70,403 results match your criteria addressed study


Biofabrication Strategies for Musculoskeletal Disorders: Evolution towards Clinical Applications.

Bioengineering (Basel) 2021 Sep 10;8(9). Epub 2021 Sep 10.

Institute of Orthopaedic & Musculoskeletal Science, Royal National Orthopaedic Hospital, University College London, Stanmore HA7 4LP, UK.

Biofabrication has emerged as an attractive strategy to personalise medical care and provide new treatments for common organ damage or diseases. While it has made impactful headway in e.g. Read More

View Article and Full-Text PDF
September 2021

Association between osteosarcopenia and cognitive frailty in older outpatients visiting a frailty clinic.

Arch Gerontol Geriatr 2021 Sep 17;98:104530. Epub 2021 Sep 17.

Department of Geriatric Medicine, Hospital, National Center for Geriatrics and Gerontology, 7-430 Morioka, Obu, Aichi 474-8511, Japan. Electronic address:

Purpose: Osteosarcopenia and cognitive frailty are both risk factors for falls and fractures. The purpose of this study was to determine the association between osteosarcopenia and cognitive frailty.

Materials And Methods: This was a cross-sectional secondary data analysis of the Frailty Registry Study with outpatients aged ≥65 years who visited a frailty clinic at a geriatric hospital. Read More

View Article and Full-Text PDF
September 2021

Barriers and Facilitators to Behavior Change for Individuals with Severe Mental Illness who Received the Transdiagnostic Intervention for Sleep and Circadian Dysfunction in a Community Mental Health Setting.

J Behav Health Serv Res 2021 Sep 24. Epub 2021 Sep 24.

Department of Psychology, University of California, Berkeley, 2121 Berkeley Way, Berkeley, CA, 94720-1650, USA.

The Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) was implemented in a community mental health center (CMHC) setting. The goal of TranS-C is to improve sleep and circadian dysfunction among people with severe mental illness. The present study uses the Theoretical Domains Framework (TDF) to uncover barriers and facilitators to changing behaviors learned in TranS-C. Read More

View Article and Full-Text PDF
September 2021

Breviolum and Cladocopium Are Dominant Among Symbiodiniaceae of the Coral Holobiont Madracis decactis.

Microb Ecol 2021 Sep 24. Epub 2021 Sep 24.

Institute of Biology and Coppe, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21941-599, Brazil.

The scleractinian reef building coral Madracis decactis is a cosmopolitan species. Understanding host-symbiont associations is critical for assessing coral's habitat requirements and its response to environmental changes. In this study, we performed a fine grained phylogenetic analyses of Symbiodiniaceae associated with Madracis in two locations in the Southwest Atlantic Ocean (Abrolhos Bank and St. Read More

View Article and Full-Text PDF
September 2021

Sleep problems in pain patients entering tertiary pain care: the role of pain-related anxiety, medication use, self-reported diseases, and sleep disorders.

Pain 2021 Sep 23. Epub 2021 Sep 23.

Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki, Helsinki University Hospital, Helsinki, Finland Research Unit of Oral Health Sciences, University of Oulu, Oulu, Finland Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki University Hospital, Helsinki, Finland Department of Law, Psychology and Social Work, Centre for Health and Medical Psychology, Örebro University, Örebro, Sweden Research Unit of Oral Health Sciences, University of Oulu, Finland, and Oral and Maxillofacial Department, Medical Research Centre Oulu, Oulu University Hospital, Oulu, Finland Department of Pharmacology and SleepWell Research Programme, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Abstract: Chronic pain and sleep problems frequently co-occur. Pain itself disturbs sleep, but other factors may also contribute to sleep problems in pain patients. This cross-sectional study of 473 patients (69. Read More

View Article and Full-Text PDF
September 2021

Improving communication on medical ward rounds with patients who speak limited English with implementation of medical communication charts.

BMJ Open Qual 2021 Sep;10(3)

Department of Respiratory Medicine, King's College Hospital, London, UK

Aim: To improve communication on the medical ward round with patients with limited English through implementation of a medical communication chart.

Local Problem: King's College Hospital (KCH), London, is situated in Southwark in which 11% of households have no members that speak English as a first language, 4.1% of London's population report they do not speak English well. Read More

View Article and Full-Text PDF
September 2021

Cellulose nanofibril/carbon nanotube composite foam-stabilized paraffin phase change material for thermal energy storage and conversion.

Carbohydr Polym 2021 Dec 20;273:118585. Epub 2021 Aug 20.

Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea; Laboratory of Natural Materials Technology, Åbo Akademi University, Turku 20500, Finland. Electronic address:

The leakage and low thermal conductivity of paraffin phase change material (PCM) must be addressed to achieve a more efficient energy storage process. In this study, cellulose nanofibril (CNF) foams were prepared as the porous support of paraffin to prevent its leakage, and multiwalled carbon nanotubes (CNTs) were incorporated in the foams to improve heat transfer performance. Treatment of CNF with methyltrimethoxysilane improved compatibility between the foams and paraffin. Read More

View Article and Full-Text PDF
December 2021

Maternal and neonatal outcomes in mothers with diabetes mellitus in qatari population.

BMC Pregnancy Childbirth 2021 Sep 24;21(1):651. Epub 2021 Sep 24.

Neonatal Intensive Care Unit (NICU), Women's Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC), Doha, P.O. Box 3050, Qatar.

Background: Diabetes Mellitus (DM) is a major cause of maternal, fetal, and neonatal morbidities. Our objective was to estimate the effect of both pre-pregnancy and gestational DM on the growth parameters of newborns in the Qatari population.

Methods: In this population-based cohort study, we compared the data of neonates born to Qatari women with both pre-pregnancy and gestational diabetes mellitus in 2017 with neonates of healthy non-diabetic Qatari women. Read More

View Article and Full-Text PDF
September 2021

Development of bifunctional anti-PD-L1 antibody MMAE conjugate with cytotoxicity and immunostimulation.

Bioorg Chem 2021 Sep 17;116:105366. Epub 2021 Sep 17.

National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address:

In recent years, tumor immunotherapy, especially the combination of PD1/PD-L1 inhibitors and chemotherapy, has developed rapidly. However, the systemic side effects induced by chemotherapy remain a crucial problem that needs to be addressed. Antibody drug conjugates (ADCs) are exceptional target-specific prodrugs that greatly improve the therapeutic window of chemotherapy drugs. Read More

View Article and Full-Text PDF
September 2021

The effect of silica exposure on the risk of lung cancer: A dose-response meta-analysis.

Cancer Epidemiol 2021 Sep 22;75:102024. Epub 2021 Sep 22.

Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran; Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:

Background: The relationship between silica and the risk of developing lung cancer has been established in previous literature, but how much the level of exposure to silica can increase the risk of lung cancer is a question that has been addressed in this review.

Methods: Three electronic databases, including MEDLINE, Scopus, and Web of Science were searched for relevant literature. For the dose-response relationship between exposure to silica and developing lung cancer, we performed a meta-analysis using the random-effects model. Read More

View Article and Full-Text PDF
September 2021

Insight into Shenqi Jiangtang Granule on the improved insulin sensitivity by integrating in silico and in vivo approaches.

J Ethnopharmacol 2021 Sep 21;282:114672. Epub 2021 Sep 21.

Department of Endocrinology, Jining No. 1 People's Hospital, Jining, Shandong, 272000, China; Institute for Chronic Disease Management, Jining No. 1 People's Hospital, Jining, Shandong, 272000, China. Electronic address:

Ethnopharmacological Relevance: Presently, insulin resistance has been a growing concern that urgently needs to be addressed, because it not only places patients at risk of developing type 2 diabetes mellitus but also results in metabolic syndrome and different aspects of cardiovascular diseases. Shenqi Jiangtang Granule (SJG) is a classic traditional Chinese medicine (TCM) prescription that is widely used to treat diabetes mellitus and its complications in clinical practice. While studies have revealed that SJG with multi-ingredients and multi-targets characteristics possesses potential anti-insulin resistance pharmacological properties, its mechanisms of action and molecular targets for the treatment of insulin resistance are still obscure, which prompt us to conduct an in-depth research. Read More

View Article and Full-Text PDF
September 2021

At What Point Should the Thoracolumbar Region Be Addressed in Patients Undergoing Corrective Cervical Deformity Surgery?

Spine (Phila Pa 1976) 2021 Oct;46(20):E1113-E1118

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA.

Study Design: Retrospective cohort study.

Objective: The aim of this study was to investigate the impact of cervical to thoracolumbar ratios on poor outcomes in cervical deformity (CD) corrective surgery.

Summary Of Background Data: Consideration of distal regional and global alignment is a critical determinant of outcomes in CD surgery. Read More

View Article and Full-Text PDF
October 2021

Developing State Health Improvement Plans: Exploring States' Use of Healthy People.

J Public Health Manag Pract 2021 Nov-Dec 01;27(Suppl 6):S274-S279

NORC at the University of Chicago, Bethesda, MD.

Background: While Healthy People outlines a national framework for improving the health of the nation, many states develop State Health Improvement Plans (SHIPs) to set priorities to improve the health of their residents. The purpose of this study was to understand the processes that states use to develop their SHIPs, how states align their SHIPs with Healthy People, and challenges that states face using Healthy People.

Methods: NORC conducted semistructured interviews with 9 state health department representatives who were responsible for SHIPs. Read More

View Article and Full-Text PDF
September 2021

Utility of a Telephone Triage Hotline in Response to the COVID-19 Pandemic.

J Med Internet Res 2021 Jun 24. Epub 2021 Jun 24.

Department of Anesthesiology, Columbia University Irving Medical Center, 622 West 168th Street, New York, US.

Background: During the initial months of the COVID-19 pandemic, rapidly rising disease prevalence in the United States created a demand for patient-facing information exchanges that addressed questions and concerns about the disease. One approach to managing increased patient volumes during a pandemic involves the implementation of telephone-based triage systems. During a pandemic, telephone triage hotlines can be employed in innovative ways to conserve medical resources and offer useful population-level data about disease symptomatology and risk factor profiles. Read More

View Article and Full-Text PDF

Revealing the Underestimated Anticancer Effect of Azurin by Mechanical Unfolding.

ACS Biomater Sci Eng 2021 Sep 24. Epub 2021 Sep 24.

Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China.

As a potential anticancer agent, azurin has attracted extensive attraction among chemists, physicists, and material scientists. Its structural and unfolding/folding information has been partially understood, but some detailed information, such as the difference in the unfolding processes between apo-azurin and holo-azurin, the mechanical stability, and the role of the copper cluster in its stability, has not been addressed adequately, especially at the single-molecule level. Here, we employed AFM-based single-molecule force spectroscopy to investigate the unfolding process of azurin in the apo and holo forms under an external force. Read More

View Article and Full-Text PDF
September 2021

Standardized applications for genetic counseling graduate programs: Opinions of program directors.

J Genet Couns 2021 Sep 24. Epub 2021 Sep 24.

Cancer Genetics Program, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas, USA.

Genetic Counseling Graduate Programs (GCGPs) have progressively increased in number and class size, and implementation of the National Matching Services in 2018 was a major step toward streamlining the admissions process. Standardized applications (SAs), which have been incorporated into the admissions process for undergraduate studies as well as several professional graduate programs, could also be considered for GCGPs. In this study, we assessed the opinions of GCGP Program Directors (PDs) regarding the implementation of an SA for GCGP admissions processes. Read More

View Article and Full-Text PDF
September 2021

Factors associated with late antenatal care initiation among pregnant women attending a comprehensive healthcare facility in Kandahar Province, Afghanistan.

Indian J Public Health 2021 Jul-Sep;65(3):298-301

Lecturer, Paraclinic Department, Faculty of Medicine, Malaly Institute of Higher Education, Kandahar, Afghanistan.

Appropriate and timely care during pregnancy and delivery can improve maternal health. The present study aimed at determining factors associated with late antenatal care (ANC) initiation among pregnant women attending a comprehensive health clinic in Kandahar Province of Afghanistan. Of the 420 pregnant women, 281 (66. Read More

View Article and Full-Text PDF
September 2021

WIC Participants' Perceptions of COVID-19-Related Changes to WIC Recertification and Service Delivery.

J Community Health 2021 Sep 23. Epub 2021 Sep 23.

Division of Research and Evaluation, Public Health Foundation Enterprises WIC Program, 12781 Schabarum Ave, Irwindale, CA, 91706, USA.

Many Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) clinics implemented alternatives to in-person service delivery in response to the COVID-19 pandemic, including virtual visits and electronic document sharing. The objective of this cross-sectional study was to describe WIC participants' experiences with remote service delivery and recertification during the pandemic. Participants included mothers and infants who participated in a WIC-based intervention between June 2019-August 2020. Read More

View Article and Full-Text PDF
September 2021

Brief Report: Feasibility of the Probabilistic Reversal Learning Task as an Outcome Measure in an Intervention Trial for Individuals with Autism Spectrum Disorder.

J Autism Dev Disord 2021 Sep 23. Epub 2021 Sep 23.

Cincinnati Children's Hospital Medical Center, Cincinnati, USA.

Cognitive flexibility deficits are a hallmark feature of autism spectrum disorder (ASD), but few evidence-based behavioral interventions have successfully addressed this treatment target. Outcome measurement selection may help account for previous findings. The probabilistic reversal learning task (PRL) is a measure of cognitive flexibility previously validated for use in ASD, but its use as an outcome measure has not yet been assessed. Read More

View Article and Full-Text PDF
September 2021

Adolescents' symptoms of anxiety and depression before and during the Covid-19 outbreak - A prospective population-based study of teenagers in Norway.

Lancet Reg Health Eur 2021 Jun 28;5:100093. Epub 2021 Mar 28.

Department for Child and Adolescent Research, Norwegian Centre for Violence and Traumatic Stress Studies, Gullhaugveien 1-3, 0409 Oslo, Norway.

Background: Lockdown policies related to the Sars-Cov-2 pandemic has potential negative consequences for mental health in youths.

Methods: Anxiety and depressive symptoms were assessed in 3 572 adolescents, age 13 to 16 using the Hopkins Symptom Checklist (HSCL-10), in a representative longitudinal survey of Norwegian youths between February 2019 (T1) and June 2020 (T2). Predictors for symptom change were analysed with linear mixed-effects models. Read More

View Article and Full-Text PDF

Evaluation of Cold Chain Management Performance for Temperature-Sensitive Pharmaceuticals at Public Health Facilities Supplied by the Jimma Pharmaceuticals Supply Agency Hub, Southwest Ethiopia: Pharmaceuticals Logistic Management Perspective Using a Multicentered, Mixed-Method Approach.

Adv Pharmacol Pharm Sci 2021 14;2021:5167858. Epub 2021 Sep 14.

Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Effective and efficient cold chain management maximizes utilization of healthcare resources, reduces cold chain products wastage, and improves the quality of health services. It eventually guarantees that clients receive cold chain products they need at service delivery points. The objective of this study was to evaluate cold chain management performance for temperature-sensitive medicines at public health facilities in Southwest Ethiopia supplied by the Jimma Pharmaceuticals Fund and Supply Agency hub. Read More

View Article and Full-Text PDF
September 2021

Magnetic resonance imaging under isoflurane anesthesia alters cortical cyclooxygenase-2 expression and glial cell morphology during sepsis-associated neurological dysfunction in rats.

Animal Model Exp Med 2021 Sep 3;4(3):249-260. Epub 2021 May 3.

INCIA Institut de Neurosciences Cognitives et Intégratives d'Aquitaine CNRS UMR 5287 Bordeaux France.

Background: Magnetic resonance imaging (MRI) of rodents combined with histology allows to determine what mechanisms underlie functional and structural brain changes during sepsis-associated encephalopathy. However, the effects of MRI performed in isoflurane-anesthetized rodents on modifications of the blood-brain barrier and the production of vasoactive prostaglandins and glia cells, which have been proposed to mediate sepsis-associated brain dysfunction, are unknown.

Methods: This study addressed the effect of MRI under isoflurane anesthesia on blood-brain barrier integrity, cyclooxygenase-2 expression, and glial cell activation during cecal ligature and puncture-induced sepsis-associated brain dysfunction in rats. Read More

View Article and Full-Text PDF
September 2021

Survivor Guilt: A Cognitive Approach.

Cogn Behav Therap 2021 16;14:e28. Epub 2021 Sep 16.

Royal Holloway, University of London.

Survivor guilt is a common experience following traumatic events in which others have died. However, little research has addressed the phenomenology of survivor guilt, nor has the issue been conceptualised using contemporary psychological models which would help guide clinicians in effective treatment approaches for this distressing problem. This paper summarises the current survivor guilt research literature and psychological models from related areas, such as posttraumatic stress disorder, moral injury and traumatic bereavement. Read More

View Article and Full-Text PDF
September 2021

Somatosensory Gating Is Modulated by Anodal Transcranial Direct Current Stimulation.

Front Neurosci 2021 7;15:651253. Epub 2021 Sep 7.

Research Institute of Health Sciences (IUNICS), Balearic Islands Health Research Institute (IdISBa), University of the Balearic Islands (UIB), Palma, Spain.

Background: Anodal transcranial direct current stimulation (tDCS) of the somatosensory cortex causes cerebral hyperexcitability and a significant enhancement in pain thresholds and tactile spatial acuity. Sensory gating is a brain mechanism to suppress irrelevant incoming inputs, which is elicited by presenting pairs of identical stimuli (S1 and S2) within short time intervals between stimuli (e.g. Read More

View Article and Full-Text PDF
September 2021

Blood analysis of laboratory used for neuroscience research: Investigation of long-term and cumulative effects of implants, fluid control, and laboratory procedures.

eNeuro 2021 Sep 23. Epub 2021 Sep 23.

Brain Research Institute, Center for Cognitive Science, University of Bremen, 28334 Bremen, Germany.

The non-human primate (NHP) constitutes an extraordinarily important model in neuroscience research for understanding the neuronal underpinnings of perceptual, motor, cognitive, and executive functions of the primate brain, and to study the physiological causes, effects, and potential treatments of brain disorders. Due to their cognitive capabilities, NHPs receive special attention in Animal Welfare Regulations around the world, and their well-being is a benchmark for the evaluation, monitoring, and refinement of experimental procedures. As a consequence, many typical neuroscientific procedures are considered only mildly severe by animal welfare boards. Read More

View Article and Full-Text PDF
September 2021

Recent advances in pericarditis.

Eur J Intern Med 2021 Sep 20. Epub 2021 Sep 20.

University of Milano, Department of biomedical and clinical sciences "Luigi Sacco", Fatebenefratelli Hospital, Piazzale Principessa Clotilde 3, 20121, Milano, Italy. Electronic address:

Pericardial diseases are an heterogeneous group of entities, ranging from acute pericarditis to asymptomatic pericardial effusions. New advances in understanding the processes underlying them have been made. In 2020 a prospective study defined the reference intervals of the component of normal pericardial fluid, that was found to be rich in nucleated cells, proteins, albumin and LDH, at levels compatible with the inflammatory exudates of other biological fluids such as pleural or peritoneal fluid; Light's criteria should not be used to evaluate it. Read More

View Article and Full-Text PDF
September 2021

Association of the 3' untranslated region polymorphisms of HLA-G with susceptibility to chronic hepatitis C virus infection in the Chinese population.

Hum Immunol 2021 Sep 20. Epub 2021 Sep 20.

Department of Blood Group, Dalian Blood Center, Dalian, China. Electronic address:

Hepatitis C virus (HCV) infection is a global health problem. Several previous studies have addressed the role of host single-nucleotide polymorphisms (SNPs) in HCV infection. SNPs in the regulatory region of the human leukocyte antigen G (HLA-G) gene play an important role in several diseases. Read More

View Article and Full-Text PDF
September 2021

Effects of sensory distraction and salience priming on emotion identification in autism: an fMRI study.

J Neurodev Disord 2021 Sep 23;13(1):42. Epub 2021 Sep 23.

Jane and Terry Semel Institute of Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, USA.

Background: Social interaction often occurs in noisy environments with many extraneous sensory stimuli. This is especially relevant for youth with autism spectrum disorders (ASD) who commonly experience sensory over-responsivity (SOR) in addition to social challenges. However, the relationship between SOR and social difficulties is still poorly understood and thus rarely addressed in interventions. Read More

View Article and Full-Text PDF
September 2021

Principles of brain aging: Status and challenges of modeling human molecular changes in mice.

Ageing Res Rev 2021 Sep 20:101465. Epub 2021 Sep 20.

Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, 37073 Göttingen, Germany and Center for Biostructural Imaging of Neurodegeneration (BIN), 37075 Göttingen, Germany. Electronic address:

Due to the extension of human life expectancy, the prevalence of cognitive impairment is rising in the older portion of society. Developing new strategies to delay or attenuate cognitive decline is vital. For this purpose, it is imperative to understand the cellular and molecular events at the basis of brain aging. Read More

View Article and Full-Text PDF
September 2021

Self-harm in children and adolescents by ethnic group: an observational cohort study from the Multicentre Study of Self-Harm in England.

Lancet Child Adolesc Health 2021 Sep 20. Epub 2021 Sep 20.

Centre for Mental Health and Safety, School of Health Sciences, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK; Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK; The National Institute for Health Research Greater Manchester Patient Safety Translational Research Centre, Manchester, UK.

Background: Studies report an increasing incidence of self-harm in children and adolescents, but the extent to which this is seen in different ethnic groups is unclear. We aimed to investigate rates of emergency department presentations for self-harm in children and adolescents by ethnicity, as well as to examine their demographic characteristics, clinical characteristics, and outcomes.

Methods: In this observational cohort study, we used data on hospital emergency department presentations for self-harm in children and adolescents aged 10-19 years between 2000 and 2016 from the Multicentre Study of Self-harm in England. Read More

View Article and Full-Text PDF
September 2021