10,832 results match your criteria addition influencing

The impact of severe rare chronic neurological disease in childhood on the quality of life of families-a study on MLD and PCH2.

Orphanet J Rare Dis 2021 May 10;16(1):211. Epub 2021 May 10.

Department of Child Neurology, Children's Hospital, University of Tübingen, Hoppe-Seyler-Str. 1, 72072, Tübingen, Germany.

Background: Rare and severe neurological disorders in childhood not only heavily affect the life perspective of the patients, but also their caregivers and families. The aim of this study was to investigate the impact of such diseases on the family, especially on the quality of life and life perspectives of parents, but also on the families' everyday life, based on the model of two diseases which have been well described in recent years with respect to symptoms and course: metachromatic leukodystrophy (MLD) and pontocerebellar hypoplasia type 2 (PCH2). PCH2 is a primary severe developmental disorder, while children with MLD initially develop normally and then progressively deteriorate. Read More

View Article and Full-Text PDF

Electrostatic Self-Assembly Synthesis of Three-Dimensional Mesoporous Lepidocrocite-Type Layered Sodium Titanate as a Superior Adsorbent for Selective Removal of Cationic Dyes via an Ion-Exchange Mechanism.

Langmuir 2021 May 9. Epub 2021 May 9.

Department of Advanced Materials Science, Faculty of Engineering and Design, Kagawa University, 2217-20 Hayashi-cho, Takamatsu 761-0396, Japan.

Three-dimensional mesoporous lepidocrocite-type layered sodium titanate (LST) was constructed at room temperature by the electrostatic interaction between TiO nanosheets and Na ions. The results of a systematic X-ray diffraction investigation manifested the transition from the TiO nanosheets phase to the titanate/titania phase, which determined a phase diagram as a function of the temperature and NaCl concentration. In addition, scanning electron microscopy, inductively coupled plasma-mass spectrometry, thermogravimetric and differential thermal, N adsorption-desorption, Raman spectroscopy, Fourier transform infrared spectroscopy, as well as ζ-potential analyses were utilized for adequate characterization of the LST physical and chemical properties. Read More

View Article and Full-Text PDF

Predictive Factors for Live Birth in Fresh Fertilization/Intracytoplasmic Sperm Injection Treatment in Poor Ovarian Reserve Patients Classified by the POSEIDON Criteria.

Front Endocrinol (Lausanne) 2021 12;12:630832. Epub 2021 Apr 12.

Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

The mechanisms underlying poor ovarian response (POR) in assisted reproductive technology remain unclear, there is no consensus on the management of poor responders, the POSEIDON stratification classifies infertility patients into "expected" or "unexpected" groups to provide a more nuanced picture of POR, but few researchers have discussed the independent predictive factors (smoothed plots and the threshold effect) for live birth in POR patients classified by the new criteria. We conducted a retrospective cohort study using clinical data from 6,580 POR patients classified by the POSEIDON criteria in the First Affiliated Hospital of Zhengzhou University, and explored the live birth based on the results before and after the threshold inflection point of each independent influencing factor. Among 6,580 poor ovarian reserve patients classified by the POSEIDON criteria, 1,549 (23. Read More

View Article and Full-Text PDF

Rheological and textural properties of acid-induced soybean protein isolate gel in the presence of soybean protein isolate hydrolysates or their glycosylated products.

Food Chem 2021 Apr 30;360:129991. Epub 2021 Apr 30.

College of Food Science, Sichuan Agricultural University, No. 46, Xinkang Road, Ya'an 625014, Sichuan, PR China. Electronic address:

Enzymatic hydrolysis and glycosylation were successively applied to modify soybean protein isolate (SPI) and rheological and textural properties of acid-induced SPI gel added with the obtained SPI hydrolysates and their glycosylated products were then investigated. The incorporation of SPI hydrolysates decreased the elastic modulus (G') and hardness of SPI gel, which might be related to the random aggregation between SPI hydrolysates and native SPI molecules via hydrophobic interactions. In addition, as the molecular weight of SPI hydrolysates decreased, the reduction in G' and hardness became more significant. Read More

View Article and Full-Text PDF

NAC domain gene VvNAC26 interacts with VvMADS9 and influences seed and fruit development.

Plant Physiol Biochem 2021 Apr 30;164:63-72. Epub 2021 Apr 30.

State Key Laboratory of Crop Stress Biology in Arid Areas, College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China; Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China, Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address:

Grapevine (Vitis vinifera), as one of the potential gardening fruit have important economic and nutritional values. Seedless grapes are popular due to their convenience and excellent taste. As multifunctional proteins, the NAC family involves hormonal pathways, plant aging, and biological stress. Read More

View Article and Full-Text PDF

Directed Evolution of Unspecific Peroxygenase in Organic Solvents.

Biotechnol Bioeng 2021 May 8. Epub 2021 May 8.

Department of Biocatalysis, Institute of Catalysis, CSIC, Cantoblanco, Madrid, Spain.

Fungal unspecific peroxygenases (UPOs) are efficient biocatalysts that insert oxygen atoms into non-activated C-H bonds with high selectivity. Many oxyfunctionalization reactions catalyzed by UPOs are favored in organic solvents, a milieu in which their enzymatic activity is drastically reduced. Using as departure point the UPO secretion mutant from Agrocybe aegerita (PaDa-I variant), in the current study we have improved its activity in organic solvents by directed evolution. Read More

View Article and Full-Text PDF

Preparation of new hydrophobic deep eutectic solvents and their application in dispersive liquid-liquid microextraction of Sudan dyes from food samples.

Anal Bioanal Chem 2021 May 8. Epub 2021 May 8.

Department of Chemical Science & Technology, Kunming University, Kunming, 650214, Yuannan, China.

In this work, a new generation of hydrophobic deep eutectic solvents (DESs) was prepared using eugenol (as hydrogen bond donor) and benzyltriethylammonium bromide, benzyltributylammonium bromide, benzyltriethylammonium chloride and benzyltributylammonium chloride (as hydrogen bond acceptor) in different molar ratios. These DESs were applied to vortex-assisted dispersive liquid-liquid microextraction of Sudan dyes from food samples, followed by high-performance liquid chromatographic determination. The influencing parameters, including the type of DES, amount of DES, extraction time, solution pH and salt addition, were investigated and optimized. Read More

View Article and Full-Text PDF

Developmental effects of early-life stress on dopamine D2 receptor and proteins involved in noncanonical D2 dopamine receptor signaling pathway in the prefrontal cortex of male rats.

J Complement Integr Med 2021 May 7. Epub 2021 May 7.

Neurophysiology Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.

Objectives: Dopamine neurotransmission is implicated in multiple neuropsychiatric disorders, most strikingly in Parkinson's disease, bipolar disorder, attention-deficit hyperactivity disorder and schizophrenia. In addition to canonical pathway, D2-receptor (D2R) exerts some of its biological actions through regulating the activity of Akt and GSK3, which in turn were found to be altered in several psychiatric illnesses. The present study examined the impacts of maternal separation, an early-life stress model which has been associated with disturbed neurodevelopment and appearance of many psychiatric disorders, on developmental changes in dopamine concentration and the expression of D2Rs, Akt and GSK-3β in the medial prefrontal cortex (PFC; a key target of stress) in adolescent and young adult male rats. Read More

View Article and Full-Text PDF

Diabetes in a TB and HIV-endemic South African population: Analysis of a virtual cohort using routine health data.

PLoS One 2021 7;16(5):e0251303. Epub 2021 May 7.

Division of Computational Biology, Integrative Biomedical Sciences Department, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Background: It is widely accepted that people living with diabetes (PLWD) are at increased risk of infectious disease, yet there is a paucity of epidemiology studies on the relationship between diabetes and infectious disease in SSA. In a region with a high burden of infectious disease, this has serious consequences for PLWD.

Methods And Findings: Using routinely collected longitudinal health data, we describe the epidemiology of diabetes in a large virtual cohort of PLWD who have a high burden of HIV and TB, from the Khayelitsha subdistrict in the Western Cape Province in South Africa. Read More

View Article and Full-Text PDF

Studying factors influencing facial developmental instability.

Ann Hum Biol 2021 May 7:1-25. Epub 2021 May 7.

Department of Anthropology, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.

Background: Developmental instability is a component of non-genetic variation that results from random variation in developmental processes. It is considered a sensitive indicator of the physiological state of individuals. It is reflected in various ways, but in this study we focused on its reflection in fluctuating asymmetry (FA) and morphological integration. Read More

View Article and Full-Text PDF

A GWAS identifies novel gene associations with facial skin wrinkling and mole count in Latin-Americans.

Br J Dermatol 2021 May 6. Epub 2021 May 6.

Instituto de Alta Investigación, Universidad de Tarapacá, Arica, Arica, 1000000, Chile.

Background: Genome-wide association studies (GWAS) have identified genes influencing skin ageing and mole count in Europeans but little is known about the relevance of these (or other genes) in non-Europeans.

Objective: To conduct a GWAS for facial skin ageing and mole count in adults < 40 years old, of mixed European, Native American and African ancestry, recruited in Latin America.

Methods: Skin ageing and mole count scores were obtained from facial photographs of >6,000 individuals. Read More

View Article and Full-Text PDF

Contribution of the Gut Microbiome to Drug Disposition, Pharmacokinetic and Pharmacodynamic Variability.

Clin Pharmacokinet 2021 May 7. Epub 2021 May 7.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, San Diego, CA, 90293-0657, USA.

The trillions of microbes that make up the gut microbiome are an important contributor to health and disease. With respect to xenobiotics, particularly orally administered compounds, the gut microbiome interacts directly with drugs to break them down into metabolic products. In addition, microbial products such as bile acids interact with nuclear receptors on host drug-metabolizing enzyme machinery, thus indirectly influencing drug disposition and pharmacokinetics. Read More

View Article and Full-Text PDF

Low Intra-Individual Variation in Mean Platelet Volume Over Time in Systemic Lupus Erythematosus.

Front Med (Lausanne) 2021 20;8:638750. Epub 2021 Apr 20.

Section of Rheumatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Platelets have recently emerged as important immune modulators in systemic lupus erythematosus (SLE), in addition to their role in thrombosis and cardiovascular disease. However, studies investigating mean platelet volume (MPV) in SLE are often scarce, conflicting and cross-sectional. In this study, MPV was measured in clinical routine throughout a defined time-period to quantify both individual MPV fluctuations and investigate if such variations are associated with disease activity and clinical phenotypes of SLE. Read More

View Article and Full-Text PDF

MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD-Sirt1 pathway.

Stem Cell Res Ther 2021 May 6;12(1):271. Epub 2021 May 6.

The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, 126 Xin Min Street, Changchun, Jilin Province, People's Republic of China.

Background: Expansion-mediated replicative senescence and age-related natural senescence have adverse effects on mesenchymal stem cell (MSC) regenerative capability and functionality, thus severely impairing the extensive applications of MSC-based therapies. Emerging evidences suggest that microRNA-34a (miR-34a) has been implicated in the process of MSC senescence; however, the molecular mechanisms with regard to how miR-34a influencing MSC senescence remain largely undetermined.

Methods: MiR-34a expression in MSCs was evaluated utilizing RT-qPCR. Read More

View Article and Full-Text PDF

Factors influencing healthy menopause among immigrant women: a scoping review.

BMC Womens Health 2021 May 6;21(1):189. Epub 2021 May 6.

School of Nursing, University of South China, 28 Changshengxi Street, Hengyang, 421001, Hunan, China.

Background: Many factors influence the menopausal transition and the complexity of this transition increases with the addition of immigration transition. This review aims to identify the factors that influence the menopausal transition for immigrant women based on ecosocial theory.

Methods: A scoping review of English publications was conducted according to PRISMA guidelines using CINAHL, AgeLine, MEDLINE, PsycINFO, ERIC, Nursing and Allied Health Database, PsycARTICLES, Sociology Database, and Education Research Complete. Read More

View Article and Full-Text PDF

Tracking Ultrafast Structural Dynamics in a Dual-Emission Anti-Kasha-Active Fluorophore Using Femtosecond Stimulated Raman Spectroscopy.

J Phys Chem Lett 2021 May 6:4466-4473. Epub 2021 May 6.

School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.

The anti-Kasha process provides the possibility of using high-energy excited states to develop novel applications. Our previous research (Nature communications, 2020, 11, 793) has demonstrated a dual-emission anti-Kasha-active fluorophore for bioimaging application, which exhibits near-infrared emissions from the S state and visible anti-Kasha emissions from the S state. Here, we applied tunable blue-side femtosecond stimulated Raman spectroscopy (FSRS) and transient absorption spectroscopy, assisted by quantum calculations, to reveal the anti-Kasha dual emission mechanism, in which the emergence of two fluorescing states is due to the retardation of internal conversion from the S state to the S state. Read More

View Article and Full-Text PDF

Patients' Perception of Vitiligo Severity.

Acta Derm Venereol 2021 May 6. Epub 2021 May 6.

Department of Dermatology, Ghent University Hospital, BE-9000 Gent, Belgium. E-mail:

Identifying which factors contribute to vitiligo severity and determining their individual weight are important in the management of vitiligo. The aim of this study is to investigate the predictive variables concerning vitiligo severity as perceived by the patients. Based on a questionnaire, several factors that may contribute to the Patient Global Assessment (PtGA) of severity were investigated within a Belgian vitiligo population (n = 291). Read More

View Article and Full-Text PDF

Long noncoding RNAs in cancer metastasis.

Nat Rev Cancer 2021 May 5. Epub 2021 May 5.

Department of Internal Medicine, Washington University in St Louis, St Louis, MO, USA.

Metastasis is a major contributor to cancer-associated deaths. It is characterized by a multistep process that occurs through the acquisition of molecular and phenotypic changes enabling cancer cells from a primary tumour to disseminate and colonize at distant organ sites. Over the past decade, the discovery and characterization of long noncoding RNAs (lncRNAs) have revealed the diversity of their regulatory roles, including key contributions throughout the metastatic cascade. Read More

View Article and Full-Text PDF

Non-linear association of body composition and its components with bone density in Iranian children and adolescents.

Arch Osteoporos 2021 May 4;16(1):77. Epub 2021 May 4.

Endocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Postal Box, Shiraz, 71345-1414, Iran.

Peak bone mass is established during childhood. This study aimed to evaluate the associations of the components of overall body mass with areal bone mineral density Z-score in children. The findings of this study showed that children with greater overall body mass had higher aBMD Z-score. Read More

View Article and Full-Text PDF

Factors influencing thrombectomy decision making for primary medium vessel occlusion stroke.

J Neurointerv Surg 2021 May 4. Epub 2021 May 4.

Diagnostic Imaging, University of Calgary, Calgary, Alberta, Canada

Background: We aimed to explore the preference of stroke physicians to treat patients with primary medium vessel occlusion (MeVO) stroke with immediate endovascular treatment (EVT) in an international cross-sectional survey, as there is no clear guideline recommendation for EVT in these patients.

Methods: In the survey MeVO-Finding Rationales and Objectifying New Targets for IntervEntional Revascularization in Stroke (MeVO-FRONTIERS), participants were shown four cases of primary MeVOs (six scenarios per case) and asked whether they would treat those patients with EVT. Multivariable logistic regression with clustering by respondent was performed to assess factors influencing the decision to treat. Read More

View Article and Full-Text PDF

Cracks in consolidants containing TiO as a habitat for biological colonization: A case of quaternary bioreceptivity.

Mater Sci Eng C Mater Biol Appl 2021 May 25;124:112058. Epub 2021 Mar 25.

CINTECX, GESSMin Group, Departamento de Enxeñaría dos Recursos Naturais e Medio Ambiente, Escola de Enxeñaría de Minas e Enerxía, University of Vigo, Vigo 36310, Spain.

The recently proposed concept of quaternary bioreceptivity applies to substrates treated with coating materials and it is considered in the present study with the alga Bracteacoccus minor and the cyanobacterium Nostoc sp. onto granite specimens treated with ethyl silicate and nano-sized silica doped with different amounts of TiO (0, 0.5, 1 and 3 wt%). Read More

View Article and Full-Text PDF

Dutch Preadolescents' Food Consumption at School: Influence of Autonomy, Competence and Parenting Practices.

Nutrients 2021 Apr 29;13(5). Epub 2021 Apr 29.

Marketing and Consumer Behavior Group, Wageningen University and Research, 6706 KN Wageningen, The Netherlands.

Eating habits appear to become less healthy once children move into adolescence. Adolescence is characterized by increasing independence and autonomy. Still, parents continue influencing adolescents' eating habits. Read More

View Article and Full-Text PDF

Price Fairness of Processed Tomato Agro-Food Chain: The Italian Consumers' Perception Perspective.

Foods 2021 Apr 30;10(5). Epub 2021 Apr 30.

Department of Agricultural and Food Sciences, University of Bologna, Viale Fanin 50, 40137 Bologna, Italy.

Food consumers are increasingly searching for emotions and values when purchasing and consuming food. They search for products that ensure social and environmental sustainability, in addition to more common extrinsic product attributes, such as price, packaging, origin, and brand. In particular, there is increasing interest towards product price fairness. Read More

View Article and Full-Text PDF

Factors affecting revisit intention for medical services at dental clinics.

PLoS One 2021 4;16(5):e0250546. Epub 2021 May 4.

Department of Medical Humanities and Social Medicine, Ajou University School of Medicine, Suwon, South Korea.

Recent changes in the medical paradigm highlight the importance of patient-centered communication. However, because of the lack of awareness of dental clinics and competency of medical personnel, the quality of medical services in terms of the communication between doctors and patients has not improved. This study analyzed the impact of health communication and medical service quality, service value, and patient satisfaction on the intention to revisit dental clinics. Read More

View Article and Full-Text PDF

Dead or alive: microbial viability treatment reveals both active and inactive bacterial constituents in the fish gut microbiota.

J Appl Microbiol 2021 May 4. Epub 2021 May 4.

Faculty of Science Engineering and Built Environment, School of Life and Environmental Sciences, Deakin University, Geelong, Vic., Australia.

Aims: This study evaluated the microbial viability of fish gut microbiota in both digesta (faecal) and mucosal samples using a modified propidium monoazide (PMA) protocol, followed by 16S ribosomal RNA (rRNA) gene sequencing.

Methods And Results: Digesta and gut mucosal samples from farmed yellowtail kingfish (Seriola lalandi) were collected and a modified PMA treatment was applied prior to DNA extraction to differentiate both active and nonviable microbial cells in the samples. All samples were then sequenced using a standard 16S rRNA approach. Read More

View Article and Full-Text PDF

Choroid Plexus and Drug Removal Mechanisms.

AAPS J 2021 May 3;23(3):61. Epub 2021 May 3.

Department of Pharmaceutics, University of Washington, Health Science Building Room H-272J, Box 357610, Seattle, Washington, 98195-7610, USA.

Timely and efficient removal of xenobiotics and metabolites from the brain is crucial in maintaining the homeostasis and normal function of the brain. The choroid plexus (CP) forms the blood-cerebrospinal fluid barrier and vitally removes drugs and wastes from the brain through several co-existing clearance mechanisms. The CP epithelial (CPE) cells synthesize and secrete the cerebrospinal fluid (CSF). Read More

View Article and Full-Text PDF

Factors affecting interictal unilateral and bilateral discharges and ictal diffusion patterns of scalp electroencephalogram in temporal lobe epilepsy.

Neurol Sci 2021 May 4. Epub 2021 May 4.

Department of Neurology, Shengjing Hospital of China Medical University, 39 Huaxiang Road, Shenyang, 110022, China.

Background: The interictal discharges of temporal lobe epilepsy (TLE) can be unilateral or bilateral. In addition, the ictal electroencephalogram (EEG) showed the discharges also tend to spread to the contralateral brain in TLE.

Objective: The factors influencing unilateral and bilateral interictal discharges in TLE as well as ictal diffusion patterns in scalp EEG during onset of seizure were evaluated in the present study. Read More

View Article and Full-Text PDF

Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation.

Commun Biol 2021 May 3;4(1):517. Epub 2021 May 3.

Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Erythropoiesis involves complex interrelated molecular signals influencing cell survival, differentiation, and enucleation. Diseases associated with ineffective erythropoiesis, such as β-thalassemias, exhibit erythroid expansion and defective enucleation. Clear mechanistic determinants of what make erythropoiesis effective are lacking. Read More

View Article and Full-Text PDF

Spatial distribution of microplastics in the fluvial sediments of a transboundary river - A case study of the Tisza River in Central Europe.

Sci Total Environ 2021 Apr 26;785:147306. Epub 2021 Apr 26.

Department of Physical Geography and Geoinformatics, University of Szeged, Egyetem u. 2-6, Szeged 6722, Hungary.

The geographical environment fundamentally influences the transport and deposition of sediments, including microplastics. In addition, the socioeconomic differences inherent in transboundary catchments result in various waste management strategies among the different countries influencing the input of microplastics into rivers. The catchment of the Tisza River in Central Europe is shared by five countries with different economic statuses and wastewater treatment practices. Read More

View Article and Full-Text PDF

A data-driven framework for spatiotemporal characteristics, complexity dynamics, and environmental risk evaluation of river water quality.

Sci Total Environ 2021 Apr 16;785:147134. Epub 2021 Apr 16.

College of Water Sciences, Beijing Normal University, Beijing 100875, China; Chinese Research Academy of Environmental Sciences, Beijing 100012, China.

To evaluate the evolution of river water quality in a changing environment, measuring the objective water quality is critical for understanding the rules of river water pollution. Based on the sample entropy theory and a nonlinear statistical method, this study aims to identify the spatiotemporal dynamics of water quality and its complexity in the Yangtze River basin using time series data, to separate the contributions of human activity and climate change to water quality, and to establish a data-driven risk assessment framework for the spatial (potential risk) and temporal (direct risk) aspects of water pollution. The results demonstrate that the spatiotemporal dynamics of water quality and sample entropy in each monitoring section are closely related to the characteristics of the corresponding location. Read More

View Article and Full-Text PDF