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Reduced-dose intravenous thrombolysis for acute intermediate high-risk pulmonary embolism: Rationale and design of the PEITHO-3 trial.

Thromb Haemost 2021 Sep 24. Epub 2021 Sep 24.

Hopital Europeen Georges Pompidou, Paris, France.

Intermediate high-risk pulmonary embolism (PE) is characterised by right ventricular (RV) dysfunction and elevated circulating cardiac troponin levels despite apparent haemodynamic stability at presentation. In these patients, full-dose systemic thrombolysis reduced the risk of haemodynamic decompensation or death but increased the risk of life-threatening bleeding. Reduced-dose thrombolysis may be capable of improving safety while maintaining reperfusion efficacy. Read More

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September 2021

Adaptation of stochastic microdosimetric kinetic model to hypoxia for hypo-fractionated multi-ion therapy treatment planning.

Phys Med Biol 2021 Sep 24. Epub 2021 Sep 24.

QST hospital, National Institutes for Quantum and Radiological Science and Technology, Chiba, Chiba, JAPAN.

For hypo-fractionated multi-ion therapy (HFMIT), the stochastic microdosimetric kinetic (SMK) model had been developed to estimate the biological effectiveness of radiation beams with wide linear energy transfer (LET) and dose ranges. The HFMIT will be applied to radioresistant tumors with oxygen-deficient regions. The response of cells to radiation is strongly dependent on the oxygen condition in addition to radiation type, LET and absorbed dose. Read More

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September 2021

Molecular characteristics of biochar-derived organic matter sub-fractions extracted by ultrasonication.

Sci Total Environ 2021 Sep 9;806(Pt 1):150190. Epub 2021 Sep 9.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:

Biochar-derived organic matter is key to carbon dynamics and pollutant transport in soils remediated by biochar. A limited understanding of the molecular composition of biochar-derived organic matter limits the ability to accurately predict the chemical cycle within soil and how biochar-derived organic matter will interact with contaminants. To describe the relatively comprehensive structure information of soybean straw biochar-extractable organic matter (BEOM) at the molecular level, we used solvents of different polarities, namely, petroleum ether (PE), carbon disulfide (CS), methanol (CHOH) and acetone (CHCOCH), to extract organic samples from soybean straw biochar and used Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) for analysis. Read More

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September 2021

Physicochemical and biological evaluation of a triazine-methacrylate monomer into a dental resin.

J Dent 2021 Sep 21:103818. Epub 2021 Sep 21.

Department of Dental Materials, School of Dentistry, Federal University of Rio Grande do Sul. Ramiro Barcelos Street, 2492, Rio Branco, 90035-003, Porto Alegre, RS, Brazil. Electronic address:

Objectives: This study aimed to (1) formulate blend resins with 2.5 or 5 wt.% of the methacrylate monomer 1,3,5-triacryloylhexahydro-1,3,5-triazine (TAT), and (2) to evaluate the blend resins regarding the physicochemical and biological properties. Read More

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September 2021

MK212, a 5-hydroxytryptamine 2C receptor agonist, reverses prepulse inhibition deficits in the medial prefrontal cortex and ventral hippocampus.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Sep 21:110441. Epub 2021 Sep 21.

Key Laboratory of Cognition and Personality (Southwest University), Ministry of Education, Chongqing, China; Faculty of Psychology, Southwest University, Chongqing, China. Electronic address:

Prepulse inhibition (PPI) is disrupted in many neuropsychiatric diseases. Molecules such as 5-HT receptor agonists alleviate PPI deficits in rodents; however, the precise mechanisms and critical regions of the brain responsible for the reversal effect of these agonists remain inconclusive. The present study aimed to investigate the areas of the brain critical for the reversal effect of 5-HT receptor agonists on PPI deficits in mice. Read More

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September 2021

Current update on psyllium and alginate incorporate for interpenetrating polymer network (IPN) and their biomedical applications.

Int J Biol Macromol 2021 Sep 21. Epub 2021 Sep 21.

School of Pharmacy, Suresh GyanVihar University, Jagatpura 302017, Mahal Road, Jaipur, India; Department of Pharmacology, Saveetha Dental College, Saveetha University, Chennai, India. Electronic address:

Natural polysaccharides and their designed structures are extremely valuable due to their intrinsic pharmacological properties and are also used as pharmaceutical aids. These naturally occurring polysaccharides (e.g. Read More

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September 2021

Healthy People 2030 Leading Health Indicators and Overall Health and Well-being Measures: Opportunities to Assess and Improve the Health and Well-being of the Nation.

J Public Health Manag Pract 2021 Nov-Dec 01;27(Suppl 6):S235-S241

Office of Disease Prevention and Health Promotion, Office of the Assistant Secretary for Health, Office of the Secretary, US Department of Health and Human Services, Washington, District of Columbia (Ms Ochiai, Ms Kigenyi, and Ms Blakey); Secretary's Advisory Committee on National Health Promotion and Disease Prevention Objectives for 2030 (former) (Dr Sondik, Dr Pronk, and Dr Kleinman); NORC at the University of Chicago, Bethesda, Maryland (Ms Fromknecht and Ms Heffernan); and Health ConTexts, LLC, Silver Spring, Maryland (Ms Brewer).

Context: Released by the US Department of Health and Human Services (HHS) every decade since 1980, Healthy People identifies science-based objectives with targets to monitor progress and motivate and focus action. Healthy People 2030 is the current iteration of the Healthy People initiative.

Program: Healthy People 2030 includes 3 sets of measures-Healthy People 2030 objectives, Leading Health Indicators (LHIs), and Overall Health and Well-being Measures (OHMs). Read More

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September 2021

Selective Single-Cell Sorting Using a Multisectorial Electroactive Nanowell Platform.

ACS Nano 2021 Sep 24. Epub 2021 Sep 24.

Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada.

Current approaches in targeted patient treatments often require the rapid isolation of specific rare target cells. Stream-based dielectrophoresis (DEP) based cell sorters have the limitation that the maximum number of sortable cell types is equivalent to the number of output channels, which makes upscaling to a higher number of different cell types technically challenging. Here, we present a microfluidic platform for selective single-cell sorting that bypasses this limitation. Read More

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September 2021

The effect of creatine ingestion on urinary creatinine concentration - does supplementation mask a heavy dilution?

Drug Test Anal 2021 Sep 24. Epub 2021 Sep 24.

Forensic Toxicological Centre Munich GmbH, Munich, Germany.

A high volume of fluid can strongly reduce a drug's concentration in urine. Therefore, to detect diluted samples the concentration of creatinine in urine is determined during testing drugs of abuse. If the concentration is below 20 mg creatinine/dL urine, the urine sample is usually rejected for drug testing. Read More

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September 2021

A Phase 1b Trial of Prexasertib in Combination with Standard-of-Care Agents in Advanced or Metastatic Cancer.

Target Oncol 2021 Sep 24. Epub 2021 Sep 24.

Sarah Cannon Research Institute, Nashville, TN, USA.

Background: The checkpoint kinase 1 (CHK1) inhibitor prexasertib exhibited modest monotherapy antitumor activity in prior trials, suggesting that combination with chemotherapy or other targeted agents may be needed to maximize efficacy.

Objectives: The aim of this study was to determine the recommended phase II dose and schedule of prexasertib in combination with either cisplatin, cetuximab, pemetrexed, or 5-fluorouracil in patients with advanced and/or metastatic cancer, and to summarize preliminary antitumor activity of these combinations.

Patients And Methods: This phase Ib, nonrandomized, open-label study comprised dose-escalation phase(s) with multiple sub-arms evaluating different prexasertib-drug combinations: Part A, prexasertib + cisplatin (n = 63); Part B, prexasertib + cetuximab (n = 41); Part C, prexasertib + pemetrexed (n = 3); Part D, prexasertib + 5-fluorouracil (n =8). Read More

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September 2021

Variability in Contraceptive Clinical Trial Design and the Challenges in Making Comparisons Across Trials.

Adv Ther 2021 Sep 23. Epub 2021 Sep 23.

Evofem Biosciences, Inc., 12400 High Bluff Drive, Suite 600, San Diego, CA, 92130, USA.

Clinical trials of contraceptives have often differed in their study designs, making cross-trial comparisons difficult. This brief report outlines some of the technical design features that can vary from trial to trial. For example, the overall number of menstrual cycles in a study has substantial impact on the final efficacy determination; however, the rules related to qualifying cycles can differ based on the length of the study and the statistical analysis plan. Read More

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September 2021

Efficacy and safety of traditional Chinese medicine injections in the treatment of chronic obstructive pulmonary disease: A protocol for systematic review and network meta-analysis.

Medicine (Baltimore) 2021 Sep;100(38):e27324

Chongqing Three Gorges Medical College, Chongqing, China.

Background: Chronic obstructive pulmonary disease (COPD) is a widespread, heterogeneous disease characterized by chronic inflammation of the airway and the gradual blockage of air flow due to bronchial obstruction. At present, a large number of traditional Chinese medicine injections (TCMIs) has been applied in the clinical treatment of COPD. However, there is insufficient evidence of evidence-based medicine of the interaction between them. Read More

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September 2021

Radical Form of PbI: A New Defect Passivator for Efficient Perovskite Solar Cells.

ACS Appl Mater Interfaces 2021 Sep 24. Epub 2021 Sep 24.

School of Physics and Electronic Science, Ministry of Education Nanophotonics & Advanced Instrument Engineering Research Center, East China Normal University, Shanghai 200062, China.

PbI is a commonly used passivator for defect passivation in perovskite solar cells (PSCs). However, the poor conductivity nature of PbI may limit the further improvement of device performance. Here, we report a radical form of PbI with high conductivity to passivate defects for efficient PSCs through a combination of ,,','-tetramethylbenzidine (TMB). Read More

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September 2021

The Place and Prognostic Value of TERT Promoter Mutation in Molecular Classification in Grade II-III Glial Tumors and Primary Glioblastomas.

Turk Patoloji Derg 2021 Sep 24. Epub 2021 Sep 24.

Department of Pathology, University of Health Sciences Gaziosmanpasa Research and Training Hospital, ISTANBUL, TURKEY.

Objective: Diffuse gliomas, the most common primary malignant brain tumors, have been classified by the World Health Organization as class II-IV gliomas. After 2016, two mutations in the promoter region of the telomerase reverse transcriptase (TERT) gene were identified in addition to the IDH, 1p / 19q, and ATRX status.

Material And Method: We identified 84 patients with grade II-IV glioma with IDH, ATRX, 1p / 19q and TERT status. Read More

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September 2021

Outstanding Questions on the Beneficial Role of Silicon in Crop Plants.

Plant Cell Physiol 2021 Sep 24. Epub 2021 Sep 24.

National Agri-Food Biotechnology Institute (NABI), Mohali, 140308India.

Silicon (Si) is widely accepted as a beneficial element for plants. Despite the substantial progress made in understanding Si transport mechanisms and modes of action in plants, several questions remain unanswered. In this review, we discuss such outstanding questions and issues commonly encountered by biologists studying the role of Si in plants in relation to Si bioavailability. Read More

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September 2021

Decrease in new diagnosis of HIV/AIDS in the two years period 2019-2020: impact of COVID-19 pandemic.

J Public Health Res 2021 Sep 24. Epub 2021 Sep 24.

Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili General Hospital, Brescia.

The emergence SARS-CoV-2 in late 2019 and early 2020 has caused a pandemic of unprecedented proportions. Management of COVID-19 became emergent public health priorities, and the impact on other public health initiatives, such as expanded HIV screening and linkage to care, remain largely unknown. In this Single-Center retrospective observational study, we describe the characteristics and circumstance of the new HIV cases during 2020 compared to 2019. Read More

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September 2021

Preferences and Experiences Regarding the Use of the Self-Sampling Device in hrHPV Screening for Cervical Cancer.

Patient 2021 Sep 24. Epub 2021 Sep 24.

Department of Epidemiology, University of Groningen, University Medical Centre Groningen, Huispostcode FA40, PO BOX 30 001, 9700 RB, Groningen, The Netherlands.

Background: To improve participation in the Dutch cervical cancer screening, a self-sampling device (SSD) was introduced in 2017 into the Dutch population-based screening programme (PBS) for the early detection of cervical cancer. The aim of this study was to gather potential preferences and experiences that might influence a woman's decision to use the SSD in the Dutch PBS.

Methods: A scoping review was performed in the PubMed database. Read More

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September 2021

Eosinophils and T cell surface molecule transcript levels in the blood differentiate eosinophilic esophagitis (EoE) from GERD.

Int J Basic Clin Immunol 2021 ;4(1-2):1-8

John W. Deming Department of Medicine, Pulmonary Diseases, Tulane Eosinophilic Disorder Center, Tulane University School of Medicine, New Orleans, LA 70112, USA.

We recently rereported that blood mRNA levels of T cells and IgE receptors are the novel non-invasive biomarkers for eosinophilic esophagitis (EoE) with the aim to establish the panel of T cells and IgE receptor as the novel non-invasive biomarkers for EoE. In addition to earlier proposed cell surface molecules, we now added T cell receptor CXCR6 and eosinophils expressed cell surface molecules CD101 and CD274 mRNA levels. The mRNA levels of eosinophils cell surface molecule CD101 and CD274 and T cell receptor CXCR6, Vβ11, CD1d and chemokine CXCL16 levels were examined using the blood of normal, EoE and GERD patients. Read More

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January 2021

Increased Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B in Patients With Kidney Allograft Antibody-mediated Rejection.

Transplant Direct 2021 Oct 20;7(10):e768. Epub 2021 Sep 20.

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Antibody-mediated rejection (AMR) causes more than 50% of late kidney graft losses. In addition to anti-human leukocyte antigen (HLA) donor-specific antibodies, antibodies against non-HLA antigens are also linked to AMR. Identifying key non-HLA antibodies will improve our understanding of AMR. Read More

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October 2021

Eradication of Bovine Viral Diarrhoea (BVD) in Cattle in Switzerland: Lessons Taught by the Complex Biology of the Virus.

Front Vet Sci 2021 7;8:702730. Epub 2021 Sep 7.

Federal Food Safety and Veterinary Office (FSVO), Bern, Switzerland.

Bovine viral diarrhoea virus (BVDV) and related ruminant pestiviruses occur worldwide and cause considerable economic losses in livestock and severely impair animal welfare. Switzerland started a national mandatory control programme in 2008 aiming to eradicate BVD from the Swiss cattle population. The peculiar biology of pestiviruses with the birth of persistently infected (PI) animals upon infection in addition to transient infection of naïve animals requires vertical and horizontal transmission to be taken into account. Read More

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September 2021

Immunomodulatory Role of Nutrients: How Can Pulmonary Dysfunctions Improve?

Front Nutr 2021 7;8:674258. Epub 2021 Sep 7.

Laboratório de Dermatologia e Imunodeficiências (LIM-56), Departamento de Dermatologia, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo - FMUSP, São Paulo, Brazil.

Nutrition is an important tool that can be used to modulate the immune response during infectious diseases. In addition, through diet, important substrates are acquired for the biosynthesis of regulatory molecules in the immune response, influencing the progression and treatment of chronic lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD). In this way, nutrition can promote lung health status. Read More

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September 2021

B-Cell Immunophenotyping to Predict Vaccination Outcome in the Immunocompromised - A Systematic Review.

Front Immunol 2021 7;12:690328. Epub 2021 Sep 7.

Department of Immunology, Leiden University Medical Center (LUMC), Leiden, Netherlands.

Vaccination is the most effective measure to prevent infections in the general population. Its efficiency strongly depends on the function and composition of the immune system. If the immune system lacks critical components, patients will not be fully protected despite a completed vaccination schedule. Read More

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September 2021

Early Intervention via Stimulation of the Medial Septal Nucleus Improves Cognition and Alters Markers of Epileptogenesis in Pilocarpine-Induced Epilepsy.

Front Neurol 2021 7;12:708957. Epub 2021 Sep 7.

Department of Neurological Surgery, University of California, Davis, Sacramento, CA, United States.

Over one-third of patients with temporal lobe epilepsy are refractory to medication. In addition, anti-epileptic drugs often exacerbate cognitive comorbidities. Neuromodulation is an FDA treatment for refractory epilepsy, but patients often wait >20 years for a surgical referral for resection or neuromodulation. Read More

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September 2021

In the Eye of the Beholder: Challenge and Hindrance Appraisals of Work Characteristics and Their Implications for Employee's Well-Being.

Front Psychol 2021 7;12:708309. Epub 2021 Sep 7.

Department of Management, Robert C. Vackar College of Business & Entrepreneurship, University of Texas Rio Grande Valley, Edinburg, TX, United States.

Previous research on the association between job characteristics and employee well-being has returned mixed results. In particular, the possible impact of individual appraisal of these job characteristics has not been well-acknowledged. To address this limitation, we drew on appraisal theory and examined: (a) how workers appraise particular job characteristics, and (b) how these appraisals affect the relationships between these job characteristics and well-being (i. Read More

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September 2021

Systematic Review of Efficacy of Interventions for Social Isolation of Older Adults.

Front Psychol 2021 7;12:554145. Epub 2021 Sep 7.

School of Social Development and Public Policy, Fudan University, Shanghai, China.

The social isolation of older people is a growing public health concern. The proportion of older people in society has increased in recent decades, and it is estimated that ~40% of the population will be aged 50 or above within the next few decades. This systematic review aims to summarize and renew knowledge of the effectiveness of existing interventions for alleviating social isolation of older adults. Read More

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September 2021

Radiology Reporting Errors: Learning from Report Addenda.

Indian J Radiol Imaging 2021 Apr 12;31(2):333-344. Epub 2021 Aug 12.

Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India.

The addition of new information to a completed radiology report in the form of an "addendum" conveys a variety of information, ranging from less significant typographical errors to serious omissions and misinterpretations. Understanding the reasons for errors and their clinical implications will lead to better clinical governance and radiology practice. This article assesses the common reasons which lead to addenda generation to completed reports and their clinical implications. Read More

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A database of travel-related behaviors and attitudes before, during, and after COVID-19 in the United States.

Sci Data 2021 Sep 23;8(1):245. Epub 2021 Sep 23.

School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, AZ, USA.

The COVID-19 pandemic has impacted billions of people around the world. To capture some of these impacts in the United States, we are conducting a nationwide longitudinal survey collecting information about activity and travel-related behaviors and attitudes before, during, and after the COVID-19 pandemic. The survey questions cover a wide range of topics including commuting, daily travel, air travel, working from home, online learning, shopping, and risk perception, along with attitudinal, socioeconomic, and demographic information. Read More

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September 2021

Bayesian interpretation of p values in clinical trials.

Authors:
John Ferguson

BMJ Evid Based Med 2021 Sep 23. Epub 2021 Sep 23.

Clinical Research Facility, National University of Ireland Galway, Galway, Ireland

Commonly accepted statistical advice dictates that large-sample size and highly powered clinical trials generate more reliable evidence than trials with smaller sample sizes. This advice is generally sound: treatment effect estimates from larger trials tend to be more accurate, as witnessed by tighter confidence intervals in addition to reduced publication biases. Consider then two clinical trials testing the same treatment which result in the same p values, the trials being identical apart from differences in sample size. Read More

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September 2021

Exploring electronic health records to estimate the extent of catch-up immunisation and factors associated with under-immunisation among refugees and asylum seekers in south east Queensland.

Vaccine 2021 Sep 20. Epub 2021 Sep 20.

Lecturer, Health Services Management, School of Medicine, Griffith University, South Bank, QLD 4101, Australia. Electronic address:

Background: Australia is one of the leading countries resettling people from refugee-like backgrounds. Catch-up immunisation is a key priority in this cohort. However, few studies have included asylum seekers and the adult age group in their study sample. Read More

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September 2021

Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases.

Kidney Int 2021 Oct;100(4):753-779

Cochrane Kidney and Transplant, Sydney, New South Wales, Australia; Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.

The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Management of Glomerular Diseases is an update to the KDIGO 2012 guideline. The aim is to assist clinicians caring for individuals with glomerulonephritis (GN), both adults and children. The scope includes various glomerular diseases, including IgA nephropathy and IgA vasculitis, membranous nephropathy, nephrotic syndrome, minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), infection-related GN, antineutrophil cytoplasmic antibody (ANCA) vasculitis, lupus nephritis, and anti-glomerular basement membrane antibody GN. Read More

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October 2021