1,143 results match your criteria adhd epilepsy

Neuroendoscopic treatment of symptomatic cyst of the septum pellucidum in children: A case series.

Clin Neurol Neurosurg 2021 May 8;207:106671. Epub 2021 May 8.

Pediatric Neurosurgery Santobono-Pausilipon Children's Hospital, Naples, Italy.

Background: Symptomatic cysts of the septum pellucidum (CSP) are extremely rare in children and surgical indications are not well defined. A very careful clinical and neuroradiologic evaluation is necessary to consider a patient for surgical indication.

Methods: We present a surgical series of 7 pediatric patients. Read More

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Regulation of the NMDA receptor by its cytoplasmic domains: (how) is the tail wagging the dog?

Neuropharmacology 2021 Jun 4:108634. Epub 2021 Jun 4.

Departments of Molecular Biophysics and Biochemistry and Neuroscience, Yale School of Medicine, Yale University.

Excitatory neurotransmission mediated by N-methyl-D-aspartate receptors (NMDARs) is critical for synapse development, function, and plasticity in the brain. NMDARs are tetra-heteromeric cation-channels that mediate synaptic transmission and plasticity. Extensive human studies show the existence of genetic variants in NMDAR subunits genes (GRIN genes) that are associated with neurodevelopmental and neuropsychiatric disorders, including autism spectrum disorders (ASD), epilepsy (EP), intellectual disability (ID), attention deficit hyperactivity disorder (ADHD), and schizophrenia (SCZ). Read More

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Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective.

Neuroscientist 2021 Jun 4:10738584211021018. Epub 2021 Jun 4.

Department of Physiology, Zhejiang University School of Medicine, Hangzhou, China.

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are activated by glutamate in the central nervous system (CNS). Basically, mGluRs contribute to fine-tuning of synaptic efficacy and control the accuracy and sharpness of neurotransmission. Among eight subtypes, mGluR1 and mGluR5 belong to group 1 (Gp1) family, and are implicated in multiple CNS disorders, such as Alzheimer's disease, autism, Parkinson's disease, and so on. Read More

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A retrospective analysis of memantine use in a pediatric neurology clinic.

Brain Dev 2021 May 29. Epub 2021 May 29.

Division of Neurology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada; Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada; Department of Neurology and Neurosurgery, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:

Background: Memantine is an N-methyl-D-aspartate receptor (NMDA-R) antagonist, approved for dementia, but also studied in pediatric autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD).

Methods: We reviewed children treated with memantine in a single-centre pediatric neurology clinic. Clinical data extracted included age, sex, weight, clinical history, reason for memantine prescription, period of treatment trial and dosage, treatment response, side effects, and concomitant medications. Read More

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Clinical and electrophysiological predictors of behavioral disorders in patients with benign childhood epilepsy with centrotemporal spikes.

Epilepsy Behav 2021 May 28;121(Pt A):108037. Epub 2021 May 28.

Department of Pediatrics, Division of Child Neurology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.

Purpose: Long-term seizure and developmental outcomes of benign childhood epilepsy with centrotemporal spikes (BECTS) are thought to be good. Studies have shown that behavioral disorders may accompany BECTS. We aimed to investigate the frequency of behavioral disorders in patients with BECTS and evaluate their relationship to epilepsy features. Read More

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Agitation and Sugar Craving Related to Epilepsy Seizure.

Case Rep Psychiatry 2021 3;2021:9969854. Epub 2021 May 3.

Landmo Nursing Home and Rehabilitation Center, Nordre Land, Norway.

Introduction: Epilepsy is a chronic central nervous system disorder characterized by the recurrence of unprovoked seizures and can affect people of all ages. Seizure symptoms can vary widely in patients. Many papers have been published about agitation and epileptic seizures, but almost nothing about sugar cravings and agitation related to epilepsy. Read More

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variant in focal cortical dysplasia: a case report and review of the literature.

Oxf Med Case Reports 2021 May 24;2021(5):omab027. Epub 2021 May 24.

iCBR/CIMAGO, Faculty of Medicine, University of Coimbra, Coimbra 3000, Portugal.

Germline and 2-hit brain somatic variants in gene, a negative regulator of the mammalian target of rapamycin (mTOR) pathway, are increasingly recognized in patients with focal cortical dysplasia (FCD). Next-generation targeted sequencing identified a heterozygous germline variant in gene (c.3241A>C, p. Read More

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A study on the relationship between non-epileptic fast (40 - 200 Hz) oscillations in scalp EEG and development in children.

Brain Dev 2021 May 26. Epub 2021 May 26.

Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Okayama, Japan.

Objective: Physiological gamma and ripple activities may be linked to neurocognitive functions. This study investigated the relationship between development and non-epileptic, probably physiological, fast (40-200 Hz) oscillations (FOs) including gamma (40 - 80 Hz) and ripple (80 - 200 Hz) oscillations in scalp EEG in children with neurodevelopmental disorders.

Methods: Participants were 124 children with autism spectrum disorder (ASD) and/or attention deficit/hyperactivity disorder (ADHD). Read More

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Differential Clinical Features in Colombian Patients With Rolandic Epilepsy and Suggestion of Unlikely Association With , , or Gene Variants.

J Child Neurol 2021 May 27:8830738211015017. Epub 2021 May 27.

Grupo Mapeo Genético, Departamento de Pediatría, 27983Universidad de Antioquia UdeA, Medellín, Colombia.

Purpose: Our purpose was to describe the phenotypic features and test for association of genes , and with rolandic epilepsy in patients from Colombia.

Methods: Thirty patients were enrolled. A structured interview was applied. Read More

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Can Deep Learning Hit a Moving Target? A Scoping Review of Its Role to Study Neurological Disorders in Children.

Saman Sargolzaei

Front Comput Neurosci 2021 5;15:670489. Epub 2021 May 5.

Department of Engineering, College of Engineering and Natural Sciences, University of Tennessee at Martin, Martin, TN, United States.

Neurological disorders dramatically impact patients of any age population, their families, and societies. Pediatrics are among vulnerable age populations who differently experience the devastating consequences of neurological conditions, such as attention-deficit hyperactivity disorders (ADHD), autism spectrum disorders (ASD), cerebral palsy, concussion, and epilepsy. System-level understanding of these neurological disorders, particularly from the brain networks' dynamic perspective, has led to the significant trend of recent scientific investigations. Read More

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Term Birth Weight and Neurodevelopmental Outcomes.

Epidemiology 2021 Jul;32(4):583-590

National Institute of Environmental Health Sciences, Durham, NC.

Background: Preterm birth is an important risk factor for neurodevelopmental disabilities. The vast majority of these disabilities occur, however, among term births. The role of fetal growth restriction specifically among term babies has been incompletely described. Read More

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Methylphenidate treatment for cognitive symptoms associated with ADHD in a pediatric epilepsy patient following resection of a left frontal cortical dysplasia.

Epilepsy Behav Rep 2021 10;16:100435. Epub 2021 Feb 10.

Center for Rare Neurological Diseases, Atlanta, GA, USA.

We present data on a 10-year-old patient with drug-resistant epilepsy who was treated with methylphenidate for symptoms of attention deficit hyperactivity disorder (ADHD) that developed after she underwent surgical resection of a left frontal cortical dysplasia. . The patient's parents reported methylphenidate was helpful in improving their child's reading performance. Read More

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February 2021

Genetic mosaicism, intrafamilial phenotypic heterogeneity, and molecular defects of a novel missense SLC6A1 mutation associated with epilepsy and ADHD.

Exp Neurol 2021 Aug 5;342:113723. Epub 2021 May 5.

Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, 37232, United States of America. Electronic address:

Background: Mutations in SLC6A1, encoding γ-aminobutyric acid (GABA) transporter 1 (GAT-1), have been recently associated with a spectrum of neurodevelopmental disorders ranging from variable epilepsy syndromes, intellectual disability (ID), autism and others. To date, most identified mutations are de novo. We here report a pedigree of two siblings associated with myoclonic astatic epilepsy, attention deficit hyperactivity disorder (ADHD), and ID. Read More

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The long-term prognosis of hippocampal neurogenesis and behavioral changes of offspring from rats exposed to valproic acid during pregnancy.

Neuropsychopharmacol Rep 2021 Jun 5;41(2):260-264. Epub 2021 May 5.

Department of Psychiatry, Juntendo Koshigaya Hospital, Saitama, Japan.

Aim: In pregnant women with epilepsy, it is essential to balance maternal safety and the potential teratogenicity of anticonvulsants. Recently, growing evidence has indicated that valproic acid (VPA) can produce postnatal congenital malformations and impair cognitive function. However, the mechanisms underlying cognitive dysfunction in long-term prognoses remain unclear. Read More

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Childhood neurodevelopmental disorders and maternal hypertensive disorder of pregnancy.

Dev Med Child Neurol 2021 Apr 21. Epub 2021 Apr 21.

Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.

Aim: To examine the association of maternal chronic hypertension and pregnancy-induced hypertension (PIH)/preeclampsia with childhood neurodevelopmental disorders (NDDs) in a large-scale population-based cohort.

Method: We conducted a linked Taiwan National Health Insurance Research Database cohort study of children born between 2004 and 2008 (n=877 233). Diagnoses of autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), developmental delay, intellectual disability, cerebral palsy (CP), and epilepsy/infantile spasms were identified from birth to the end of 2015. Read More

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Assessment of tuberous sclerosis-associated neuropsychiatric disorders using the MINI-KID tool: a pediatric case-control study.

Orphanet J Rare Dis 2021 Apr 17;16(1):181. Epub 2021 Apr 17.

Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, No. 399 Wanyuan Road, Minhang District, Shanghai, 201102, China.

Background: The tuberous sclerosis-associated neuropsychiatric disorders (TAND) have not previously been studied in China. We aimed to assess the psychiatric level of individuals with TAND using the Mini International Neuropsychiatric Interview for Children (MINI-KID) in China.

Results: A total of 83. Read More

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Long-term epilepsy control, motor function, cognition, sleep and quality of life in children with West syndrome.

Epilepsy Res 2021 Jul 2;173:106629. Epub 2021 Apr 2.

Pediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India. Electronic address:

Purpose: To assess epilepsy, motor function, cognitive, sleep, and quality of life outcomes and their predictors in a follow-up cohort with West syndrome (WS) at ≥5 years of age.

Methods: Cross-sectional evaluation in a follow-up cohort of WS (aged 5-14 years), between July 2018 and December 2019, was performed at a tertiary-care referral center in Northern India. 164 children were assessed in-person for epilepsy severity, functional status (gross motor and hand function), social quotient, behavioral comorbidities, sleep problems, and quality of life (QoL) using Early Childhood Epilepsy Severity Scale, Gross Motor Function Classification System, Manual Ability Classification System, Vineland Social Maturity Scale, Diagnostic and Statistical Manual of Mental disorders-5 criteria, Children's Sleep Habits Questionnaire, and PedsQL-Epilepsy module respectively. Read More

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Long-term risk of epilepsy, cerebral palsy and attention-deficit/hyperactivity disorder in children affected by a threatened abortion in utero.

Int J Epidemiol 2021 Apr 13. Epub 2021 Apr 13.

Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.

Background: The birth of a child affected by a threatened abortion (TAB) in utero is associated with autism spectrum disorder; association with other neurological disorders is unknown.

Methods: This nationwide registry-based cohort study included singletons live-born in Denmark (1979-2010), followed through 2016. The outcomes were epilepsy, cerebral palsy (CP) and attention-deficit/hyperactivity disorder (ADHD). Read More

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Psychiatric Comorbidities in People With Epilepsy.

Neurol Clin Pract 2021 Apr;11(2):e112-e120

Institute of Medical and Biomedical Education (MM), St George's University of London and the Atkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust, London, United Kingdom; Department of Neurology (AMK), Comprehensive Epilepsy Center and Epilepsy Division, University of Miami, Miller School of Medicine, FL; Division of Epilepsy and Division of Health Outcomes and Knowledge Translation Research (NJ), Department of Neurology, Icahn School of Medicine at Mount Sinai, New York; NIHR UCL Hospitals Biomedical Research Centre (JWS), UCL Queen Square Institute of Neurology, London, and Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom; and Stichting Epilepsie Instellingen Nederland-SEIN (JWS), Heemstede, the Netherlands.

Purpose Of Review: To review the latest evidence concerning the epidemiology, clinical implications, and management of psychiatric disorders in epilepsy.

Recent Findings: People with epilepsy have a 2-5 times increased risk of developing any psychiatric disorder, and 1 in 3 patients with epilepsy have a lifetime psychiatric diagnosis. Psychiatric comorbidities represent a poor prognostic marker as they have been associated with a poor response to treatment (drugs and surgery), increased morbidity, and mortality. Read More

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Systemic Review on Transcranial Electrical Stimulation Parameters and EEG/fNIRS Features for Brain Diseases.

Front Neurosci 2021 26;15:629323. Epub 2021 Mar 26.

Department of Rehabilitation Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan-si, South Korea.

Background: Brain disorders are gradually becoming the leading cause of death worldwide. However, the lack of knowledge of brain disease's underlying mechanisms and ineffective neuropharmacological therapy have led to further exploration of optimal treatments and brain monitoring techniques.

Objective: This study aims to review the current state of brain disorders, which utilize transcranial electrical stimulation (tES) and daily usable noninvasive neuroimaging techniques. Read More

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Mental health and psychosocial support in conflict: children's protection concerns and intervention outcomes in Syria.

Confl Health 2021 Apr 1;15(1):19. Epub 2021 Apr 1.

Division of Psychology, Department of Life Sciences, College of Health, Medicine and Life Sciences, Brunel University London, Kingston Lane, Uxbridge, London, UB8 3PH, UK.

Child protection and mental health during conflict intersects with a variety of adverse conflict-related factors, and intervention outcomes in the field are often difficult to predict. Using the casefiles of 376 school children registered in a Mental Health and Psychosocial Support (MHPSS) project in the Northwest governorate of Idleb in Syria, this study aimed to determine (i) the rates of various protection concerns (potential mental health conditions, psychosocial deprivation issues, and social, behavioural and emotional issues) for students enrolled in this project, (ii) whether the rates of any of the protection concerns varied between children and adolescents, or between boys and girls, and (iii) which of the identified demographic and protection sector factors predicted the presence of potential mental health conditions and MHPSS intervention outcomes. MHPSS interventions (including individual MHPSS sessions tailored for children in conflict, resilience building activities, tutoring, peer building activities, community awareness, and other tailored services) were implemented at schools operated by the UK-based organization, Syria Relief. Read More

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Trans-Synaptic Regulation of Metabotropic Glutamate Receptors by Elfn Proteins in Health and Disease.

Front Neural Circuits 2021 15;15:634875. Epub 2021 Mar 15.

Department of Medical Pharmacology, Nagasaki University Institute of Biomedical Sciences, Nagasaki, Japan.

Trans-regulation of G protein-coupled receptors (GPCRs) by leucine-rich repeat (LRR) transmembrane proteins has emerged as a novel type of synaptic molecular interaction in the last decade. Several studies on LRR-GPCR interactions have revealed their critical role in synapse formation and in establishing synaptic properties. Among them, LRR-GPCR interactions between extracellular LRR fibronectin domain-containing family proteins (Elfn1 and Elfn2) and metabotropic glutamate receptors (mGluRs) are particularly interesting as they can affect a broad range of synapses through the modulation of signaling by glutamate, the principal excitatory transmitter in the mammalian central nervous system (CNS). Read More

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The Efficacy of Parent-Child Interaction Therapy (PCIT) in Children with Attention Problems, Hyperactivity, and Impulsivity in Dubai.

Case Rep Psychiatry 2021 4;2021:5588612. Epub 2021 Mar 4.

Mental Health Centre of Excellence, Al Jalila Children's Specialty Hospital, Dubai, UAE.

Disruptive behaviors can be associated with significant functional impairment. Early intervention for young children is essential to prevent long-term consequences. Parent-Child Interaction Therapy (PCIT) is a psychotherapeutic intervention, which has shown to be effective for children with externalizing symptoms. Read More

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Maternal rheumatoid arthritis during pregnancy and neurodevelopmental disorders in offspring: a systematic review.

Scand J Rheumatol 2021 Mar 23:1-9. Epub 2021 Mar 23.

Department of Public Health, Aarhus University, Aarhus, Denmark.

To summarize the available literature on in utero exposure to maternal rheumatoid arthritis (RA) and its influence on the risk of neurodevelopmental disorders (NDDs) in offspring. We conducted a systematic literature review and assessed the internal validity of studies with the Newcastle Ottawa Scale tool. Six studies were included. Read More

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PLXNA2 and LRRC40 as candidate genes in autism spectrum disorder.

Autism Res 2021 Jun 22;14(6):1088-1100. Epub 2021 Mar 22.

Laboratory of Neurogenetics and Molecular Medicine - IPER, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.

Autism spectrum disorder (ASD) is a neurodevelopmental disability with high heritability yet the genetic etiology remains elusive. Therefore, it is necessary to elucidate new genotype-phenotype relationships for ASD to improve both the etiological knowledge and diagnosis. In this work, a copy-number variant and whole-exome sequencing analysis were performed in an ASD patient with a complex neurobehavioral phenotype with epilepsy and attention deficit hyperactivity disorder. Read More

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Neurologic Care of COVID-19 in Children.

Susana Boronat

Front Neurol 2020 18;11:613832. Epub 2021 Feb 18.

Pediatric Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Most children with SARS-CoV-2 infection have relatively mild clinical symptoms without fever or pneumonia, although severe cases with multiple-organ failure have been reported. Neurological symptoms, which have been mainly reported in adults, are very rare in children. This article will review 2 different aspects of neurological involvement related to this infection in children. Read More

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February 2021

Epileptic phenotype in late-onset hyperinsulinemic hypoglycemia successfully treated by diazoxide.

J Pediatr Endocrinol Metab 2021 May 4;34(5):667-673. Epub 2021 Mar 4.

Department of Pediatric Endocrinology, HFME, Hospices Civils de Lyon, Bron, France.

Objectives: Serious hyperinsulinemic hypoglycemia (HH) is generally the main initial symptom of hyperinsulinism. Epilepsy, without any overt feature of hypoglycemia, might be a very rare initial presentation of late-onset isolated hyperinsulinism.

Case Presentation: We describe a case of late-onset HH in a 15-year-old boy with a history of idiopathic generalized epilepsy, now named genetic generalized epilepsy (IGE/GGE), beginning with a tonic-clonic seizure at the age of 11 years. Read More

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16p11.2 Duplication Syndrome - a Case Report.

Folia Med (Plovdiv) 2021 Feb;63(1):138-141

Medical University of Varna, Varna, Bulgaria.

16p11.2 duplication syndrome is a rare disorder, often associated with intellectual disability, attention deficit, hyperactivity disorder, and a predisposition to epilepsy and schizophrenia. There are no specific dysmorphic features for this genetic condition, but micro-cephaly, micrognathia and hypertelorism could be present. Read More

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February 2021

Infant Stroke Associated With Left Atrial Thrombus and Supraventricular Tachycardia.

Child Neurol Open 2021 Jan-Dec;8:2329048X21995296. Epub 2021 Feb 16.

Department of Pediatrics, Division of Child Neurology, Penn State Health College of Medicine, Hershey, PA, USA.

We report a rare case of cardioembolic stroke in the setting of supraventricular tachycardia (SVT) in an infant. After a week of irritability, a 10-week-old male presented to the emergency department with SVT requiring treatment with adenosine. He developed right-sided hemiparesis and focal motor seizures. Read More

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February 2021

Association of psychiatric comorbidities with the risk of transport accidents in ADHD and MPH.

Epidemiol Psychiatr Sci 2021 Feb 15;30:e14. Epub 2021 Feb 15.

National Addiction Centre, Institute of Psychiatry, King's College London, London, UK.

Aims: Although the relationship between attention-deficit/hyperactivity disorder (ADHD) and transport accidents has been shown, there is limited information on the relationship between medication and dose-response effects and transport accident risk. This study aims to determine whether young people with ADHD, including adolescents, are more prone to transport accidents than those without, and the extent to which methylphenidate (MPH) prescription in these patients reduces the risk.

Methods: We identified 114 486 patients diagnosed with ADHD from Taiwan's National Health Insurance Research Database from 1997 to 2013. Read More

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February 2021