17,151 results match your criteria addition endoscopic

Sporadic fundic gland polyps with dysplasia or carcinoma: Clinical and endoscopic characteristics.

World J Gastrointest Oncol 2021 Jul;13(7):662-672

Gastrointestinal Center, Sano Hospital, Kobe 655-0031, Hyogo, Japan.

Fundic gland polyps (FGPs) are the most common gastric polyps and have been regarded as benign lesions with little malignant potential, except in the setting of familial adenomatous polyposis. However, in recent years, the prevalence of FGPs has been increasing along with the widespread and frequent use of proton pump inhibitors (PPIs). To date, several cases of FGPs with dysplasia or carcinoma (FGPD/CAs) have been reported. Read More

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Simultaneous Endoscopic Management of Urethral Duplication and Postposterior Sagittal Anorectoplasty Urethral Diverticulum in a Boy with Anorectal Malformation.

J Indian Assoc Pediatr Surg 2021 May-Jun;26(3):200-202. Epub 2021 May 17.

Department of Paediatric Surgery, Maulana Azad Medical College, Associated Lok Nayak Hospital, New Delhi, India.

We report a case of urethral duplication with high anorectal malformation (ARM). A 12-year-old boy who had undergone transverse colostomy on day 2 of life and posterior sagittal anorectoplasty (PSARP) for ARM (rectobulbar fistula) at 8 years and also had urinary dribbling from a midscrotal opening in addition to normal voiding, presented with recurrent urinary tract infections and dysuria. Midscrotal dribbling had continued postoperatively. Read More

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Video Consent for Colonoscopy Improves Knowledge Retention and Patient Satisfaction: A Randomized Controlled Study.

J Clin Gastroenterol 2021 Jul 28. Epub 2021 Jul 28.

Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute Department of Internal Medicine, Community Care Institute, Cleveland Clinic, Cleveland, OH.

Background And Aim: Informed consent for endoscopy is variable across institutions and remains understudied in gastrointestinal endoscopy. This study aims to standardize informed consent for screening and diagnostic colonoscopies with a supplemental video tool that includes the key components of informed consent.

Methods: A video tool was developed that incorporated the key components of informed consent for colonoscopy. Read More

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Endoscopic Transcortical Selective Amygdalohippocampectomy for Mesial Temporal Lobe Epilepsy: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Jul 28. Epub 2021 Jul 28.

Department of Neurosurgery, Graduate School of Medicine, Osaka City University, Osaka, Japan.

This surgical video shows a 19-yr-old woman with focal impaired awareness seizures. Seizure semiology showed no lateralizing signs. Ictal electroencephalography (EEG) failed to determine the seizure origin. Read More

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Endoscopic ultrasonography-guided hepaticogastrostomy using a novel laser-cut type partially covered self-expandable metal stent (with video).

Dig Endosc 2021 Jul 28. Epub 2021 Jul 28.

2nd Department of Internal Medicine, Osaka Medical College, Osaka, Japan.

Endoscopic ultrasonography (EUS)-guided hepaticogastrostomy (HGS) is of clinical benefit in patients with failed endoscopic retrograde cholangiopancreatography (ERCP). However, some endoscopists are concerned about the potential risk of adverse events. Bile peritonitis due to bile leakage through the fistula is one of the possible adverse events following EUS-HGS. Read More

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The role of computer-assisted systems for upper-endoscopy quality monitoring and assessment of gastric lesions.

Gastroenterol Rep (Oxf) 2021 Jun 12;9(3):185-204. Epub 2021 Mar 12.

Department VII of Internal Medicine II, Discipline of Gastroenterology and Hepatology, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Romania, Timișoara, Romania.

This article analyses the literature regarding the value of computer-assisted systems in esogastroduodenoscopy-quality monitoring and the assessment of gastric lesions. Current data show promising results in upper-endoscopy quality control and a satisfactory detection accuracy of gastric premalignant and malignant lesions, similar or even exceeding that of experienced endoscopists. Moreover, artificial systems enable the decision for the best treatment strategies in gastric-cancer patient care, namely endoscopic vs surgical resection according to tumor depth. Read More

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Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer.

Sci Rep 2021 Jul 27;11(1):15282. Epub 2021 Jul 27.

Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Yonago, Tottori, 683-8504, Japan.

The tumour microenvironment (TME) plays an important role in cancer development, progression, and metastasis. Various cytokines are present in the TME in oesophageal cancer. Oesophageal stricture is a major complication of endoscopic submucosal dissection (ESD) for oesophageal cancer, and inflammatory cytokines are closely related to its pathogenesis. Read More

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Lumen-apposing metal stents (with videos).

Gastrointest Endosc 2021 Jul 23. Epub 2021 Jul 23.

Division of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA.

Background And Aims: Lumen-apposing metal stents (LAMSs) are a novel class of devices that have expanded the spectrum of endoscopic GI interventions. LAMSs with their dumbbell configuration, short saddle length, and large inner luminal diameter provide favorable stent characteristics to facilitate anastomosis formation between the gut lumen and adjacent structures.

Methods: The MEDLINE database was searched through April 2021 for articles related to LAMSs by using additional relevant keywords such as "walled-off pancreatic necrosis," "pseudocysts," "pancreatic fluid collection," "cholecystitis," "gastroenterostomy," in addition to "endoscopic treatment" and "endoscopic management," among others. Read More

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Physiological and pathophysiological roles of acidic mammalian chitinase (CHIA) in multiple organs.

Biomed Pharmacother 2021 Jun 9;138:111465. Epub 2021 Apr 9.

Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province 563003, China; Digestive Disease Institute of Guizhou Province, Zunyi, Guizhou Province 563003, China; Endoscopy center, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province 563003, China. Electronic address:

Acidic mammalian chitinase (CHIA) belongs to the 18-glycosidase family and is expressed in epithelial cells and certain immune cells (such as neutrophils and macrophages) in various organs. Under physiological conditions, as a hydrolase, CHIA can degrade chitin-containing pathogens, participate in Type 2 helper T (Th2)-mediated inflammation, and enhance innate and adaptive immunity to pathogen invasion. Under pathological conditions, such as rhinitis, ocular conjunctivitis, asthma, chronic atrophic gastritis, type 2 diabetes, and pulmonary interstitial fibrosis, CHIA expression is significantly changed. Read More

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pH and specific gravity of corrosive agents as indicators in caustic injuries.

Pediatr Int 2021 Jul 23. Epub 2021 Jul 23.

Mersin University, Faculty of Medicine, Department of Pediatric Surgery, Mersin, Turkey.

Background: Video endoscopy, which remains the diagnostic gold standard after ingestion of a corrosive substance, is performed under general anesthesia in children, requires advanced technology, and is costly. Therefore, simple and accessible methods are needed to determine the need for endoscopy. The aim of this study was to evaluate the role of pH and specific gravity of ingested substance in determining endoscopy indications after corrosive ingestion. Read More

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Post-COVID-19 rhino-orbito-cerebral mucormycosis: a new addition to challenges in pandemic control.

Eur Arch Otorhinolaryngol 2021 Jul 26. Epub 2021 Jul 26.

Institute of Otorhinolaryngology and Head & Neck Surgery, Institute of Post-Graduate Medical Education & Research, Kolkata, India.

Objective: To document and analyse demographic data, clinical presentation, possible interventions for early clinical detection and management of post-COVID-19 rhino-orbito-cerebral mucormycosis (ROCM).

Method: 32 patients having history of SARS-CoV-2 infection with features of ROCM were observed in terms of their history, presenting features, clinical, microbiological examination, type of surgical intervention, surgical sites of involvement which were subsequently analyzed.

Results: The mean (± S. Read More

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Artificial Intelligence Enhances Studies on Inflammatory Bowel Disease.

Front Bioeng Biotechnol 2021 8;9:635764. Epub 2021 Jul 8.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD), is an idiopathic condition related to a dysregulated immune response to commensal intestinal microflora in a genetically susceptible host. As a global disease, the morbidity of IBD reached a rate of 84.3 per 100,000 persons and reflected a continued gradual upward trajectory. Read More

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Surgical Treatment of Sinonasal Mucosal Melanoma in Patients Treated with Systemic Immunotherapy.

J Neurol Surg B Skull Base 2021 Jul 7;82(Suppl 3):e148-e154. Epub 2020 Feb 7.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania, United States.

 Surgical resection is widely accepted as a critical component for definitive treatment of sinonasal mucosal melanoma. Systemic immunotherapy, including multiple newer agents, has been used to treat metastatic or unresectable disease. In this study, we examine its efficacy in locoregional control when used in conjunction with surgical resection for primary mucosal lesions. Read More

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Long non-coding RNA B3GALT5-AS1 contributes to the progression of gastric cancer via interacting with CSNK2A1.

Exp Ther Med 2021 Sep 30;22(3):927. Epub 2021 Jun 30.

Center of Digestive Endoscopy, Tianjin Fifth Central Hospital, Tianjin 300451, P.R. China.

Gastric cancer is a type of cancer that is characterized by high morbidity and mortality rates. Long non-coding RNA (lncRNA) β-1,3-galactosyltransferase 5-AS1 (B3GALT5-AS1) was previously found to be highly expressed in the serum of patients with gastric cancer. However, the regulatory effects of B3GALT5-AS1 in gastric cancer remain poorly understood. Read More

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September 2021

Current Status of Image-Enhanced Endoscopy for Early Identification of Esophageal Neoplasms.

Clin Endosc 2021 Jul 26. Epub 2021 Jul 26.

Digestive Disease Center and Research Institute, Department of Internal Medicine, Department of Biostatistics, Soonchunghyang University School of Medicine, Bucheon, Korea.

Advanced esophageal cancer is known to have a poor prognosis. The early detection of esophageal neoplasms, including esophageal dysplasia and early esophageal cancer, is highly important for the accurate treatment of the disease. However, esophageal dysplasia and early esophageal cancer are usually subtle and can be easily missed. Read More

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Identification of Blood-Based Biomarkers for the Prediction of the Response to Neoadjuvant Chemoradiation in Rectal Cancer.

Cancers (Basel) 2021 Jul 20;13(14). Epub 2021 Jul 20.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

The current standard of care for patients with locally advanced rectal cancer (LARC) is neoadjuvant chemoradiation (nCRT) followed by total mesorectal excision surgery. However, the response to nCRT varies among patients and only about 20% of LARC patients achieve a pathologic complete response (pCR) at the time of surgery. Therefore, there is an unmet need for biomarkers that could predict the response to nCRT at an early time point, allowing for the selection of LARC patients who would or would not benefit from nCRT. Read More

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Modified Tumor Budding as a Better Predictor of Lymph Node Metastasis in Early Gastric Cancer: Possible Real-World Applications.

Cancers (Basel) 2021 Jul 7;13(14). Epub 2021 Jul 7.

Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

Endoscopic resection (ER) is a minimally invasive treatment for early gastric cancer (EGC) with a low risk of lymph node metastasis (LNM). Recently, tumor budding (TB) has emerged as a potential predictor of LNM in EGC. We assessed the clinical significance of modified TB (mTB) that excludes the signet ring cell component and compared several TB assessment methods. Read More

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Narrative review of penile distal urethroplasties and suggestions for optimizing outcomes.

Transl Androl Urol 2021 Jun;10(6):2609-2616

University of Lisbon, Lisbon, Portugal.

Distal urethral strictures can be a challenging entity for urologists. Endoscopic maneuvers such as optical internal urethrotomies or dilations are even less successful than in other urethral locations and the repeated trauma will increase the scarring which advocates for a urethroplasty as primary option for patient management. Success rates of distal urethroplasties have been lower than those for other urethral strictures due to the anatomy of the distal urethra with a very thin corpus spongiosum associated with decreased mucosal blood supply. Read More

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Acute gastrointestinal bleeding: proposed study outcomes for new randomised controlled trials.

Aliment Pharmacol Ther 2021 Jul 20. Epub 2021 Jul 20.


Background: Acute gastrointestinal bleeding (GIB) remains a common cause of hospitalisation. However, interpretation and comparisons of published studies in GIB have been hampered by disparate study methodology.

Aims: To make recommendations about outcome measures to be used in future randomised controlled trials (RCTs) of patients with acute bleeding from any GI source (nonvariceal UGI, variceal, small bowel, or colon) and suggest new RCTs in acute GIB for future peer-reviewed funding. Read More

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Pediatric stone disease: Current management and future concepts.

Turk Arch Pediatr 2021 Mar 3;56(2):99-107. Epub 2021 Feb 3.

Department of Urology, İstanbul University-Cerrahpaşa, Cerahpaşa Faculty of Medicine, İstanbul, Turkey.

Treatment of pediatric urolithiasis consists of medical and surgical approaches. The main goal of the treatment is to prevent stone recurrence by avoiding multiple surgical interventions. In recent years, many innovations have been reported in the medical diagnostic evaluation protocol and in surgical treatment. Read More

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Long-term outcomes of antibiotic combination therapy for ulcerative colitis.

Ther Adv Chronic Dis 2021 6;12:20406223211028790. Epub 2021 Jul 6.

Department of Microbiota Research, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan Department of Gastroenterology and Hepatology, The Jikei University Kashiwa Hospital, Chiba, Japan.

Aims: An antibiotic combination of amoxicillin, tetracycline and metronidazole (ATM) is effective for ulcerative colitis (UC), but this regimen is discontinued in some cases due to adverse events. This study aimed to assess a revised combination, namely, amoxicillin, fosfomycin and metronidazole (AFM), in UC patients with the goal of reducing side effects while maintaining therapeutic efficacy.

Methods: A prospective open-label trial was undertaken in 104 adult UC patients. Read More

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[Position paper on endoscopic reporting in IBD].

Z Gastroenterol 2021 Jul 20. Epub 2021 Jul 20.

Medizinische Klinik 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

The complete and reliable documentation of endoscopic findings make up the crucial foundation for the treatment of patients with inflammatory bowel diseases such as Crohn´s disease and ulcerative colitis. These findings are, on the one hand, a prerequisite for therapeutic decisions and, on the other hand, important as a tool for assessing the response to ongoing treatments. Endoscopic reports should, therefore, be recorded according to standardized criteria to ensure that the findings of different endoscopists can be adequately compared and that changes in the course of the disease can be traced back. Read More

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A novel prognostic model based on epithelial-mesenchymal transition-related genes predicts patient survival in gastric cancer.

World J Surg Oncol 2021 Jul 19;19(1):216. Epub 2021 Jul 19.

Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Background: Gastric cancer (GC) represents a major malignancy and is the third deathliest cancer globally. Several lines of evidence indicate that the epithelial-mesenchymal transition (EMT) has a critical function in the development of gastric cancer. Although plentiful molecular biomarkers have been identified, a precise risk model is still necessary to help doctors determine patient prognosis in GC. Read More

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Novel Transgastric Endoluminal Segmental Esophagectomy and Primary Anastomosis Technique: A Hybrid Transgastric Thoracoscopic Esophagectomy for the Treatment of High Grade Dysplasia and Early Esophageal Cancer in a Porcine Model.

Front Surg 2021 1;8:676031. Epub 2021 Jul 1.

The Azrieli Faculty of Medicine, Bar-Ilan University, Tzfat, Israel.

Multiple modalities are currently employed in the treatment of high grade dysplasia and early esophageal carcinoma. While they are the subject of ongoing investigation, surgery remains the definitive modality for oncological resection. Esophagectomy, however, is traditionally a challenging surgical procedure and carries a significant incidence of morbidity and mortality. Read More

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A Rare Cause of Chronic Liver Disease Diagnosed by Endoscopic Ultrasound-Guided Liver Biopsy.

Am J Case Rep 2021 Jul 19;22:e933002. Epub 2021 Jul 19.

Haya Al-Habeeb Gastroenterology and Hepatology Center, Mubarak Al-Kabeer Hospital, Jabriyah, Kuwait.

BACKGROUND Elevated liver enzymes is a common clinical problem with many possible etiologies, yet some are rare and can be missed. Patients with sickle cell disease (SCD) may be at risk of liver disease due to recurrent blood transfusion predisposing to viral hepatitis. Furthermore, recurrent transfusions can increase the risk of iron overload, which can create deposits in the liver, eventually resulting in chronic liver disease. Read More

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Primary hypogammaglobulinemia with IBD-like features: An ECCO CONFER Multicenter Case Series.

J Crohns Colitis 2021 Jul 18. Epub 2021 Jul 18.

Gastroenterology Department, Sheba Medical Center and Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Background: Hypogammaglobulinemia is a disorder characterized by low serum immunoglobulin levels and had high prevalence of gastrointestinal manifestations. In some cases, clinical and endoscopic features are indistinguishable from those of inflammatory bowel disease (IBD).

Methods: This was a multicenter case series performed as a part of the European Crohn's and Colitis Organisation (ECCO) Collaborative Network of Exceptionally Rare case reports (CONFER) project. Read More

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Eosinophilic gastrointestinal disorders in children and adolescents: A single-center experience.

Dig Liver Dis 2021 Jul 14. Epub 2021 Jul 14.

Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy. Electronic address:

Background: To date, few studies have been conducted in Italy on pediatric eosinophilic gastrointestinal diseases (EGIDs).

Aims: To assess clinical features of pediatric patients with EGIDs who are followed in a tertiary pediatric center.

Methods: From January 2015 to December 2019, we retrospectively enrolled patients with EGIDs, and collected clinical, endoscopic, and histological data. Read More

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Sodium butyrate alleviates cholesterol gallstones by regulating bile acid metabolism.

Eur J Pharmacol 2021 Jul 14;908:174341. Epub 2021 Jul 14.

Shanghai Jiao Tong University Affiliated Sixth People's Hospital, School of Medicine, Shanghai, China; Digestive Endoscopic Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, China. Electronic address:

Cholesterol overloading and bile acid metabolic disorders play an important role in the onset of cholesterol gallstone (CGS). Short-chain fatty acids (SCFAs) can regulate bile acid metabolism by modulating the gut microbiota. However, the role and mechanism by which sodium butyrate (NaB) targets bile acids to attenuate CGS are still unknown. Read More

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The Toronto Ibd Global Endoscopic Reporting (Tiger) Score: A Single, Easy To Use Endoscopic Score For Both Crohn's Disease And Ulcerative Colitis Patients.

J Crohns Colitis 2021 Jul 17. Epub 2021 Jul 17.

Mount Sinai Hospital, Zane Cohen Centre for Digestive Diseases; Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, Canada.

Background And Aims: We constructed the Toronto IBD global endoscopic reporting (TIGER) score for inflammatory bowel disease (IBD). The aim of our study was to develop and validate the TIGER score against fecal calprotectin (FC), C-reactive protein (CRP) and IBD Disk.

Methods: A cross-sectional study was performed among 113 adult patients (60 CD and 53 UC). Read More

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