780 results match your criteria addition pyrazole


Reduced 3,4'-bi-pyrazoles carrying thio-phene and thia-zole substituents: structures of two intermediates and two products.

Acta Crystallogr E Crystallogr Commun 2021 Apr 5;77(Pt 4):335-340. Epub 2021 Mar 5.

School of Chemistry, University of St Andrews, St Andrews, Fife KY16 9ST, UK.

Cyclo-addition reactions between 3-(5-ar-yloxy-3-methyl-1-phenyl-1-pyrazol-4-yl)-1-(thio-phen-2-yl)prop-2-en-1-ones and thio-semicarbazide leads to the formation of reduced 3,4'-bi-pyrazole-2-carbo-thio-amides. Further cyclo-addition of these inter-mediates with either diethyl acetyl-enedi-carboxyl-ate or 4-bromo-phenacyl bromide leads to reduced 3,4'-bi-pyrazoles carrying oxo-thia-zole or thia-zole substituents, respectively. The structures of two representative inter-mediates and two representative products established unambiguously the regiochemistry of the cyclo-addition reactions. Read More

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Synthesis of Difluoroglycine Derivatives from Amines, Difluorocarbene, and CO2: Computational Design, Scope, and Application.

Chemistry 2021 Apr 30. Epub 2021 Apr 30.

Hokkaido University, Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Kita 21, Nishi 10, Kita-ku, 001-0021, Sapporo, JAPAN.

A three-component reaction (3CR) for the synthesis of difluoroglycine derivatives has been achieved using amines, difluorocarbene (generated in situ ), and the abundant, inexpensive, and non-toxic C1 source CO 2 . Various tert -amines and pyridine, (iso)quinoline, imidazole, thiazole, and pyrazole derivatives were incorporated, and the corresponding products were isolated in solid form without purification using column chromatography on silica gel. Detailed reaction profiles of the 3CR were obtained via computational analysis using DFT calculations, and the results critically suggest that simple ammonia is not applicable to this reaction. Read More

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Asynchronous Double Schiff Base Formation of Pyrazole Porous Polymers for Selective Pd Recovery.

Adv Sci (Weinh) 2021 Apr 2;8(8):2001676. Epub 2021 Mar 2.

Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro, Yuseong-gu Daejeon 34141 Korea.

Pyrazole-linked covalent organic polymer is synthesized using an asynchronous double Schiff base from readily available monomers. The one-pot reaction features no metals as a building block or reagent, hence facilitating the structural purity and industrial scalability of the design. Through a single-crystal study on a model compound, the double Schiff base formation is found to follow addition, a kinetically favored product, suggesting that reactivity of the amine and carbonyls dictate the order and geometry of the framework building. Read More

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Retentive efficacy, antimicrobial and cytotoxicity comparisons between different types of commercial and experimental denture adhesives with antifungal action.

Dent Mater J 2021 Apr 22. Epub 2021 Apr 22.

Department of Restorative Dentistry, Faculty of Dentistry, Federal University of Pelotas.

The effect of the addition of nystatin and an alternative antifungal derived from pyrazoles in different commercial denture adhesives on their retentive efficacy, cytotoxicity and antimicrobial activity against Candida albicans was evaluated. Commercial denture adhesives were prepared with the inclusion of nystatin and 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamide (pyrazole) in three concentrations: 23.78 %w/w, 3. Read More

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Synthesis of pyrazole anchored three-coordinated organoboranes and their application in the detection of picric acid.

Dalton Trans 2021 May;50(18):6204-6212

School of Chemical Sciences, National Institute of Science Education and Research (NISER), HBNI, Bhubaneswar-752050, Odisha, India.

Three-coordinated organoboron fluorophores bearing 3,5-diphenyl pyrazoles have been synthesized. The pyrazole anchored boron fluorophores show selective fluorescence quenching response to trinitrophenol (or) picric acid (PA) and have the ability to discriminate picric acid over other analytes. We investigated nonlinear optical (NLO) properties of these three-coordinated organoboron compounds (in solutions) in the presence and absence of PA. Read More

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Regioselective synthesis of functionalized pyrazole-chalcones a base mediated reaction of diazo compounds with pyrylium salts.

Org Biomol Chem 2021 Apr 19. Epub 2021 Apr 19.

Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow-226031, India. and Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.

A base-mediated reaction of triaryl/alkyl pyrylium tetrafluoroborate salts with α-diazo-phosphonates, sulfones and trifluoromethyl compounds affords the corresponding functionalized pyrazole-chalcones as 5-P-5 and 3-P-3 tautomeric mixture. The reaction proceeds through an initial nucleophilic addition of diazo substrates to pyrylium salts followed by a base-mediated pyrylium ring-opening and intramolecular 1,5-cyclization to afford formal 1,3-dipolar cycloaddition products. The products underwent a Nazarov-type cyclization upon hydride reduction followed by acidic-workup, furnishing the corresponding indenyl-pyrazoles in high yields. Read More

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Non-ulcerogenic pyrazolyl 2-hydroxychalcones and pyrazolylpyrazolines derived from naturally existing furochromone (khellin): semi-synthesis, docking study and anti-inflammatory activity.

Nat Prod Res 2021 Apr 5:1-8. Epub 2021 Apr 5.

Medicinal and Aromatic Plants Department, Desert Research Centre, Cairo, Egypt.

Novel pyrazolyl 2-hydroxychalcone derivatives and pyrazolylpyrazoline derivatives and derived from the naturally existing furochromone (Khellin) were synthesized and evaluated for their anti-inflammatory activity. Most of the synthesized compounds showed better or comparable activity to that of Diclofenac as reference drug. Twelve compounds were evaluated for their ulcerogenic potential and exhibited no ulcerogenic effect. Read More

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Construction of a Stable Lanthanide Metal-Organic Framework as a Luminescent Probe for Rapid Naked-Eye Recognition of Fe and Acetone.

Molecules 2021 Mar 18;26(6). Epub 2021 Mar 18.

Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China.

Four lanthanide metal-organic frameworks (Ln-MOFs), namely {[MeNH][LnL]·2HO} (Ln = Eu , Tb , Dy , Gd ), have been constructed from a new tetradentate ligand 1-(3,5-dicarboxylatobenzyl)-3,5-pyrazole dicarboxylic acid (HL). These isostructural Ln-MOFs, crystallizing in the monoclinic 2/c space group, feature a 3D structure with 7.5 Å × 9. Read More

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Design and synthesis of novel coumarin derivatives as potential acetylcholinesterase inhibitors for Alzheimer's disease.

Bioorg Chem 2021 May 6;110:104792. Epub 2021 Mar 6.

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt. Electronic address:

Twenty novel 7-benzyloxycoumarin based compounds were synthesized with a variety of bioactive chemical fragments. The synthesized compounds showed remarkable acetylcholinesterase (AChE) inhibitory activity. In vitro assay revealed that compounds 7-benzyloxy-4-{[(4-phenylthiazol-2(3H)-ylidene)hydrazono]methyl}-2H-chromen-2-one (5b, IC= 0. Read More

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Three-Component 1,2-Carboamidation of Bridged Bicyclic Alkenes via Rh-Catalyzed Addition of C-H Bonds and Amidating Reagents.

Org Lett 2021 Apr 19;23(7):2836-2840. Epub 2021 Mar 19.

Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.

A three-component method is described for the preparation of -1,2-disubstituted bridged bicyclic compounds. The reaction was demonstrated for readily available aromatic and heteroaromatic C-H bond substrates with tertiary and secondary amide, lactam, pyrazole, and triazole directing groups and a variety of bridged bicyclic alkenes, including norbornene, benzonorbornadiene, oxygen- and nitrogen-bridged analogs, and an unsaturated tropinone. A broad dioxazolone scope was also observed. Read More

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Pyrazole (1, 2-diazole) induce apoptosis in lymphoma cells by targeting BCL-2 and BCL-XL genes and mitigate murine solid tumour development by regulating cyclin-D1 and Ki-67 expression.

Toxicol Appl Pharmacol 2021 05 15;418:115491. Epub 2021 Mar 15.

Laboratory of Immunopharmacology and Experimental Therapeutics, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, 695011 Kerala, India. Electronic address:

Pyrazole or 1,2-Diazole is a five-membered heteroaromatic ring with two nitrogen atoms which is widely used in pharmacological research and organic synthesis. Several natural and synthetic pyrazole derivatives possess anti-cancer potential and some of them have underwent clinical trials. In this aspect, an investigation into the efficiency of the pyrazole nucleus to inhibit the growth and progression of various cancer cell lines/ experimental tumours would help in giving a better clarity to the anti-cancer behaviour of pyrazole containing drugs. Read More

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Synthesis of novel antioxidant and antitumor 5-aminopyrazole derivatives, 2D/3D QSAR, and molecular docking.

Mol Divers 2021 Mar 8. Epub 2021 Mar 8.

Chemistry Department, Faculty of Science, Mansoura University, 25 El Gomhouria St, Mansoura, Dakahlia Governorate, 35516, Egypt.

5-Aminopyrazole serves as a vital precursor for several biologically active pyrazoloazines, including pyrazolopyridine, pyrazolopyrimidine, and pyrazolotriazine, as well as Schiff bases, thiourea, and phthalimide derivatives. In this study, we structurally characterized novel pyrazole derivatives by spectral IR, H and C NMR, and MASS spectroscopy. We also evaluated antioxidant activity of various derivatives using ABTS and DPPH methods and cytotoxicity in the hepatocellular carcinoma Hep-G2 cells by SRB assay. Read More

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New sulphonamide pyrolidine carboxamide derivatives: Synthesis, molecular docking, antiplasmodial and antioxidant activities.

PLoS One 2021 24;16(2):e0243305. Epub 2021 Feb 24.

Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.

Carboxamides bearing sulphonamide functionality have been shown to exhibit significant lethal effect on Plasmodium falciparum, the causative agent of human malaria. Here we report the synthesis of thirty-two new drug-like sulphonamide pyrolidine carboxamide derivatives and their antiplasmodial and antioxidant capabilities. In addition, molecular docking was used to check their binding affinities for homology modelled P. Read More

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February 2021

Electrochemical synthesis of versatile ammonium oxides under metal catalyst-, exogenous-oxidant-, and exogenous-electrolyte-free conditions.

Chem Commun (Camb) 2021 Mar;57(22):2768-2771

National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, P. R. China. and College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, P. R. China.

An electrochemical oxidative cross-coupling reaction between 2.5-substituted-pyrazolin-5-ones and ammonium thiocyanate has been developed, which resulted in a series of unprecedented cross-coupling products under metal catalyst-, exogenous-oxidant-, and exogenous-electrolyte-free conditions. It is worth noting that since the resulting cross-coupling products are nearly insoluble in MeCN, the pure product could be afforded without silica gel column purification. Read More

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Design, Synthesis and Biological Screening of Novel 1,5-Diphenyl-3-(4-(trifluoromethyl)phenyl)-2-pyrazoline Derivatives.

Acta Chim Slov 2020 Dec;67(4):1139-1147

1-Phenyl-5-substituted-3-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole derivatives were synthesized from chalcone derivatives. The structures of compounds were characterized by IR, 1H NMR spectroscopic methods and elemental analysis. All compounds were evaluated for their in vitro antioxidant activity using DPPH and ABTS methods, anti-inflammatory activity using lipoxygenase inhibitory method and antidiabetic activity using the ?-glucosidase inhibitory method. Read More

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December 2020

Synthesis and Evaluation on Anticonvulsant and Antidepressant Activities of Naphthoquinone Derivatives Containing Pyrazole and Pyrimidine Fragments.

Acta Chim Slov 2020 Sep;67(3):934-939

Novel heterocyclic dichloronaphthoquinone derivatives have been synthesized by chlorine atom substitution in 2,3-dichloro-1,4-naphthoquinone to pyrazole or pyrimidine fragments. The structures of these compounds have been confirmed by FT-IR, ESI-MS, 1H?NMR, 13C-NMR and elementary analysis. Synthesized compounds were evaluated for their anticonvulsant action in a pentylenetetrazole (PTZ)-convulsion model and antidepressant activity in the forced swimming test (FST). Read More

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September 2020

Luminescent silver(i) complexes with pyrazole-tetraphenylethene ligands: turn-on fluorescence due to the coordination-driven rigidification and solvent-oriented structural transformation.

Dalton Trans 2021 Feb 26;50(6):2183-2191. Epub 2021 Jan 26.

Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, China.

A new tetrapyrazole-modified tetraphenylethene (TPE) ligand L was designed and found to display "turn-on" fluorescence when it combines with Ag ions in dilute solution by restricting intramolecular rotation of TPE. A series of Ag complexes 1-7 were obtained, and they exhibit excellent fluorescence properties in the solid state. Compared with PF, the silver complex with the CFSO anion can further enhance its fluorescence due to the transformation of its structure from AgL (2) to AgL (3). Read More

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February 2021

Evaluation of the cellular protection by novel spiropyrazole compounds in dopaminergic cell death.

Eur J Med Chem 2021 Mar 6;213:113140. Epub 2021 Jan 6.

Department of Biochemistry, Faculty of Pharmacy, Ege University, 35100, Bornova, Izmir, Turkey. Electronic address:

The loss of neurons is strongly correlated with aging and aging-associated disorders. In this study, cell viability assays and mitochondrial function were performed to evaluate the effect of new spiro-pyrazole derivatives, prepared from aldehydes and 3-amino-1-phenyl-2-pyrazolin-5-one, on neuroprotection in an in vitro model of dopaminergic cell death induced by 1-methyl-4-phenylpyridinium (MPP). The percentages of neuroprotection by derivatives were found between 21. Read More

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Catalytic Asymmetric Addition of Diorganozinc Reagents to Pyrazole-4,5-Diones and Indoline-2,3-Diones.

Chemistry 2021 Mar 8;27(13):4302-4306. Epub 2021 Feb 8.

Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P. R. China.

The catalytic enantioselective diorganozinc additions to cyclic diketones including pyrazolin-4,5-diones and isatins have been developed. In the presence of morpholine-containing chiral amino alcohol ligand, the corresponding chiral cyclic tertiary alcohols were produced in good to excellent yields (up to 97 %) and enantioselectivities (up to 95 % ee). The notable feature of this protocol includes its mild reaction conditions, Lewis acid additives free and broad functional group tolerance. Read More

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Multi-Component Reactions of Cyclohexan-1,3-dione: Synthesis of Fused Pyran, Pyridine, Thiophene and Pyrazole Derivatives with c-Met, AntiProliferative Activities.

Anticancer Agents Med Chem 2021 Jan 11. Epub 2021 Jan 11.

National Organization for Research and control of Biologicals.51 Wezaret El-Zeraa St, Dokki, Giza, A. R. Egypt.

Background: Recently products of multi-component reactions (MCR's) acquired a special attention due to their wide range of pharmacological activities especially the therapeutic activities. Through the market it was found that many pharmacological drugs containing the pyran and pyridine nucleus that were produced through MCR's were known.

Objective: We are aiming in this work to synthesize target molecules not only possess anti-tumour activities but also cMet and prostate cancer inhibitors. Read More

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January 2021

Highly Chemoselective [2+1] Annulation of α-Alkylidene Pyrazolones with α-Bromonitroalkenes: Synthesis of Pyrazolone-Based Vinylcyclopropanes and Computational Studies.

J Org Chem 2021 Feb 10;86(3):2582-2592. Epub 2021 Jan 10.

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, People's Republic of China.

A highly chemoselective [2+1] annulation of α-alkylidene pyrazolones with α-bromonitroalkenes has been achieved under mild conditions. α-Alkylidene pyrazolones were unprecedentedly used as a C1 synthon to participate in annulation reactions, providing access to diverse vinylcyclopropane-based pyrazolone products. In addition, a spectrum of pharmaceutically interesting pyrazole-fused pyranone oximes could be rapidly obtained through a [2+1] annulation/rearrangement sequential process. Read More

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February 2021

A Molecular Dynamics Simulation Based Investigation of the Proton Conductivity of Anhydrous Pyrazole Doped Poly(Vinylphosphonic Acid) Composite System.

Polymers (Basel) 2020 Dec 4;12(12). Epub 2020 Dec 4.

Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.

With the recognition of the multiple advantages of proton transport membranes that can operate under anhydrous conditions and offer promising opportunities as fuel cells working at high temperatures, a number of such membranes have been developed, but the proton transport mechanism of these materials has not been fully understood. In this work, a theoretical investigation based on molecular dynamics simulations is carried out on a system that is very similar to a real anhydrous proton transport membrane. The location and type of hydrogen bonds have been precisely identified by intermolecular pair correlation functions. Read More

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December 2020

Fe(III) Complexes Based on Mono and Bis-pyrazolyl--triazine Ligands: Synthesis, Molecular Structure, Hirshfeld, and Antimicrobial Evaluations.

Molecules 2020 Dec 5;25(23). Epub 2020 Dec 5.

Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt.

The self-assembly of iron(III) chloride with three pyrazolyl--triazine ligands, namely 2,4-bis(3,5-dimethyl-1-pyrazol-1-yl)-6-(piperidin-1-yl)-1,3,5-triazine (), 4-(4,6-bis(3,5-dimethyl-1-pyrazol-1-yl)-1,3,5-triazin-2-yl)morpholine (), and 4,4'-(6-(3,5-dimethyl-1-pyrazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine () afforded [Fe(BPT)Cl][FeCl] (), [Fe(BPT)Cl][FeCl] (), and [H(PT)][FeCl]. PT.2HO (), respectively, in good yield. Read More

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December 2020

New Approaches for the Synthesis of Fused Thiophene, Pyrazole , Pyran and Pyridine Derivatives with Anti-Proliferative Together with c-Met Kinase and Prostate Cancer Cell Inhibitions.

Anticancer Agents Med Chem 2020 Nov 10. Epub 2020 Nov 10.

Training Sector, Ministry of Military Production, Alsalam City, Cairo, A. R.. Egypt.

Background: Recently multi-component reactions producing pyran and pyridine derivatives acquired a special attention due to their wide range of pharmacological activities especially the therapeutic activities. Through the market it was found that many pharmacological drugs containing the pyran and pyridine nucleus were known.

Objective: We are aiming in this work to synthesize target molecules not only possess anti-tumor activities but also kinase inhibitors. Read More

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November 2020

A Novel Fluorescent Probe Based on Pyrazole-Pyrazoline for Fe (III) Ions Recognition.

J Fluoresc 2021 Jan 13;31(1):29-38. Epub 2020 Oct 13.

College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.

Firstly, a novel pyrazole-pyrazoline fluorescent probe was developed and synthesized. The probe can be used to determine Fe ions in a series of cations in tetrahydrofuran aqueous solution with high selectivity and high sensitivity. After the addition of iron ions, the fluorescence intensity is significantly reduced, Its structure was characterized by H NMR, C NMR and HR-ESI-MS. Read More

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January 2021

Gold(I)-Catalyzed Reactions between 2-(1-Alkynyl)-2-alken-1-ones and Vinyldiazo Ketones for Divergent Synthesis of Nonsymmetric Heteroaryl-Substituted Triarylmethanes: versus -Attack Paths.

Org Lett 2020 Nov 12;22(21):8229-8233. Epub 2020 Oct 12.

Frontier Research Center of Matter Science and Technology, Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC.

Gold-catalyzed synthesis of nonsymmetrical heteroaryl-substituted triarylmethanes using 2-(1-alkynyl)-2-alken-1-ones and vinyldiazo ketones is described. In this catalytic sequence, vinyldiazo ketones attack gold-containing 3-furylbenzyl cations to form the observed C(1)-addition products. We also note that vinyldiazo ketones can be thermally cyclized to yield pyrazole derivatives, which can react with 3-furylbenzyl cations to afford pyrazole-containing triarylmethanes, corresponding to a N(5)-addition path. Read More

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November 2020

Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE, TNF-α, IL-6 and histopathological study.

Bioorg Chem 2020 11 24;104:104308. Epub 2020 Sep 24.

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

To search for effective and selective COX-2 inhibitors, four novel series of tetrazole derivatives were designed based on bioisosteric replacement of SONH in celecoxib with tetrazole ring incorporating different central moieties as chalcone (2a-f), isoxazole (3a-c) or pyrazole (4a-c & 5a-c). Target tetrazoles were synthesized and their structures were confirmed by spectroscopic techniques and elemental analyses. All target compounds were more selective for COX-2 isozyme than COX-1 when compared to standard drugs indomethacin and celecoxib. Read More

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November 2020

Mechanism of Action of Novel Pyrazole Carboxamide Containing a Diarylamine Scaffold against .

J Agric Food Chem 2020 Oct 24;68(40):11068-11076. Epub 2020 Sep 24.

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China.

In the last few decades, causing rice sheath blight has resulted in a lot of economic losses in the world. Therefore, many novel pyrazole carboxamide fungicides have been intensively researched and employed to fight against it. In this regard, in recent years, our group reported a novel pyrazole carboxamide containing a diarylamine scaffold with good antifungal activity against rice sheath blight in the pot test and field trial. Read More

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October 2020

Asymmetric Construction of Cyclobutanes via Direct Vinylogous Michael Addition/Cyclization of β,γ-Unsaturated Amides.

Org Lett 2020 09 9;22(18):7135-7140. Epub 2020 Sep 9.

Research Center of Chinese Herbal Resource Science and Engineering, Key Laboratory of Chinese Medicinal Resource from Lingnan, Ministry of Education, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

The construction of cyclobutanes has attracted much attention because of its unique four-membered ring skeleton. Herein, we report the highly enantioselective direct vinylogous Michael reaction of β,γ-unsaturated pyrazole amides and nitroolefin using a squaramide catalyst. Cyclobutane derivatives were obtained by subsequent cyclization in good yields (up to 85%) with excellent enantioselectivities (up to 99% ee). Read More

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September 2020

Attacking the mitochondria of colorectal carcinoma by novel 2-cyanoacrylamides linked to ethyl 1,3-diphenylpyrazole-4-carboxylates moiety as a new trend for chemotherapy.

Bioorg Chem 2020 10 26;103:104195. Epub 2020 Aug 26.

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt. Electronic address:

A novel set of 2-cyanoacrylamides linked to ethyl 1,3-diphenylpyrazole-4-carboxylates moiety were synthesized and elucidated by different spectroscopic tools. In vitro cytotoxic assay was carried out against different cell lines (Hct, A, MDA-MB, and HFB). Ethyl 5-(2-cyano-3-(furan-2-yl)acrylamido)-1,3-diphenylpyrazole-4-carboxylate 5 achieved the potent cytotoxic effect toward all tested cancer cell lines especially colon cancer (HCT) with IC value (30. Read More

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October 2020