Virus Res 2021 Apr 25;295:198280. Epub 2020 Dec 25.
Institute of Virology, Hannover Medical School, Hannover, Germany; Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany; Institute of Virology Helmholtz Zentrum München, Munich, Germany; Cluster of Excellence RESIST (Resolving Infection Susceptibility, EXC 2155), Hannover Medical School, Hannover, Germany. Electronic address:
PML nuclear bodies are matrix-bound nuclear structures with a variety of functions in human cells. These nuclear domains are interferon regulated and play an essential role during virus infections involving accumulation of SUMO-dependent host and viral factors. PML-NBs are targeted and subsequently manipulated by adenoviral regulatory proteins, illustrating their crucial role during productive infection and virus-mediated oncogenic transformation. Read More