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Inhibition of gastric H,K-ATPase by new dihydropyrazole derivative KYY-008.

Biochem Biophys Res Commun 2021 Aug 21;567:177-182. Epub 2021 Jun 21.

Department of Pharmaceutical Physiology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan.

The gastric proton pump (H,K-ATPase) responsible for the H secretion of gastric acid is an essential therapeutic target for acid-related diseases. H,K-ATPase belongs to a P-type ATPase family. Here, we examined the effects of a newly synthesized dihydropyrazole derivative KYY-008 on the H,K-ATPase. Read More

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