6,035 results match your criteria additional optimization


Plate-Assisted Bone Segment Transport Versus Precice Bone Transport Nail.

J Orthop Trauma 2021 Oct;35(Suppl 4):S19-S24

Division of Orthopaedic Surgery, Department of Surgery, Southern Illinois University School of Medicine, Springfield, IL; and.

Summary: Management of segmental long bone defects is a complex and challenging undertaking for orthopaedic surgeons. These defects can be encountered in cases of high-energy trauma, tumor resection, or infection, and they are often associated with significant soft tissue injury. Traditional approaches of bone transport rely on external fixation and principles of distraction osteogenesis. Read More

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October 2021

Current neurologic treatment and emerging therapies in CDKL5 deficiency disorder.

J Neurodev Disord 2021 Sep 16;13(1):40. Epub 2021 Sep 16.

Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, 300 Longwood Avenue, Mailstop 3063, Boston, MA, 02115, USA.

Background: CDKL5 deficiency disorder (CDD) is associated with refractory infantile onset epilepsy, global developmental delay, and variable features that include sleep, behavioral disturbances, and movement disorders. Current treatment is primarily symptom-based and informed by experience in caring for this population.

Methods: We describe medication and non-medication approaches to treatment of epilepsy and additional key neurologic symptoms (sleep disturbances, behavioral issues, movement disorders, and swallowing dysfunction) in a cohort of 177 individuals meeting criteria for CDD, 154 evaluated at 4 CDKL5 Centers of Excellence in the USA and 40 identified through the NIH Natural History Study of Rett and Related Disorders. Read More

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September 2021

Beam orientation optimization for coherent X-ray scattering from distributed deep targets.

Biomed Eng Online 2021 Sep 15;20(1):92. Epub 2021 Sep 15.

Division of Imaging, Diagnostics, and Software Reliability, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.

Background: Amyloid deposits in the temporal and frontal lobes in patients with Alzheimer's disease make them potential targets to aid in early diagnosis. Recently, spectral small-angle X-ray scattering techniques have been proposed for interrogating deep targets such as amyloid plaques.

Results: We describe an optimization approach for the orientation of beams for deep target characterization. Read More

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September 2021

Assessment of the anti-norovirus activity in cell culture using the mouse norovirus: Early mechanistic studies.

Antivir Chem Chemother 2021 Jan-Dec;29:20402066211025175

KU Leuven - Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.

Human norovirus is the main cause of viral gastroenteritis, resulting annually in ∼ 700 million infections and 200,000 deaths, of whom most are children <5 years. Mouse norovirus-infected macrophages are the most widely used system to screen and characterize the antiviral effect of norovirus-targeting small molecules. We have previously established antiviral assays using this system, identified novel inhibitors and performed additional studies in order to have a first insight into their mechanism of action. Read More

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September 2021

Optimal radial basis for density-based atomic representations.

J Chem Phys 2021 Sep;155(10):104106

Laboratory of Computational Science and Modeling, Institute of Materials, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

The input of almost every machine learning algorithm targeting the properties of matter at the atomic scale involves a transformation of the list of Cartesian atomic coordinates into a more symmetric representation. Many of the most popular representations can be seen as an expansion of the symmetrized correlations of the atom density and differ mainly by the choice of basis. Considerable effort has been dedicated to the optimization of the basis set, typically driven by heuristic considerations on the behavior of the regression target. Read More

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September 2021

Optimization and validation of capillary electrophoresis- and gas chromatography-tandem mass spectrometry methods for the analysis of intermediate metabolites in glycolysis and pentose phosphate pathways within biological samples.

J Chromatogr A 2021 Sep 4;1656:462531. Epub 2021 Sep 4.

Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute, Seoul 03759, Republic of Korea; Department of Chenistry and Nano Science, Ewha Womans University, Seoul 03760, Republic of Korea. Electronic address:

Highly selective methods for the analysis of intermediate metabolites involved in glycolysis and phosphate pentose pathways are essential for metabolism and metabolic flux studies. However, the successful separation of phosphorylated compounds is difficult due to their high polarity, as well as their structural isomers. In this study, phosphorylated compounds in spiked serum samples were analyzed using capillary electrophoresis tandem mass spectrometry (CE-MS/MS) and gas chromatography (GC)-MS/MS. Read More

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September 2021

Optimization of a liquid chromatography-ion mobility-high resolution mass spectrometry platform for untargeted lipidomics and application to HepaRG cell extracts.

Talanta 2021 Dec 17;235:122808. Epub 2021 Aug 17.

University of Antwerp, Toxicological Centre, Universiteitsplein 1, 2610, Antwerp, Belgium. Electronic address:

Analytical methods to evaluate the lipidome of biological samples need to provide high data quality to ensure comprehensive profiling and reliable structural elucidation. In this perspective, liquid chromatography-high resolution mass spectrometry (LC-HRMS) is the state-of-the-art technique for lipidomic analysis of biological samples. There are thousands of lipids in most biological samples, and therefore separation methods before introduction to the mass spectrometer is key for relative quantitation and identification. Read More

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December 2021

High-resolution computational modelling of the current flow in the outer ear during transcutaneous auricular Vagus Nerve Stimulation (taVNS).

Brain Stimul 2021 Sep 10. Epub 2021 Sep 10.

Department of Biomedical Engineering, The City College of New York, New York, NY, USA. Electronic address:

Background: Transcutaneous auricular Vagus Nerve Stimulation (taVNS) applies low-intensity electrical current to the ear with the intention of activating the auricular branch of the Vagus nerve. The sensitivity and selectivity of stimulation applied to the ear depends on current flow pattern produced by a given electrode montage (size and placement).

Objective: We compare different electrodes designs for taVNS considering both the predicted peak electric fields (sensitivity) and their spatial distribution (selectivity). Read More

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September 2021

Efficacy and safety of acupuncture in the treatment of postherpetic neuralgia: A protocol for systematic review and network meta-analysis.

Medicine (Baltimore) 2021 Sep;100(36):e27088

Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China.

Background: It is simple, convenient, inexpensive, proven, extensive, and safe for acupuncture in the treatment of postherpetic neuralgia (PHN). However, there are no comparisons between various acupuncture therapies that can directly and effectively provide specific guidance to clinicians. The development of a guideline for the optimization of acupuncture for PHN is of great importance for the development of clinical acupuncture. Read More

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September 2021

Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies.

Crit Care Explor 2021 Sep 7;3(9):e0511. Epub 2021 Sep 7.

Department of Surgery and Emory Critical Care Center, Emory University, Atlanta, GA.

Patients with infection can develop sepsis, and their mortality can be high. An important aspect in the treatment of sepsis is adequate management of the infection.

Data Sources: Using a modified Delphi approach, the Surviving Sepsis Campaign research committee recently published a series of 26 priorities for sepsis and septic shock. Read More

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September 2021

An estimation of the effects of social distancing measures on transit vehicle capacity and operations.

Transp Res Interdiscip Perspect 2021 Jun 29;10:100398. Epub 2021 May 29.

The University Transportation Research Center, The City College of New York, 160 Convent Avenue, New York, NY 10031, USA.

The COVID-19 pandemic has a direct impact on public transport operations. In this paper, impacts on transit operations of the physical distancing measures deployed to slow the spread of the virus are analyzed and recommendations are provided. At first, two social distancing optimization solutions are provided in order to keep riders at a safe distance. Read More

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Primary care heart failure service identifies a missed cohort of heart failure patients with reduced ejection fraction.

Eur Heart J 2021 Sep 11. Epub 2021 Sep 11.

Cardiology Department, Institute of Cardiovascular Sciences, University of Manchester, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK.

Aims: We explored whether a missed cohort of patients in the community with heart failure (HF) and left ventricular systolic dysfunction (LVSD) could be identified and receive treatment optimization through a primary care heart failure (PCHF) service.

Methods And Results: PCHF is a partnership between Inspira Health, National Health Service Cardiologists and Medtronic. The PCHF service uses retrospective clinical audit to identify patients requiring a prospective face-to-face consultation with a consultant cardiologist for clinical review of their HF management within primary care. Read More

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September 2021

Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase.

Bioorg Med Chem 2021 Aug 4;46:116347. Epub 2021 Aug 4.

Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, United States. Electronic address:

Human platelet 12-(S)-Lipoxygenase (12-LOX) is a fatty acid metabolizing oxygenase that plays an important role in platelet activation and cardiometabolic disease. ML355 is a specific 12-LOX inhibitor that has been shown to decrease thrombosis without prolonging hemostasis and protect human pancreatic islets from inflammatory injury. It has an amenable drug-like scaffold with nM potency and encouraging ADME and PK profiles, but its binding mode to the active site of 12-LOX remains unclear. Read More

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Linkage of Emergency Medical Services and Hospital Data: A Necessary Precursor to Improve Understanding of Outcomes of Prehospital Care.

Prehosp Emerg Care 2021 Sep 10:1-13. Epub 2021 Sep 10.

Alberta Health Services, Emergency Medical Services, Emergency, Critical Care, Alberta, Canada.

Objective: Linking emergency medical services (EMS) data to hospital outcomes is important for quality assurance and research initiatives. However, non-linkage due to missing or incomplete patient information may increase the risk of bias and distort findings. The purpose of this study was to explore if an optimization strategy, in addition to an existing linkage process, improved the linkage rate and reduced selection and information bias. Read More

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September 2021

Reshaping cortical connectivity in traumatic spinal cord injury: a novel effect of hyperbaric oxygen therapy.

Spinal Cord Ser Cases 2021 Sep 9;7(1):80. Epub 2021 Sep 9.

Dipartimento di Scienze Mediche e Sanita' Pubblica, University of Cagliari, Cagliari, Italy.

Introduction: Spinal cord injuries (SCIs) represent a severe neuro-traumatic occurrence and an excruciating social burden. Though the hyperbaric oxygen (HBO2) has been credited as a first line therapeutic resource for SCIs, its mechanism of action in the spine is only partially known, while the impingement upon other areas of the nervous system deserves additional investigation. In this study we deem to describe a novel effect of HBO2 in a subject affected by SCI who, along with the clinical improvement, showed a reshaped connectivity in cortical sensory-motor areas. Read More

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September 2021

Extracellular Matrix Optimization for Enhanced Physiological Relevance in Hepatic Tissue-Chips.

Polymers (Basel) 2021 Sep 6;13(17). Epub 2021 Sep 6.

Department of Mechatronics Engineering, Jeju National University, Jeju-si 63243, Korea.

The cellular microenvironment is influenced explicitly by the extracellular matrix (ECM), the main tissue support biomaterial, as a decisive factor for tissue growth patterns. The recent emergence of hepatic microphysiological systems (MPS) provide the basic physiological emulation of the human liver for drug screening. However, engineering microfluidic devices with standardized surface coatings of ECM may improve MPS-based organ-specific emulation for improved drug screening. Read More

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September 2021

Development of Highly Crystalline Polylactic Acid with β-Crystalline Phase from the Induced Alignment of Electrospun Fibers.

Polymers (Basel) 2021 Aug 25;13(17). Epub 2021 Aug 25.

Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain.

Polylactic acid (PLA) is one of the known synthetic polymers with potential piezoelectric activity but this property is directly related to both the crystalline structure and crystalline degree. Depending on the process conditions, PLA can crystallize in three different forms: α-, β-, and γ- form, with β-crystalline phase being the piezoelectric one. To obtain this crystalline structure, transformation of α to β is required. Read More

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Dissemination and Implementation Science in Cardiothoracic Surgery: A Review and Case Study.

Ann Thorac Surg 2021 Sep 6. Epub 2021 Sep 6.

Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO. Electronic address:

Dissemination and implementation (D&I) science is the practice of taking evidence-based interventions (EBI) and sustainably incorporating them in routine clinical practice. As a relatively young field, D&I techniques are underutilized in cardiothoracic surgery. This review offers an overview of D&I science from the context of the cardiothoracic surgeon. Read More

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September 2021

Facial Anatomical Landmark Detection using Regularized Transfer Learning with Application to Fetal Alcohol Syndrome Recognition.

IEEE J Biomed Health Inform 2021 Sep 8;PP. Epub 2021 Sep 8.

Fetal alcohol syndrome (FAS) caused by prenatal alcohol exposure can result in a series of cranio-facial anomalies, and behavioral and neurocognitive problems. Current diagnosis of FAS is typically done by identifying a set of facial characteristics, which are often obtained by manual examination. Anatomical landmark detection, which provides rich geometric information, is important to detect the presence of FAS associated facial anomalies. Read More

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September 2021

G Protein-Coupled Receptor-Ligand Dissociation Rates and Mechanisms from τRAMD Simulations.

J Chem Theory Comput 2021 Sep 8. Epub 2021 Sep 8.

Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, Schloss-Wolfsbrunnenweg 35, 69118 Heidelberg, Germany.

There is a growing appreciation of the importance of drug-target binding kinetics for lead optimization. For G protein-coupled receptors (GPCRs), which mediate signaling over a wide range of time scales, the drug dissociation rate is often a better predictor of efficacy than binding affinity, although it is more challenging to compute. Here, we assess the ability of the τ-Random Acceleration Molecular Dynamics (τRAMD) approach to reproduce relative residence times and reveal dissociation mechanisms and the effects of allosteric modulation for two important membrane-embedded drug targets: the β2-adrenergic receptor and the muscarinic acetylcholine receptor M2. Read More

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September 2021

An interaction regression model for crop yield prediction.

Sci Rep 2021 Sep 7;11(1):17754. Epub 2021 Sep 7.

Department of Agronomy, Iowa State University, Ames, IA, 50011, USA.

Crop yield prediction is crucial for global food security yet notoriously challenging due to multitudinous factors that jointly determine the yield, including genotype, environment, management, and their complex interactions. Integrating the power of optimization, machine learning, and agronomic insight, we present a new predictive model (referred to as the interaction regression model) for crop yield prediction, which has three salient properties. First, it achieved a relative root mean square error of 8% or less in three Midwest states (Illinois, Indiana, and Iowa) in the US for both corn and soybean yield prediction, outperforming state-of-the-art machine learning algorithms. Read More

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September 2021

Complete genome sequences of the antibiotic sulfamethoxazole-mineralizing bacteria Paenarthrobacter sp. P27 and Norcardiodes sp. N27.

Environ Res 2021 Sep 4:112013. Epub 2021 Sep 4.

State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin, 150090, China; Shenzhen Key Laboratory of Organic Pollution Prevention and Control, School of Civil & Environmental Engineering, Harbin Institute of Technology, Shenzhen, Shenzhen, 518055, China; Key Laboratory of Environmental Biotechnology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.

Sulfonamide antibiotics (SAs) have been produced and consumed on a large scale over the last few decades. SAs are a typical class of refractory contaminants that are omnipresent in various environments. Although several [phenyl]-SA-degrading bacteria and their corresponding genomes have been documented, limited genetic information is available for the degraders of heterocyclic products (e. Read More

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September 2021

Bioprospecting thermotolerant yeasts from distillery effluent and molasses for high-temperature ethanol production.

J Appl Microbiol 2021 Sep 6. Epub 2021 Sep 6.

Biodiversity and Palaeobiology Group, National Fungal Culture Collection of India (NFCCI), MACS-Agharkar Research Institute, Pune, India.

Aims: Isolation, characterization and assessment of inhibitor tolerance of thermotolerant yeasts associated with distillery effluent and molasses, and their use in high-temperature ethanol production from alkali-treated rice straw.

Methods And Results: A total of 92 thermotolerant yeasts were isolated from seven different distillery effluent and molasses samples. Based on MSP-PCR, 34 yeasts were selected and identified by sequencing the D1/D2 domain of LSU rDNA. Read More

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September 2021

[The day hospitals as preventive hospitalization of patients of able-bodied age].

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2021 Jul;29(4):957-962

The Federal State Budget Scientific Institution "The N. A. Semashko National Research Institute of Public Health" of the Minobrnauka of Russia, 105064, Moscow, Russia.

In accordance with the Russian Federal Law No. 350 of January 2019 the retirement age for Russians is increased for men from 60 up to 65 years, for women from 55 up to 60 years that requires implementation of organizational technologies of health-preserving, promotion of life and labor potential of population of late able-bodied age. In this regard, the role of day hospitals (DH) functioning directed at maximal possible prolongation of autonomous life and working capacity of elderly population increases. Read More

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Motor planning under uncertainty.

Elife 2021 09 6;10. Epub 2021 Sep 6.

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, United States.

Actions often require the selection of a specific goal amongst a range of possibilities, like when a softball player must precisely position her glove to field a fast-approaching ground ball. Previous studies have suggested that during goal uncertainty the brain prepares for all potential goals in parallel and averages the corresponding motor plans to command an intermediate movement that is progressively refined as additional information becomes available. Although intermediate movements are widely observed, they could instead reflect a neural decision about the single best action choice given the uncertainty present. Read More

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September 2021

Versatile Locomotion Planning and Control for Humanoid Robots.

Front Robot AI 2021 13;8:712239. Epub 2021 Aug 13.

Human Centered Robotics Lab, Department of Aerospace Engineering and Engineering Mechanics, The University of Texas at Austin, Austin, TX, United States.

We propose a locomotion framework for bipedal robots consisting of a new motion planning method, dubbed trajectory optimization for walking robots plus (TOWR+), and a new whole-body control method, dubbed implicit hierarchical whole-body controller (IHWBC). For versatility, we consider the use of a composite rigid body (CRB) model to optimize the robot's walking behavior. The proposed CRB model considers the floating base dynamics while accounting for the effects of the heavy distal mass of humanoids using a pre-trained centroidal inertia network. Read More

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From outbreak of COVID-19 to launching of vaccination drive: invigorating single-use plastics, mitigation strategies, and way forward.

Environ Sci Pollut Res Int 2021 Sep 3. Epub 2021 Sep 3.

Department of Materials Science and Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India.

The unforeseen outbreak of the COVID-19 epidemic has significantly stipulated the use of plastics to minimize the exposure and spread of the novel coronavirus. With the onset of the vaccination drive, the issue draws even more attention due to additional demand for vaccine packaging, transport, disposable syringes, and other allied devices scaling up to many million tonnes of plastic. Plastic materials in personal protective equipment (PPE), disposable pharmaceutical devices, and packaging for e-commerce facilities are perceived to be a lifesaver for the frontline healthcare personnel and the general public amidst recurring waves of the pandemic. Read More

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September 2021

Transmission Kikuchi diffraction: The impact of the signal-to-noise ratio.

Ultramicroscopy 2021 Aug 14;230:113372. Epub 2021 Aug 14.

Academic Centre for Materials and Nanotechnology, AGH University of Science and Technology, al. A. Mickiewicza 30, 30-059 Krakow, Poland. Electronic address:

Signal optimization for transmission Kikuchi diffraction (TKD) measurements in the scanning electron microscope is investigated by a comparison of different sample holder designs. An optimized design is presented, which uses a metal shield to efficiently trap the electron beam after transmission through the sample. For comparison, a second holder configuration allows a significant number of the transmitted electrons to scatter back from the surface of the sample holder onto the diffraction camera screen. Read More

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Fault Estimation and Control for Unknown Discrete-Time Systems Based on Data-Driven Parameterization Approach.

IEEE Trans Cybern 2021 Sep 3;PP. Epub 2021 Sep 3.

This study investigates the problem of fault estimation and control for unknown discrete-time systems. Such a problem was first formulated as an multiobjective optimization problem. Then, a data-driven parameterization controller design method was proposed to optimize both fault estimation and robust control performances. Read More

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September 2021

GeodesicEmbedding (GE): A High-Dimensional Embedding Approach for Fast Geodesic Distance QUERIES.

IEEE Trans Vis Comput Graph 2021 Sep 3;PP. Epub 2021 Sep 3.

In this paper, we develop a novel method for fast geodesic distance queries. The key idea is to embed the mesh into a high-dimensional space, such that the Euclidean distance in the high-dimensional space can induce the geodesic distance in the original manifold surface. However, directly solving the high-dimensional embedding problem is not feasible due to the large number of variables and the fact that the embedding problem is highly nonlinear. Read More

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September 2021