Biomed Pharmacother 2021 Jun 9;138:111465. Epub 2021 Apr 9.
Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province 563003, China; Digestive Disease Institute of Guizhou Province, Zunyi, Guizhou Province 563003, China; Endoscopy center, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province 563003, China. Electronic address:
Acidic mammalian chitinase (CHIA) belongs to the 18-glycosidase family and is expressed in epithelial cells and certain immune cells (such as neutrophils and macrophages) in various organs. Under physiological conditions, as a hydrolase, CHIA can degrade chitin-containing pathogens, participate in Type 2 helper T (Th2)-mediated inflammation, and enhance innate and adaptive immunity to pathogen invasion. Under pathological conditions, such as rhinitis, ocular conjunctivitis, asthma, chronic atrophic gastritis, type 2 diabetes, and pulmonary interstitial fibrosis, CHIA expression is significantly changed. Read More