6,346 results match your criteria adequately described

Latent profile analysis of blood marker phenotypes and their relationships with clinical pain and interference reports in people with acute musculoskeletal trauma.

Can J Pain 2021 Feb 16;5(1):30-42. Epub 2021 Feb 16.

Faculty of Health Sciences, Western University, London, Ontario, Canada.

: The prevalence of inadequate treatments for chronic pain has necessitated the search for biological factors that influence the transition to chronicity. : Antecubital blood was drawn from those who experienced acute, noncatastrophic musculoskeletal trauma. Follow-up occurred at 1, 3, 6, and 12 months with the primary outcome being Brief Pain Inventory (BPI) Functional Interference scores. Read More

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February 2021

Encephalitis as Neurological Complication of COVID-19: A Systematic Review and Meta Analysis of Incidence, Outcomes and Predictors.

Eur J Neurol 2021 May 13. Epub 2021 May 13.

Department of Neurology, National Neuroscience Institute, Singapore, Singapore.

Introduction: Although COVID-19 predominantly affects the respiratory system, recent studies have reported the occurrence of neurological disorders such as stroke, in relation to COVID-19 infection. Encephalitis is an inflammatory condition of the brain that has been described as a severe neurological complication of COVID-19. Despite a growing number of reported cases, encephalitis related to COVID-19 infection has not been adequately characterized. Read More

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Radiographers and COVID-19 pneumonia: Diagnostic performance using CO-RADS.

Radiography (Lond) 2021 Apr 30. Epub 2021 Apr 30.

Department of Radiological Sciences, Oncology and Pathology, "Sapienza" University of Rome, I.C.O.T. Hospital, Via Franco Faggiana, 1668, 04100, Latina, Italy.

Introduction: A more structured role of radiographers is advisable to speed up the management of patients with suspected COVID-19. The purpose of our study was to evaluate the diagnostic performance of radiographers in the detection of COVID-19 pneumonia on chest CT using CO-RADS descriptors.

Methods: CT images of patients who underwent RT-PCR and chest CT due to COVID-19 suspicion between March and July 2020 were analysed retrospectively. Read More

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Outbreaks of healthcare-associated infections linked to water-containing hospital equipment: a literature review.

Antimicrob Resist Infect Control 2021 May 10;10(1):77. Epub 2021 May 10.

Department of Medical Microbiology, Radboud Centre for Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands.

Background: Healthcare-associated infections (HAIs) are a significant cause of morbidity and mortality in hospitalized patients. Water in the environment can be a source of infection linked to outbreaks and environmental transmission in hospitals. Water safety in hospitals remains a challenge. Read More

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Longitudinal study based on a safety registry for malaria patients treated with artenimol-piperaquine in six European countries.

Malar J 2021 May 8;20(1):214. Epub 2021 May 8.

TropNet, A European Network for Tropical and Travel Medicine, Verona, Italy.

Background: European travellers to endemic countries are at risk of malaria and may be affected by a different range of co-morbidities than natives of endemic regions. The safety profile, especially cardiac issues, of artenimol (previously dihydroartemisinin)-piperaquine (APQ) Eurartesim during treatment of uncomplicated imported falciparum malaria is not adequately described due to the lack of longitudinal studies in this population. The present study was conducted to partially fill this gap. Read More

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A new intestinal model for analysis of drug absorption and interactions considering physiological translocation of contents.

Drug Metab Dispos 2021 May 7. Epub 2021 May 7.

Graduate School of Pharmaceutical Sciences, Chiba University, Japan

Precise prediction of drug absorption is key to the success of new drug development and efficacious pharmacotherapy. In this study, we developed a new absorption model, the advanced translocation model (ATOM), by extending our previous model, the translocation model. ATOM reproduces the translocation of a substance in the intestinal lumen using a partial differential equation with variable dispersion and convection terms to describe natural flow and micro-mixing within the intestine, under not only fasted but also fed conditions. Read More

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'It's our job': Constraints to investigation of atypical disease events-Opinions of Australian veterinarians.

Zoonoses Public Health 2021 May 7. Epub 2021 May 7.

Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Camperdown, NSW, Australia.

Frontline health practitioners need to be adequately prepared to recognize and respond to atypical disease presentations, some of which may have zoonotic potential. Data from previous research have suggested that veterinarians may face challenges in investigation of disease events due to time and money constraints. As part of an Australia-wide survey project, veterinarians were asked to answer an open-ended question regarding potential constraints in investigation of atypical disease events where there may be concern about a zoonosis or emerging infectious disease. Read More

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Population Pharmacokinetics of CC-122.

Clin Pharmacol 2021 28;13:61-71. Epub 2021 Apr 28.

Clinical Pharmacology & Pharmacometrics, Bristol Myers Squibb, Summit, NJ, USA.

Background: CC-122 is a cereblon-modulating agent that exerts direct cell-autonomous activity against malignant B cells and immunomodulatory effects. Herein, a population pharmacokinetic (popPK) model of CC-122 was developed and the influence of demographic and disease-related covariates on population pharmacokinetic parameters was assessed based on data from three clinical studies of CC-122 (dose range, 0.5-15 mg) in healthy subjects and cancer patients. Read More

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Anticancer drugs repurposed for Alzheimer's disease: a systematic review.

Alzheimers Res Ther 2021 May 5;13(1):96. Epub 2021 May 5.

National Center for Disease Prevention and Health Promotion, Italian National Institute of Health, Via Giano della Bella 34, 00162, Rome, Italy.

Background: The relationship between cancer and dementia is triggering growing research interest. Several preclinical studies have provided the biological rationale for the repurposing of specific anticancer agents in Alzheimer's disease (AD), and a growing number of research protocols are testing their efficacy and safety/tolerability in patients with AD.

Methods: The aim of the present systematic review was to provide an overview on the repurposing of approved anticancer drugs in clinical trials for AD by considering both ongoing and completed research protocols in all phases. Read More

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The working of values in ethics and religion.

David M Black

Int J Psychoanal 2020 Oct 4;101(5):992-1013. Epub 2020 Sep 4.

British Psychoanalytical Society, London, UK.

This paper attempts to understand further the working of values in ethics and religion. Its premise is that the psyche is organized by its internal objects, and that understanding the effective working of values therefore requires understanding the relevant internal objects. It begins with a brief outline of the history of internal objects in the thought of Freud, Klein, Fairbairn, Winnicott and Loewald, and suggests that they are best thought of as "phenomenological" in nature, meaning that, whether conscious or unconscious, they appear in the mind without an enduring substrate. Read More

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October 2020

Molecular Detection of Coxiella burnetii in Unstandardized Minas Artisanal Cheese Marketed in Southeastern Brazil.

Acta Trop 2021 May 2:105942. Epub 2021 May 2.

Department of Veterinary Pathobiology and Theriogenology Faculdade de Ciências Agrárias e Veterinárias (FCAV) - UNESP Jaboticabal, São Paulo, Brasil. Electronic address:

Q fever is a zoonotic disease caused by Coxiella burnetii. The causative pathogen has been detected in dairy products, which raises the possibility of consumption of dairy products as a possible route of transmission; however, this has not been adequately described. Therefore, the aim of the present study was to investigate the presence of C. Read More

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Broadening the Scope.

Am J Clin Pathol 2021 May 5. Epub 2021 May 5.

Departments of Pathology, Ann Arbor, MI, USA.

Objectives: This study qualitatively explored and described pathologists' attitudes toward patient interaction.

Methods: In a survey to pathologists, we asked, "How interested would you be in meeting with patients to discuss their pathology report and show them microscopic images of their tissue?" Then, we asked "Why," followed by a free-text box. We asked pathologists to assume that their time would be adequately compensated and that patients' treating clinicians had already told them their diagnosis. Read More

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Pharmacokinetics and Pharmacodynamics of Cefepime in Adults with Hematological Malignancies and Febrile Neutropenia after Chemotherapy.

Antibiotics (Basel) 2021 Apr 29;10(5). Epub 2021 Apr 29.

Facultad de Medicina, Universidad Nacional de Colombia, 111321 Bogotá, Colombia.

Patients with chemotherapy-induced febrile neutropenia (CIFN) may have changes in the pharmacokinetics (PK) compared to patients without malignancies or neutropenia. Those changes in antibiotic PK could lead to negative outcomes for patients if the therapy is not adequately adjusted to this. In this, open-label, non-randomized, prospective, observational, and descriptive study, a PK model of cefepime was developed for patients with hematological neoplasms and post-chemotherapy febrile neutropenia. Read More

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Determining the vocational competencies required to deliver community-based rehabilitation and inclusive development services in India.

Disabil Rehabil 2021 May 4:1-15. Epub 2021 May 4.

Nossal Institute of Global Health, University of Melbourne, Melbourne, Australia.

Purpose: To identify the competencies required by Community-Based Rehabilitation (CBR) practitioners in India and determine typical pathways of competency development, including minimum practice standards.

Methods: Following a literature review of existing frameworks and guidelines for CBR delivery, Delphi methods were used with Indian CBR experts to identify the main competency requirements of CBR personnel. Rubric writing workshops with CBR experts then expressed the performance of these competencies developmentally as learning progressions. Read More

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Resected pancreatic adenocarcinoma: An Asian institution's experience.

Cancer Rep (Hoboken) 2021 May 3:e1393. Epub 2021 May 3.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore.

Background: Pancreatic adenocarcinoma (PDAC) is highly lethal. Surgery offers the only chance of cure, but 5-year overall survival (OS) after surgical resection and adjuvant therapy remains dismal. Adjuvant trials were mostly conducted in the West enrolling fit patients. Read More

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Model-based evaluation of image-guided fractionated whole-brain radiation therapy in pediatric diffuse intrinsic pontine glioma xenografts.

CPT Pharmacometrics Syst Pharmacol 2021 May 3. Epub 2021 May 3.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.

Radiation therapy (RT) is currently the standard treatment for diffuse intrinsic pontine glioma (DIPG), the most common cause of death in children with brain cancer. A pharmacodynamic model was developed to describe the radiation-induced tumor shrinkage and overall survival in mice bearing DIPG. CD1-nude mice were implanted in the brain cortex with luciferase-labeled patient-derived orthotopic xenografts of DIPG (SJDIPGx7 H3F3A and SJDIPGx37 H3F3A ). Read More

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Mandibular guidance prosthesis: Conventional and innovative approach: A case series.

J Indian Prosthodont Soc 2021 Apr-Jun;21(2):208-214

Department of Prosthodontics and Crown and Bridge, Army Dental Center (Research and Referral), New Delhi, India.

Surgical resection of the lower jaw due to the presence of a benign or malignant tumor is the most frequent cause of mandibular deviation. Location and extent of the tumor decide the surgical modality of mandibulectomy to be performed. The clinician must wait for an adequate span of time for completion of the healing and acceptance of the osseous graft before considering a definitive prosthesis. Read More

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Analyzing Description, User Understanding and Expectations of AI in Mobile Health Applications.

AMIA Annu Symp Proc 2020 25;2020:1170-1179. Epub 2021 Jan 25.

University of California, Irvine, Irvine, CA, USA.

Previous research has studied medical professionals' perception of artificial intelligence (AI). However, there has been a limited understanding of how healthcare consumers perceive and use AI-powered technologies such as mobile health apps. We collected 40 popular mobile health apps that claim to have adopted AI, to study how AI is explained in these apps' descriptions, and how users react to it through app reviews. Read More

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January 2021

Population Pharmacokinetics of Lithium in Young Pediatric Patients With Intellectual Disability.

Front Pharmacol 2021 15;12:650298. Epub 2021 Apr 15.

Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, Institute of Neuroscience and Third Affiliated Hospital and of Zhengzhou University, Zhengzhou, China.

Lithium is a well-established treatment for bipolar disorders and has been shown to be neuroprotective, and thus low doses might be useful for the treatment of childhood brain injury and neurological sequelae. However, pharmacokinetic (PK) data in children are limited. This study was to investigate the PKs after oral administration of low-dose lithium carbonate in young children with intellectual disability. Read More

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Exposure-response modeling of peficitinib efficacy in patients with rheumatoid arthritis.

Pharmacol Res Perspect 2021 May;9(3):e00744

Astellas Pharma Inc, Tokyo, Japan.

The aim was to analyze the relationship between peficitinib exposure and efficacy response according to American College of Rheumatology (ACR) 20 criteria and 28-joint disease activity score based on C-reactive protein (DAS28-CRP) in rheumatoid arthritis (RA) patients, and to identify relevant covariates by developing exposure-response models. The analysis incorporated results from three multicenter, placebo-controlled, double-blind studies. As an exposure parameter, individual post hoc pharmacokinetic (PK) parameters were obtained from a previously constructed population PK model. Read More

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The Impact of Healthcare-Associated Infections in Patients Undergoing Oncological Microvascular Head and Neck Reconstruction: A Prospective Multicentre Study.

Cancers (Basel) 2021 Apr 27;13(9). Epub 2021 Apr 27.

Oral and Maxillofacial Surgery Department, "La Paz" University Hospital, Institute for Biomedical Research IdiPAZ, Universidad Autónoma, 28046 Madrid, Spain.

(1) Background: Healthcare-associated infections (HAIs) after head and neck free-flap reconstruction are a common postoperative complication. Risk factors for HAIs in this context and their consequences have not been adequately described. (2) Methods: Ongoing prospective multicentre study between 02/2019 and 12/2020. Read More

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Public Health Workforce Burnout in the COVID-19 Response in the U.S.

Int J Environ Res Public Health 2021 04 20;18(8). Epub 2021 Apr 20.

Epidemiology Program, University of Delaware, Newark, DE 19713, USA.

While the health impacts of the COVID-19 pandemic on frontline health care workers have been well described, the effects of the COVID-19 response on the U.S. public health workforce, which has been impacted by the prolonged public health response to the pandemic, has not been adequately characterized. Read More

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Safety.Net: A Pilot Study on a Multi-Risk Internet Prevention Program.

Int J Environ Res Public Health 2021 Apr 16;18(8). Epub 2021 Apr 16.

Faculty of Education, Universidad Internacional de la Rioja (UNIR), Avenida de la Paz, 137, 26006 Logroño, Spain.

Many programs exist to prevent bullying and cyberbullying. Nevertheless, despite evidence of the numerous overlapping risks of the Internet, programs that jointly and adequately address large sets of risks are not presently described in the scientific literature. This study's main objective was to assess the effectiveness of the Safety. Read More

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Plastic Recycling Practices in Vietnam and Related Hazards for Health and the Environment.

Int J Environ Res Public Health 2021 Apr 15;18(8). Epub 2021 Apr 15.

Faculty of Chemistry, University of Science, Vietnam National University, No. 19 Le Thanh Tong Street, Hanoi 11021, Vietnam.

Waste plastic today is a global threat. The rapid increase in global production and use has led to increasing quantities of plastics in industrial and municipal waste streams. While in industrialized countries plastic waste is taken up by a waste management system and at least partly recycled, in low-income countries adequate infrastructure to collect and treat waste adequately is often not in place. Read More

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Clinical Manifestations and Treatment Outcomes in Degos Disease: A Systematic Review.

J Eur Acad Dermatol Venereol 2021 Apr 29. Epub 2021 Apr 29.

Faculty of Medicine, University of Toronto, Canada.

Degos disease (atrophic papulosis) is a rare vasculopathy with cutaneous and systemic manifestations. Although potentially fatal, the characteristics of and treatments for Degos disease variants are not adequately described. We conducted a systematic review to summarize cutaneous and systemic presentations, treatments, and outcomes of malignant (MAP) and benign (BAP) variants of Degos disease. Read More

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Progression risk in people with HIV and COVID-19: Predictive performance of current risk scores.

AIDS Res Hum Retroviruses 2021 Apr 29. Epub 2021 Apr 29.

Ramon y Cajal University Hospital, 16507, Infectious Diseases, Madrid, Madrid, Spain;

People with HIV (PWH) might have a higher risk of adverse coronavirus disease 2019 (COVID-19) outcomes. Several scores were developed to predict COVID-19 progression to critical disease and are often used among PWH. We assessed the performance of two commonly used risk equations among PWH and COVID-19. Read More

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Psychologic Status and Influence of Surgery Techniques on Acute Nonneuropathic Pain After Dental Implant Surgery: Systematic Review and Meta-analyses.

Int J Oral Maxillofac Implants 2021 Mar-Apr;36(2):248-269

Purpose: Dental implant placement is often followed by acute pain, which is one of the most important patient-centered matters of treatment. However, this pain is often not adequately appreciated by clinicians, and knowledge about risk factors associated with acute pain is scant. An understanding of these factors is important to help clinicians deliver efficient pain control advice based on individual demand. Read More

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Pelvic congestion syndrome (PCS) as a pathology of postmenopausal women: a case report with literature review.

BMC Womens Health 2021 Apr 27;21(1):181. Epub 2021 Apr 27.

Department of Obstetrics and Gynecology, Division of General Gynecology and Gynecologic Oncology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Background: Due to the scarcity of adequately powered, randomized controlled trials and internationally standardized diagnostic criteria, evidence on the diagnosis and treatment of pelvic congestion syndrome (PCS) is limited. Earlier epidemiologic observations led to the attribution of PCS to the premenopausal state, and a remission of symptoms after menopause is frequently described a hallmark of the pathology. This concept has currently been challenged by radiological studies reporting a notable prevalence of ovarian venous congestion in adult female patients of advanced age. Read More

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Self-collected and clinician-collected anal swabs show modest agreement for HPV genotyping.

PLoS One 2021 26;16(4):e0250426. Epub 2021 Apr 26.

Department of Obstetrics and Gynaecology, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.

Background & Aim: Women with HIV/HPV coinfection and cervical lesions are at increased risk of developing HPV related anal cancer. Self-collection of anal swabs may facilitate HPV molecular testing in anal cancer screening, especially in high-risk groups, and yet it is not adequately studied. We evaluated level of agreement between self-collected anal swabs (SCAS) and clinician-collected anal swabs (CCAS) when used for HPV genotyping. Read More

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