12,146 results match your criteria adenocarcinoma clinically


TIMP-1 triggers neutrophil extracellular trap formation in pancreatic cancer.

Cancer Res 2021 May 3. Epub 2021 May 3.

Institut fur Molekulare Immunologie und Experimentelle Onkologie, Klinikum rechts der Isar Technischen Universitat Munchen

Tumor-derived protein tissue inhibitor of metalloproteinases-1 (TIMP-1) correlates with poor prognosis in many cancers, including highly lethal pancreatic ductal adenocarcinoma (PDAC). The non-canonical signaling activity of TIMP-1 is emerging as one basis for its contribution to cancer progression. However, TIMP-1-triggered progression-related biological processes are largely unknown. Read More

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Metastatic small bowel adenocarcinoma: role of metastasectomy and systemic chemotherapy.

ESMO Open 2021 Apr 30;6(3):100132. Epub 2021 Apr 30.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address:

Background: Metastatic small bowel adenocarcinoma (SBA) has a poor prognosis. Due to its rarity, high-quality data are lacking to guide treatment. This retrospective analysis was conducted to help characterize the treatment options for patients with metastatic SBA while providing clinically meaningful prognostic information. Read More

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Targeted dual inhibition of c-Met/VEGFR2 signalling by foretinib improves antitumour effects of nanoparticle paclitaxel in gastric cancer models.

J Cell Mol Med 2021 May 3. Epub 2021 May 3.

Department of Surgery, Indiana University School of Medicine, South Bend, IN, USA.

Elevated expression of multiple growth factors and receptors including c-Met and VEGFR has been reported in gastric adenocarcinoma (GAC) and thus provides a potentially useful therapeutic target. The therapeutic efficacy of foretinib, a c-Met/VEGFR2 inhibitor, was determined in combination with nanoparticle paclitaxel (NPT) in GAC. Animal studies were conducted in NOD/SCID mice in subcutaneous and peritoneal dissemination xenografts. Read More

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Mesonephric Adenocarcinoma of Uterine Cervix: A Case Report and Review of the Literature.

Iran J Pathol 2021 21;16(2):227-231. Epub 2020 Dec 21.

Radiation Oncology Research Center (RORC), Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Mesonephric adenocarcinoma of the uterine cervix is an extremely rare tumor of the female genital tract which derives from the remnants of embryonic mesonephric ducts and its prognosis, diagnosis and treatment is rather challenging. We report a case of a 46-year-old woman with history of abnormal uterine bleeding and an enlarged uterine cervix on physical examination without obvious mass lesion. She was clinically underdiagnosed with cervical myoma and mesonephric hyperplasia. Read More

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December 2020

Radical prostatectomy versus external beam radiation therapy for high-grade, clinically localized prostate cancer: Emulation of a target clinical trial.

Urol Oncol 2021 Apr 29. Epub 2021 Apr 29.

Harvard Medical School, Boston, MA; Division of Urologic Surgery, Beth Israel Deaconess Medical Center, Boston, MA. Electronic address:

Purpose: The comparative effectiveness of surgery and radiation therapy for high-grade, clinically localized prostate cancer remains a seminal, open question in urologic oncology, with no randomized controlled trials to inform management. We therefore emulated a hypothetical target clinical trial of radical prostatectomy (RP) versus external beam radiotherapy (EBRT) for high-grade, clinically localized prostate cancer.

Materials And Methods: We conducted observational analyses using the National Cancer Database from 2006-2015 to emulate a target clinical trial in men 55-69 years with cT1-3cN0cM0, PSA<20 ng/mL, Gleason 8 to 10 prostate adenocarcinoma treated with RP or 75 to 81 Gy EBRT with androgen deprivation therapy (EBRT+ADT). Read More

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Bilateral secondary testicular, epididymal and spermatic cords carcinoma of prostatic origin: a case report and review of the literature.

J Med Case Rep 2021 May 1;15(1):222. Epub 2021 May 1.

Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Osun, Nigeria.

Background: Prostatic carcinoma is emerging as the most common male malignancy in Nigeria and the second most common male cancer worldwide. Patients often present with locally advances stages, and common sites of metastasis are the spine, pelvis, chest, and long bones. Metastases to the testes and spermatic cords are reputed to be rare and may be indicative of a worse outcome, when they occur. Read More

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Evolutionary genetic algorithm identifies as a potential predictive biomarker for immune-checkpoint therapy in colorectal cancer.

NAR Genom Bioinform 2021 Jun 20;3(2):lqab016. Epub 2021 Apr 20.

Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, BT9 7AE, Northern Ireland.

Identifying robust predictive biomarkers to stratify colorectal cancer (CRC) patients based on their response to immune-checkpoint therapy is an area of unmet clinical need. Our evolutionary algorithm Atlas Correlation Explorer (ACE) represents a novel approach for mining The Cancer Genome Atlas (TCGA) data for clinically relevant associations. We deployed ACE to identify candidate predictive biomarkers of response to immune-checkpoint therapy in CRC. Read More

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Cancer Essential Genes Stratified Lung Adenocarcinoma Patients with Distinct Survival Outcomes and Identified a Subgroup from the Terminal Respiratory Unit Type with Different Proliferative Signatures in Multiple Cohorts.

Cancers (Basel) 2021 Apr 28;13(9). Epub 2021 Apr 28.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.

: Heterogeneous features of lung adenocarcinoma (LUAD) are used to stratify patients into terminal respiratory unit (TRU), proximal-proliferative (PP), and proximal-inflammatory (PI) subtypes. A more-accurate subtype classification would be helpful for future personalized medicine. However, these stratifications are based on genes with variant expression levels without considering their tumor-promoting roles. Read More

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Somatic Copy-Number Alterations in Plasma Circulating Tumor DNA from Advanced EGFR-Mutated Lung Adenocarcinoma Patients.

Biomolecules 2021 Apr 21;11(5). Epub 2021 Apr 21.

Comprehensive Cancer Center, Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria.

Background: To assess the clinical relevance of genome-wide somatic copy-number alterations (SCNAs) in plasma circulating tumor DNA (ctDNA) from advanced epidermal growth factor receptor ()-mutated lung adenocarcinoma patients.

Methods: We included 43 patients with advanced T790M-positive lung adenocarcinoma who were treated with osimertinib after progression under previous EGFR-TKI therapy. We performed genomic profiling of ctDNA in plasma samples from each patient obtained pre-osimertinib and after patients developed resistance to osimertinib. Read More

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NRF2 Enables EGFR Signaling in Melanoma Cells.

Int J Mol Sci 2021 Apr 7;22(8). Epub 2021 Apr 7.

Institute of Pathology, University of Würzburg, 97080 Würzburg, Germany.

Receptor tyrosine kinases (RTK) are rarely mutated in cutaneous melanoma, but the expression and activation of several RTK family members are associated with a proinvasive phenotype and therapy resistance. Epidermal growth factor receptor (EGFR) is a member of the RTK family and is only expressed in a subgroup of melanomas with poor prognosis. The insight into regulators of EGFR expression and activation is important for the understanding of the development of this malignant melanoma phenotype. Read More

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The Prognostic Impact of HER2 Genetic and Protein Expression in Pancreatic Carcinoma-HER2 Protein and Gene in Pancreatic Cancer.

Diagnostics (Basel) 2021 Apr 4;11(4). Epub 2021 Apr 4.

Department of Pathology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam-si 13496, Korea.

Pancreatic ductal adenocarcinoma (PDAC) is a lethal and clinically heterogeneous disease with a limited benefit from human epidermal growth factor receptor 2 (HER2)-targeted therapy. Recently, some studies have addressed the antitumoral effect of novel anti-HER2 drugs in HER2 low-expressing tumors. However, there have been few studies on the significance of low HER2 expression and genetic heterogeneity in PDAC. Read More

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Development of a highly pulmonary metastatic orthotopic renal cell carcinoma murine model.

Biol Open 2021 Apr 20;10(4). Epub 2021 Apr 20.

Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul 03722, Korea.

The incidence of renal cell carcinoma (RCC) is high, and its outcomes remain poor. Mortality is attributable largely to metastatic disease and a dearth of effective therapeutic interventions. The lungs are the most common metastatic site. Read More

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Signet ring cell cancer of Ampulla of Vater-first ever case reported in a teenager and a review of literature.

Rare Tumors 2021 12;13:20363613211007767. Epub 2021 Apr 12.

Cancer Foundation Hospital, Karachi, Pakistan.

Ampullary cancers are rare accounting for 0.2% of all gastrointestinal cancers. Signet ring is a rare variant of adenocarcinoma, characterized by having more than 50% of mucin secreting cells and clinically having a worse prognosis. Read More

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Nomogram for Predicting the Probability of Permanent Stoma after Laparoscopic Intersphincteric Resection.

J Gastrointest Surg 2021 Apr 26. Epub 2021 Apr 26.

Department of General Surgery, Peking University First Hospital, 8 Xishiku Street, Xicheng District, Beijing, 100034, China.

Purpose: The purpose of this study was to determine the risk factors for the development of a permanent stoma in laparoscopic intersphincteric resection (LS-ISR) for ultralow rectal adenocarcinoma and to develop and validate a prediction model to predict the probability of permanent stoma after surgery.

Methods: A primary cohort consisting of 301 consecutive patients who underwent LS-ISR was enrolled in this study. Multivariable logistic regression analysis was used to identify risk factors and develop the nomogram. Read More

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[Preliminary study of superselective lymph node dissection in regional lateral cervical lymph node metastasis of papillary thyroid carcinoma].

Zhonghua Zhong Liu Za Zhi 2021 Apr;43(4):484-489

Department of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China.

To explore the applied value of super-selective cervical lymph node dissection in papillary thyroid carcinoma (PTC) patients with clinically suspicious lateral lymph node metastasis (LNM). We retrospectively analyzed the clinical data of 232 cN1b PTC patients who underwent surgery from September 2013 to May 2018 in the Department of Head and Neck Surgical Oncology, National Cancer Center. Among them, 90 cases received super-selective neck dissection (level Ⅲ and IV) and 142 cases underwent selective neck dissection (level Ⅱ-Ⅳ). Read More

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Predictors of early recurrence following neoadjuvant chemotherapy and surgical resection for localized pancreatic adenocarcinoma.

J Surg Oncol 2021 Apr 24. Epub 2021 Apr 24.

Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Background And Objectives: Neoadjuvant chemotherapy (NAT) for pancreatic adenocarcinoma (PDAC) is increasingly being utilized. However, a significant number of patients will experience early recurrence, possibly negating the benefit of surgery. We aimed to identify factors implicated in early disease recurrence. Read More

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Multifocal serous retinopathy with pemigatinib therapy for metastatic colon adenocarcinoma.

Int J Retina Vitreous 2021 Apr 23;7(1):34. Epub 2021 Apr 23.

Department of Ophthalmology, Duke University, 2351 Erwin Rd., Durham, NC, 27705, USA.

Background: Pemigatinib is an inhibitor of the fibroblast growth factor receptor (FGFR), recently approved for the treatment of cholangiocarcinoma. FGFR retinopathy is a newly recognized entity, with only two other FGFR inhibitors reported to cause serous retinopathy. Herein, we describe the first published report of a multifocal serous retinopathy secondary to pemigatinib. Read More

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Retrospective assessment of radiation toxicity from a definitive-intent, moderately hypofractionated image-guided intensity-modulated protocol for anal sac adenocarcinoma in dogs.

Vet Comp Oncol 2021 Apr 23. Epub 2021 Apr 23.

Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Switzerland.

A recent calculation study predicted acceptable toxicity in pelvic organs at risk for a new definitive-intent, moderately hypofractionated radiation therapy (RT) protocol (12 x 3.8 Gy), when used with image-guided intensity-modulated radiation therapy (IG-IMRT). We hypothesized this protocol to result in clinically acceptable radiation toxicities. Read More

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Gastrointestinal-type chemotherapy prolongs survival in an atypical primary ovarian mucinous carcinoma: A case report.

World J Clin Cases 2021 Apr;9(11):2533-2541

Department of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China.

Background: Primary ovarian mucinous carcinoma is a rare histologic subtype of epithelial ovarian carcinoma and exhibits considerable morphologic overlap with secondary tumour. It is hard to differentiate primary from metastatic ovarian mucinous carcinoma by morphological and immunohistochemical features. Because of the histologic similarity between primary ovarian mucinous carcinoma and metastatic gastrointestinal carcinoma, it has been hypothesized that ovarian mucinous carcinomas might respond better to non-gynecologic regimens. Read More

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Whole exome sequencing characterization of individuals presenting extreme phenotypes of high and low risk of developing tobacco-induced lung adenocarcinoma.

Transl Lung Cancer Res 2021 Mar;10(3):1327-1337

Health Research Institute of Navarra (IdisNA), Pamplona, Spain.

Background: Tobacco is the main risk factor for developing lung cancer. Yet, some heavy smokers do not develop lung cancer at advanced ages while others develop it at young ages. Here, we assess for the first time the genetic background of these clinically relevant extreme phenotypes using whole exome sequencing (WES). Read More

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Development of RECLS score to predict survival in lung cancer patients with malignant pleural effusion.

Transl Lung Cancer Res 2021 Mar;10(3):1318-1326

Department of Respiratory and Critical Care Medicine, Jinling Hospital, Medical School of Southeast University, Nanjing, China.

Background: Malignant pleural effusion (MPE) is usually caused by lung cancer, and the prognostic factors are poorly understood. We aimed to develop models to predict the survival of lung cancer patients and lung adenocarcinoma patients with MPE.

Methods: We enrolled lung cancer patients with MPE in Nanjing Jinling Hospital from January 2008 to June 2018 into our study. Read More

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Sarcomatoid Urothelial Carcinoma With Myxoid Stroma: A Case Report and Diagnostic Approach.

Cureus 2021 Mar 20;13(3):e14007. Epub 2021 Mar 20.

Pathology, Obeid Specialized Hospital, Riyadh, SAU.

Bladder cancer is the seventh most common cancer in the world. Urothelial carcinoma is the most common type of bladder cancer. Other subtypes like squamous cell carcinoma and adenocarcinoma are less common. Read More

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DNA methylation of tumor associated calcium signal transducer 2 (TACSTD2) loci shows association with clinically aggressive renal cell cancers.

BMC Cancer 2021 Apr 21;21(1):444. Epub 2021 Apr 21.

Department of Urology and Urologic Oncology, Hannover Medical School, 30625, Hannover, Germany.

Background: DNA methylation is frequently observed in the development and progression of many human tumors as well as renal cell cancer (RCC). Tumor Associated Calcium Signal Transducer 2 (TACSTD2) participates in cell cycle progression through MAPK signalling pathway activation. Moreover, tumor-specific hypermethylation and association with aggressive cancer characteristics has been found for lung adenocarcinoma, hepatocellular carcinoma and cholangiocarcinoma. Read More

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Surgical Outcomes of Non-Small Cell Lung Cancer in Single-Zone N2 in the Aortopulmonary Zone.

Thorac Cardiovasc Surg 2021 Apr 21. Epub 2021 Apr 21.

Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Seoul, Korea.

Objectives:  We evaluate the surgical outcome of clinically single-zone N2 lung cancer limited to aortopulmonary zone (AP zone; lymph node #5 or #6).

Patients And Methods:  We performed a retrospective analysis of patients with non-small cell lung cancer, in whom mediastinal lymph node metastasis was confined to AP zone.

Results:  A total of 84 patients who underwent upfront surgery were included in final analysis. Read More

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De novo adenocarcinoma of the lacrimal gland: Case report.

Ann Med Surg (Lond) 2021 Apr 25;64:102234. Epub 2021 Mar 25.

Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, B.P 5696, Casablanca, Morocco.

Adenocarcinoma of the lacrimal gland is an epithelial malignancy with an incidence according to the literature of 5-7%. It is clinically revealed by an upper palpebral mass often associated with an inflammatory exophthalmos. It is a high-grade malignancy and there are no pathognomonic clinical or radiological signs. Read More

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Characteristics of the PI3K/AKT and MAPK/ERK pathways involved in the maintenance of self-renewal in lung cancer stem-like cells.

Int J Biol Sci 2021 15;17(5):1191-1202. Epub 2021 Mar 15.

Department of Laboratory Medicine, the Affiliated Hospital of Southwest Medical University, Sichuan, China.

Lung cancer is the leading cause of cancer-related mortality worldwide due to its early asymptomatic and late metastasis. While cancer stem cells (CSCs) may play a vital role in oncogenesis and development of lung cancer, mechanisms underlying CSCs self-renewal remain less clear. In the present study, we constructed a clinically relevant CSCs enrichment recognition model and evaluated the potential functions of phosphatidylinositol 3-kinase (PI3K)/AKT pathway (PI3K/AKT) and mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) pathways in lung cancer via bioinformatic analysis, providing the basis for in depth mechanistic inquisition. Read More

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Pituitary metastasis unveiling a lung adenocarcinoma.

Endocrinol Diabetes Metab Case Rep 2021 Feb 26;2021. Epub 2021 Feb 26.

Endocrinology Department, Centro Hospitalar e Universitário do Porto, EPE, Porto, Portugal.

Summary: Pituitary metastasis (PM) can be the initial presentation of an otherwise unknown malignancy. As PM has no clinical or radiological pathognomonic features, diagnosis is challenging. The authors describe the case of a symptomatic PM that revealed a primary lung adenocarcinoma. Read More

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February 2021

The intra-class heterogeneity of immunophenotyping and immune landscape in oesophageal cancer and clinical implications.

Ann Med 2021 Dec;53(1):626-638

Department of Thoracic Surgery, The People's Hospital of Gaozhou, Gaozhou, China.

Background: The response rate and survival benefit of immunotherapy vary among patients, implying specific immune status of an individual could be associated with the effect of immunotherapy. However, in-depth studies of immune subtypes (ISs), immune landscape and tumour microenvironment of oesophageal cancer (ESCA) and their clinical implications are less reported.

Methods: We first accessed data from publicly available databases and preprocessed it based on a standard protocol. Read More

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December 2021

Germline cancer susceptibility gene testing in unselected patients with colorectal adenocarcinoma: A multi-center prospective study.

Clin Gastroenterol Hepatol 2021 Apr 12. Epub 2021 Apr 12.

Background & Aim: Hereditary factors play a role in the development of colorectal cancer (CRC). Identification of germline predisposition can have implications on treatment and cancer prevention. To determine prevalence of pathogenic germline variants (PGV) in CRC patients using an universal testing approach, association with clinical outcomes and the uptake of family variant testing. Read More

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A novel recurrence-associated metabolic prognostic model for risk stratification and therapeutic response prediction in patients with stage I lung adenocarcinoma.

Cancer Biol Med 2021 Apr 15. Epub 2021 Apr 15.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Objective: The proportion of patients with stage I lung adenocarcinoma (LUAD) has dramatically increased with the prevalence of low-dose computed tomography use for screening. Up to 30% of patients with stage I LUAD experience recurrence within 5 years after curative surgery. A robust risk stratification tool is urgently needed to identify patients who might benefit from adjuvant treatment. Read More

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