index in the transition from adolescence to adulthood in the United States.

Pediatr Obes 2019 05 10;14(5):e12498. Epub 2019 Jan 10.

Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: While attention-deficit/hyperactivity disorder (ADHD) has been associated with higher body mass index (BMI), little research has focused on how this association differs by sex or race/ethnicity.

Objective: To investigate the association between ADHD and BMI by sex and race/ethnicity (ie, European [EA], African [AA], and Hispanic American [HA]).

Methods: Data came from the National Longitudinal Survey of Adolescent to Adult Health Waves II to IV (n = 13 332, age: 12-34 years). Read More

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Large-scale brain functional network topology disruptions underlie symptom heterogeneity in children with attention-deficit/hyperactivity disorder.

Neuroimage Clin 2019 19;21:101600. Epub 2018 Nov 19.

Center for Cognitive Neuroscience, Neuroscience & Behavioral Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, Singapore 169857, Singapore; Clinical Imaging Research Centre, The Agency for Science, Technology and Research-National University of Singapore, Singapore, Singapore. Electronic address:

Accumulating evidence suggests brain network dysfunction in attention-deficit/hyperactivity disorder (ADHD). Whether large-scale brain network connectivity patterns reflect clinical heterogeneity in ADHD remains to be fully understood. This study aimed to characterize the differential within- and between-network functional connectivity (FC) changes in children with ADHD combined (ADHD-C) or inattentive (ADHD-I) subtypes and their associations with ADHD symptoms. Read More

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December 2019

Neuropsychological Profile Related with Executive Function of Chinese Preschoolers with Attention-Deficit/Hyperactivity Disorder: Neuropsychological Measures and Behavior Rating Scale of Executive Function-Preschool Version.

Chin Med J (Engl) 2018 Mar;131(6):648-656

Ministry of Education and Shanghai Key Laboratory of Children's Environment Health; Department of Developmental Behavioral and Child Healthcare, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

Background:: Previous studies have found that schoolchildren with attention-deficit/hyperactivity disorder (ADHD) showed difficulties in neuropsychological function. This study aimed to assess neuropsychological function in Chinese preschoolers with ADHD using broad neuropsychological measures and rating scales and to test whether the pattern and severity of neuropsychological weakness differed among ADHD presentations in preschool children.

Methods:: The 226 preschoolers (163 with ADHD and 63 controls) with the age of 4-5 years were included and assessed using the Behavior Rating Scale of Executive Function-Preschool Version (BRIEF-P) and a series of tests to investigate neuropsychological function. Read More

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Salivary cortisol and alpha-amylase diurnal profiles and stress reactivity in children with Attention Deficit Hyperactivity Disorder.

Psychoneuroendocrinology 2018 04 23;90:174-181. Epub 2018 Feb 23.

Unit of Developmental and Behavioral Pediatrics, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, Thivon and Papadiamantopoulou Str., 115 27, Athens, Greece.

There is growing evidence for dysregulation of the stress system in individuals with Attention Deficit Hyperactivity Disorder (ADHD). The stress system includes neuroanatomical and functional components that function in concert to maintain homeostasis and its main effectors are the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic/adrenomedullary nervous system (SNS). As stress system activity demonstrates a distinct circadian variation, we aimed to describe simultaneously, diurnal rhythms of both the HPA axis and the SNS in children with ADHD and a comparison group. Read More

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Sluggish Cognitive Tempo as a Possible Predictor of Methylphenidate Response in Children With ADHD: A Randomized Controlled Trial.

J Clin Psychiatry 2018 Mar/Apr;79(2)

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Objective: To examine whether sluggish cognitive tempo (SCT) symptomatology moderates dose response to methylphenidate and whether the impact of SCT on medication response is distinct from attention-deficit/hyperactivity disorder (ADHD) subtype effects.

Methods: Stimulant-naive children with ADHD predominantly inattentive type (ADHD-I; n = 126) or ADHD combined type (ADHD-C; n = 45) aged 7-11 years were recruited from the community from September 2006 to June 2013 to participate in a prospective, randomized, double-blind, 4-week crossover trial of long-acting methylphenidate. ADHD diagnosis and subtype were established according to DSM-IV criteria using a structured interview and teacher ADHD symptom ratings. Read More

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Comparative Analysis of the WISC between Two ADHD Subgroups.

Psychiatry Investig 2018 Feb 21;15(2):172-177. Epub 2017 Nov 21.

Department of Neuropsychiatry, Osaka Medical College, Osaka, Japan.

Objective: The prevalence of attention deficit/hyperactivity disorder (ADHD) in school-age children is 7.2%, and ADHD is divided into clinical subtypes.

Methods: The current study explored whether specific cognitive profiles as assessed using the Wechsler Intelligence Scale for Children (WISC)-IV could be obtained for each clinical ADHD subtype (ADHD-Inattentive type and ADHD-Combined type) and investigated the correlation between WISC scores and parental age at their children's birth or birthweight. Read More

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February 2018

Psychoradiologic Utility of MR Imaging for Diagnosis of Attention Deficit Hyperactivity Disorder: A Radiomics Analysis.

Radiology 2018 05 22;287(2):620-630. Epub 2017 Nov 22.

From the Department of Radiology, Huaxi MR Research Center (H.S., Y.C., S.L., X.H., J.A.S., Q.G.), Research Core Facilities (H.S., Q.H.), and Department of Psychiatry (Y.C., Y.S., X.X.), West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China; Department of Psychoradiology, Chengdu Mental Health Center, Chengdu, Sichuan, China (Y.C., Y.S., X.X., Q.G.); and Department of Psychology, School of Public Administration, Sichuan University, Chengdu, Sichuan, China (Y.S.,Q.G.).

Purpose To identify cerebral radiomic features related to diagnosis and subtyping of attention deficit hyperactivity disorder (ADHD) and to build and evaluate classification models for ADHD diagnosis and subtyping on the basis of the identified features. Materials and Methods A consecutive cohort of 83 age- and sex-matched children with newly diagnosed and never-treated ADHD (mean age 10.83 years ± 2. Read More

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Functional Brain Connectivity Differences Between Different ADHD Presentations: Impaired Functional Segregation in ADHD-Combined Presentation but not in ADHD-Inattentive Presentation.

Basic Clin Neurosci 2017 Jul-Aug;8(4):267-278

Department of Physics, Faculty of Sciences, University of Zanjan, Zanjan, Iran.

Introduction: Contrary to Diagnostic and Statistical Manual of Mental Disorders (DSM-5), fifth edition, some studies indicate that ADHD-inattentive presentation (ADHD-I) is a distinct diagnostic disorder and not an ADHD presentation.

Methods: In this study, 12 ADHD-combined presentation (ADHD-C), 10 ADHD-I, and 13 controls were enrolled and their resting state EEG recorded. Following this, a graph theoretical analysis was performed and functional integration and segregation of brain network was calculated. Read More

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November 2017

Childhood ADHD and Negative Self-Statements: Important Differences Associated With Subtype and Anxiety Symptoms.

Behav Ther 2017 11 16;48(6):793-807. Epub 2017 May 16.

Louisiana State University.

The current study examined the role negative self-statements have on the comorbidity between anxious symptomatology and ADHD-combined presentation (ADHD-C) and ADHD-predominantly inattentive (ADHD-I). A total of 114 children and adolescents with ADHD (M age = 10.15; SD = 2. Read More

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November 2017

Investigation of attention deficit hyperactivity disorder (ADHD) sub-types in children via EEG frequency domain analysis.

Int J Neurosci 2018 Apr 30;128(4):349-360. Epub 2017 Oct 30.

d Department of Biomedical Engineering, Faculty of Engineering , Erciyes University , Kayseri , Turkey.

Aim Of The Study: To investigate the frequency domain effects and changes in electroencephalography (EEG) signals in children diagnosed with attention deficit hyperactivity disorder (ADHD).

Patients And Methods: The study contains 40 children. All children were between the ages of 7 and 12 years. Read More

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The Impact of Pharmacotherapy on Substance Use in Adolescents With Attention-Deficit/Hyperactivity Disorder: Variations Across Subtypes.

Subst Use Misuse 2017 08 21;52(10):1266-1274. Epub 2017 Mar 21.

a Department of Pharmaceutical Health Outcomes & Policy , University of Houston , Houston , Texas , USA.

Objective: The primary purpose of this study was to investigate the impact of attention-deficit/hyperactivity disorder (ADHD) pharmacotherapy on the risk of substance use within each ADHD subtype.

Methods: The study used data from the National Comorbidity Survey-Adolescent supplement, a nationally representative sample of US adolescents (ages 13-18) collected from 6,483 adolescent-parent interviews conducted between 2001 and 2004. ADHD was categorized into three subtypes: ADHD-predominantly hyperactive-impulsive type (ADHD-H); ADHD-predominantly inattentive type (ADHD-I); and ADHD-combined type (ADHD-C) using Diagnostic and Statistical Manual of Mental Disorders-IV criteria. Read More

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Are Anxiety Disorders in Children and Adolescents Less Impairing Than ADHD and Autism Spectrum Disorders? Associations with Child Quality of Life and Parental Stress and Psychopathology.

Child Psychiatry Hum Dev 2017 12;48(6):891-902

Research Priority Area Yield, Research Institute of Child Development and Education, University of Amsterdam, Postbus 15780, 1001 NG, Amsterdam, The Netherlands.

We compared clinically referred children with anxiety disorders (AD; n = 63) to children with autism spectrum disorder (ASD; n = 39), ADHD Combined (ADHD-C; n = 62), ADHD Predominantly Inattentive (ADHD-I; n = 64), and typically developing children (n = 42) on child quality of life (QOL), paternal and maternal psychopathology and parental stress. Diagnoses were based on DSM-IV-TR criteria. Multilevel analyses showed that QOL in AD was higher on school and social functioning, compared to respectively ADHD and ASD, and lower compared to normal controls on all five domains. Read More

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December 2017

Multiclass Classification for the Differential Diagnosis on the ADHD Subtypes Using Recursive Feature Elimination and Hierarchical Extreme Learning Machine: Structural MRI Study.

PLoS One 2016 8;11(8):e0160697. Epub 2016 Aug 8.

Department of Biomedical Science and Engineering (BMSE), Institute of Integrated Technology (IIT), Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea.

The classification of neuroimaging data for the diagnosis of certain brain diseases is one of the main research goals of the neuroscience and clinical communities. In this study, we performed multiclass classification using a hierarchical extreme learning machine (H-ELM) classifier. We compared the performance of this classifier with that of a support vector machine (SVM) and basic extreme learning machine (ELM) for cortical MRI data from attention deficit/hyperactivity disorder (ADHD) patients. Read More

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Global and local grey matter reductions in boys with ADHD combined type and ADHD inattentive type.

Psychiatry Res Neuroimaging 2016 Aug 20;254:119-26. Epub 2016 Jun 20.

Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville Australia; Developmental Imaging, Murdoch Childrens Research Institute, Parkville, Australia. Electronic address:

Attention-deficit/hyperactivity disorder (ADHD) has reliably been associated with global grey matter reductions but local alterations are largely inconsistent with perhaps the exception of the caudate nucleus. The aim of this study was to examine local and global brain volume differences between typically developing children (TD) and children with a diagnosis of ADHD. We also addressed whether these parameters would differ between children with the ADHD-combined type (ADHD-C) and those with the ADHD-inattentive type (ADHD-I). Read More

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Altered structural connectivity is related to attention deficit/hyperactivity subtypes: A DTI study.

Psychiatry Res Neuroimaging 2016 Oct 14;256:57-64. Epub 2016 Apr 14.

ADHD Outpatient Program, Hospital de Clinicas de Porto Alegre, Department of Psychiatry, Federal University of Rio Grande do Sul, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, Brazil.

This study aimed to provide novel insights into the white matter (WM) microstructural properties of Attention Deficit/Hyperactivity Disorder (ADHD) subtypes by recruiting a relatively large sample of stimulant-naïve children and adolescents who had no comorbidity other than Oppositional Defiant Disorder and were homogenous according to the DAT1 gene polymorphism. A sample of 72 ADHD subjects and 24 controls aged 8-15 years were enrolled in the study. We applied tract-based spatial statistics to the DTI measures for obtaining fractional anisotropy (FA) and axial, radial diffusivity (AD, RD) measures to explore ADHD type-related differences in WM for the whole brain. Read More

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October 2016

Sleep habits in children with attention-deficit/hyperactivity disorder predominantly inattentive type and associations with comorbid psychopathology symptoms.

Sleep Med 2016 05 2;21:151-9. Epub 2015 Dec 2.

Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.

Objectives: Much of what is currently known about the sleep functioning of children with attention-deficit/hyperactivity disorder (ADHD) is based on samples of children with ADHD combined type, and no study to date has examined the association between sluggish cognitive tempo (SCT) and sleep functioning in children diagnosed with ADHD. Accordingly, the objectives of this study were to (1) describe the sleep habits of children diagnosed with ADHD predominantly inattentive type (ADHD-I) and (2) examine whether comorbid internalizing, oppositional, and/or SCT symptoms are associated with poorer sleep functioning in children with ADHD-I. This study extends the current literature by using a large, clinical sample of children with ADHD-I to examine the association between SCT and other psychopathology symptoms with children's sleep functioning. Read More

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Executive Functioning in Subtypes of Attention Deficit Hyperactivity Disorder.

Noro Psikiyatr Ars 2015 Dec 1;52(4):386-392. Epub 2015 Dec 1.

Department of Child and Adolescent Psychiatry, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.

Introduction: This study aims to evaluate executive functions (EF), such as inhibition, planning, working memory, and set shifting, in children with attention deficit hyperactivity disorder (ADHD) by comparing three ADHD subtype groups (ADHD-Inattentive, ADHD-Combined, and ADHD-Comorbid) and a normal control group.

Methods: Participants included 147 children. In total, 111 children were assigned to the ADHD groups of the study. Read More

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December 2015

Postural control and sensory information integration abilities of boys with two subtypes of attention deficit hyperactivity disorder: a case-control study.

Chin Med J (Engl) 2014 ;127(24):4197-203

Department of Child Psychiatry Research, Peking University Sixth Hospital, Peking University Institute of Mental Health, Key Laboratory of Ministry of Health (Peking University), Beijing 100191, China. Email:

Background: Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed psychiatric disorder in childhood. ADHD children with overlapping symptoms and signs of motor problems have more serious prognosis than that of children with ADHD only. However, the motor and sensory processing problems in children with ADHD have not been studied well. Read More

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Screening for the ADHD Phenotype Using the Strengths and Difficulties Questionnaire in a Clinical Sample of Newly Referred Children and Adolescents.

J Atten Disord 2018 09 16;22(11):1032-1039. Epub 2014 Dec 16.

1 Universidad Autónoma de Madrid, Spain.

Objective: To examine the screening ability of the Strengths and Difficulties Questionnaire (SDQ) for ADHD subtypes in a clinical sample.

Method: Parents of 523 children (3 to 17 years old) referred to Child and Adolescent Mental Health Services completed the Spanish version of the SDQ and the ADHD Rating Scale-IV. Receiver operating curve (ROC) curve analyses and likelihood ratios (LRs) were conducted. Read More

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September 2018