83,411 results match your criteria additionally clinical


Factors associated with seizures at initial presentation in pediatric patients with cerebral arteriovenous malformations.

J Neurosurg Pediatr 2021 Sep 24:1-6. Epub 2021 Sep 24.

1Department of Neurological Surgery, University of California San Francisco, San Francisco.

Objective: Children with cerebral arteriovenous malformations (AVMs) can present with seizures, potentially increasing morbidity and impacting clinical management. However, the factors that lead to seizures as a presenting sign are not well defined. While AVM-related seizures have been described in case series, most studies have focused on adults and have included patients who developed seizures after an AVM rupture. Read More

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September 2021

Regulation of decorin by ursolic acid protects against non-alcoholic steatohepatitis.

Biomed Pharmacother 2021 Sep 21;143:112166. Epub 2021 Sep 21.

Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; Baiyun Hospital of The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address:

Non-alcoholic steatohepatitis (NASH) has become a global health issue, which poses additional financial burden to public health care. However, no specific pharmacological therapy is recommended in current guidelines. Ursolic acid (UA) has been proven to perform multiple biological activities, thereby having a broad application prospect in healthcare field. Read More

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September 2021

Feasibility assessment of infectious keratitis depicted on slit-lamp and smartphone photographs using deep learning.

Int J Med Inform 2021 Sep 17;155:104583. Epub 2021 Sep 17.

School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China. Electronic address:

Background: This study aims to investigate how infectious keratitis depicted on slit-lamp and smartphone photographs can be reliably assessed using deep learning.

Materials And Methods: We retrospectively collected a dataset consisting of 5,673 slit-lamp photographs and 400 smartphone photographs acquired on different subjects. Based on multiple clinical tests (e. Read More

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September 2021

Process-oriented and personalized psychotherapeutic care for epilepsy: Interim results of a feasibility study.

Epilepsy Behav 2021 Sep 21;124:108313. Epub 2021 Sep 21.

Institute of Synergetics and Psychotherapy Research, Paracelsus Medical University, Salzburg, Austria; University Hospital of Psychiatry, Psychotherapy and Psychosomatics, Paracelsus Medical University, Salzburg, Austria.

Background: There is great scientific and clinical interest in the effective integration of psychological treatments into comprehensive epilepsy care to optimize treatment outcomes and psychosocial functioning in people with epilepsy. Stepped care is a promising approach to accommodate personalized psychotherapeutic care in academic and regular outpatient settings. It aims at providing patients with the most adequate treatment duration, number of sessions, and treatment method while systematically monitoring their treatment processes. Read More

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September 2021

Mechanistic insights into genetic susceptibility to prostate cancer.

Cancer Lett 2021 Sep 21. Epub 2021 Sep 21.

Fudan University Shanghai Cancer Center, Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, 200032, China. Electronic address:

Prostate cancer (PCa) is the second most common cancer in men and is a highly heritable disease that affects millions of individuals worldwide. Genome-wide association studies have to date discovered nearly 270 genetic loci harboring hundreds of single nucleotide polymorphisms (SNPs) that are associated with PCa susceptibility. In contrast, the functional characterization of the mechanisms underlying PCa risk association is still growing. Read More

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September 2021

Molecular Characterization and Antigenic analysis of reassortant H9N2 subtype avian influenza viruses in Eastern China in 2016.

Virus Res 2021 Sep 21:198577. Epub 2021 Sep 21.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, and National Clinical Research Center for Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China. Electronic address:

H9N2 avian influenza viruses (AIVs) can cause respiratory symptoms and decrease the egg production. Additionally, H9N2 AIVs can provide internal genes for reassortment with other subtypes. During the monitoring of live poultry markets in 2016, a total of 32 (32/179, 17. Read More

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September 2021

Cyclodextrins-modified metallic nanoparticles for effective cancer therapy.

J Control Release 2021 Sep 21. Epub 2021 Sep 21.

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai, India. Electronic address:

Cancer, a disease of unknown origin is the second most common reason of death worldwide after heart attacks and therefore is a major threat to human beings. Currently, chemotherapy is the only approach for delivering anti-cancer drugs but shows severe systemic toxicities such as alopecia, loss of appetite, anemia, gastric irritation, neurotoxicity and nephrotoxicity. Additionally, chemotherapeutics fails to achieve the expected therapeutic outcome due to their limited solubility, in-vivo instability and lack of targeting efficiency. Read More

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September 2021

Nephrotoxicity induced by cisplatin is primarily due to the activation of the 5-hydroxytryptamine degradation system in proximal renal tubules.

Chem Biol Interact 2021 Sep 21:109662. Epub 2021 Sep 21.

Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:

As a widely used anticancer drug in the clinic, cisplatin has obvious side effects, especially nephrotoxicity. Previous studies have suggested that the accumulation of intracellular reactive oxygen species (ROS) is a hallmark of cisplatin-induced acute kidney injury. This study aimed to investigate the relationship between ROS accumulation induced by cisplatin and 5-HT degradation. Read More

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September 2021

The unexplored role of sedentary time and physical activity in glucose and lipid metabolism related placental mRNAs in obese pregnant women: The DALI Lifestyle Randomized Controlled Trial.

BJOG 2021 Sep 24. Epub 2021 Sep 24.

Institute of Human Movement Science, Sport and Health, University of Graz, Austria.

Objectives: To explore i) the association of sedentary time (ST) and physical activity (PA) during pregnancy with placental expression of genes related to glucose and lipid metabolism in obese pregnant women; ii) maternal metabolic factors mediating changes in these placental transcripts; and iii) cord blood markers related to these mRNAs mediating neonatal adiposity.

Study Design: Multicentre-randomized controlled trial.

Setting: Hospitals; 9-European countries. Read More

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September 2021

What contributes to good outcomes? The perspective of young people on short-term psychoanalytic psychotherapy for depressed adolescents.

PLoS One 2021 24;16(9):e0257334. Epub 2021 Sep 24.

Research Department of Clinical, Educational and Health Psychology, University College London, London [UCL], United Kingdom.

Depression is the fourth leading cause of adolescent illness and disability worldwide. A growing evidence base demonstrates that Short Term Psychoanalytic Psychotherapy [STPP] is an efficacious treatment for moderate to severe adolescent depression. However, with research in its infancy, key factors contributing to efficacy are unknown. Read More

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September 2021

Intolerance of uncertainty and decisions about delayed, probabilistic rewards: A replication and extension of Luhmann, C. C., Ishida, K., & Hajcak, G. (2011).

PLoS One 2021 24;16(9):e0256210. Epub 2021 Sep 24.

Universidad de Granada, Granada, Spain.

Intolerance of Uncertainty (IU) is thought to lead to maladaptive behaviours and dysfunctional decision making, both in the clinical and healthy population. The seminal study reported by Luhmann and collaborators in 2011 [1] showed that IU was negatively associated with choosing a delayed, but more probable and valuable, reward over choosing an immediate, but less probable and valuable, reward. These findings have been widely disseminated across the field of personality and individual differences because of their relevance for the understanding of the role of IU in the development and maintenance of anxiety-related disorders. Read More

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September 2021

Impact of Clinical Sepsis Phenotypes on Mortality and Fluid Status in Critically Ill Patients.

Shock 2021 Sep 23. Epub 2021 Sep 23.

UF Health Jacksonville, 655 W. 8 St., C-89, Jacksonville, FL 32209, United States of America.

Background: Sepsis is associated with high rates of in-hospital mortality, despite being the focus of medical research and public health initiatives for several years. The primary objective of this study was to determine the influence of septic phenotypes on rates of in-hospital mortality throughout ICU admission.

Materials And Methods: Retrospective, single center cohort study. Read More

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September 2021

Treatment of tibial plateau fractures involving the posterolateral column using the extended anterolateral approach.

Medicine (Baltimore) 2021 Sep;100(38):e27316

Yangzhou Jiangdu People's Hospital, 9 Dongfanghong Road, Jiangdu District, Yangzhou City, Jiangsu Province, China.

Abstract: To summarize the surgical technique and clinical effects of the extended anterolateral approach for the treatment of Schatzker type II and Schatzker type V/VI involving the posterolateral column tibial plateau.From January 2015 through December 2018, 28 patients with tibial plateau fractures involving the posterolateral column were included in the study. Among them, 16 patients were Schatzker type II treated using an extended anterolateral approach with lateral tibial locking compression plate fixation. Read More

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September 2021

Predictive value of the monocyte-to-lymphocyte ratio in the diagnosis of prostate cancer.

Medicine (Baltimore) 2021 Sep;100(38):e27244

Department of Urology, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, PR China.

Abstract: It has been reported that inflammation and immune system are related to prostate cancer. The neutrophil-to-lymphocyte ratio (NLR), as well as the platelet-to-lymphocyte ratio (PLR), have already been proposed as new indices to help diagnose prostate cancer (PCa). However, the monocyte-to-lymphocyte ratio (MLR) with regard to PCa has rarely been mentioned. Read More

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September 2021

Increased PYCR1 mRNA predicts poor prognosis in kidney adenocarcinoma: A study based on TCGA database.

Medicine (Baltimore) 2021 Sep;100(38):e27145

Department of Anatomy, Histology and Embryology, Jinzhou Medical University, Jinzhou, China.

Abstract: The pyrroline-5-carboxylate reductase 1 (PYCR1) plays important roles in cancers, but its contribution to adenocarcinoma of the kidney (AK) and the potential mechanism remain to be clarified. In this study, we aimed to demonstrate the relationship between PYCR1 mRNA and AK based on The Cancer Genome Atlas database.PYCR1 mRNA in AK and normal tissues was compared using Wilcoxon rank sum test. Read More

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September 2021

Effect of Digital Care Platforms on Quality of Care for Oncological Patients and Barriers and Facilitators for Their Implementation: Systematic Review.

J Med Internet Res 2021 Sep 24;23(9):e28869. Epub 2021 Sep 24.

Department of IQ Healthcare, Radboud University Medical Center, Nijmegen, Netherlands.

Background: Oncological health care services are challenged by the increasing number of cancer survivors, long-term follow-up care, and fragmentation of care. Digital care platforms are potential tools to deliver affordable, patient-centered oncological care. Previous reviews evaluated only one feature of a digital care platform or did not evaluate the effect on enhancement of information, self-efficacy, continuity of care, or patient- and health care provider-reported experiences. Read More

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September 2021

Combined Angio-CT Systems: A Roadmap Tool for Precision Therapy in Interventional Oncology.

Radiol Imaging Cancer 2021 Sep;3(5):e210039

From the Departments of Interventional Radiology (R.T., E.Y.L., Y.M.L., S.Y., R.A., R.A.S., S.G., B.C.O.), Anesthesiology (J.R.R.), and Imaging Physics (A.K.J.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030; Siemens Healthineers, USA (G.C.); and Department of Radiology, Nara Medical University, Nara, Japan (R.T., H.N., T.T., K.K.).

Combined angiography-CT (angio-CT) systems, which combine traditional angiographic imaging with cross-sectional imaging, are a valuable tool for interventional radiology. Although cone-beam CT (CBCT) technology from flat-panel angiography systems has been established as an adjunct cross-sectional imaging tool during interventional procedures, the intrinsic advantages of angio-CT systems concerning superior soft-tissue imaging and contrast resolution, along with operational ease, have sparked renewed interest in their use in interventional oncology procedures. Owing to increases in affordability and usability due to an improved workflow, angio-CT systems have become a viable alternative to stand-alone flat-panel angiographic systems equipped with CBCT. Read More

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September 2021

Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice.

Hepatol Commun 2021 Aug 28. Epub 2021 Aug 28.

Systems Toxicology, Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany.

Mouse models are frequently used to study chronic liver diseases (CLDs). To assess their translational relevance, we quantified the similarity of commonly used mouse models to human CLDs based on transcriptome data. Gene-expression data from 372 patients were compared with data from acute and chronic mouse models consisting of 227 mice, and additionally to nine published gene sets of chronic mouse models. Read More

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Role of salt‑inducible kinase 2 in the malignant behavior and glycolysis of colorectal cancer cells.

Mol Med Rep 2021 Nov 24;24(5). Epub 2021 Sep 24.

Department of General Surgery, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570105, P.R. China.

Colorectal cancer (CRC) is the third most common type of cancer worldwide. Currently, surgery, chemotherapy and radiation therapy are the conventional approaches used to treat CRC. However, these therapy strategies cause several side effects. Read More

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November 2021

miR‑383 increases the cisplatin sensitivity of lung adenocarcinoma cells through inhibition of the RBM24‑mediated NF‑κB signaling pathway.

Int J Oncol 2021 Nov 24;59(5). Epub 2021 Sep 24.

Department of Thoracic Surgery, Southwest Hospital, Army Medical University, Chongqing 400038, P.R. China.

The expression of microRNA‑383 (miR‑383) is downregulated in a variety of tumor tissues, and it exhibits antiproliferative activity in non‑small cell lung cancer cells. In the present study, an association between the downregulation of miR‑383 expression and the deletion of chr8p22 in patients with lung adenocarcinoma was identified. The promoting effect of miR‑383 on cisplatin sensitivity was verified both and . Read More

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November 2021

Investigation of Patients With Eye Closure Sensitive Epilepsy With Magnetic Resonance Spectroscopy.

Clin EEG Neurosci 2021 Sep 24:15500594211040953. Epub 2021 Sep 24.

University of Health Sciences, Umraniye Training and Research Hospital, İstanbul, Turkey.

A proportion of patients diagnosed with genetic generalized epilepsy (GGE) experience eye-closure sensitivity (ECS), the underlying pathogenesis of which is unknown. In this study, we compare magnetic resonance spectroscopy (MRS) findings of healthy volunteers with patients diagnosed with GGE, with and without ECS, to detect possible explanatory differences between groups. A total of 33 patients diagnosed with GGE: 17 with ECS and 16 without, and 12 healthy volunteers are included. Read More

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September 2021

Apoptosis and its therapeutic implications in neurodegenerative diseases.

Authors:
Nour S Erekat

Clin Anat 2021 Sep 23. Epub 2021 Sep 23.

Department of Anatomy, Faculty of Medicine, Jordan University of Science and Technology (JUST), Jordan.

Neurodegenerative disorders are characterized by progressive loss of particular populations of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative diseases, including Parkinson disease, Alzheimer disease, Huntington disease, and amyotrophic lateral sclerosis. In this review, we focus on the existing notions relevant to comprehending the apoptotic death process, including the morphological features, mediators and regulators of cellular apoptosis. Read More

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September 2021

Activated N-methyl-D-aspartate receptor ion channels detected in focal epilepsy with [ F]GE-179 positron emission tomography.

Epilepsia 2021 Sep 23. Epub 2021 Sep 23.

Department of Nuclear Medicine and PET Center, Institute of Clinical Medicine, Aarhus University and University Hospital, Aarhus, Denmark.

Objective: Imaging activated glutamate N-methyl-D-aspartate receptor ion channels (NMDAR-ICs) using positron emission tomography (PET) has proved challenging due to low brain uptake, poor affinity and selectivity, and high metabolism and dissociation rates of candidate radioligands. The radioligand [ F]GE-179 is a known use-dependent marker of NMDAR-ICs. We studied whether interictal [ F]GE-179 PET would detect foci of abnormal NMDAR-IC activation in patients with refractory focal epilepsy. Read More

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September 2021

Antimicrobial Protein REG3A and Signaling Networks are Predictive of Stroke Outcomes.

J Neurochem 2021 Sep 24. Epub 2021 Sep 24.

Department of Neurology, University of Kentucky, Lexington, Kentucky, USA.

Regenerating Family Member 3 Alpha (REG3A) is a multifunctional protein with antimicrobial activity, and primarily secreted by the intestine and pancreas. Studies have shown an increased expression of REG3A in systemic inflammatory responses to acute injury and infection, but studies investigating REG3A during the pathogenesis of ischemic stroke are limited. The aims of this study were to examine the associations between arterial expression of REG3A and other arterial inflammatory proteins implicated in stroke pathogenesis, as well as associations between REG3A and markers of poor outcome for ischemic stroke. Read More

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September 2021

Establishment of a Modular Hemodynamic Simulator for Accurate In Vitro Simulation of Physiological and Pathological Pressure Waveforms in Native and Bioartificial Blood Vessels.

Cardiovasc Eng Technol 2021 Sep 23. Epub 2021 Sep 23.

Hannover Medical School, Lower Saxony Centre for Biomedical Engineering, Implant Research and Development (NIFE), Stadtfelddamm 34, 30625, Hannover, Germany.

Purpose: In vitro stimulation of native and bioartificial vessels in perfusable systems simulating natural mechanical environments of the human vasculature represents an emerging approach in cardiovascular research. Promising results have been achieved for applications in both regenerative medicine and etiopathogenetic investigations. However, accurate and reliable simulation of the wide variety of physiological and pathological pressure environments observed in different vessels still remains an unmet challenge. Read More

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September 2021

Immunopathogenesis and proposed clinical score for identifying Kelch-like protein-11 encephalitis.

Brain Commun 2021 26;3(3):fcab185. Epub 2021 Aug 26.

French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, 69677 Bron, France.

In this study, we report the clinical features of Kelch-like protein 11 antibody-associated paraneoplastic neurological syndrome, design and validate a clinical score to facilitate the identification of patients that should be tested for Kelch-like protein 11 antibodies, and examine in detail the nature of the immune response in both the brain and the tumour samples for a better characterization of the immunopathogenesis of this condition. The presence of Kelch-like protein 11 antibodies was retrospectively assessed in patients referred to the French Reference Center for paraneoplastic neurological syndrome and autoimmune encephalitis with (i) antibody-negative paraneoplastic neurological syndrome [limbic encephalitis ( = 105), cerebellar degeneration ( = 33)] and (ii) antibody-positive paraneoplastic neurological syndrome [Ma2-Ab encephalitis ( = 34), antibodies targeting N-methyl-D-aspartate receptor encephalitis with teratoma ( = 49)]. Additionally, since 1 January 2020, patients were prospectively screened for Kelch-like protein 11 antibodies as new usual clinical practice. Read More

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Homozygous missense variants cause a congenital disorder of autophagy with neurodevelopmental impairments of variable clinical severity and disease course.

Brain Commun 2021 3;3(3):fcab183. Epub 2021 Sep 3.

Human Genetics and Genome Research Division, Clinical Genetics Department, National Research Centre, 12311 Cairo, Egypt.

is a member of the human WIPI protein family (seven-bladed b-propeller proteins binding phosphatidylinositols, PROPPINs), which play a pivotal role in autophagy and has been implicated in the pathogenesis of several neurological conditions. The homozygous variant c.745G>A; p. Read More

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September 2021

Identification of a Novel Ferroptosis-Related Gene Prognostic Signature in Bladder Cancer.

Front Oncol 2021 7;11:730716. Epub 2021 Sep 7.

Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: Ferroptosis is a newly found non-apoptotic forms of cell death that plays an important role in tumors. However, the prognostic value of ferroptosis-related genes (FRG) in bladder cancer (BLCA) have not been well examined.

Methods: FRG data and clinical information were collected from The Cancer Genome Atlas (TCGA). Read More

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September 2021

The Significance of MET Expression and Strategies of Targeting MET Treatment in Advanced Gastric Cancer.

Front Oncol 2021 7;11:719217. Epub 2021 Sep 7.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.

Background: Accurate assessment of predictive biomarker expression is critical in patient selection in clinical trials or clinical practice. However, changes in biomarker expression may occur after treatment. The aim of the present study was to evaluate the effects of chemotherapy on MET expression in gastric cancer (GC). Read More

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September 2021

Malignant Tumor Purity Reveals the Driven and Prognostic Role of in Low-Grade Glioma Microenvironment.

Front Oncol 2021 7;11:676124. Epub 2021 Sep 7.

Department of Nursing and Health Management, Shanghai University of Medicine & Health Sciences, Shanghai, China.

The tumor microenvironment (TME) contributes to the initiation and progression of many neoplasms. However, the impact of low-grade glioma (LGG) purity on carcinogenesis remains to be elucidated. We selected 509 LGG patients with available genomic and clinical information from the TCGA database. Read More

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September 2021