164 results match your criteria adhd-combined subtype


Classifying ADHD subtypes/presentations considering the joint effect of three levels of investigation.

Nord J Psychiatry 2021 Jan 14;75(1):31-37. Epub 2020 Oct 14.

Institute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran.

Aim: Discriminant validity of the Attention Deficits/Hyperactive Disorders (ADHD) subtypes/presentations is not yet clear. The purpose of this study was to investigate joint contribution of the strongest factors of the three dimensions, namely psychopathology, neuropsychology and electrophysiology for subtyping of presentations.

Method: A sample of 104 boys aged 7-12 years was subdivided into three groups with ADHD combined ( = 22), inattentive ( = 25) and hyperactive/impulsive subtype ( = 14), and 43 typically developing controls (TDC). Read More

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January 2021

Presenting problem profiles for adolescents with ADHD: differences by sex, age, race, and family adversity.

Child Adolesc Ment Health 2020 Dec 17. Epub 2020 Dec 17.

Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Background: Adolescents with attention-deficit/hyperactivity disorder (ADHD) experience developmentally distinct challenges from children and adults with ADHD. Yet no work in this age group identifies treatment-related phenotypes that can inform treatment matching, development of tailored treatments, and screening efforts.

Method: This study uses Latent Profile Analysis to detect unique presenting problem profiles among adolescents with ADHD and to test whether these profiles differ by key individual characteristics (age, sex, race, family adversity level). Read More

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December 2020

Efficacy and safety of guanfacine extended-release in Japanese adults with attention-deficit/hyperactivity disorder: Exploratory post hoc subgroup analyses of a randomized, double-blind, placebo-controlled study.

Neuropsychopharmacol Rep 2021 03 10;41(1):26-39. Epub 2020 Dec 10.

Department of Psychiatry, Showa University, School of Medicine, Tokyo, Japan.

Aim: Previously, we reported on the efficacy and safety of guanfacine extended-release (GXR) in Japanese adults with attention-deficit/hyperactivity disorder (ADHD) from a phase 3, double-blind, placebo-controlled, randomized trial. In this exploratory post hoc analysis, we assessed the efficacy and/or safety of GXR in the following subgroups: ADHD-combined (ADHD-C) and ADHD-predominantly inattentive (ADHD-I) subtypes, age (≥31, <31 years), sex (male, female), and body weight (≥50, <50 kg).

Methods: The primary efficacy endpoint was change from baseline in the Japanese version of the investigator-rated ADHD-Rating Scale-IV (ADHD-RS-IV) with adult prompts (total scores) at week 10. Read More

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ADHD subtypes are associated differently with circadian rhythms of motor activity, sleep disturbances, and body mass index in children and adolescents: a case-control study.

Eur Child Adolesc Psychiatry 2020 Oct 15. Epub 2020 Oct 15.

Department of Nutrition, Food Science, and Gastronomy, University of Barcelona, Av. Prat de la Riba 171. Recinte Torribera. Edifici Verdaguer, Santa Coloma de Gramenet, 08921, Barcelona, Spain.

To date, few studies have examined the circadian pattern of motor activity in children and adolescents newly diagnosed with attention-deficit/hyperactivity disorder (ADHD). The objective was to study the circadian pattern of motor activity in subjects with ADHD (medication naïve) and to investigate the relationships between alterations in circadian patterns, the ADHD subtype (combined or inattentive), sleep disturbances and body mass index (BMI). One-hundred twenty children and adolescents (60 medication naïve ADHD and 60 controls) were included in a gender- and age-matched case-control study. Read More

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October 2020

Exposure to Manganese in Drinking Water during Childhood and Association with Attention-Deficit Hyperactivity Disorder: A Nationwide Cohort Study.

Environ Health Perspect 2020 09 21;128(9):97004. Epub 2020 Sep 21.

National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.

Background: Manganese (Mn) in drinking water may increase the risk of several neurodevelopmental outcomes, including attention-deficit hyperactivity disorder (ADHD). Earlier epidemiological studies on associations between Mn exposure and ADHD-related outcomes had small sample sizes, lacked spatiotemporal exposure assessment, and relied on questionnaire data (not diagnoses)-shortcomings that we address here.

Objective: Our objective was to assess the association between exposure to Mn in drinking water during childhood and later development of ADHD. Read More

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September 2020

Symptom Level Associations Between Attention-Deficit Hyperactivity Disorder and School Performance.

Clin Pediatr (Phila) 2020 09 22;59(9-10):874-884. Epub 2020 May 22.

Vermont Department of Health, Burlington, VT, USA.

Attention-deficit hyperactivity disorder (ADHD) is associated with reduced school performance. To determine which ADHD symptoms and subtypes have the strongest association, we used type and frequency of symptoms on the 2014 National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome (NS-DATA) to create symptom scores for inattention and hyperactivity-impulsivity and define subtypes (ADHD-Inattentive [ADHD-I], ADHD-Hyperactive-Impulsive, ADHD-Combined [ADHD-C]). Regression methods were used to examine associations between symptoms and subtype and a composite measure of school performance. Read More

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September 2020

Inconsistency in Abnormal Functional Connectivity Across Datasets of ADHD-200 in Children With Attention Deficit Hyperactivity Disorder.

Front Psychiatry 2019 27;10:692. Epub 2019 Sep 27.

Institute of Psychological Sciences, College of Education, Hangzhou Normal University, Hangzhou, China.

Many studies have shown abnormal functional connectivity in children with attention deficit hyperactivity disorder (ADHD) by using resting-state functional magnetic resonance imaging (rs-fMRI). However, few studies illustrated that to what extent these findings were consistent across different datasets. The present study aimed to assess the consistency of abnormal functional connectivity in children with ADHD across the four datasets from a public-assess rs-fMRI ADHD cohort, namely, ADHD-200. Read More

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September 2019

Fine motor deficits and attention deficit hyperactivity disorder in primary school children.

S Afr J Psychiatr 2019 22;25:1232. Epub 2019 Jan 22.

Department of Behavioural Medicine, University of KwaZulu-Natal, South Africa.

Background: Many children with attention deficit hyperactivity disorder (ADHD) display motor deficiencies during their daily routine, which may have impact on their developmental course. Children with ADHD who experience motor deficiencies often display deficits in tasks requiring movements, such as handwriting.

Aim: This study investigated deficiencies in fine motor skills in primary school children with ADHD. Read More

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January 2019

Psychiatric comorbid patterns in adults with attention-deficit hyperactivity disorder: Treatment effect and subtypes.

PLoS One 2019 7;14(2):e0211873. Epub 2019 Feb 7.

Department of Psychiatry, National Taiwan University and College of Medicine, Taipei, Taiwan.

Psychiatric comorbidities are common in individuals with attention-deficit/hyperactivity disorder (ADHD). In this study, we sought to evaluate the effects of medication and childhood ADHD subtypes on psychiatric comorbidities among adults with ADHD as compared to healthy adult controls. We assessed 121 drug-naïve adults with ADHD, 93 treated adults with ADHD, and 145 healthy controls (age 18-36 years) using semi-structured psychiatric interviews, intelligence tests, and medical records. Read More

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November 2019

Comorbidity of Attention Deficit Hyperactivity Disorder and Generalized Anxiety Disorder in children and adolescents.

Psychiatry Res 2018 12 31;270:780-785. Epub 2018 Oct 31.

Department of Human Sciences, Roma Tre University, Rome, Italy.

The aim of the study is to explore the impact of Generalized Anxiety Disorder (GAD) comorbidity in children with Attention Deficit Hyperactivity Disorder (ADHD). Six hundred children with ADHD (mean age = 9.12 years), recruited from 2013 to 2017, participated in the study. Read More

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December 2018

Neurocognitive Pathways in Attention-Deficit/Hyperactivity Disorder and White Matter Microstructure.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 03 29;4(3):233-242. Epub 2018 Sep 29.

Olin Neuropsychiatry Research Center, The Institute of Living, Hartford, Connecticut; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

Background: This study sought to identify attention-deficit/hyperactivity disorder (ADHD) abnormalities in relationships between brain white matter structure and individual differences in several types of impulsive behavior.

Methods: Adolescents, n = 67 with ADHD combined subtype and n = 68 without ADHD, were given neuropsychological tests and underwent diffusion tensor imaging scans. Principal component analysis reduced test scores into factors representing different types of impulsive behavior. Read More

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Large-scale brain functional network topology disruptions underlie symptom heterogeneity in children with attention-deficit/hyperactivity disorder.

Neuroimage Clin 2019 19;21:101600. Epub 2018 Nov 19.

Center for Cognitive Neuroscience, Neuroscience & Behavioral Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, Singapore 169857, Singapore; Clinical Imaging Research Centre, The Agency for Science, Technology and Research-National University of Singapore, Singapore, Singapore. Electronic address:

Accumulating evidence suggests brain network dysfunction in attention-deficit/hyperactivity disorder (ADHD). Whether large-scale brain network connectivity patterns reflect clinical heterogeneity in ADHD remains to be fully understood. This study aimed to characterize the differential within- and between-network functional connectivity (FC) changes in children with ADHD combined (ADHD-C) or inattentive (ADHD-I) subtypes and their associations with ADHD symptoms. Read More

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December 2019

Changes in Sleep Problems Across Attention-Deficit/Hyperactivity Disorder Treatment: Findings from the Multimodal Treatment of Attention-Deficit/Hyperactivity Disorder Study.

J Child Adolesc Psychopharmacol 2018 12 2;28(10):690-698. Epub 2018 Nov 2.

Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California.

Stimulant medication and behavior therapy are efficacious for youth with attention-deficit/hyperactivity disorder (ADHD). However, research suggests that stimulants may start and/or worsen sleep problems for youth. Further, the impact of behavior therapy for ADHD on sleep is unknown. Read More

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December 2018

Moderator Role of Monitoring in the Inhibitory Control of Adolescents With ADHD.

J Atten Disord 2021 01 28;25(2):188-198. Epub 2018 May 28.

Departamento de Psicología, Universidad de Concepción, Chile.

The aim of this research was to analyze the role of monitoring in the causal relationship between inhibitory control and symptoms of combined ADHD. It has been conducted a quantitative investigation of two phases. In the first study, a moderation model was analyzed ( = 144 adolescents with combined ADHD), where monitoring was considered as a moderating variable in the causal relationship between the inhibitory control and the symptomatology of ADHD (3, 140) = 28. Read More

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January 2021

Neuropsychological Performance Patterns of Adult ADHD Subtypes.

J Atten Disord 2019 08 17;23(10):1136-1147. Epub 2018 May 17.

1 Pacific University, Hillsboro, OR, USA.

: Neuropsychological performance patterns associated with adult ADHD subtypes are unknown. The aim of the current systematic review was to identify and synthesize available literature regarding neuropsychological performance associated with adult ADHD subtypes. Searches were completed using the databases PsycINFO and PubMed for studies published before March 2017 addressing adult ADHD subtypes and neuropsychological performance. Read More

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Sluggish Cognitive Tempo as a Possible Predictor of Methylphenidate Response in Children With ADHD: A Randomized Controlled Trial.

J Clin Psychiatry 2018 Mar/Apr;79(2)

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Objective: To examine whether sluggish cognitive tempo (SCT) symptomatology moderates dose response to methylphenidate and whether the impact of SCT on medication response is distinct from attention-deficit/hyperactivity disorder (ADHD) subtype effects.

Methods: Stimulant-naive children with ADHD predominantly inattentive type (ADHD-I; n = 126) or ADHD combined type (ADHD-C; n = 45) aged 7-11 years were recruited from the community from September 2006 to June 2013 to participate in a prospective, randomized, double-blind, 4-week crossover trial of long-acting methylphenidate. ADHD diagnosis and subtype were established according to DSM-IV criteria using a structured interview and teacher ADHD symptom ratings. Read More

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Comparative Analysis of the WISC between Two ADHD Subgroups.

Psychiatry Investig 2018 Feb 21;15(2):172-177. Epub 2017 Nov 21.

Department of Neuropsychiatry, Osaka Medical College, Osaka, Japan.

Objective: The prevalence of attention deficit/hyperactivity disorder (ADHD) in school-age children is 7.2%, and ADHD is divided into clinical subtypes.

Methods: The current study explored whether specific cognitive profiles as assessed using the Wechsler Intelligence Scale for Children (WISC)-IV could be obtained for each clinical ADHD subtype (ADHD-Inattentive type and ADHD-Combined type) and investigated the correlation between WISC scores and parental age at their children's birth or birthweight. Read More

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February 2018

The Characteristics and Age Effects of Emotional Lability in ADHD Children With and Without Oppositional Defiant Disorder.

J Atten Disord 2020 12 9;24(14):2042-2053. Epub 2017 Dec 9.

Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.

This study evaluated the concurrent validity of emotional lability (EL) in children with ADHD. A total of 2,015 children with ADHD and 745 typically developed controls (TDCs) were assessed and compared on EL. ADHD participants expressed higher EL scores than TDCs, not influenced by gender or IQ. Read More

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December 2020

Childhood ADHD and Negative Self-Statements: Important Differences Associated With Subtype and Anxiety Symptoms.

Behav Ther 2017 11 16;48(6):793-807. Epub 2017 May 16.

Louisiana State University.

The current study examined the role negative self-statements have on the comorbidity between anxious symptomatology and ADHD-combined presentation (ADHD-C) and ADHD-predominantly inattentive (ADHD-I). A total of 114 children and adolescents with ADHD (M age = 10.15; SD = 2. Read More

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November 2017

[Do children with attention deficit and hyperactivity disorder (ADHD) have a diferent gait pattern? Relationship between idiopathic toe-walking and ADHD].

An Pediatr (Engl Ed) 2018 Apr 10;88(4):191-195. Epub 2017 Jul 10.

Servicio de Rehabilitación, Hospital Universitario Fundación Jiménez Díaz, Madrid, España.

Introduction: Idiopathic toe-walking (ITW) is described as a gait pattern with no contact between the heels and the ground in children older than 3years. The diagnosis is clinical, making it necessary to rule out other neurological and orthopaedic conditions. A relationship between ITW and vestibular dysfunction and/or proprioceptive sensibility has been proposed. Read More

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Weeding Out the Justification for Marijuana Treatment in Patients with Developmental and Behavioral Conditions.

J Dev Behav Pediatr 2017 Jul/Aug;38(6):446-448

*Division of General Academic Pediatrics and Child Development, University of California San Diego, Rady Children's Hospital, San Diego, CA; †Department of Psychiatry, University of California San Diego, Rady Children's Hospital, San Diego, CA.

Case: Alex is a 13-year-old adolescent with high-functioning autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD)-combined type, anxiety, and depression. He has been resistant to engaging in therapy and treatment with various medications has been unsuccessful. Alex's parents are concerned about his anxiety, isolation, oppositional behaviors, academic underachievement, truancy, and substance use. Read More

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Variation in the Oxytocin Receptor Gene Is Associated With Social Cognition and ADHD.

J Atten Disord 2019 May 6;23(7):702-711. Epub 2017 May 6.

2 Ege University, İzmir, Turkey.

Objective: Children with ADHD show substantial deficits in social cognitive abilities. Oxytocin, mediated through its specific receptor (OXTR), is involved in the regulation of social behavior and social cognition.

Method: The entire coding sequence of the human OXT and OXTR genes were sequenced to identify mutations and single nucleotide polymorphisms (SNPs) in 151 children with ADHD (ADHD-combined, n = 51; inattentive subtype, n = 50; ADHD-C plus conduct disorder [CD], n = 50; 11-18 years) and 100 healthy controls. Read More

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The Impact of Pharmacotherapy on Substance Use in Adolescents With Attention-Deficit/Hyperactivity Disorder: Variations Across Subtypes.

Subst Use Misuse 2017 08 21;52(10):1266-1274. Epub 2017 Mar 21.

a Department of Pharmaceutical Health Outcomes & Policy , University of Houston , Houston , Texas , USA.

Objective: The primary purpose of this study was to investigate the impact of attention-deficit/hyperactivity disorder (ADHD) pharmacotherapy on the risk of substance use within each ADHD subtype.

Methods: The study used data from the National Comorbidity Survey-Adolescent supplement, a nationally representative sample of US adolescents (ages 13-18) collected from 6,483 adolescent-parent interviews conducted between 2001 and 2004. ADHD was categorized into three subtypes: ADHD-predominantly hyperactive-impulsive type (ADHD-H); ADHD-predominantly inattentive type (ADHD-I); and ADHD-combined type (ADHD-C) using Diagnostic and Statistical Manual of Mental Disorders-IV criteria. Read More

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Auditory Processing Assessment in Children with Attention Deficit Hyperactivity Disorder: An Open Study Examining Methylphenidate Effects.

Int Arch Otorhinolaryngol 2017 Jan 31;21(1):72-78. Epub 2016 Mar 31.

Department of Phisiology, Universidade Federal do Espírito Santo, Vitoria, Espirito Santo, Brazil.

 Children with Attention Deficit Hyperactivity Disorder can present Auditory Processing (AP) Disorder.  The study examined the AP in ADHD children compared with non-ADHD children, and before and after 3 and 6 months of methylphenidate (MPH) treatment in ADHD children.  Drug-naive children diagnosed with ADHD combined subtype aging between 7 and 11 years, coming from public and private outpatient service or public and private school, and age-gender-matched non-ADHD children, participated in an open, non-randomized study from February 2013 to December 2013. Read More

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January 2017

Bullying Mediates Between Attention-Deficit/Hyperactivity Disorder in Childhood and Psychotic Experiences in Early Adolescence.

Schizophr Bull 2017 09;43(5):1036-1044

Clinical Psychology and Psychotherapy, Institute of Psychology, University of Hamburg, Hamburg, Germany.

Although a childhood diagnosis of attention-deficit/hyperactivity disorder (ADHD) is known to be linked to psychotic experiences and psychotic disorders in later life, the developmental trajectories that could explain this association are unknown. Using a sample from the prospective population-based Avon Longitudinal Study of Parents and Children (ALSPAC) (N = 8247), we hypothesized that the previously reported association of ADHD combined subtype in childhood and psychotic experiences in early adolescence is mediated by traumatic events and by involvement in bullying. Moreover, we expected this mediation to be specific to ADHD and tested this by comparison with specific phobia. Read More

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September 2017

Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism Is a Risk Factor for Attention-Deficit Hyperactivity Disorder in a Turkish Sample.

Psychiatry Investig 2016 Sep 30;13(5):518-525. Epub 2016 Sep 30.

Child and Adolescent Psychiatry Department, Ege University Medical Faculty, Izmir Turkey.

Objective: Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that negatively affects different areas of life. We aimed to evaluate the associations between the Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) and ADHD and to assess the effect of the BDNF polymorphism on the neurocognitive profile and clinical symptomatology in ADHD.

Methods: Two hundred one ADHD cases and 99 typically developing subjects (TD) between the ages of 8 and 15 years were involved in the study. Read More

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September 2016

Associations of attention-deficit/hyperactivity and other childhood disorders with psychotic experiences and disorders in adolescence.

Eur Child Adolesc Psychiatry 2017 Apr 13;26(4):421-431. Epub 2016 Sep 13.

Clinical Psychology and Psychotherapy, Institute of Psychology, University of Hamburg, Hamburg, Germany.

Prodromal symptoms of psychosis are associated with an increased risk of transition, functional impairment, poor mental health, and unfavorable developmental prospects. Existing interventions targeting the prodrome are non-satisfactory. It may thus be more promising to attempt to identify risk factors in the premorbid phase preceding the prodrome to increase the chances of successful preventive approaches. Read More

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Decision-making in social contexts in youth with ADHD.

Eur Child Adolesc Psychiatry 2017 Mar 23;26(3):335-344. Epub 2016 Aug 23.

Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.

This study examined reward-related decision-making in children and adolescents with ADHD in a social context, using economic games. We furthermore examined the role of individual differences in reward-related decision-making, specifically, the roles of reward sensitivity and prosocial skills. Children and adolescents (9-17 years) with ADHD-combined subtype (n = 29; 20 boys) and healthy controls (n = 38; 20 boys) completed the ultimatum game and dictator game as measures of reward-related decision-making in social contexts. Read More

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Global and local grey matter reductions in boys with ADHD combined type and ADHD inattentive type.

Psychiatry Res Neuroimaging 2016 Aug 20;254:119-26. Epub 2016 Jun 20.

Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville Australia; Developmental Imaging, Murdoch Childrens Research Institute, Parkville, Australia. Electronic address:

Attention-deficit/hyperactivity disorder (ADHD) has reliably been associated with global grey matter reductions but local alterations are largely inconsistent with perhaps the exception of the caudate nucleus. The aim of this study was to examine local and global brain volume differences between typically developing children (TD) and children with a diagnosis of ADHD. We also addressed whether these parameters would differ between children with the ADHD-combined type (ADHD-C) and those with the ADHD-inattentive type (ADHD-I). Read More

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Health-related impairments in young children with ADHD: a community-based study.

Child Care Health Dev 2016 09 12;42(5):709-17. Epub 2016 Jun 12.

Murdoch Childrens Research Institute, Melbourne, Vic., Australia.

Background: We aimed to examine health-related impairments in young children with attention-deficit/hyperactivity disorder (ADHD) and non-ADHD controls and explore differences in children with ADHD by gender, ADHD subtype and mental health co-morbidity status.

Methods: Children with ADHD (n = 177) and controls (n = 212) aged 6-8 years were recruited across 43 schools in Melbourne, Australia following a screening (Conners 3 ADHD Index) and case confirmation procedure (Diagnostic Interview Schedule for Children IV). Direct and blinded assessments of height and weight were used to calculate body mass index z-score and to identify overweight/obesity. Read More

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September 2016