75,608 results match your criteria addition products


Utilization of fruit and vegetable waste to produce value-added products: Conventional utilization and emerging opportunities-A review.

Chemosphere 2021 Sep 9;287(Pt 3):132221. Epub 2021 Sep 9.

Department of Chemical Engineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, 603 203, India. Electronic address:

Fruit and vegetables are one of the most consumed commodities globally, accounting for more than 42% of total food wastage. These vegetal foods can be consumed raw, processed, or taken as an addition to other food items. The continuous rise in population, in addition to technological advancements, has led to an imbalance in demand supply, resulting in increased food wastage globally. Read More

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September 2021

Hydroxyl Ethyl Starch (HES) preserves intrarenal microcirculatory perfusion shown by contrast-enhanced ultrasound (CEUS), and renal function in a severe hemodilution model in pigs.

Shock 2021 Sep 23. Epub 2021 Sep 23.

Department of Intensive Care, Laboratory of Translational Intensive Care, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands Department of Biomedical Engineering, Thorax Center, Erasmus MC, Rotterdam, the Netherlands Laboratory of Experimental Anesthesiology, Department of Anesthesiology, Erasmus MC, Rotterdam, the Netherlands Laboratory of Acoustical Wavefield Imaging, Department of Applied Sciences, Delft University of Technology, Delft, the Netherlands.

Abstrac: Acute normovolemic hemodilution (ANH) is associated with low oxygen carrying capacity of blood and purposed to cause renal injury in perioperative setting. It is best accomplished in a perioperative setting by a colloid such as hydroxyl ethyl starch (HES) due its capacity to fill the vascular compartment and maintain colloidal pressure. However, alterations of intra renal microvascular perfusion, flow and its effects on renal function and damage during ANH has not been sufficiently clarified. Read More

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September 2021

Variability in Contraceptive Clinical Trial Design and the Challenges in Making Comparisons Across Trials.

Adv Ther 2021 Sep 23. Epub 2021 Sep 23.

Evofem Biosciences, Inc., 12400 High Bluff Drive, Suite 600, San Diego, CA, 92130, USA.

Clinical trials of contraceptives have often differed in their study designs, making cross-trial comparisons difficult. This brief report outlines some of the technical design features that can vary from trial to trial. For example, the overall number of menstrual cycles in a study has substantial impact on the final efficacy determination; however, the rules related to qualifying cycles can differ based on the length of the study and the statistical analysis plan. Read More

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September 2021

Carbocation Footprinting of Soluble and Transmembrane Proteins.

Anal Chem 2021 Sep 24. Epub 2021 Sep 24.

Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States.

Here, we introduce carbocations (RC) as laser-initiated footprinting reagents for proteins. We screened seven candidates and selected trifluomethoxy benzyl bromide (TFBB) as an effective precursor for the electrophilic trifluomethoxy benzyl carbocation (TFB) under laser (248 nm) irradiation on the fast photochemical oxidation of proteins (FPOP) platform. Initial results demonstrate that this electrophilic cation reagent affords residue coverage of nucleophilic amino acids including H, W, M, and S. Read More

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September 2021

Black raspberries attenuate colonic adenoma development in mice: Relationship to hypomethylation of promoters and gene bodies.

Food Front 2020 Sep 9;1(3):234-242. Epub 2020 Sep 9.

Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.

Recent studies have suggested that in addition to promoter region, DNA methylation in intragenic and intergenic regions also changes during physiological processes and disease. The current study showed that feeding of black raspberries (BRBs) to mice suppressed colon and intestinal tumors. MBDCap-seq suggested that dietary BRBs hypomethylated promoter, intragenic, and intergenic regions. Read More

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September 2020

Draft genome sequence data of methanotrophic strain S1L and strain S2AM isolated from hypoxic water column layers of boreal lakes.

Data Brief 2021 Oct 12;38:107364. Epub 2021 Sep 12.

Faculty of Engineering and Natural Sciences, Tampere University, P.O. Box 541, Tampere 33014, Finland.

Methanotrophic bacteria inhabit a wide range of natural (e.g. wetlands, lakes and soils) and anthropogenic (e. Read More

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October 2021

Azole Use in Agriculture, Horticulture, and Wood Preservation - Is It Indispensable?

Front Cell Infect Microbiol 2021 7;11:730297. Epub 2021 Sep 7.

Department of Agroecology, Aarhus University, Slagelse, Denmark.

Plant pathogens cause significant damage to plant products, compromising both quantities and quality. Even though many elements of agricultural practices are an integral part of reducing disease attacks, modern agriculture is still highly reliant on fungicides to guarantee high yields and product quality. The azoles, 14-alpha demethylase inhibitors, have been the fungicide class used most widely to control fungal plant diseases for more than four decades. Read More

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September 2021

B-Cell Immunophenotyping to Predict Vaccination Outcome in the Immunocompromised - A Systematic Review.

Front Immunol 2021 7;12:690328. Epub 2021 Sep 7.

Department of Immunology, Leiden University Medical Center (LUMC), Leiden, Netherlands.

Vaccination is the most effective measure to prevent infections in the general population. Its efficiency strongly depends on the function and composition of the immune system. If the immune system lacks critical components, patients will not be fully protected despite a completed vaccination schedule. Read More

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September 2021

A terahertz time-domain super-resolution imaging method using a local-pixel graph neural network for biological products.

Anal Chim Acta 2021 Oct 31;1181:338898. Epub 2021 Jul 31.

Food Refrigeration and Computerized Food Technology (FRCFT), Agriculture and Food Science Centre, University College Dublin, National University of Ireland, Belfield, Dublin 4, Ireland. Electronic address:

The low image acquisition speed of terahertz (THz) time-domain imaging systems limits their application in biological products analysis. In the current study, a local pixel graph neural network was built for THz time-domain imaging super-resolution. The method could be applied to the analysis of any heterogeneous biological products as it only required a small number of sample images for training and particularly it focused on THz feature frequencies. Read More

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October 2021

Protective effect of standardised fruit extract of Roxb. ex Choisy against ethanol induced gastric mucosal lesions in Wistar rats.

Ann Med 2021 Dec;53(1):1696-1708

ICAR-Directorate of Medicinal and Aromatic Plants Research, Boriavi, Anand, India.

Background And Aim: The fruit of is a rich and valuable source of bioactive compounds and is traditionally used for treating wounds and ulcers. The present study was carried out to investigate the protective effect of chromatographically standardized fruit extract of (GCE) on ethanol-induced gastric lesions in rats and its possible mechanisms.

Methods: The effect of GCE (200 and 400 mg/kg body weight) was evaluated by determining various gastric ulcer parameters like gastric wall mucus, non-protein sulfhydryls (NP-SH) content, microvascular permeability, endogenous antioxidant enzyme, and gastric histopathological study. Read More

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December 2021

Fabrication of magnetic-responsive controlled-release herbicide by a palygorskite-based nanocomposite.

Colloids Surf B Biointerfaces 2021 Sep 12;208:112115. Epub 2021 Sep 12.

Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, 350 Shushanhu Road, Hefei 230031, People's Republic of China; Key Laboratory of Environmental Toxicology and Pollution Control Technology of Anhui Province, Hefei Institutes of Physical Science, Chinese Academy of Sciences, 350 Shushanhu Road, Hefei 230031, People's Republic of China. Electronic address:

In this work, a type of magnetic-responsive controlled-release herbicide (MCRH) was developed using a nanocomposite including palygorskite (Pal), ferroferric oxide (FeO), glyphosate (Gly), and amino silicon oil (ASO). In this system, Pal with the structure of micro/nanonetworks can bind a large quantity of Gly and FeO. The movement of FeO particles can be driven by a magnetic field to ensure the controlled release of pesticides. Read More

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September 2021

Addiction and the cerebellum with a focus on actions of opioid receptors.

Neurosci Biobehav Rev 2021 Sep 20. Epub 2021 Sep 20.

Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran. Electronic address:

Increasing evidence suggests that the cerebellum could play a role in the higher cognitive processes involved in addiction as the cerebellum contains anatomical and functional pathways to circuitry controlling motivation and saliency. In addition, the cerebellum exhibits a widespread presence of receptors, including opioid receptors which are known to play a prominent role in synaptic and circuit mechanisms of plasticity associated with drug use and development of addiction to opioids and other drugs of abuse. Further, the presence of perineural nets (PNNs) in the cerebellum which contain proteins known to alter synaptic plasticity could contribute to addiction. Read More

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September 2021

The Ligand Free Palladium(II)-Catalyzed Regioselective 1,2-Addition of Enol Silanes to Quinones to Access 4-Hydroxy-4-(2-oxo-2-arylethyl)cyclohexadien-1-ones and Synthetic Applications.

J Org Chem 2021 Sep 23. Epub 2021 Sep 23.

Department of Chemistry, Bharathidasan University, Palkalaiperur, Thiruchirapalli, Tamil Nadu 620024, India.

In contrast to the conventional 1,4-addition process, regioselective 1,2-addition of silyl enol ethers to quinones can now be achieved a palladium(II) enolate pathway that provides access to 4-hydroxy-4-(2-oxo-2-arylethyl)cyclohexa-2,5-dien-1-one derivatives. This quinone alkylation protocol proceeds under mild reaction conditions at ambient temperature under open air and does not require either an external ligand for the palladium or the use of a base. Additionally, the cyclohexadienone products have been exploited as synthetic precursors for the construction of fused heteroaryl systems. Read More

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September 2021

Trace arsenic analysis in edible seaweeds by miniature dielectric barrier discharge microplasma optical emission spectrometry based on gas phase enrichment.

Anal Methods 2021 Sep 23;13(36):4079-4089. Epub 2021 Sep 23.

College of Instrumentation & Electrical Engineering, Jilin University, Changchun 130023, China.

In this work, a novel method using low-cost miniaturized hydride generation optical emission spectrometry equipment coupled with an dielectric barrier discharge trap (HG- DBD trap-OES) was established for the determination of As in edible seaweed samples. An improved peak volume algorithm, where the start time point and end time point of the spectrum at each concentration are determined according to the unified judgment criteria, was first proposed to extend the linear range from 1-100 μg L to 1-200 μg L, and increase the sensitivity by about 30%. In addition, a modification was done on the DBD implementation, providing an enhancement of sensitivity by a factor of about 4 for As. Read More

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September 2021

Nitrosobenzene-Enabled Chiral Phosphoric Acid Catalyzed Enantioselective Construction of Atropisomeric N-Arylbenzimidazoles.

Angew Chem Int Ed Engl 2021 Sep 23. Epub 2021 Sep 23.

Hangzhou Normal University, chemistry, CHINA.

Described herein is an imidazole ring formation strategy for the synthesis of axially chiral N-arylbenzimidazoles by means of chiral phosphoric acid catalysis. Two sets of conditions were developed to transform two classes of 2-naphthylamine derivatives into structurally diverse N-arylbenzimidazole atropisomers with excellent chemo- and regioselectivity as well as high levels of enantiocontrol. It is worth reflecting on the unique roles played by the nitroso group in this domino reaction. Read More

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September 2021

Novel Insight Into Glycosaminoglycan Biosynthesis Based on Gene Expression Profiles.

Front Cell Dev Biol 2021 6;9:709018. Epub 2021 Sep 6.

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, China.

Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, heparan sulfate, and keratan sulfate, except for hyaluronan that is a free polysaccharide, are covalently attached to core proteins to form proteoglycans. More than 50 gene products are involved in the biosynthesis of GAGs. We recently developed a comprehensive glycosylation mapping tool, GlycoMaple, for visualization and estimation of glycan structures based on gene expression profiles. Read More

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September 2021

Functional Characterization of the Gene Involved in Flowering in .

Front Plant Sci 2021 21;12:681166. Epub 2021 Jun 21.

College of Horticulture and Gardening, Yangtze University, Jingzhou, China.

has edible, medicinal, and ornamental value. However, the long juvenile phase prevents the development of the industry, and there are few reports on the identification and functional analysis of genes regulating the flowering time of . EMBRYONIC FLOWER 2 (EMF), an important protein in flower development, functions to promote vegetative growth and repress flowering. Read More

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Development of a Loop-Mediated Isothermal Amplification Method for the Rapid Detection of .

Front Microbiol 2021 6;12:720485. Epub 2021 Sep 6.

Institute of Bast Fiber Crops and Center of Southern Economic Crops, Chinese Academy of Agricultural Sciences, Changsha, China.

Brown root rot caused by is a new destructive root disease on many plants such as Gingko, Citrus, kiwifruit, and ramie. The establishment of loop-mediated isothermal amplification (LAMP) technology for detecting can help monitor and control brown root rot quickly, efficiently, and accurately. LAMP technology is known for its simplicity, sensitivity, and speed; and it does not require any specialized equipment - a water bath or a thermoblock is sufficient for isothermal amplifications. Read More

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September 2021

Formulation and fluoride content of dentifrices: a review of current patterns.

Br Dent J 2021 Sep 21. Epub 2021 Sep 21.

National Lead for Oral Health Improvement, Public Health England, UK.

Introduction Consumer oral hygiene products play a key role in improving and maintaining population oral health. The oral personal care market is rapidly diversifying; a growing number of dentifrices marketed a 'natural' and fluoride-free are entering mainstream retailers, which may have implications for the oral health of the population 'with regards to caries risk.Aims To investigate the range of fluoride concentrations, flavour formulations and delivery mechanisms of dentifrices available on the UK market. Read More

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September 2021

Effect of fermentation time on the content of bioactive compounds with cosmetic and dermatological properties in Kombucha Yerba Mate extracts.

Sci Rep 2021 Sep 22;11(1):18792. Epub 2021 Sep 22.

Department of Analytical Chemistry, Medical University of Lublin, Lublin, Poland.

Kombucha is a beverage made by fermenting sugared tea using a symbiotic culture of bacteria belonging to the genus Acetobacter, Gluconobacter, and the yeasts of the genus Saccharomyces along with glucuronic acid, which has health-promoting properties. The paper presents the evaluation of ferments as a potential cosmetic raw material obtained from Yerba Mate after different fermentation times with the addition of Kombucha. Fermented and unfermented extracts were compared in terms of chemical composition and biological activity. Read More

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September 2021

Phylogenetic analysis and development of molecular markers for five medicinal Alpinia species based on complete plastome sequences.

BMC Plant Biol 2021 Sep 22;21(1):431. Epub 2021 Sep 22.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, 100193, Beijing, People's Republic of China.

Background: Alpinia species are widely used as medicinal herbs. To understand the taxonomic classification and plastome evolution of the medicinal Alpinia species and correctly identify medicinal products derived from Alpinia species, we systematically analyzed the plastome sequences from five Alpinia species. Four of the Alpinia species: Alpinia galanga (L. Read More

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September 2021

Syringe Filling of High-Concentration mAb Products Using Peristaltic Pump-Based Mechanism: Challenges and Mitigation Strategies.

J Pharm Sci 2021 Sep 19. Epub 2021 Sep 19.

New Product Introduction and Product Technology, Pharma Supply Chain, GlaxoSmithKline, Strada Asolana 90, San Polo di Torrile, Parma, 43046, Italy.

Syringe filling of high-concentration mAb formulation during manufacturing of large-scale drug product batches may present challenges such as product deposition onto the area of the syringe barrel where the stopper is inserted, product splashing or dripping, droplets left after the fill cycle, filling needle clogging, product build-up inside the needle during line stoppages, variation in fill weight/volume, and potential impact on product quality attributes. In this article, a summary of these issues and approaches to overcome them are summarized. Potential failure modes of the syringe filling process and appropriate in-process controls are provided. Read More

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September 2021

In vitro virucidal activity of the theaflavin-concentrated tea extract TY-1 against influenza A virus.

J Nat Med 2021 Sep 22. Epub 2021 Sep 22.

Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido, 080-8555, Japan.

The annual spread of influenza A virus (IAV) infection is a global concern. We examined the IAV-inactivating potential of theaflavin-concentrated tea extract TY-1, which contains abundant polyphenols, including concentrated theaflavins and catechins. TY-1 exhibited concentration- and time-dependent virucidal activity against IAV. Read More

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September 2021

Bovine Milk Microbiota: Comparison among Three Different DNA Extraction Protocols To Identify a Better Approach for Bacterial Analysis.

Microbiol Spectr 2021 Sep 22:e0037421. Epub 2021 Sep 22.

Institute of Agricultural Biology and Biotechnology, National Research Council, Lodi, Italy.

The bovine udder is colonized by a huge quantity of microorganisms that constitute the intramammary ecosystem, with a specific role in modulating not only udder homeostasis and mastitis susceptibility, but also the quality of the dairy products. However, generating high-quality bacterial DNA can be critical, especially starting from a complex biological matrix like milk, characterized by high fat, protein, and calcium contents. Here, bacterial DNA was recovered from a commercial ultra-high-temperature (UHT) milk sample artificially spiked with a predetermined mock community composition and from three bulk tank milk (raw milk) samples. Read More

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September 2021

Biomimetic Synthesis of Natural Products: A Journey To Learn, To Mimic, and To Be Better.

Acc Chem Res 2021 Sep 22. Epub 2021 Sep 22.

School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.

ConspectusTotal synthesis of natural products has been one of the most exciting and dynamic areas in synthetic organic chemistry. Nowadays, the major challenge in this field is not whether a given target of interest can be synthesized but how to make it with commendable efficiency and practicality. To meet this grand challenge, a wise way is to learn from Mother Nature who is recognized for her superb capability of forging complicated and sometimes beyond-imagination molecules in her own delicate way. Read More

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September 2021

A bifunctional squaramide-catalysed enantioselective vinylogous Michael addition/cyclization cascade reaction of 4-unsaturated isoxazol-5-ones and α,α-dicyanoalkenes.

Org Biomol Chem 2021 Sep 22. Epub 2021 Sep 22.

Key Laboratory of Medical Molecule Science & Pharmaceutics Engineering, Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing 100081, People's Republic of China.

An effective strategy for the stereoselective synthesis of spiro isoxazolone-cyclohexenimines was developed using a bifunctional squaramide-catalysed vinylogous Michael addition/cyclization cascade reaction of 4-unsaturated isoxazol-5-ones and α,α-dicyanoalkenes. The atom-economical cascade process can proceed smoothly under extremely low catalyst loading (1 mol%) and mild conditions, and the corresponding products were obtained in moderate to good yields (45% to 90%) and enantioselectivitites (51% to 96% ee). Meanwhile, the scale-up reaction and transformation of the products were also demonstrated. Read More

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September 2021

Kombucha ameliorates LPS-induced sepsis in a mouse model.

Food Funct 2021 Sep 22. Epub 2021 Sep 22.

Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, Fujian Normal University, Fuzhou, Fujian Province 350117, PR China.

As a popular traditional fermented beverage, kombucha has been extensively studied for its health benefits. However, the science behind the anti-inflammatory effect of kombucha has not been well studied, and there is an urgent need to uncover the secrets of the anti-inflammatory properties of kombucha. Here, we investigate kombucha's protective effects against lipopolysaccharide (LPS)-induced sepsis and on the intestinal microecology in mice. Read More

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September 2021

The use of matrix-assisted laser desorption/ionization mass spectrometry in enzyme activity assays and its position in the context of other available methods.

Authors:
Marek Šebela

Mass Spectrom Rev 2021 Sep 21:e21733. Epub 2021 Sep 21.

Department of Biochemistry, Faculty of Science, and CATRIN, Palacký University, Olomouc, Czech Republic.

Activity assays are indispensable for studying biochemical properties of enzymes. The purposes of measuring activity are wide ranging from a simple detection of the presence of an enzyme to kinetic experiments evaluating the substrate specificity, reaction mechanisms, and susceptibility to inhibitors. Common activity assay methods include spectroscopy, electrochemical sensors, or liquid chromatography coupled with various detection techniques. Read More

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September 2021

[Impact of Nurse Practitioners and Nursing Education on COVID-19 Pandemics: Innovative Strategies of Authentic Technology-Integrated Clinical Simulation].

Authors:
Chih-Ling Huang

Hu Li Za Zhi 2021 Oct;68(5):4-6

PhD, RN, Distinguished Professor, School of Nursing, Fooyin University, Taiwan, ROC.

Taiwan Nurses Association and the International Council of Nurses recognize nurse practitioners (NPs) as advanced-practice nurses. A total of 11,266 registered nurses held NP certificates in April 2021 in Taiwan (Tsay, 2021). While international organizations recognize NPs with graduate degrees, over 85% of NPs in Taiwan hold a bachelor degree only. Read More

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October 2021

Bacterial Biofilm Destruction: A Focused Review On The Recent Use of Phage-Based Strategies With Other Antibiofilm Agents.

Nanotechnol Sci Appl 2021 14;14:161-177. Epub 2021 Sep 14.

School of Medical Laboratory Sciences, Institute of Health, Jimma University, Jimma, Ethiopia.

Biofilms are bacterial communities that live in association with biotic or abiotic surfaces and enclosed in an extracellular polymeric substance. Their formation on both biotic and abiotic surfaces, including human tissue and medical device surfaces, pose a major threat causing chronic infections. In addition, current antibiotics and antiseptic agents have shown limited ability to completely remove biofilms. Read More

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September 2021